• 대한전자공학회논문지SD
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• 제43권11호
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• pp.69-76
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• 2006

본 논문에서는 생명체의 구조를 모방하여, 다중고장에 대한 효율적인 자가치유시스템 구조를 제안한다. 기존의 자가치유시스템은 인공 셀의 데이터의 패스가 좌우상하로만 가능하여 열 단위 치유만이 가능했다. 또한, 인공 셀의 게놈블록의 설계에 있어서, gene정보 저장방식을 이용함으로써 하드웨어 오버헤드가 큰 문제점이 있다. 본 논문에서는 인공 셀의 데이터의 패스를 대각선으로도 가능하게 설계하여, 열 단위가 아닌 셀 단위로 고장 셀의 용이한 대체가 가능하고 다중고장에 대해서도 효율적으로 자가치유가 가능하다. 또한, 게놈블록은 로직기반 생성방식을 이용하여 설계함으로써 저면적 설계가 가능하다. 2진 up/down 카운터를 예제로 하여 설계한 결과 하드웨어 오버 헤드를 약 40.3% 개선했다.

• Journal of the Korean Wood Science and Technology
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• 제21권1호
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• pp.39-50
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• 1993

The purpose of this study was to describe the micromorphological changes in Korean red pine (Pinus densiflora S. et Z.) wood decayed by a major brown-rot fungus, Lentinus lepideus, using scanning electron microscope and transmission electron microscope. At the end of the 12-week exposure to the fungus in soil block procedure(ASTM 1971), test blocks sustained 5.02% weight loss. The formation of bore hole by hyphae and penetration of hyphae through bordered pit were not observed. Instead, fungal hyphae appeared to penetrate axially tracheid luminar from the the ray cells via cross field pits. Hyphae were mainly found in lignin rich cell corner regions of tracheids, and also extensive degradation of tracheid wall occurred in this region. Extensive degradation of $S_2$ layer occurred without noticeable alteration of the $S_3$ layer, but warty layer and compound middle lamella remained relatively intact. Localized erosion, the characteristic of white rot, was observed in some cell wall and wall components including lignin were found to be decomposed.

• Biomolecules & Therapeutics
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• 제18권4호
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• pp.463-468
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• 2010

T-cell activation depends on signals received by the T-cell receptor and CD28 co-stimulatory receptor. Since B7.1 and B7.2 molecules expressed on the surface of antigen presenting cells provide co-stimulatory signals through CD28 to T-cells, an inhibitor of CD28-B7.1/B7.2 binding has been proposed as a therapeutic agent for suppression of excessive T-cell activity. Although anti-B7.1/B7.2 antibodies are known to block B7.1 and B7.2 molecules, their effects on intracellular events in antigen presenting cells remain unclear. In this study, anti-B7.1/B7.2 antibodies decreased secretion of nitric oxide and pro-inflammatory cytokines such as TNF-$\alpha$, IL-$1{\beta}$, and IL-12 in LPS-activated RAW264.7 macrophage-like cells and peritoneal macrophages. Moreover, anti-B7.1/B7.2 antibodies inhibited $I{\kappa}B{\alpha}$ phosphorylation and down-regulated expression of co-stimulatory molecules including B7.1, B7.2, and PD-L1 in LPS-stimulated peritoneal macrophages. These findings suggest that CTLA4-Ig and anti-B7.1/B7.2 antibodies may be candidates to treat chronic inflammatory diseases and autoimmune responses caused by excessive activation of both T-cells and macrophages.

• The Korean Journal of Physiology and Pharmacology
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• 제5권2호
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• pp.157-163
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• 2001

The effects of dimethyl sulfoxide (DMSO) were studied in two groups of Xenopus oocytes, one expressing ATP sensitive $K^+\;(K_{ATP})$ channel comprised of sulfonylurea receptor SUR1 and inwardly rectifying $K^+$ channel subunit Kir6.2, and the other expressing renal $K_{ATP}$ channel ROMK2. At concentrations of $0.3{\sim}10%$ (vol/vol) DMSO inhibited whole cell Kir6.2/SUR1 currents elicited by bath application of sodium azide (3 mM) in a concentration-dependent manner. The inhibition constant and Hill coefficient were 2.93% and 1.62, respectively. ROMK2 currents, however, was not affected significantly by DMSO. The results support the idea that DMSO inhibits $K_{ATP}$ channel expressed in Xenopus oocyte through a protein-specific mechanism(s) that remains to be further elucidated.

• 한국식품영양학회지
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• 제2권2호
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• pp.8-13
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• 1989

A strain of Saccharomyces cerevisiae BY-366 was found to produce a strong sucrose-hydrolyzing enzyme Using this strain, the optimal culture conditions for the production of invertase were investigated. The results are as follows : 1. For enzyme production, optimal temperature, initial pH and critical concentrations of sucrose and raffinose were 3$0^{\circ}C$, 5.0 and 3.0%, respectively. 2. Enzyme production was reached maximum by organic nitrogen source, 0.3% yeast extract plus 0.5% bactopeptone. 3. It was appeared the presence of 0.1 M Mn2+ and Fe2+ ion was essential factors, on the other hand, 0.1 M Ag+ and Hg2+ ion almost block in yeast growth and enzyme production. 4. Invertase productivity was reached maximum within 3 days on stationary culture with medium-composed of sucrose 3%, bactopeptone 0.5%, yeast extract 0.3%, KEHPO. 0,1%, MgSO4.7H2O 0.05%.

• 전기화학회지
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• 제25권2호
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• pp.88-94
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• 2022

알칼리막 연료전지에 사용되는 음이온 교환막은 OH^-을 전달하는 역할을 하며 연료전지의 성능에 많은 영향을 미친다. 따라서 음이온 교환막의 정확한 OH^- 전도도를 측정하는 것은 매우 중요하다. 그러나 OH^-은 대기 중의 CO₂에 의해 중탄산염 형태로 쉽게 피독되어 전해질막의 정확한 OH^- 전도도를 측정하는 것은 매우 어렵다. 본 연구에서는 음이온 교환막의 정확한 OH^- 전도도를 측정하기 위하여 전기화학적 이온교환 처리법을 검증하였다. 또한 CO₂에 노출된 전해질막의 거동을 OH^- 전도도 변화를 통하여 확인하였다. 상용 음이온 교환 막인 Fumatech사의 FAA-3-50과 Orion Polymer사의 Orion TM1와 함께 본 연구 그룹에서 개발한 QPP-6F를 사용하여 정확한 OH^- 전도도 측정 및 CO₂ 피독 효과에 대해서 분석하였다.

• 한국정보통신학회논문지
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• 제15권4호
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• pp.913-920
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• 2011

본 논문에서는 수동형 900MHz RFID 태그 칩용 로직 공정 기반 저면적.저전력 1Kb EEPROM를 설계하였다. 1Kb 셀 배열 (cell array)은 1 워드 (word)의 EEPROM 팬텀 셀 (phantom cell)을 2차원 배열 형태인 (16행 ${\times}$ 16열) ${\times}$ 4블록으로 구성하였으며, 4개의 메모리 블록이 CG (Control Gate)와 TG (Tunnel Gate) 구동회로를 공유하므로 저면적 IP 설계를 하였다. TG 구동회로를 공유하기 위해 소자간의 전압을 신뢰성이 보장되는 5.5V 이내로 유지하면서 동작 모드별 TG 바이어스 전압을 스위칭해 주는 TG 스위치 회로를 제안하였다. 그리고 4 메모리 블록 중 하나의 블록만 활성화하는 partial activation 방식을 사용하므로 읽기 모드에서 전력소모를 줄였다. 그리고 하나의 열 (column)당 연결되는 셀의 수를 줄이므로 읽기 모드에서 BL (Bit-Line)의 스위칭 시간을 빠르게 하여 액세스 시간 (access time)을 줄였다. Tower $0.18{\mu}m$ CMOS 공정을 이용하여 (32행 ${\times}$ 16열) ${\times}$ 2블록과 (16행 ${\times}$ 16열) ${\times}$ 4블록의 2가지 배열 형태의 1Kb EEPROM IP를 설계하였으며, (16행 ${\times}$ 16열) ${\times}$ 4블록의 IP가 (32행 ${\times}$ 16열) ${\times}$ 2블록의 IP에 비해 레이아웃 면적은 11.9% 줄였으며, 읽기 모드 시 전력소모는 51% 줄였다.

• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.254-254
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• 2006

The sensitivity of plasmid DNA (pDNA) to S1 nuclease, an enzyme to cleave a single-strand DNA, was dramatically modulated through a supramolecular assembly (polyion complex micelle) with a synthetic block copolymer, poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL). The pDNA condensed in stoichiometric charge ratio was cleaved into 7 fragments each being 10/12, 9/12, 8/12, 6/12, 4/12, 3/12, and 2/12 of the original DNA length, on the other hand, the pDNA condensed in higher charge ratios (>4), were digested into non-specific manner. Condensation of the pDNA was investigated from two viewpoints that how does the rigid DNA molecules fold and condense and how does the condensation influence their biological activity.

• 한국전산유체공학회지
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• 제2권1호
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• pp.46-53
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• 1997

The flow field around a three dimensional minivan-like body has been simulated. This study solves 3-D unsteady incompressible Navier-Stokes equations on a non-orthogonal curvilinear coordinate system using second-order accurate schemes for the time derivatives, and third/second-order scheme for the spatial derivatives. The Marker-and-Cell concept is applied to efficiently solve continuity equation. A H-H type of multi-block grid system is generated around a three dimensional minivan-like body. Turbulent flows have been modeled by the Baldwin-Lomax turbulent model. To validate present procedure, the flows around the Ahmed body with 12.5° of slant angle are simulated. A good agreement with other numerical results is achived. After code validation, the flows around a mimivan-like body are simulated. The simulation shows three dimensional vortex-pair just behind body. The flow separation is also observed on the rear of the body. It has concluded that the results of present study properly agreed with physical flow phenomena.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2004년도 ICEIC The International Conference on Electronics Informations and Communications
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• pp.199-203
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• 2004

In this paper, we only describe the digital block of two-channel 18-bit analog-to-digital (A/D) converter employing sigma-delta method and xl28 decimation. The device contains two fourth comb filters with 1-bit input from sigma­delta modulator. each followed by a digital half band FIR(Finite Impulse Response) filters. The external analog sigma-delta modulators are sampled at 6.144MHz and the digital words are output at 48kHz. The fourth-order comb filter has designed 3 types of ways for optimal power consumption and signal-to-noise ratio. The following 3 digital filters are designed with 12tap, 22tap and 116tap to meet the specification. These filters eliminate images of the base band audio signal that exist at multiples of the input sample rate. We also designed these filters with 8bit and 16bit filter coefficient to analysis signal-to-noise ratio and hardware complexity. It also included digital output interface block for I2S serial data protocol, test circuit and internal input vector generator. It is fabricated with 0.35um HYNIX standard CMOS cell library with 3.3V supply voltage and the chip size is 2000um by 2000um. The function and the performance have been verified using Verilog XL logic simulator and Matlab tool.