• 한국토양비료학회지
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• 제7권4호
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• pp.221-225
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• 1974

일반(一般)밭 토양(土壤)에 있어서 대두(大豆) 재배시(栽培時) 근류균(根瘤菌)의 접종(接種) 효과와 질소(窒素) 시용량(施用量)과의 관계(關係)를 밝히고저 주구(主區)로 질소(窒素) 시용량(施用量) 0, 2, 6, 12kg/10a 사수준(四水準)으로 하고 세구(細區)로 근류균(根瘤菌) 접종(接種), 무접종(無接種)으로한 분할구배치(分割區配置) 사반복(四反覆)으로 포장시험(圃場試驗)을 실시(實施)한 결과(結果)는 다음과 같다. 1. 대두수량(大豆收量)은 유의성(有意性)있는 차이(差異)가 없이 질소시용양간(窒素施用量間) 거의 같았으며 근류균(根瘤菌) 접종간(接種間)에도 유의성(有意性)없는 차이(差異)였으나 근류균(根瘤菌)을 접종(接種)하므로서 야간(若干) 수량(收量)이 증수(增收)되었다. 2. 사엽기(四葉期) 및 개화기(開花期)에 근류(根瘤) 형성(形成) 정도(程度)를 보면 양시기(兩時期) 공(共)히 질소(窒素) 시용량(施用量)이 증가(增加)할수륵 유의성(有意性)있게 근류형성(根瘤形成)이 적었고 근류균 접종구(接種區)에서는 무접종(無接種)보다 근류(根瘤)의 형성(形成)은 유의성(有意性) 있게 많았고 생육상황(生育狀況)도 접종구(接種區)에서 무접종(無接種)보다 경장(莖長)이 컸으며 이러한 차이(差異)는 개화기(開花期) 보다도 사엽기(四葉期)에 커서 근류균(根瘤菌)의 접종효과는 초기(初期) 생육(生育)을 좋게 하는것 같았다. 3. 수확후(收穫後) 토양중(土壤中) 전질소(全窒素) 함량(含量)은 질소(窒素) 시용량(施用量)을 증가(增加)할수록 증가(增加)했으며 접종(接種) 무접종간(無接種間)에는 질소(窒素) 무시용구(無施用區)를 제외(除外)하고는 전질소(全窒素) 시용량간(施用量間)에 근류균(根瘤菌)을 접종(接種)함으로서 증가(增加)했으며 표준시비량(標準施肥量) 6kg/10a 수준(水準)에서 근류균(根瘤菌) 접종(接種)으로 인(因)하여 반당(反當) 15kg의 토양잠재질소(土壤潛在窒素)를 갖게 되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.493-501
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• 2018

The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines and histological studies in type 2 diabetes mellitus (DM). Type 2 DM was induced by injecting nicotinamide (120 mg/kg, i.p.) 15 min before STZ (60 mg/kg) injection. Canagliflozin (5 and 10 mg/kg) and omega-3 fatty acid (300 mg/kg) were given for 28 days after confirmation of diabetes. Biochemical estimations revealed elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines in diabetic group. Daily dosing of alone canagliflozin and omega-3 fatty acid slightly reduced elevated levels of glucose, insulin, HOMA-R and inflammatory cytokines ($IL-1{\beta}$, IL-2, and $TNF{\alpha}$), whereas canagliflozin and omega-3 fatty acid combination has reduced these biochemical parameters significantly when compared with diabetic group. Similarly in diabetic group the levels of cardiac biomarkers such as lipid profile, LDH, CKMB and troponin were significantly increased. Elevated levels of cardiac biomarkers were significantly reduced after daily dosing of alone canagliflozin and omega-3 fatty acid. Canagliflozin and omega-3 fatty acid combination has offered better improvement in cardiac biomarkers compared to alone canagliflozin and omega-3 fatty acid. Histopathological analysis also supported the above hypothesis that combination therapy (canagliflozin and omega-3 fatty acid) offered better protection against degenerative changes in ${\beta}-cells$ of pancreas as compared to alone treatment with these drugs. Thus the present study revealed that canagliflozin and omega-3 fatty acid can be used as potential combination therapy in type 2 DM along with cardiac complication.

• Nutritional Sciences
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• 제4권2호
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• pp.73-78
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• 2001

This study investigated the effect of different dietary fats and fibers on colon tumor incidence and cell proliferation, the levels of eicosanoids and polyamines in colonic mucosa of DMH-treated rats. The experiment was conducted on male Sprague Dawley rats using a 2 $\times$3 factorial design with two fats (corn oil and DHA-rich fish oil) and two fibers (cellulose and pectin) and a fiber-free control. The rats were find an experimental diet containing 15% (w/w) dietary fat and 6% (w/w) fiber for 25 weeks. Tumor incidence was Bower in rats fed fish oil as opposed to corn oil. The levels of arachidonic acid (AA) and eicosanoids ($PGE_2, and TXB_2$) in normal colonic mucosa were significantly lower in rats fed fish oil and there was a concomitant increase of docosahexaenoic acid (DHA). The levels of eicosanoids and AA in tumor tissues were significantly higher than those of normal colonic mucosa. The level of polyamines in normal colonic mucosa was not affected by dietary fats but was significantly lower than that in rumor tissues. Dietary fiber did not have a significant effect on rumor incidence and the levels of AA, eicosanoids and polyamines. Overall, fish oil rich in DHA reduced cell prolifiration and thus inhibited colon carcinogenesis through its effect on the distribution of AA and production of eicosanoids in normal colonic mucosa. However, its effect on colon carcinogenesis revealed a lack of consistency depending on the type of dietary fiber in diet.

• Journal of Electrical Engineering and Technology
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• 제10권1호
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• pp.261-270
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• 2015

In this paper, the Optimal Harmonic Stepped Waveform (OHSW) method is proposed in order to eliminate the selective harmonic orders available at the output of cascaded multilevel inverter (CMLI) fed by solar photovoltaic (SPV). This technique is used to solve the harmonic elimination equations based on stepped waveform analysis in order to obtain the optimal switching angles which in turn reduce the Total Harmonic Distortion (THD). The OHSW method considers the output voltage waveform as four equal symmetries in each half cycle. In the proposed method, a solar fed fifteen level cascaded multilevel is considered where the magnitude of six numbers of harmonic orders is reduced. A programmable pulse generator is developed to carry the switching angles directly to the semiconductor switches obtained as a result of OHSW analysis. Simulations are carried out in MATLAB/Simulink in which a separate model is developed for solar photovoltaic which serves as the input for cascaded multilevel inverter. A 3kWp solar plant with multilevel inverter system is implemented in hardware to show the effectiveness of the proposed system. Based on the observation the OHSW method provides the reduced THD thereby improving power quality in renewable energy applications.

• Molecules and Cells
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• 제38권6호
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• pp.540-547
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• 2015

Attention deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, affecting approximately 5% of children. However, the neural mechanisms underlying its development and treatment are yet to be elucidated. In this study, we report that an ADHD mouse model, which harbors a deletion in the Git1 locus, exhibits severe astrocytosis in the globus pallidus (GP) and thalamic reticular nucleus (TRN), which send modulatory GABAergic inputs to the thalamus. A moderate level of astrocytosis was displayed in other regions of the basal ganglia pathway, including the ventrobasal thalamus and cortex, but not in other brain regions, such as the caudate putamen, basolateral amygdala, and hippocampal CA1. This basal ganglia circuit-selective astrocytosis was detected in both in adult (2-3 months old) and juvenile (4 weeks old) $Git1^{\check{s}/\check{s}}$ mice, suggesting a developmental origin. Astrocytes play an active role in the developing synaptic circuit; therefore, we performed an immunohistochemical analysis of synaptic markers. We detected increased and decreased levels of GABA and parvalbumin (PV), respectively, in the GP. This suggests that astrocytosis may alter synaptic transmission in the basal ganglia. Intriguingly, increased GABA expression colocalized with the astrocyte marker, GFAP, indicative of an astrocytic origin. Collectively, these results suggest that defects in basal ganglia circuitry, leading to impaired inhibitory modulation of the thalamus, are neural correlates for the ADHD-associated behavioral manifestations in $Git1^{\check{s}/\check{s}}$ mice.

• 대한감각통합치료학회지
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• 제2권1호
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• pp.33-42
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• 2004

Objective : To evaluate the sensory processing ability in relation to parenting stress and find the sensory modulation areas affecting the parenting stress in disabled children Methods : Parents of 124 children with disabilities between 3 to 7 years receiving occupational therapy in Seoul and Gyeonggi-do made out the questionnaire and in items of questionnaire, Short Sensory Profile and Parenting Stress Index of short form was included. Results : Among general information, parenting stress of parents had significant correlation with the degree of disability and correlation with the lower level 2 of Parenting Stress Index. The more sensory processing disability was increased, the more parenting stress was increased. Parenting stress showed the significant correlation with movement sensitivity area and under-responsiveness/behaivor area seeking specific stimulation among sensory processing areas and had significant correlation with tactile sensitivity and auditory filtering. Sensory processing areas which affect the most the Parenting Stress were movement sensitivity and under-responsiveness/behaivor area seeking the specific behavior among sensory control disabilities. Conclusion : The parenting stress of parents with the disabled children had the correlation with sensory processing ability. The difficulty of sensory processing increased the parenting stress. Hence, in order to improve children's sensory processing ability, the appropriately coping program should be developed and the appropriate intervention for improvement of sensory processing ability of children will be necessary.

• 한국초전도ㆍ저온공학회논문지
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• 제5권1호
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• pp.21-26
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• 2003

We designed and constructed a multichannel superconducting quantum interference device (SQUID) magnetometer system to measure magnetic fields from the human brain. We used a new type of SQUID, the double relaxation oscillation SQUID (DROS). With high flux-to-voltage transfers of the DROS, about 10 times larger than the dc SQUIDs, simple flux-locked loop circuits could be used for SQUID operation. Also the large modulation voltage of the DROS, typically being 100 $mutextrm{V}$, enabled stable flux-locked loop operation against the thermal offset voltage drift of the preamplifier. The magnetometers were fabricated using the Nb/AlOx/Nb junction technology. The SQUID system consists of 37 signal magnetometers, distributed on a semispherical surface, and 11 reference channels were installed to pickup background noises. External feedback was used to eliminate the magnetic coupling with the adjacent channels. The liquid helium dewar has a capacity of 29 L and boil-off rate of about 4 L/d with the total 48 channel insert. The magnetometer system has an average noise level of 3 fT/√Hz at 100 Hz, inside a shielded loon, and was applied to measure auditory-evoked fields.

• Journal of Power Electronics
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• 제17권1호
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• pp.106-114
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• 2017

In this paper, the Selective Harmonic Mitigation-PWM (SHM-PWM) method is used in single-phase and three-phase Cascaded H-Bridge (CHB) inverters in order to fulfill different power quality standards such as EN 50160, CIGRE WG 36-05, IEC 61000-3-6 and IEC 61000-2-12. Non-equal DC link voltages are used to increase the degrees of freedom for the proposed SHM-PWM technique. In addition, it will be shown that the obtained solutions become continuous and without sudden changes. As a result, the look-up tables can be significantly reduced. The proposed three-phase modulation method can mitigate up to the 50th harmonic from the output voltage, while each switch has just one switching in a fundamental period. In other words, the switching frequency of the power switches are limited to 50 Hz, which is the lowest switching frequency that can be achieved in the multilevel converters, when the optimal selective harmonic mitigation method is employed. In single-phase mode, the proposed method can successfully mitigate harmonics up to the 50th, where the switching frequency is 150 Hz. Finally, the validity of the proposed method is verified by simulations and experiments on a 9-level CHB inverter.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 추계학술대회 논문집 Vol.17
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• pp.57-60
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• 2004

This paper presents multibit Sigma-Delta ADC using Leslie-Singh Structure to Improve nonlinearity of feedback loop. 4-bit flash ADC for multibit Quantization in Sigma Delta modulator offers the following advantages such as lower quantization noise, more accurate white-noise level and more stability over single quantization. For the feedback paths consisting of DAC, the DAC element should have a high matching requirement in order to maintain the linearity performance which can be obtained by the modulator with a multibit quantizer. Thus a Sigma-Delta ADC usually adds the dynamic element matching digital circuit within feedback loop. It occurs complexity of Sigma-Delta Circuit and increase of power dissipation. In this paper using the Leslie-Singh Structure for improving nonliearity of ADC. This structure operate at low oversampling ratio but is difficult to achieve high resolution. So in this paper propose improving loop filter for single-bit feedback multi-bit quantization Sigma-Delta ADC. It obtained 94.3dB signal to noise ratio over 615kHz bandwidth, and 62mW power dissipation at a sampling frequency of 19.6MHz. This Sigma Delta ADC is fabricated in 0.25um CMOS technology with 2.5V supply voltage.

• 생태와환경
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• 제40권4호
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• pp.489-494
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• 2007

Transcriptional modulation of metallothionein (MT) during acute metal exposures (cadmium, copper or zinc) was examined in fry of Hemibarbus mylodon, a threatened fish species in Korean peninsula. Viability of H. mylodon fry was most affected by copper exposure (up to 79% of mortality at 1 ppm for 48 hours) and considerably by cadmium exposure (21 to 54% of mortality). On the other hand, Zn showed the least adverse effect on the viability (0 to 13% of mortality) of this species. Based on the semi-quantitative RT-PCR analysis, the stimulation of MT mRNA in response to metal exposures followed generally in a dose-dependent fashion where cadmium was the most potent inducer for the induction of MT transcripts in fry (up to more than 5-fold) while the lowest response was observed in zinc-exposed group (2-fold at maximum). From the exposure using environmentally realistic doses of cadmium (0 to 0.05 ppm for 24 hours), MT expression at mRNA level was also sensitively modulated toward upregulation up to more than 3-fold as relative to non-exposed control. Results from the present study would be a good basis for understanding the adaptive capacity and stress physiology of this endangered fish species during metal pollution.