• BMB Reports
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• 제33권6호
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• pp.469-475
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• 2000

The purpose of this study was to examine the chemopreventive potential of taurine at various levels on the diethylnitrosamine (DEN)·induced hepatocarcinogenesis. Male Sprague-Dawley rats were fed on diets containing 0, 1, 2, 3% taurine or 5% ${\beta}-alanine$ for taurine depletion. Then they were treated with DEN and 2/3 partial hepatectomy. The number of placental glutathione S-transferase positive ($GST-P^+$) foci, as a preneoplastic marker in the 1 % taurine group was lower than the control diet group. However the difference was insignificant. Although taurine diets reduced the thiobarbituric acid reactive substance (TBARS) level, the number of $GST-P^+$ foci was increased in 3% taurine diet group. The 1 % taurine diet increased the glutathione (GSH) level and GST activity, however they unfortunately did not suppress the foci formation. In the 3% taurine group, the GSH level and GSH peroxidase (GPx) activity were significantly decreased. Excess taurine supplementation of the pharmaceutical dose worked against hepatic chemoprevention, which might result from modulation of GPx activity and GSH utility. On the contrary, taurine might work as an antioxidant against TBARS production as the 1 % taurine diet increased GSH level. The potency of the cancer preventive effect of taurine still remains and further studies should investigate the effect of taurine with less than 1 % levels on the prevention of hepatic cancer.

• Journal of Power Electronics
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• 제5권3호
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• pp.224-232
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• 2005

A new three phase three-level Pulse Width Modulation (PWM) Switched Voltage Source (SVS) inverter with zero neutral point potential is proposed. It consists of three single-phase inverter modules. Each module is composed of a switched voltage source and inverter switches. The major advantage is that the peak value of the phase output voltage is twice as high as that of a conventional neutral-point-clamped (NPC) PWM inverter. Thus, the proposed inverter is suitable for applications with low voltage sources such as batteries, fuel cells, or solar cells. Furthermore, three-level waveforms of the proposed inverter can be achieved without the switch voltage imbalance problem. Since the average neutral point potential of the proposed inverter is zero, a common ground between the input stage and the output stage is possible. Therefore, it can be applied to a transformer-less Power Conditioning System (PCS). The proposed inverter is verified by a PSpice simulation and experimental results based on a laboratory prototype.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4655-4660
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• 2012

Opuntia humifusa, member of the Cactaceae family, was previously demonstrated to have radical scavenging, anti-inflammatory and anti-proliferative effects in in vitro models. It was suggested that O. humifusa could function in the prevention of carcinogenesis. To investigate the in vivo chemopreventive effect of O. humifusa, mice were fed a diet containing either 1% or 3% following 7, 12-dimethylbenz[a] anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) induction of skin carcinogenesis. Significant decrease in the numbers of papilloma and epidermal hyperplasia were observed in mice fed with O. humifusa, compared to the control group. O. humifusa also upregulated high total antioxidant capacity and level of phase II detoxifying enzyme such as superoxide dismutase and glutathione S-transferase activity in the skin. Lipid peroxidation activity level was measured in skin cytosol and significantly inhibited in 3% OH fed group compared to the control group. These results suggest that O. humifusa exerts chemopreventive effects on chemical carcinogenesis in mouse skin and that prevention effects are associated with reduction of oxidative stress via the modulation of cutaneous lipid peroxidation, enhancing of total antioxidant capacity especially in phase II detoxifying enzyme system and partial apoptotic influence.

• Journal of Electrical Engineering and Technology
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• 제10권3호
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• pp.1066-1074
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• 2015

This paper presents the reverse recovery characteristic according to the change of switching states when Si diode and SiC diode are used as clamp diode and proposes a method to minimize the switching loss containing the reverse recovery loss in the neutral-point-clamped inverter at low modulation index. The previous papers introduce many multiple circuits replacing Si diode with SiC diode to reduce the switching loss. In the neutral-point-clamped inverter, the switching loss can be also reduced by replacing device in the clamp diode. However, the switching loss in IGBT is large and the reduced switching loss cannot be still neglected. It is expected that the reverse recovery effect can be infrequent and the switching loss can be considerably reduced by the proposed method. Therefore, it is also possible to operate the inverter at the higher frequency with the better system efficiency and reduce the volume, weight and cost of filters and heatsink. The effectiveness of the proposed method is verified by numerical analysis and experiment results.

• 한국분무공학회지
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• 제21권3호
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• pp.155-161
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• 2016

Injected fuel pressure waves of a common rail injector with various current profiles supplied to the injecor were measured using Bosch method. In order to drive the common rail injector, the current in the solenoid should be controlled using what is known as a peak and hold pattern, which consists of a high current level with a short time duration (peak) in the first step and a low current level with a long time duration (hold) in the subsequent step. The current profile can be shaped by swithcing an injector driving power source with the peak and hold waves. The capture, compare and PWM (CCP) pin in the microprocessor was used to generate the combined peak and hold waves. The PWM square wave generated from the CCP pin has a duty ratio of 100% for the peak current and 10% or 30% for the hold pattern. Five patterns of the current profile were generated by combining the peak and hold wave. The common rail pressure is controlled at 75, 100, and 130 MPa. As the fuel rail pressure increases, the variations of the measured fuel injection pressure wave according to the current profiles decrease.

• Journal of Power Electronics
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• 제16권3호
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• pp.960-969
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• 2016

High-power three-level voltage-source converters are widely utilized in high-performance AC drive systems. In several ultra-power instances, the harmonics on the grid side should be reduced through multiple rectifications. A combined harmonic elimination method that includes a dual primary-side series-connected winding transformer and selective harmonic elimination pulse-width modulation is proposed to eliminate low-order current harmonics on the primary and secondary sides of transformers. Through an analysis of the harmonic influence caused by dead time and DC magnetic bias, a synthetic compensation control strategy is presented to minimize the grid-side harmonics in the dual primary side series-connected winding transformer application. Both simulation and experimental results demonstrate that the proposed control strategy can significantly reduce the converter input current harmonics and eliminates the DC magnetic bias in the transformer.

• Archives of Pharmacal Research
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• 제19권3호
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• pp.213-218
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• 1996

Multidrug resistance (MDR) has been a major problem in cancer chemotherapy. To overcome this problem, we prepared minor ginsenosides stereoselectively from ginseng saponins and searched for a ginseng component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of several ginseng components, 20(S)-ginsenoside Rg_3$, a red ginseng saponin, was found to have the most potent inhibitory activity on MDR and it's concentration capable of inhibiting 50% growth was $82\muM$.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2000년도 하계학술대회 논문집
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• pp.5-8
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• 2000

The population density of excited species in dc, rf and laser ablation plume plasmas has been measured using laser absorption spectroscopy. It was shown that, when the plasma was modulated by on and off with, the sensitivity and signal to noise (S/N) ratio became high. For example, the atomic O(3$^{5}$ S$^{o}$ $_2$) Population density, No* in $O_2$/He mixtures was obtained by the highest S/N ratio at a frequency of 2.7kHz. In a 20Torr room air, the lowest No* level to be detectable was shown to be an order of 10$^{7}$ cm$^{-3}$ . The population densities of resonance Ar(1S$_2$) and Xe(1S$_4$) levels were also measured in barrier discharges and laser ablation plasmas.

• Journal of Power Electronics
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• 제13권3호
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• pp.437-446
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• 2013

This paper proposes a design scheme for an LCL-filter used for the three-parallel operation of the power converters in high-capacity wind turbines. The designs of the power devices and grid connected filter are difficult due to the high level voltages and currents in huge-capacity wind turbines. To solve these problem, this paper presents three-parallel operation and LCL-filter design techniques optimized by parallel operation. Furthermore, the design of an inverter side inductance of the LCL-filter is discussed in detail considering the switching modulation method. Simulation and experimental results demonstrate the validity of the designed filter and wind turbines.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2015년도 전력전자학술대회 논문집
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• pp.315-316
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• 2015

본 논문에서는 3-레벨 Neutral-Point-Clamped (NPC) 인버터의 DC-Link 중성점 전압 리플을 저감하여 인버터 출력 전압의 품질 신뢰성 향상이 가능한 새로운 Discontinuous Pulse Width Modulation (DPWM) 기법을 제안한다. NPC 인버터에서는 두 개의 커패시터로 이루어진 DC-Link 구조로 인해 상, 하단 DC-Link 커패시터 전압 불평형인 상황에서 DC-Link 중 성점 전압 리플이 발생한다. 중성점 전압 리플 발생 시 출력 전압의 품질을 보장할 수 없으며, 민감한 부하에 손상을 입힐 수 있다. 제안한 DPWM 알고리즘은 DC-Link 커패시터 전압을 조정하는 두 개의 오프셋을 사용하여 중성점 전압 리플을 저감한다. 또한, 시뮬레이션을 통해 본 논문에서 제안한 알고리즘의 타당성을 검증한다.