• Asian Pacific Journal of Cancer Prevention
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• v.14 no.3
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• pp.1819-1823
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• 2013

Objective: Microarray data were analyzed to explore key genes and their functions in progression of colorectal cancer (CRC). Methods: Two microarray data sets were downloaded from Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified using corresponding packages of R. Functional enrichment analysis was performed with DAVID tools to uncover their biological functions. Results: 631 and 590 DEGs were obtained from the two data sets, respectively. A total of 32 common DEGs were then screened out with the rank product method. The significantly enriched GO terms included inflammatory response, response to wounding and response to drugs. Two interleukin-related domains were revealed in the domain analysis. KEGG pathway enrichment analysis showed that the PPAR signaling pathway and the renin-angiotensin system were enriched in the DEGs. Conclusions: Our study to systemically characterize gene expression changes in CRC with microarray technology revealed changes in a range of key genes, pathways and function modules. Their utility in diagnosis and treatment now require exploration.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5849-5854
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• 2013

Background: Apoptosis may be induced after Bcl-2 expression is inhibited in proliferative cancer cells. This study focused on the effect of autophagy activation by ABT737 on anti-tumor effects of epirubicin. Methods: Cytotoxic effects of ABT737 on the HepG2 liver cancer cell line were assessed by MTT assay and cell apoptosis through flow cytometry. Mitochondrial membrane potential was measured by fluorescence microscopy. Monodansylcadaverin (MDC) staining was used to detect activation of autophagy. Expression of p53, p62, LC3, and Beclin1, apoptotic or autophagy related proteins, was detected by Western blotting. Results: ABT737 and epirubicin induced growth inhibition in HepG2 cells in a dose- and time-dependent manner. Both ABT737 and epirubicin alone could induce cell apoptosis with a reduction in mitochondrial membrane potential as well as increased apoptotic protein expression. Further increase of apoptosis was detected when HepG2 cells were co-treated with ABT373 and epirubicin. Furthermore, our results demonstrated that ABT373 or epirubicin ccould activate cell autophagy with elevated autophagosome formation, increased expression of autophagy related proteins and LC3 fluorescent puncta. Conclusions: ABT737 influences cancer cells through both apoptotic and autophagic mechanisms, and ABT737 may enhance the effects of epirubicin on HepG2 cells by activating autophagy and inducing apoptosis.

• Journal of Home Health Care Nursing
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• v.30 no.3
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• pp.264-275
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• 2023

Purpose: The aim of this study was to examine the influence of second victim experiences following patient safety incidents and positive psychological capital on the intention to remain among advanced beginner nurses working at tertiary hospitals. Methods: The participants were 179 nurses with a clinical experience of 13 to 36 months at two tertiary hospitals. We collected data using questionnaires related to second victim experiences, positive psychological capital, and intention to remain. Data were analyzed using descriptive statistics, independent t-test, a one-way analysis of variance (ANOVA), Scheffé test, Pearson correlation, and hierarchical regression analysis. Results: The intention to remain in advanced beginner nurses was negatively correlated with second victim experiences and positively correlated with positive psychological capital. A hierarchical multiple regression model with control variables (subjective job satisfaction and self-assessed work proficiency), psychological capital, and second victim experience accounted for 26% of the factors that influenced advanced beginner nurses' intention to remain. Among the related factors, the most influential was subjective job satisfaction. Second victim experience and positive psychological capital also influenced the advanced beginner nurses' intention to remain. Conclusion: The results of this study suggest a need to develop a program that helps promote intention to remain for nurses at the advanced beginner stage by minimizing second victim experiences and improving positive psychological capital and the work environment.

• Journal of the korean academy of Pediatric Dentistry
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• v.6 no.1
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• pp.53-63
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• 1979

To Study the eruption pattern of the mandibular second permanent molar, the author took 425 cases of Oblique Cephalogram from 6 to 13 years old children and observed the vertical and mesiodistal directional change and tooth axis change. The following results were obtained. : 1. The eruption pattern of the mandibular second permanent molar was changed at about 10.0~10.1 ages or calcification stage IX. 2. At the early stage, the path of eruption of the mandibular second parmanent molar directed upward and forward and after calcification stage IX it changed to the direction of upward. 3. At the early stage, the distance from the distal end of the mandibular first permanent molar to the anterior portion of the ascending ramus was 0.9~1.0 times larger than the mesio-distal diameter of the mandibular second molar, but at the later stage it was increased 1.4 times larger than the mesio-distal diameter of the mandibular second permanent molar.

• Knowledge Management Research
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• v.9 no.4
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• pp.91-112
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• 2008

Recently, the virtual world where avatars are playing crucial roles in connecting users with each other receives much attention from practioners as well as academicians. Especially, Second Life is one of the most prevailing website where 3-D avatars can be easily designed in line with for users' personal tastes. However, there are no studies showing how the selling agents designed in 3-D avatars can affect customer trust and purchase intention in the context of virtual world. This study is concerned with suggesting the empirical results to fill in the research void like this. Results reveal that the proposed hypotheses are proven with statistical significance.

• The Journal of the Korean dental association
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• v.25 no.11 s.222
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• pp.1069-1077
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• 1987

Two brothers aged 15 1/6 and 12 2/3 years were diagnosed as Class I malocclusion with ectopic eruption of the upper left central incisor in the elder brother and etopic eruption in the upper right second premolar in the younger. All 4 second molars were extracted at the same time in both brothers. The treatment results were as follows. 1. In the elder brother, the third molars were fully erupted and their angulations were excellent at 3 years post-treatment. 2. In the younger brother, the lower right third molar was mesially erupted and upper third molars were still undergoing eruption at 3 years post-treatment. 3. Assessment of panex films of both brothers at aged 15 showed an earlier eruption of the third molars in the younger brother. 4. A longer post-treatment supervision of the third molars was required in the younger brother. 5. The facial probiles were enhanced and the ectopic eruptions were corrected in both brothers.

• Journal of the Korean Ceramic Society
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• v.31 no.12
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• pp.1561-1569
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• 1994

Effect of calcining temperature on the sintering behaviors and microwave dielectric properties of BMT[Ba(Mg1/3Ta2/3)O3] ceramics was studied. The calcining temperatures were varied from 80$0^{\circ}C$ to 130$0^{\circ}C$, respectively. It was found that, as calcining temperature lowered below 125$0^{\circ}C$, second phase such as Ba5Ta4O15 phases started to appear in calcined powder with unreacted powders. After sintering, exaggerately grown Ba5TaO3 phase could be found amang the uniform BMT grains in sintered body. Basis on the infiltration experiment, Ba0.05TaO3 phase should be formed by reaction of BMT grain and BaO-MgO eutectic liquid. But increase of calcining temperature above 125$0^{\circ}C$, there was not any second phase or unreated component in calcined powder and sintered body. As result, low calcining temperature led to precipitation of second phase in specimen and resulted decrease of Q value of BMT ceramics.

• Korean Journal of Optics and Photonics
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• v.4 no.1
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• pp.84-89
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• 1993

Spatial homogenity of Mg (4 mole %):LiNb$O_3$ is investigated by studying the characteristic of Second Harmonic Generation in Mg:LiNb$O_3$ as a function of temperature and DC Electric Field. It is found that the temperaturs at which the intensity of the second harmonic is reduced to the first zero from its maximum for the phase matching condition is shifted linearly to the strength of DC Electric field applied to optic axis of Mg:LiNb$O_3$. From these results, the electro-optic coefficient of Mg:LiNb$O_3$ is estimated to be higher than that of Congruent LiNb$O_3$ by a factor of 1.5.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.168-168
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• 2011

최근 한반도는 과거 최대 강우량의 기록을 갱신하는 집중호우가 지속적으로 발생하고 있으며, 2000년대 들어 기상재해에 대한 피해 규모가 수조원에 달한다. 자연재해를 예방하여 피해를 최소화하기 위해서는 미래에 발생 가능성이 있는 재해를 사전에 예측하고, 재난발생 가능성을 감소시키며, 발생한 재난의 피해를 최소화시키기 위한 활동이 필요하다. 따라서 본 연구에서는 2003년도에 발생한 태풍 'Maemi'의 영향으로 부산과 경남지역에 발생 가능한 최대 풍피해의 정도를 예측해보고자 하였다. 이를 위해서 태풍의 중심기압과 태풍의 이동경로와 대상지역의 거리를 이용하여 3-second gust를 산정하였고, 이를 이용하여 시 군 구 단위의 주택에 대한 최대 풍피해 분포 특성을 파악하였다. 태풍 Meami에 의한 부산 경남지방의 3-second gust를 산정한 결과 풍속이 25m/s 이상의 폭풍영역에 해당되는 지역은 김해시, 강서구, 남해군, 고성군, 창원시, 사상구, 북구, 함안군, 통영시, 하동군, 거제시, 사천시이고, 강풍영역에는 대부분의 지역이 포함되었다. 그 중에서 3-second gust가 가장 높았던 지역은 북구와 사상구였고, 다음으로 강서구 창원시 사천시, 함안군 이였으며, 마산시, 김해시, 거제시 그리고 양산시가 다음으로 높게 나타났다. 고성군은 3-second gust가 가장 낮게 나타났다. 부산과 경남지방의 집 한 채 피해액은 북구와 강서구, 사상구가 가장 높게나왔고, 다음으로 사천시와 창원시 순으로 높게 나타났다. 거창군은 부산 경남지방 중에서 가장 낮은 피해액이 나타났다. 이러한 결과에는 그 지역에서 발생 가능한 3-second gust의 영향이 크게 작용한 것으로 판단된다. 본 연구에서는 태풍의 특성 자료를 제외한 자료의 경우 국내 자료의 한계로 인해 국외 자료를 이용하거나, 가정을 통해 계산을 진행하였다. 그러나 향후 보다 정확한 최대 풍피해를 평가하기 위해서는 기초자료의 마련이 반드시 이루어져야한다.

• The Journal of Korean Academic Society of Nursing Education
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• v.6 no.2
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• pp.199-217
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• 2000

This descriptive longitudinal study was done to identify the ethical value of nursing students and to compare the differences of results with one year interval. The data were collected twice in 1999 and in 2000, from the 82 first year and 64 second year nursing students who have been attending at C college in Chonnam province. The analysis of data was done by frequency, mean, paired t-test, t-test, and ANOVA. The results of data were summarized as follows: 1. The total ethical value score of the first year students was 3.48 (maximum : 5) and, one year later, the score was lowered to 3.26. Especially, the degree of their ethical value was significantly decreased in the sub-areas of human-life and nurse-nursing task. 2. The total ethical value score of the second year students was 3.24 and, one year later, the score was increased to 3.39. The degree of their ethical value was significantly increased in the subarea of nurse- client relationship. 3. In the subarea of human-life, the mean score of ethical value was 3.25 and, one year later, the score was 2.95. The degree of ethical value was significantly lowered among the first year students with an utilitarian position. 4. In the subarea of nurse-client relationship, the mean score of ethical value was 3.39 and, one year later, the score was 3.67. The degree of ethical value was significantly increased among the second year students with a deontological position. 5. In the subarea of nurse-nursing task relationship, the mean score of ethical value was 3.38 and, one year later, the mean score was 3.08. The degree of ethical value was significantly decreased among the first year students. 6. In the subarea of nurse-collaboration relationship, the mean score of ethical value was 3.96 and, one year later, the mean score was 4.08 in second year students. There was no statistically significant difference. 7. The ethical values of nursing students were significantly different depending on their religion, length of study, attitude toward nursing and the experience of dying during their clinical practice.