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Differential Expression of CXCR4 in Conventional High-grade and Low-grade Central Osteosarcoma and Its Prognostic Implications (골육종의 조직학적 등급에 따른 CXCR4 발현 및 예후로서의 의미)

  • Park, Hye-Rim;Seo, Jin-Won;Bacchini, Patrizia;Bertoni, Franco;Park, Yong-Koo
    • The Journal of the Korean bone and joint tumor society
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    • v.18 no.1
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    • pp.20-27
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    • 2012
  • Purpose: The chemokine receptor CXCR4 has been reported to be aberrantly expressed in human cancer and has been shown to participate in cancer metastasis. We compared the expression of CXCR4 in conventional high-grade and low-grade central osteosarcomas, and determined if an association between CXCR4 expression and prognosis could be made. Materials and Methods: We performed the immunohistochemistry for CXCR4 in a total of 63 patients with osteosarcoma and determined the relationships according to the clinicopathologic variables and overall survival rates. Results: CXCR4 was detected in 76.3% of conventional high-grade osteosarcoma patients and in 36% of low-grade central osteosarcomas. Diffuse expression was noted in 47.4% of the high-grade osteosarcomas and all low-grade cases were focal positive. CXCR4 expression was significantly correlated with histologic grade (p<0.0001). While overall survival rate was reduced significantly with increased CXCR4 expression (p=0.0058), higher histologic grade (p<0.0001), and younger age (p=0.0140), survival rate did not correlate with gender, tumor size, or AJCC stage. Conclusion: Our results suggest that CXCR4 expression is associated with higher-grade tumors and with poor prognosis for osteosarcoma patients.

The Development of Citation Indicators of Korean Medical Journals (한국 의학학술지 인용지표 개발 연구)

  • 이춘실
    • Journal of the Korean BIBLIA Society for library and Information Science
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    • v.13 no.1
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    • pp.27-41
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    • 2002
  • The study investigated the citation indicators and the citation analysis data developed in the KoMCI(Korean Medical Citation Index) project. With the full understanding of the current level of citation rates of Korean medical journals by Korean medical journals. and of the characteristics and problems associated with the KoMCI citation indicators, it is possible to further develop or modify citation indicators which will better represent the citation patterns of Korean medical journals. The highest impact factor reported in the KoMCI 2000 : Korean Medical Journal Citation Reports, which covered 69 Korean medical journals published in 2000 is 0.424 and the average is 0.182. It is because only 8.5% of references cited in Korean medical journal articles is to the Korean journal articles, The journal self-citation rates are very high (usually higher than 50%) due to the fact that there are only a few Korean journals published in the same subject area. The KoMCI impact factors of two Korean SCI journals for which SCI JCR reported the SCI 2000 impact factors are about 1/3 of the SCI impact factors. It is because SCI is based on the citations received from 5,900 journals whereas KoMCI is from 69 journals.

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The effect of the multi intervention program applying to dementia elderly (치매노인에게 적용한 복합 중재프로그램의 효과 비교 연구)

  • Kim, Hee-Jung;Lee, Chun-Yeop;Jung, Hye-Rim;Lee, Gyu-Han;Kim, Dong-Hyun
    • The Journal of Korean society of community based occupational therapy
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    • v.5 no.2
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    • pp.11-21
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    • 2015
  • Objective : We tried to know the effect on the ability of work performance, cognitive, balance, depression, ability of daily living, the quality of life, and time usage after applying the group cognitive therapy that based on lifestyle redesign to dementia elderly. Methods : We performanced the group cognitive therapy that based on lifestyle redesign to 15 dementia elderly for 12weeks by total 5 steps. We evaluated the ability of work performance(COPM), cognitive(MMSE-DS), balance(BBS), depression(GDS-K), ability of daily living(MBI), the quality of life(GQOL-D), and time usage(OQ) of before and after the programme. Results : There was a significant difference of the ability of work performance, balance, the quality of life, and locomotive area of time usage after applying the group cognitive therapy that based on lifestyle redesign to dementia elderly. Conclusion : The group cognitive therapy that based on lifestyle redesign programme is effective for satisfaction of work performance and improvement of the quality of life and balance ability. The programme is also effective for locomotive area of time usage. We found out the effect of the programme in variety of the life of dementia elderly.

Application of the Development Model of Day Care Center for Dementia (치매주간보호사업 개발모형의 적용)

  • Chung, Yeun-Gang;Baik, Kyung-A;Hyun, Hye-Young;Yeoum, Soon-Gyo;Kim, Kyung-Hee;Choi, Mi-Hye;Han, Sung-Hee
    • Research in Community and Public Health Nursing
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    • v.14 no.1
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    • pp.106-119
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    • 2003
  • This study was executed to develop the model of the format of the day care center which supplies the total service on the health care in the day time and social program related with the work and to evaluate the processing courses which was adjusted for 3 years from March 1999 to December 2001 in order to improve the quality of life of the family who experience dementia, dementia prevention, and the old and the burden of daily activities. The processing courses of this business model were evaluated to the confirmation on the health condition, application of the nursing processes, and the precise medical examination, and 20 sorts of social programs. The methods used in this model were the simplified MMSE-K, Ability for ,Daily Life(ADL), Instrumental Activities of Daily Living(IADL), and nursing process, and so on. The execution effects of this model are as follows. 1. It can contribute to the delay in the dementia process of the old people who are related with the dementia and maintenance and improvement of the health by confirming the stopping of the process of the dementia as the objective estimation method while the dementia symptom is maintained as the current condition through the medical and social total services. 2. The reduction of the burden for the daily care of the subject people and their families for the old people who are concerned with the dementia helped to improve the quality of life of the subject people and their family by enabling them to have jobs. 3. It enabled them to positively cope with the demand for the health and nursing of the local residents related to the old people. 4. It enabled them to enhance the recognition for the socialization of the local social organization and residents for the old people. 5. It enabled them to reinforce the related system among the local social organizations, and develop and provide the various social programs which are proper for the old people.

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The Fatigue Experience of Shift Work Nurses (교대근무간호사의 피로경험)

  • Kho Hyo Jung;Kim Myung Ye;Kwon Young Sook;Kim Chung Nam;Park Kyung Min;Park Jung Sook;Park Young Suk;Park Cheong Ja;Shin Young Hee;Lee Kyung Hee;Lee Byung Sook;Lee Eun Joo
    • Journal of Korean Public Health Nursing
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    • v.18 no.1
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    • pp.103-118
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    • 2004
  • The purpose of this study was to understand the process and investigate basic theory of fatigue experience of shift work nurses. The present study adopted grounded theory methodology on fatigue of shift work nurses. The participants for this study were 15 shift work nurses who were in the age of 25 to 35, the clinical experience of 2 to 14 years and the work department of ICU. ER. ward and delivery room. The data were collected from 2000 to 2003 by using interviews and observations. The contents of the interviews were tape-recorded and were drawn through repeated method. And then were analyzed into the concept, subcategories, and categories with the open coding process and axial coding was done to identify the relationships of the concepts and categories according to the paradigm models. The core category generated, which was a central phenomena of the exhaustion process. The causal condition is change events. The central condition of exhaustion were sorted as physical discomfort, decreasing vigor, psychological instability, feeling of sleeping desire, changing face impression and being heavy body. The intervening condition were discovered as social$\cdot$ psychology$\cdot$physical resist and positive$\cdot$negative interaction strategies. The consequences of the fatigue process is the short term exhaustion relief and long term residual exhaustion. The fatigue process of this study was 'break through exhaustion' of change event-exhaustion-resist-resolve intervention-adaptation. This study offers better understanding on fatigue process of shift work nurses and may facilitate more appropriate interventive strategies to support, information and knowledges according to fatigue process.

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System Development for Analysis and Compensation of Column Shortening of Reinforced Concrete Tell Buildings (철근콘크리트 고층건물 기둥의 부등축소량 해석 및 보정을 위한 시스템 개발)

  • 김선영;김진근;김원중
    • Journal of the Korea Concrete Institute
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    • v.14 no.3
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    • pp.291-298
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    • 2002
  • Recently, construction of reinforced concrete tall buildings is widely increased according to the improvement of material quality and design technology. Therefore, differential shortenings of columns due to elastic, creep, and shrinkage have been an important issue. But it has been neglected to predict the Inelastic behavior of RC structures even though those deformations make a serious problem on the partition wall, external cladding, duct, etc. In this paper, analysis system for prediction and compensation of the differential column shortenings considering time-dependent deformations and construction sequence is developed using the objected-oriented technique. Developed analysis system considers the construction sequence, especially time-dependent deformation in early days, and is composed of input module, database module, database store module, analysis module, and analysis result generation module. Graphic user interface(GUI) is supported for user's convenience. After performing the analysis, the output results like deflections and member forces according to the time can be observed in the generation module using the graphic diagram, table, and chart supported by the integrated environment.

Prediction of Ultimate Strength and Strain of Concrete Columns Retrofitted by FRP Using Adaptive Neuro-Fuzzy Inference System (FRP로 보강된 콘크리트 부재의 압축응력-변형률 예측을 위한 뉴로퍼지모델의 적용)

  • Park, Tae-Won;Na, Ung-Jin;Kwon, Sung-Jun
    • Journal of the Korea Concrete Institute
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    • v.22 no.1
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    • pp.19-27
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    • 2010
  • Aging and severe environments are major causes of damage in reinforced concrete (RC) structures such as buildings and bridges. Deterioration such as concrete cracks, corrosion of steel, and deformation of structural members can significantly degrade the structural performance and safety. Therefore, effective and easy-to-use methods are desired for repairing and strengthening such concrete structures. Various methods for strengthening and rehabilitation of RC structures have been developed in the past several decades. Recently, FRP composite materials have emerged as a cost-effective alternative to the conventional materials for repairing, strengthening, and retrofitting deteriorating/deficient concrete structures, by externally bonding FRP laminates to concrete structural members. The main purpose of this study is to investigate the effectiveness of adaptive neuro-fuzzy inference system (ANFIS) in predicting behavior of circular type concrete column retrofitted with FRP. To construct training and testing dataset, experiment results for the specimens which have different retrofit profile are used. Retrofit ratio, strength of existing concrete, thickness, number of layer, stiffness, ultimate strength of fiber and size of specimens are selected as input parameters to predict strength, strain, and stiffness of post-yielding modulus. These proposed ANFIS models show reliable increased accuracy in predicting constitutive properties of concrete retrofitted by FRP, compared to the constitutive models suggested by other researchers.

The Convergent Effects of Oral Health Education Feedback Using QraycamTM (QraycamTM 활용한 구강보건교육 피드백의 융합적 효과)

  • Yeo, An-Na;Lee, Su-Young
    • Journal of the Korea Convergence Society
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    • v.8 no.3
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    • pp.63-70
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    • 2017
  • The purpose of this study was to evaluate the effects of oral health education feedback using $Qraycam^{TM}$. The middle school students 118 were divided into intervention group (59) and control group (59) subjects evaluated the dental plaque score using $Qraycam^{TM}$ after oral health education at baseline. Then, the $Qraycam^{TM}$ images view only sent to students and parents of the intervention group by text message. After 4 weeks both intervention group and control group were evaluated dental plaque by $Qraycam^{TM}$ re-taking. Then, they filled out the questionnaire. Both ${\Delta}R$ value and SPS(Simple Plaque Score) were statistically significant reduced in groups performed feedback(p<0.001). The oral health behavior, toothbrushing of intervention group was significantly higher compared to the control group(p<0.001). Also the importance of oral health was significantly higher in the intervention group compared to the control group(p<0.001). The effect of dental plaque reducing, toothbrushing time and subjective oral health importance were higher in the intervention group who received feedback using $Qraycam^{TM}$ image. Therefore it was expected to be able to utilize $Qraycam^{TM}$ image as a visual feedback tool of oral health education.

Valuation of ecosystem services in the organic carbon of the Pinus densiflora forest at Mt. Namsan, Seoul Metropolitan City

  • Lee, Eung-Pill;Lee, Soo-In;Jeong, Heon-Mo;Han, Young-Sub;Lee, Seung-Yeon;Park, Jae-Hoon;Jang, Rae-Ha;Hong, Youg-Sik;Jung, Young-Ho;Kim, Eui-Joo;Lee, Sang-Hun;You, Young-Han
    • Journal of Ecology and Environment
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    • v.43 no.4
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    • pp.341-351
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    • 2019
  • Background: Standing biomass, litter production, rate of litter decomposition, amount of litter on forest floor, and amount of soil organic carbon distribution were investigated from March 2016 to November 2018 in order to evaluate the ecosystem value through organic carbon distribution in the Pinus densiflora forest at Namsan, Seoul Metropolitan City. Results: The amount of organic carbon in the Pinus densiflora forest was 261.09 ton C ha-1 during the research period, and fixed organic carbon in plant through net photosynthesis was 3.2 ton C ha-1 year-1. The organic carbon in plant was 62.77 ton C ha-1 (24.04%), in litter on the forest floor was 3.65 ton C ha-1 (1.40%), and in soil was 194.67 ton C ha-1 (74.56%). The value of plant, litter on forest floor, and soil organic carbon distribution were each 6,277,000 won ha-1, 365, 000 won ha-1, and 19,467,000 won ha-1. The value per ton of fixed organic carbon in plant through net photosynthesis was 320,000 won ha-1 year-1 and the value of ecosystem services stored in carbon in the Namsan forest ecosystem was about 26.1 million won ha-1 for 3 years. Conclusions: The results of this study suggest that the pine forests of Namsan rapidly decompose leaves due to the high atmospheric temperature and accumulate a large amount of organic carbon in the soil to provide climate control regulatory service function.

The Operational Status of the 7th Elective-Centered Curriculum (제7차 선택중심 교육과정의 운영 실태)

  • Kook, Dong-Sik;Lee, Sang-Gi
    • Journal of the Korean earth science society
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    • v.26 no.8
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    • pp.771-776
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    • 2005
  • The purpose of this study is to survey the status of the 7th elective-centered curriculum and find problems in operating the system. 485 students in the tenth and eleventh grade were randomly selected as subjects. The results are as follows. (1) Among the students, 29% of them selected their science subject without considering their future jobs, 48% did it without enough overview of the system, and 25% did without clearly understanding the details the choice centered curriculum. (2) Among the students who participated in the survey, 65% of them showed positive responses concerning the needs of individual choice centered curriculum and 96% said it increased their participation in class. However, only 39% believed that operating this type of curriculum is realistically possible. (3) 89% of students selected their science subjects accordingly with the college preparatory courses and 14% selected based on their hopes. (4) The percentage of science subjects chosen are 40% for chemistry, 25% for biology, 22% for Physics, and 13% for earth science, but 74% of students wanted to change their choices. These results showed that students recognized the object of the 7th curriculum, but selected science subjects as a means of getting into college entrances, rather than carefully considering their future and aptitude.