• Genomics & Informatics
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• v.15 no.1
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• pp.48-50
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• 2017

Tumor tissues from biopsies or surgery are major sources for the next generation sequencing (NGS) study, but these procedures are invasive and have limitation to overcome intratumor heterogeneity. Recent studies have shown that driver alterations in tumor tissues can be detected by liquid biopsy which is a less invasive technique capable of both capturing the tumor heterogeneity and overcoming the difficulty in tissue sampling. However, it is still unclear whether the driver alterations in liquid biopsy can be detected by targeted NGS and how those related to the tissue biopsy. In this study, we performed whole-exome sequencing for a breast cancer tissue and identified PTEN p.H259fs*7 frameshift mutation. In the plasma DNA (liquid biopsy) analysis by targeted NGS, the same variant initially identified in the tumor tissue was also detected with low variant allele frequency. This mutation was subsequently validated by digital polymerase chain reaction in liquid biopsy. Our result confirm that driver alterations identified in the tumor tissue were detected in liquid biopsy by targeted NGS as well, and suggest that a higher depth of sequencing coverage is needed for detection of genomic alterations in a liquid biopsy.

• Anxiety and mood
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• v.2 no.2
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• pp.115-121
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• 2006

Objectives : We performed this '2006 Korean Anxiety Research' to understand the actual state about Korean anxiety and get the basic data for mental health promotion. Methods : Semistructured questionnaire and Beck Anxiety Inventory -Korean version (BAI) were administered to total 1,000 adults (20-69 years old 501 male & 499 female adults living in Seoul and 5 metropolitan cities in Korea) on March 20th~31st, 2006. Results : Anxious subjects by the total score of BAI was 3.3%. But the responders the item 'I am in the anxious state' was 25% among total subjects. 6% (n=59) among total subjects were the responders experienced the anxiety requiring usually the counselling or treatment. The frequency of their anxiety was most commonly 1 to 2 times/month. The main causes of their anxiety were 'their health problems or illness', 'economic difficulty', 'interpersonal conflicts'. But 'help by health professional' among their usual anxiety reduction methods' was only 15% among them. Only 19% among them were under the treatment of anxiety. Only 27% among 48 subjects not under the treatment of anxiety had a desire for the anxiety treatment in the near future. Conclusion : Some people in the anxious state impairing their daily lives were not yet under the treatment. And most of them had no desire for the anxiety treatment. Therefore we will systematically plan the further health education on the anxiety-related problems for the Korean mental health promotion and the quality of life.

• The Journal of Pediatrics of Korean Medicine
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• v.17 no.2
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• pp.149-160
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• 2003

Objective : Essential oil inhalation and He-Ne laser treatment has become increasingly available in children with nasal diseases. But the reports on the effect and prognosis have been poor. In this study, we analyzed the treatment effect, recurrence rate and the degree of recurrent symptoms. Materials/Methods: 23 children(2-10 year-old) with nasal diseases, who received essential oil inhalation with He-Ne laser treatment at least 10 times in our hospital from January 1st 2001 to December 31th 2002 were studied. Result : Ten cases are male & thirteen cases are female. The average of age was 4.91 year-old. The most frequency symptoms are nasal discharge (82.6%), nasal obstruction (78.3%), cough (47.8%), secretion sound (39.1%), sneezing (17.4%). Average numbers of treatment period, interval and treatment times are 71.79 days, 4.06 days, 18.13 times respectively. Of the 23 children, 14 children were in 'all symptom improved' at the remedial ends, and 22 children relapsed. In the degree of recurrent symptoms, 15 children were in 'more improved then before-treatment and not equal to directly remedial ends'. No case was in 'worse than before-treatment'. The final result of treatment, 6 children keep the degree of remedial ends, on the other hand 17 children are not. Conclusions : Even though, the recurrence rate was high, this combined treatment improve nasal symptoms. The final assessment is good, when the treatment-result is good, when the treatment interval is regular and when parent's are cooperative. If the symptoms continue a whole year, the result is not so good.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2011.10a
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• pp.325-330
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• 2011

RCP(Reactor coolant pump) must be designed to preserve it's functions on normal or abnormal environments and seismic event same as operating basis earthquake(OBE) and safe shutdown earthquake(SSE). Generally, there are static and dynamic analytical method which can be applied by a floor response spectrum or time history analysis for the seismic qualification. Initially, It was accomplished a detailed structural FE-model for finite element analysis on the bases of 3-dimensional solid model which was made by the RCP drawing. As the result of dynamic characteristic using the detailed FE-model, it's shown about 12Hz natural frequency of 1st bending mode shape and maximum displacement has 11mm with the structural bending by single-point response spectrum(SPRS) method at all elevation. But maximum displacement has 7.6mm by multi-point response spectrum(MPRS) method which was applied to the three floor response spectrum at each elevation. Therefore, On a large heighten structures as RCP, The application by SPRS method causes to be more conservative results. Finally, A simpled equivalent beam model which was developed by use of iteration of detailed FE-model is shown the result more similar with those of natural frequencies and SPRS analysis. And maximum equivalent stress and displacement of the simpled beam has verified with 180MPa and 7.1mm each at 15sec as results by SSE time history method.

• Korean Journal of Acupuncture
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• v.21 no.2
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• pp.1-28
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• 2004

Objectives : Human physiological changes in the state of qigong has been measured using EEG(Electroencephalography), functional MRI(functional Magnetic Resonance Image), EAV(Electro-Acupuncture according to Voll) and SQUID(Superconducting Quantum Interference Device) measurements. Methods & Results : EEGs were measured to study the differences between Qigong masters and Qi receiver on the changes of EEG. During Qigong, an alpha waves were increased. The power spectra indicate that the peak frequency of alpha waves increased during Qigong. Qi receiver's EEG signals seemed to affected by the state of himself. Brain activation did not observed when qigong master concentrates the Qi at Laogong(P8). But a localization of fMRI signal in the sensory cortex was observed by electric acupuncture stimulation at Laogong(P8). Five phase deviation of EAV were clearly changed in the both cases of Qigong master and Qi receiver. When a Qigong master concentrates the Qi at Yintang, Laogong(P8), Qihai(CV6) meridian points during Qigong state, the change of magnetic field around acupoints Yintang, Laogong points has been measured using 40-Channel DROS-SQUID apparatus. After smoothing process of the continuously measured magnetic signal around acupoints for a few minutes, we could observe that a series of peaks, magnitude of -1.0~2.5pT appeared. But there was no significant difference in changes of magnetic signal around acupoints. Physical signals of magnetocardiogram has been measured by using 2-Channel DROS SQUID(Magnetocardiogram). Physical signals of magnetocardiogram were clealy changed at the ST segments after S-wave when qigong master concentrates the Qi.

• Science of Emotion and Sensibility
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• v.8 no.1
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• pp.37-45
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• 2005

This paper reports the remedial effect measurement of an obesity remedy machine for home use which has been developed by H Co. and the authors. It is expected that the machine enhances it's remedial effect and usability by utilizing medium frequency and thermotherapy belt etc. In order to measure it's remedial effect, a clinical experiment, which participates eight young female subjects, has been conducted for one month. The experiment includes the measurements on the changes of Gas-Exchange Responses of subjects through Cardio-Pulmonary Exercise Testing. The experimental results show that the obesity remedy machine helps the subjects to reduce their weights, fat rates, and $VCO_2s$. Thus, it turns out that the machine can be a good candidate for medical treatment on the obesity.

• Asian Oncology Nursing
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• v.10 no.2
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• pp.180-190
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• 2010

Purpose: The purpose of this study was to compare the improvement and maintenance effects of foot reflexology (FR) on sensations after breast cancer surgery with those of lavender foot bath (LFB). Methods: Using a single-blind design, both 18 women to receive 20-min FR by trained experts and 14 women to soak feet in $40^{\circ}C$ foot tub water with 5 drop lavender essential oil, 15-min were intervened every two days. Repeated measures were taken pre 1st-(baseline-4th op. day), pre 3rd-(2nd data), and pre 5th-intervention (3rd data) with following up at 1-week after 5th intervention (4th data). The reliable translated Korean version of Baron's Breast Sensation Assessment Scale was used to assess sensations after breast cancer surgery (SABCS) characterized by prevalence, frequency, severity, and distress. Results: A significant difference between baseline and the 3rd, and a decrease tendency from baseline to the 3rd were observed for the severity and distress in FR and for the prevalence and severity in LFB. A significant or important decrease tendency between the 3rd and the 4th were observed for the severity and distress in FR and for the severity in LFB. Conclusion: Iterative FR has the improvement and maintenance effects on the severity and distress while LFB has only those on the severity.

• Journal of the Korea Convergence Society
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• v.8 no.7
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• pp.305-313
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• 2017

The purpose of this study is to investigate the effect of the level of participation in sports for the disabled on the community attachment. The subjects of this study were 227 persons with physical disabilities in D city. The analysis method was analyzed by factor analysis, frequency analysis, independent t-test, one-way ANOVA and multiple regression analysis using SPSS 21.0 program. The results of this study are as follows: First, there is a high level of community attachment to male(sex), 40's and 50's(by age group) and 1st and 2nd grade(by disability grade). Second, in the degree of participation, the duration of exercise and duration of exercise, duration of exercise in dependency, and duration of exercise and intensity of exercise were found to have a positive effect on identity. As a result, it affected the consciousness of local community. In future research, it is necessary to study the psychological effect connected with community.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1993.05a
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• pp.79-79
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• 1993

The retrospective analysis of 285 cases with diagnoses of foreign bodies in the food and air passages that were managed at the Department of Otolaryngology, KangNam St.Mary's Hospital from Nov.1980 to Oct.1992 are reported. The results are as follows : 1) Among 285 cases, 254 cases(89.2%) were lodged in the esophagus and 31 cases (10.8%) in the air passage. The ratio between the foreign bodies in the food and those in the air passage was about 8.2 : 1 2) Among all cases, 171 cases were males(59.8%) and 114 cases were females(40.2%). 3) The group under 5 years old having foreign bodies was over half of all cases(56.5%), and the group over 51 years old was 15.5% of all cases. 4) The incidence of foreign bodies in order of frequency was coin(35.6%), fish bone (21.8%) and chicken bone(7.9%) in the food passage. Beans and peanuts were the most common foreign bodies in the air passage. 5) In the location of foreign bodies of the food passage, 208 cases(82.2%) were found in the first esophageal narrowing. In the air passage, the frequent sites of lodgement were the bronchus, trachea and larynx in order. 6) The 67.0% of all cases was removed within 24 hours. The duration of lodgement showed differences in relation with varieties of the foreign bodies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.2
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• pp.795-804
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• 2011

This study was performed to determine the levels of quality of life(QOL) according to the grade of long-term care service in the elderly people who affiliated from long-term care insurance, and to reveal its association with socio-demographic characteristics, health status and health related behaviors. The interviews were performed, during the period from March 1st, to May 31th, 2009, to 410 elderlies in rural areas. As a results, the levels of QOL were lower in the group of higher grade of long-term care insurance. In hierarchial multiple regression analysis, the factors influencing on the level QOL were age, Living status, Subjective health status, Bed ridden status, Disability of body, Urinary incontinence, Amnesia and Frequency of going out. Especially, the health status variables were higher related with QOL than other variables.