• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1219-1224
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• 2015

Background: To date several common mutations in BRCA1 and BRCA2 associated with breast cancer have been reported in different populations. However, the common BRCA1 and BRCA2 mutations among breast cancer patients in Iran have not been described in detail. Materials and Methods: To comprehensively assess the frequency and distribution of the most common BRCA1 and BRCA2 mutations in Iranian breast cancer patients, we conducted this meta-analysis on 13 relevant published studies indentified in a literature search on PubMed and SID. Results: A total of 11 BRCA1 and BRCA2 distinct common mutations were identified, reported twice or more in the articles, of which 10 (c.2311T>C, c.3113A>G, c.4308T>C, c.4837A>G, c.2612C>T, c.3119G>A, c.3548A>G, c.5213G>A c.IVS16-92A/G, and c.IVS16-68A/G) mutations were in BRCA1, and 1 (c.4770A>G) was in BRCA2. The mutations were in exon 11, exon 13, intron 16, and exon 20 of BRCA1 and exon 11 of BRCA2. All have been previously reported in different populations. Conclusions: These meta analysis results should be helpful in understanding the possibility of any first true founder mutation of BRCA1/BRCA2 in the Iranian population. In addition, they will be of significance for diagnostic testing, genetic counseling and for epidemiological studies.

• Journal of the Korean Chemical Society
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• v.36 no.4
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• pp.536-539
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• 1992

Eight-membered ring spiro orthocarbonate (C$_{25}H_{20}O_4$, M$_r$ = 384) is monoclinic, space group C2/c, with a = 15.319(4), b = 9.057(3), c = 13.168(3)${\AA}$, ${\beta}$ = 98.53(3)$^{\circ}$, Z = 4, F(000) = 808, T = 290 K, ${\mu}$(Mo-K${\alpha}$) = 0.55 cm$_1$, D$_c$ = 1.36 g/cm$^3$ and D$_m$ = 1.40 g/cm$^3$. The intensity data were collected with Mo-K${\alpha}$ radiation (${\lambda}$ = 0.7107 ${\AA}$) on an automatic four-circle diffractometer with a graphite monochromater. The structure was solved by direct methods and refined by full matrix least-squares methods. The final R value was 0.052 for 1412 observed reflections. The molecule has C$_2$point symmetry. The eight-membered ring has a chair conformation with pseudo-C$_s$ symmetry. The naphthyl ring is planar with the C-C bond lengths being in the range of 1.352∼1.444${\AA}$ and bond angles of 117.2∼123.5$^{\circ}$. The bond lengths of C(1)-C(9), C(8)-C(9) and C(9)-C(10) are somewhat longer than those of the other C-C bonds.

• Bulletin of the Korean Mathematical Society
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• v.49 no.1
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• pp.175-195
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• 2012

Representing planar Pythagorean hodograph (PH) curves by the complex roots of their hodographs, we standardize Farouki's double cubic method to become the undetermined junction point (UJP) method, and then prove the generic existence of solutions for general $C^1$ Hermite interpolation problems. We also extend the UJP method to solve $C^2$ Hermite interpolation problems with multiple PH cubics, and also prove the generic existence of solutions which consist of triple PH cubics with $C^1$ junction points. Further generalizing the UJP method, we go on to solve $C^2$ Hermite interpolation problems using two PH quintics with a $C^1$ junction point, and we also show the possibility of applying the modi e UJP method to $G^2[C^1]$ Hermite interpolation.

• Bulletin of the Korean Mathematical Society
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• v.47 no.2
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• pp.319-339
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• 2010

In this paper, we prove that if $f^nf'\;-\;P$ and $g^ng'\;-\;P$ share 0 CM, where f and g are two distinct transcendental meromorphic functions, $n\;{\geq}\;11$ is a positive integer, and P is a nonzero polynomial such that its degree ${\gamma}p\;{\leq}\;11$, then either $f\;=\;c_1e^{cQ}$ and $g\;=\;c_2e^{-cQ}$, where $c_1$, $c_2$ and c are three nonzero complex numbers satisfying $(c_1c_2)^{n+1}c^2\;=\;-1$, Q is a polynomial such that $Q\;=\;\int_o^z\;P(\eta)d{\eta}$, or f = tg for a complex number t such that $t^{n+1}\;=\;1$. The results in this paper improve those given by M. L. Fang and H. L. Qiu, C. C. Yang and X. H. Hua, and other authors.

• Journal of the Korean Applied Science and Technology
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• v.14 no.1
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• pp.61-76
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• 1997

Triacylglycerols of the seeds of Ginkgo biloba have been resolved by high-performace liquid chromatography(HPLC} in the silver-ion and reverse-phase modes. The fatty acids were identified by a combination of capillary gas chromatography and gas-chromatography /mass spectrometry as the methyl and /or picolinyl ester. The main components are $C_{18:2{\omega}6}$(39.0mol%), $C_{18:1{\omega}7}$(asclepic acid 21.5mol%), and $C_{18:1{\omega}9}$(oleic acid, 13.8mol%). Considerable amounts of unusual acid such as $C_{20:3{\Delta}^{5,11,14}$ (5.7mol%), $C_{18:2{\Delta}^{5,9}$(2.8mol%), and $C_{18:3}{\Delta}^{5,9,12}$(1.6mol%), were checked. In addition, an anteiso-branched fatty acid, 14-methylhexadecanoic acid, was also present as a minor component(0.9 mol%). The triacylglycerols were separated into 17 fractions by reverse-phase HPLC, and the fractionation was achieved according to the partition numnber(PN) in which a ${\Delta}^5$-non methylene interrupted double bond($^5$-NMDB) showed different behaviour from a methylene interrupted double bond in a molecule with a given cahinlength. Silver-ion HPLC exhibited excellent resolution in which fractions(23 fractions) were resolved on the basis of the number and configuration of double bonds. In this instance, the strength of interaction of a ${\Delta}^5$-NMDB system with silver ions seemed to be weaker than a methylene interrupted double bond system. The principal triacylglycerol species are as follows ; $(C_{18:2{\omega}6)2}/C_{18:1{\omega}7}$, $C_{18:1{\omega}9}/C_{18:1{\omega}7}/C_{18:2{\omega}6}$, $(C_{18:1{\omega}7)2}/C_{18:2{\omega}6}$, $C_{16:1{\omega}7}/C_{18:1{\omega}9}/C_{20:3}{\Delta}^{5,11,14}$, $C_{16:1{\omega}7}/C_{18:1{\omega}7}/C_{20:3}{\Delta}^{5,11,14}$, $C_{18:1{\omega}9}/C_{18:1{\omega}7}/C_{18:2{\omega}6}$, $C_{18:1{\omega}9}/C_{18:2}{\Delta}^{5,5}/C_{20:3}{\Delta}^{5,11,14}$, $(C_{18:1{\omega}7)2}/C_{18:2{\omega}6}$ and $(C_{18:1{\omega}9)2}/C_{18:2{\omega}6}$, while simple triacylglycerols without $C_{18:2{\omega}6})_3$ were not present. Stereospecific analysis showed that fatty acids with ${\Delta}^5$-NMDB system and saturated chains were predominantly located at the site of sn-3 carbon of glycerol backbones. It is evident that there is asymmetry in the distribution of fatty acids in the TG molecules of Ginkgo nut oils.

• Journal of Ginseng Research
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• v.40 no.4
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• pp.366-374
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• 2016

Background: In this study, we screened and identified an endophyte JG09 having strong biocatalytic activity for ginsenosides from Platycodon grandiflorum, converted ginseng total saponins and ginsenoside monomers, determined the source of minor ginsenosides and the transformation pathways, and calculated the maximum production of minor ginsenosides for the conversion of ginsenoside Rb1 to assess the transformation activity of endophyte JG09. Methods: The transformation of ginseng total saponins and ginsenoside monomers Rb1, Rb2, Rc, Rd, Rg1 into minor ginsenosides F2, C-K and Rh1 using endophyte JG09 isolated by an organizational separation method and Esculin-R2A agar assay, as well as the identification of transformed products via TLC and HPLC, were evaluated. Endophyte JG09 was identified through DNA sequencing and phylogenetic analysis. Results: A total of 32 ${\beta}$-glucosidase-producing endophytes were screened out among the isolated 69 endophytes from P. grandiflorum. An endophyte bacteria JG09 identified as Luteibacter sp. effectively converted protopanaxadiol-type ginsenosides Rb1, Rb2, Rc, Rd into minor ginsenosides F2 and C-K, and converted protopanaxatriol-type ginsenoside Rg1 into minor ginsenoside Rh1. The transformation pathways of major ginsenosides by endophyte JG09 were as follows: $Rb1{\rightarrow}Rd{\rightarrow}F2{\rightarrow}C-K$; $Rb2{\rightarrow}C-O{\rightarrow}C-Y{\rightarrow}C-K$; $Rc{\rightarrow}C-Mc1{\rightarrow}C-Mc{\rightarrow}C-K$; $Rg1{\rightarrow}Rh1$. The maximum production rate of ginsenosides F2 and C-K reached 94.53% and 66.34%, respectively. Conclusion: This is the first report about conversion of major ginsenosides into minor ginsenosides by fermentation with P. grandiflorum endophytes. The results of the study indicate endophyte JG09 would be a potential microbial source for obtaining minor ginsenosides.

• Journal of the Korean Society of Food Science and Nutrition
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• v.13 no.3
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• pp.263-267
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• 1984

The present study was conducted to elucidate the triglyceride composition of walnut oil. The triglycerides were separated by thin layer chromatography (TLC) and fractionated on the basis of partition numbers by reverse phase high performance liquid chromatography (HPLC) on a column packed with $\mu$-bondapak $C_{18}$ using methanol-chloroform mixture as a solvent system. Each of these collected fractions was fractionated again on the basis of acyl carbon number of triglyceride by gas liquid chromatography (GLC). The fatty acid composition of triglycerides for each partition numbered group was also analyzed by GLC. From the results, it was found that walnut oil consists of ten kinds of triglycerides, and the patterns of major ones in walnut oil were as follows: 53.3% of $(C_{18:2},\;C_{18:2},\;C_{18:2})$, 10.1% of $(C_{18:1},\;C_{18:2},\;C_{18:2})$, 5.4% of $(C_{18:1},\;C_{18:1},\;C_{18:2})$, 4.3% of $(C_{18:1},\;C_{18:2},\;C_{18:3})$, 3.9% of $(C_{18:0},\;C_{18:2},\;C_{18:2})$, 2.0% of $(C_{18:0},\;C_{18:1},\;C_{18:2})$, 1.8% of $(C_{18:0},\;C_{18:2},\;C_{18:2})$.

• Korean Journal of Mathematics
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• v.19 no.1
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• pp.17-24
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• 2011

Let X, Y be vector spaces. It is shown that if an even mapping $f:X{\rightarrow}Y$ satisfies f(0) = 0, and $$2(_{2d-2}C_{d-1}-_{2d-2}C_d)f\({\sum_{j=1}^{2d}}x_j\)+{\sum_{{\iota}(j)=0,1,{{\small\sum}_{j=1}^{2d}}{\iota}(j)=d}}\;f\({\sum_{j=1}^{2d}}(-1)^{{\iota}(j)}x_j\)=2(_{2d-1}C_d+_{2d-2}C_{d-1}-_{2d-2}C_d){\sum_{j=1}^{2d}}f(x_j)$$ for all $x_1$, ${\cdots}$, $x_{2d}{\in}X$, then the even mapping $f:X{\rightarrow}Y$ is quadratic. Furthermore, we prove the Hyers-Ulam stability of the above functional equation in Banach spaces.

• Progress in Superconductivity and Cryogenics
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• v.5 no.1
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• pp.27-30
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• 2003

The Bi2212 based HTS tubes with 4 different compositions, Bi:Sr:Ca:Cu = 2.0:2.0:1.0:2.0, 2.1:2.0:1.0:2.0,2.2:1.8:1.0:2.0 and 2.2:1.8.1.0.2:2 with 10% of SrSO$_4$ were studied. For tube fabrication the optimum range of melt temperatures and preheating temperature and time for mold were 105$0^{\circ}C$~110$0^{\circ}C$ and 55$0^{\circ}C$ for 30min respectively. The mold rotating speed was 1000rpm. Typical tube dimension was 30/24mm in outside/inside diameter and 60mm in length. A tube was annealed at 84$0^{\circ}C$ for 40 hours in oxygen atmosphere. The plate like grains more than 20${\mu}{\textrm}{m}$ were well developed along the rotating direction of mold regardless of initial chemical compositions. The specimen with Bi2212 composition exhibited $T_c$ of 83K while the specimen with other compositions are lower than 60K. The measured $I_c and J_c$ at 77K(B = 0T) in Bi2212 composition were about 80A and 266A/$\textrm{cm}^2$.

• Journal of the Korean Mathematical Society
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• v.34 no.4
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• pp.859-869
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• 1997

It is shown that for $A_{k, m}$ a k-homogeneous $C^*$-algebra over $S^{2n - 1} \times S^1$ such that no non-trivial matrix algebra can be factored out of $A_{k, m}$ and $A_{k, m} \otimes M_l(C)$ has a non-trivial bundle structure for any positive integer l, we construct an $A_{k, m^-} C(S^{2n - 1} \times S^1) \otimes M_k(C)$-equivalence bimodule to show that every k-homogeneous $C^*$-algebra over $S^{2n - 1} \times S^1)$. Moreover, we prove that the tensor product of the k-homogeneous $C^*$-algebra $A_{k, m}$ with a UHF-algebra of type $p^\infty$ has the tribial bundle structure if and only if the set of prime factors of k is a subset of the set of prime factors of pp.