• Bulletin of the Korean Chemical Society
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• 제35권7호
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• pp.2097-2108
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• 2014

Chemical feature based quantitative pharmacophore models were generated using the HypoGen module implemented in DS2.5. The best hypothesis, Hypo1, which was characterized by the highest correlation coefficient (0.96), the highest cost difference (61.60) and the lowest RMSD (0.74), consisted of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic and one ring aromatic. The reliability of Hypo1 was validated on the basis of cost analysis, test set, Fischer's randomization method and GH test method. The validated Hypo1 was used as a 3D search query to identify novel inhibitors. The screened molecules were further refined by employing ADMET, docking studies and visual inspection. Three compounds with novel scaffolds were selected as the most promising candidates for the designing of Mcl-1 antagonists. Finally, a 10 ns molecular dynamics simulation was carried out on the complex of receptor and the retrieved ligand to demonstrate that the binding mode was stable during the MD simulation.

• 공학교육연구
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• 제23권4호
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• pp.14-21
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• 2020

The aim of this study was to establish an university informal program roadmap, and also to draw up operational plans for human resources with core technologies of the fourth industry. To do this, first we derived university informal education program draft through experts workshop, then conducted a survey regarding the female university students' perception of educational programs and their educational needs on the 4th core technology matching programs. The following main results were obtained : First, students preferred 'hands-on training' by professionals and they wanted to be trained during summer or winter holidays or the night time during semesters. Also, they thought two hours of training per session was appropriate. Regarding these results, there was no difference depending on the majors. Second, while students had highly preferred for the courses related to data analysis, Arduino programing and VR(virtual reality), those related to 3D printing modeling were less preferred. Depending on the majors, preferred courses had different priorities, but non-preferred courses were similar regardless of majors. Based on these results, the university informal curriculum model and the operation plans for the core technologies of the fourth industry were proposed.

• International journal of advanced smart convergence
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• 제5권4호
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• pp.21-25
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• 2016

Recent development in multi-channel surround is emerging in various formats to provide better stereoscopic and sound effects to consumers in recent broadcasting. The ability sound localize the sound sources in space is most considerable design factor on multi-channel surround system for human earing perception model. However, this paper propose the change of the sound localization according to the spacing of the speakers, which is not covered in the existing research focus on sound system design. Presently the sound system uses the position and number of the speakers to localize the sound. In the multi-channel surround environment, the proposed design uses the sound localization is caused by the directional characteristics of the speaker, the distance between the speakers and the distance between the listener and the speaker according to the directivity is required. The proposed design is simulated using virtual measurement with MATLAB simulation environment and performances are measured.

• 복식문화연구
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• 제14권1호
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• pp.40-47
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• 2006

Three-dimensional body scanners were used for years in the clothing manufacturing fields. The 3D body surface provide essential data to draft patterns for mass customization, virtual fit model, and computerized patternmaking systems. This research proposed the methods of drafting patterns for men's jacket by using three dimensional body scan data. Eight male subjects were scanned, the surface data was flattened. The differentials of the flattened body surface and the jacket draft were measured, and analyzed the regressions. To verify the fit of the patterns, the jacket was constructed by the regression formulae and tested by experts. The fit of the jacket were significantly improved rather than a ready-made suit especially the shoulder areas. This means that the methods that we proposed were good to improve the fit of the garments and could be used effectively to implement mass customization strategies in the apparel retail industry.

• Earthquakes and Structures
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• 제13권5호
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• pp.509-518
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• 2017

The objective of the present paper is to investigate the bending behavior with stretching effect of carbon nanotube-reinforced composite (CNTRC) beams. The beams resting on the Pasternak elastic foundation, including a shear layer and Winkler spring, are considered. The single-walled carbon nanotubes (SWCNTs) are aligned and distributed in polymeric matrix with different patterns of reinforcement. The material properties of the CNTRC beams are estimated by using the rule of mixture. The significant feature of this model is that, in addition to including the shear deformation effect and stretching effect it deals with only 4 unknowns without including a shear correction factor. The single-walled carbon nanotubes (SWCNTs) are aligned and distributed in polymeric matrix with different patterns of reinforcement. The material properties of the CNTRC beams are assessed by employing the rule of mixture. The equilibrium equations have been obtained using the principle of virtual displacements. The mathematical models provided in this paper are numerically validated by comparison with some available results. New results of bending analyses of CNTRC beams based on the present theory with stretching effect is presented and discussed in details. the effects of different parameters of the beam on the bending responses of CNTRC beam are discussed.

• 한국CDE학회논문집
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• 제14권4호
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• pp.242-253
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• 2009

Nowadays, manufacturing industry has been making its effort not only for productivity elevation but also for cost reduction in order to survive in the global market which is more and more challenging. In this paper, the method for planning of digital manufacturing system is proposed and door trim assembly system is determined as the subject of our research. First of all, the process sequence is generated based on the product analysis. And, the static and dynamic relationships between system components are represented using IDEF0 and UML model. The working time is estimated through the regression analysis based on MODAPTS method. According to the system configuration strategy, initial concept system layout is implemented 3D virtual environment. The problems caused by bad working motions are detected and modified through the ergonomic analysis using RULA method. According to proposed procedure, digital door trim assembly system is implemented in DLEMIA.

• Steel and Composite Structures
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• 제49권4호
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• pp.393-405
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• 2023

In this paper, the energy absorption capability of a novel cruciform composite lattice structure was evaluated through the simulation of compression tests. For this purpose, several test samples of Polylactic acid cellular reinforced with continuous glass fibers were prepared for compression testing using the additive manufacturing method of material extrusion. Using a conventional path design for material extrusion, multiple debonding is probable to be occurred at the joint regions of adjacent cells. Therefore, an innovative printing path design was proposed for the cruciform lattice structure. Afterwards, quasistatic compression tests were performed to evaluate the energy absorption behaviour of this structure. A finite element model based on local material property degradation was then developed to verify the experimental test and extend the virtual test method. Accordingly, different combinations of unit cells' dimensions using the design of the experiment were numerically proposed to obtain the optimal configuration in terms of the total absorbed energy. Having brilliant energy absorption properties, the studied cruciform lattice with its optimized unit cell dimensions can be used as an energy absorber in crashworthiness applications. Finally, a cellular structure will be suitable with optimal behavior in crush load efficiency and high energy absorption.

• 전자공학회논문지
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• 제54권8호
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• pp.67-80
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• 2017

본 논문에서는 추정된 시공간 배경 정보를 이용하여 자유 시점에서 합성영상을 생성하기 위한 홀채움 방식을 제안한다. 시간적 배경 정보를 추정하기 위해 비겹침 패치 기반의 배경 코드북을 이용한 새로운 시간적 배경 모델을 소개한다. 더불어, 공간적 배경 후보의 하한 및 상한 값의 제약 조건을 설정하는 깊이영상 기반 공간적 국부 배경 예측 방식에 대해 제안한다. 추정된 시간적 배경 정보와 공간적 배경 정보의 유사도를 비교하여 가려짐 배경 영역의 홀채움 과정을 수행한다. 또한 3-D 워핑 후 발생하는 컬러영상과 깊이영상간의 불일치 문제를 해결하기 위해 깊이영상 기반의 고스트 제거 필터를 기술한다. 마지막으로 잔여 홀을 채우기 위해 새로운 깊이 항을 포함한 우선순위 함수를 이용하여 인페인팅 방식이 적용된다. 실험 결과를 통해 기존의 홀채움 방식들과 비교하여 제안하는 방식의 객관적, 주관적 성능의 우수성을 확인할 수 있었다.

• 한국멀티미디어학회논문지
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• 제13권5호
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• pp.802-816
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• 2010

새로운 텍스트 입력으로부터 제스처를 생성하는 것은 컴퓨터 게임, 가상현실 등의 응용분야에서 종종 요구되는 중요한 문제이다. 최근에는 유명 아나운서와 같은 특정인의 제스처를 모방하는 제스처 스타일화에 관한 관심이 증가하고 있다. 그러나 기쁨이나 슬픔과 같은 감정을 이용하여 제스처를 스타일화하려는 시도는 많지 않다. 또한 이전의 연구는 대부분 실시간 알고리즘에 초점을 맞추고 있지 않다. 본 논문에서는 SMS 문장을 캐릭터 얼굴 표정과 제스처 애니메이션으로 자동 변환하고 감정 요소를 이용하여 제스처를 스타일화하는 시스템을 제안한다. 이 시스템의 가장 큰 특징은 제스처에 희로애락의 감정을 결합하는 실시간 알고리즘을 제시하는데 있다. 모바일 단말기를 플랫폼으로 하기 때문에 서버와 단말기에 작업을 적절하게 분배하고 초당 20프레임 이상의 실시간 수행을 보장한다. 먼저, 디즈니 영상에서 감정을 표현하는 단어와 이에 해당하는 제스처를 추출하고 통계적으로 모델링 한 후, 감정과 제스처의 결합을 위하여 Laban의 움직임 이론을 도입한다. 제안된 시스템의 타당성과 기존 서비스와의 대체 적정도를 알아보기 위해서 사용자 반응을 조사 분석한다.

• 한국항공우주학회지
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• 제43권10호
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• pp.920-927
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• 2015

본 논문에서는 블레이드 해석 라이브러리를 통해 단면해석 및 응력복원 해석 결과를 VABS의 결과와 비교하였다. 강성 행렬로 연결된 1차원 보 모델을 가상일의 원리에 의해 계산된 에너지를 복원 이론에 기반한 차원 복원해석 과정을 통해 계산된 응력과 3차원 해석모델과 비교하였다. 블레이드 해석 라이브러리의 구성, 입력 및 출력 형태, 차원 축소와 복원을 통한 로터 블레이드의 구조해석 프로시져를 기술하고, 블레이드 해석 라이브러리의 검증은 고형모델, 박 벽 모델의 단면해석, 3차원 복합재료 유한요소 모델로 구성하여 VABS를 통하여 검증하였다. 차원 축소와 복원해석을 통하여 블레이드 해석 라이브러리는 복합재료 블레이드의 전후처리 프로그램와 연계되어 고고도 무인기, 로터 블레이드, 풍력 블레이드 및 틸트로터 블레이드의 모델링에 활용될 수 있을 것이다.