Journal of Korean Society for Atmospheric Environment (한국대기환경학회지)

Korean Society for Atmospheric Environment (한국대기환경학회)
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Relationship Between Exposure to Air Pollutants and Aggravation of Childhood Asthma : A Meta-Analysis

메타분석을 적용한 대기오염과 소아 천식 관련 입원의 상관성 평가 연구

  • Cho, Yong-Sung (Institute of Environmental and Industrial Medicine, Hanyang University) ;
  • Kim, Ho (Graduate School of Public Health, Seoul National University) ;
  • Lee, Jong-Tae (Institute of Environmental and Industrial Medicine, Hanyang University) ;
  • Hyun, Youn-Joo (Institute of Environmental and Industrial Medicine, Hanyang University) ;
  • Kim, Yoon-Shin (Institute of Environmental and Industrial Medicine, Hanyang University)
  • 조용성 (한양대학교 환경 및 산업의학연구소) ;
  • 김호 (서울대학교 보건대학원) ;
  • 이종태 (한양대학교 환경 및 산업의학연구소) ;
  • 현연주 (한양대학교 환경 및 산업의학연구소) ;
  • 김윤신 (한양대학교 환경 및 산업의학연구소)
  • Published : 2001.10.01
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Abstract

This study is based on the uses meta-analysis methodology to examine the statistical consistency and importance of random variation among results of epidemiologic studies between air pollutants exposure and childhood asthma. Studies for this meta-analysis were conducted by reviewing previous results and by asking researcher active in this field for recommendations. Overall, 10 cases of air pollutants exposures and childhood asthma were reviewed. A variety of statistical methods for meta-analysis have been used to assess the combined effects, to identify heterogeneity, and to provide a single summary risk estimate based on a set of simiar epidemiologic studies. In this study, classification of exposure metircs on air environmental epidemiologic studies are reported for (1) aggravation of childhood asthma by a 50 ppb increase SO$_2$(6 individual studies); (2) aggravation of childhood asthma by a 50 ppb increase NO$_2$(5 individual studies); (3) aggravation of childhood asthma by a 50 ppb increase $O_3$(7 individual studies); (4) aggravation of childhood asthma by a 10$\mu\textrm{g}$/m$^3$increase PM$_{10}$ (4 individual studies); (5) aggravation of childhood asthma by a 1 ppm increase CO (2 individual studies); and (6) comparison of results between a Korean study results and this meta-analytic study. Results of this study indicated that an inverse-variance weighted pooling of the hospital admission risk at a 1ppm increment of CO levels was 1.12% (95% CI : 1.01 ~ 1.24). The hospital admission risk was estimated to increase 5% (95% CI : 1.02~1.08), 6%(95% CI : 1.04~1.09), and 5% (95% CI : 1.02~1.09) with each 50ppb increase of SO$_2$, NO$_2$, and $O_3$, respectively. In addition, our results lead to a small but significant elevation in risk of 2% (RR = 1.02, 95% CI = 1.01~1.04) with each 10$\mu\textrm{g}$/m$^3$increase of PM$_{10}$ among 4 individual studies. We found a small elevation in risk of childhood asthma, and pooled results of 10 epidemiologic studies of childhood asthma using increase a cut-off-point levels of air pollutants showed a few pieces of evidence. The results of this meta-analysis suggested that air pollution associated with an increased incidence of childhood asthma. According to this study, relationship between exposure to air pollutants and childhood asthma in Korea seem to be high than results of this meta-analysis.sis.

Keywords

References

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