Blocking Bcl-2 Leads to Autophagy Activation and Cell Death of the HEPG2 Liver Cancer Cell Line |
Du, Peng
(Department of General Surgery, the Second Affiliated Hospital of Soochow University)
Cao, Hua (Department of General Surgery, the Second Affiliated Hospital of Soochow University) Wu, Hao-Rong (Department of General Surgery, the Second Affiliated Hospital of Soochow University) Zhu, Bao-Song (Department of General Surgery, the Second Affiliated Hospital of Soochow University) Wang, Hao-Wei (Department of General Surgery, the Second Affiliated Hospital of Soochow University) Gu, Chun-Wei (Department of General Surgery, the Second Affiliated Hospital of Soochow University) Xing, Chun-Gen (Department of General Surgery, the Second Affiliated Hospital of Soochow University) Chen, Wei (Department of General Surgery, the Second Affiliated Hospital of Soochow University) |
1 | Kirkin V, McEwan DG, Novak I, Dikic I (2009). A role for ubiquitin in selective autophagy. Mol Cell, 34, 259-69. DOI ScienceOn |
2 | Niemann A, Takatsuki A, Elsasser HP (2000). The lysosomotropic agent monodansylcadaverine also acts as a solvent polarity probe. J Histochem Cytochem, 48, 251-8. DOI ScienceOn |
3 | Lum JJ, DeBerardinis RJ, Thompson CB (2005). Thompson, Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol, 6, 439-48. DOI ScienceOn |
4 | Mathew R, Karantza-Wadsworth V, White E (2007). Role of autophagy in cancer. Nat Rev Cancer, 7, 961-7. DOI ScienceOn |
5 | Orvedahl A, Levine B (2009). Eating the enemy within: autophagy in infectious diseases. Cell Death Differ, 16, 57-69. DOI ScienceOn |
6 | Pankiv S, Clausen TH, Lamark T, et al (2007). p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem, 282, 24131-45. DOI ScienceOn |
7 | Pattingre S, Tassa A, Qu X, Garuti R, et al (2005). Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell, 122, 927-39. DOI ScienceOn |
8 | Poon D, Anderson BO, Chen LT, et al (2009). Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol, 10, 111l-8. DOI ScienceOn |
9 | Rashid SF, Moore JS, Walker E, et al (2001). Synergistic growth inhibition of prostate cancer cells by 1 alpha, 25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A. Oncogene, 15, 1860-72. |
10 | Saitoh T, Fujita N, Jang MH, et al (2008). Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature, 456, 264-8. DOI ScienceOn |
11 | Wong N, Yeo W, Wong WL, et al (2009). TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance. Int J Cancer, 124, 644-52. DOI ScienceOn |
12 | Vero V, Racco S, Biolato M, et al (2009). The treatment of hepatocellular carcinoma: an update. Minerva Med, 100, 173-93. |
13 | Wei Y, Pattingre S, Sinha S, Bassik M, Levine B (2008). JNK1-mediated phosphorylation of Bcl-2 regulates starvationinduced autophagy. Mol Cell, 30, 678-88. DOI ScienceOn |
14 | Winslow AR, Rubinsztein DC (2008). Autophagy in neurodegeneration and development. Biochim Biophys Acta, 1782, 723-9. DOI ScienceOn |
15 | Yen WL, Klionsky DJ (2008). How to live long and prosper:autophagy, mitochondria and aging. Physiology (Bethesda), 23, 248-62. DOI ScienceOn |
16 | Biederbick A, Kern HF, Elsasser HP (1995). Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol, 66, 3-14. |
17 | Abou-Alfa GK, Venook AP (2008). The impact of new data in the treatment of advanced hepatocellular carcinoma. Curr Oncol Rep, 10, 199-205. DOI ScienceOn |
18 | Al-Ejeh F, Kumar R, Wiegmans A, et al (2010). Harnessing the complexity of DNAdamage response pathways to improve cancer treatment outcomes. Oncogene, 29, 6085-98. DOI ScienceOn |
19 | Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, et al (2001). Hypoxia induced the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells. J Biol Chem, 276, 22368-74. DOI ScienceOn |
20 | Buytaert E, Callewaert G, Vandenheede JR, Agostinis P (2006). Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum. Autophagy, 2, 238-40. DOI |
21 | Erlich S, Mizrachy L, Segev O, et al (2007). Differential interactions between Beclin 1 and Bcl-2 family members. Autophagy, 3, 561-8. DOI |
22 | Cadwell K, Liu JY, Brown SL, et al (2008). A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature, 456, 259-63. DOI ScienceOn |
23 | Carew JS, Nawrocki ST, Cleveland JL (2007). Modulating autophagy for therapeutic benefit. Autophagy, 3, 464-7. DOI |
24 | Chen N, Karantza-Wadsworth V (2009). Role and regulation of autophagy in cancer. Biochim Biophys Acta, 1793, 1516-23. DOI ScienceOn |
25 | Gewirtz DA (2007). Autophagy as a mechanism of radiation sensitization in breast tumor cells. Autophagy, 3, 249-50. DOI |
26 | Gozuacik D, Kimchi A (2004). Autophagy as a cell death and tumor suppressor mechanism. Oncogene, 23, 2891-906. DOI ScienceOn |
27 | Hanahan D, Weinberg RA (2000). The hallmarks of cancer. Cell, 100, 57-70. DOI ScienceOn |
28 | John S, Nayvelt I, Hsu HC, et al (2008). Regulation of estrogenic effects by beclin 1 in breast cancer cells. Cancer Res, 68, 7855-63. DOI ScienceOn |
29 | Karantza-Wadsworth V, White E (2008). Programmed cell death. In: DeVita, VT.; Lawrence, TS.; Rosenberg, SA., editors. Cancer: principles and practice of oncology. 8th ed. Lippincott, Williams, & Wilkins; Baltimore, pp 93-101. |
30 | Bursch W, Ellinger A, Kienzl H, et al (1996). Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis, 17, 1595-607. DOI ScienceOn |
31 | Kanzawa T, Germano IM, Komata T, et al (2004). Role of autophagy in temozolomide-inducedcytotoxicity for malignant glioma cells. Cell Death Differ, 11, 448-57. DOI ScienceOn |
32 | Malicdan MC, Noguchi S, Nonaka I, Saftig P, Nishino I (2008). Lysosomal myopathies: an excessive build-up in autophagosomes is too much to handle. Neuromuscul Disord, 18, 521-9. DOI ScienceOn |