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The Effect of Yukmijihwangtanghapyijihwangagambang on Melanin Synthesis and Related Gene Expressions in B16F10 Mouse Melanoma Cell (육미지황탕합이지환가감방(六味地黃湯合二至丸加減方)이 멜라닌 생성과 관련 유전자 발현에 미치는 영향)

  • Shin, Sun-Mi;Yoo, Dong-Youl
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.4
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    • pp.28-45
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    • 2009
  • Purpose: This study was performed to elucidate the inhibitory effect of Yukmijihwangtanghapyijihwangagambang (YM) on melanin synthesis in B16F10 melanoma cells. Methods: To demonstrate the inhibitory effects of YM on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma call. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma call. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, PKA, $PKC{\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma call. Results: 1. YM decreased the release and production of melanin in B16F10 melanoma cells. 2. YM decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. YM decreased the expression of tyrosinase, TRP-1, TRP-2 in B16F10 melanoma cells. 4. YM decreased the expression of PKA, $PKC{\beta}$ in B16F10 melanoma cells. 5. YM increased the expression of ERK-1, ERK-2 and AKT-1 in B16F10 melanoma cells. 6. YM decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, it may be concluded that YM has antimelanogenetic effects.

A GENERALIZATION OF A RESULT OF CHOA ON ANALYTIC FUNCTIONS WITH HADAMARD GAPS

  • Stevic Stevo
    • Journal of the Korean Mathematical Society
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    • v.43 no.3
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    • pp.579-591
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    • 2006
  • In this paper we obtain a sufficient and necessary condition for an analytic function f on the unit ball B with Hadamard gaps, that is, for $f(z)\;=\;{\sum}^{\infty}_{k=1}\;P_{nk}(z)$ (the homogeneous polynomial expansion of f) satisfying $n_{k+1}/n_{k}{\ge}{\lambda}>1$ for all $k\;{\in}\;N$, to belong to the weighted Bergman space $$A^p_{\alpha}(B)\;=\;\{f{\mid}{\int}_{B}{\mid}f(z){\mid}^{p}(1-{\mid}z{\mid}^2)^{\alpha}dV(z) < {\infty},\;f{\in}H(B)\}$$. We find a growth estimate for the integral mean $$\({\int}_{{\partial}B}{\mid}f(r{\zeta}){\mid}^pd{\sigma}({\zeta})\)^{1/p}$$, and an estimate for the point evaluations in this class of functions. Similar results on the mixed norm space $H_{p,q,{\alpha}$(B) and weighted Bergman space on polydisc $A^p_{^{\to}_{\alpha}}(U^n)$ are also given.

A Study on the Variation of the Body surface Area by the Arm movements to Somatotype -The Subject of the College Men- (체형별 상복동작에 따른 상체의 체표면 변화에 관한 연구 -남자대학생을 중심으로-)

  • 김진경
    • Journal of the Korean Home Economics Association
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    • v.26 no.2
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    • pp.1-13
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    • 1988
  • The purpose of this study was to classify somatotype of males, to show changes of the body skin surface by the somatotype. The size of sample was 156 males between age 20 and 24. Somatotype classified into Bending somatotype, Standard somatotype, Turning over somatotype. And according to the somatotype, changing of the upper part of the body by the arm movements analyzed through gypsum experiment. The result obtained from this study were as follows; 1. the variation of the upper part of the body form by changing the am movements, by the increasing of movements, shoulder-point ws moved to be inside or upside, the anterior armpit point & armpit point were moved to the upside. 2. As a result of investigating into the rate of the expansion and contraction of the basic lines and body surface area by the arm movements, the rate of expansion and contraction of the basic lines by the arm movements, the side sea length showed the maximum rate of extension in 135 degrees, the shoulder length showed the maximum rate of contraction in 135 degrees. The rate of expansion and contraction on the body surface area by the arm movements showed the phenomenon of contraction, of items F1, F6, B1, B9 showed the phenomenon of extension, of items F3, F4, F8, F9, B8, B9. 3. According to somatotypes, items which show the significant difference were, of items f3, f8, b3, b8, F2, F7, F8, B3, B7, in all movements.

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BERRY-ESSEEN BOUNDS OF RECURSIVE KERNEL ESTIMATOR OF DENSITY UNDER STRONG MIXING ASSUMPTIONS

  • Liu, Yu-Xiao;Niu, Si-Li
    • Bulletin of the Korean Mathematical Society
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    • v.54 no.1
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    • pp.343-358
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    • 2017
  • Let {$X_i$} be a sequence of stationary ${\alpha}-mixing$ random variables with probability density function f(x). The recursive kernel estimators of f(x) are defined by $$\hat{f}_n(x)={\frac{1}{n\sqrt{b_n}}{\sum_{j=1}^{n}}b_j{^{-\frac{1}{2}}K(\frac{x-X_j}{b_j})\;and\;{\tilde{f}}_n(x)={\frac{1}{n}}{\sum_{j=1}^{n}}{\frac{1}{b_j}}K(\frac{x-X_j}{b_j})$$, where 0 < $b_n{\rightarrow}0$ is bandwith and K is some kernel function. Under appropriate conditions, we establish the Berry-Esseen bounds for these estimators of f(x), which show the convergence rates of asymptotic normality of the estimators.

Toxicity and Fumonisin B1 Production by Fusarium Isolates from Chines Corn Samples (중국산 옥수수로부터 분리한 Fusarium균주의 독성 및 Fumonisin B1의 생성)

  • 이인원;강효중
    • Korean Journal Plant Pathology
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    • v.10 no.2
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    • pp.129-135
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    • 1994
  • Ninety-two isolates of Fusarium species were obtained from Chinese corn samples. The predominant Fusarium species isolated from corn seeds were F. moniliforme, F. proliferatum, F. oxysporum and F. subglutinans, and all 13 species were identified. Each isolate was grown on autoclaved wheat grains and wheat cultures were fed by twenty-one-day-old female rats for the toxicity test. Twenty-six out of 92 isolates caused the death accompanying feed refusal, severe weight loss, liver damage, and hemorrhages in the stomach and intestines. Of the toxigenic isolates, 17 isolates of F. moniliforme, 4 of F. oxysporum, 3 of F. proliferatum, and one of each F. sporotrichioides and unknown species were lethal to rats. The analyses of fumonisin B1 production of the 26 toxigenic Fusarium isolates were carried out by thin layer chromatography and high-performance liquid chromatography, and fumonisin B1 was confirmed by mass spectrometry. Fumonisin B1 was produced in wheat culture at levels ranging from 280 $\mu\textrm{g}$/g to 3,952 $\mu\textrm{g}$/g by all of toxigenic F. moniliforme and F. proliferatum, but by none of the other toxigenic Fusarium species. The present results suggest the high possibility of natural occurrence of fumonisin B1 in corn samples imported from China.

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The Effect of Yukmijihwangtang -gagambang (YMG) on Melanin Synthesis and Gene Expression (육미지황탕가감방(六味地黃湯加減方)이 멜라닌 생성 및 유전자발현에 미치는 영향)

  • Kim, Jin-Kyung;Yoo, Dong-Youl
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.3
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    • pp.66-82
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    • 2009
  • Purpose: This study was performed to elucidate the inhibitory effect of Yukmijihwangtang-gagambang (YMG) on melanin synthesis in B16F10 mouse melanoma cell. Methods: To demonstrate the inhibitory effects of YMG on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma cell. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma cell. And to investigate the action mechanism we assessed the gene expressions of tyrosinase, TRP-1, TRP-2, MMP-2, PKA, PKC${\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma cells. Results: 1. YMG decreased the release and production of melanin in B16F10 melanoma cells. 2. YMG decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. YMG decreased the expression of tyrosinase, TRP-1, TRP-2, PKA, PKC${\beta}$ and MMP-2 in B16F10 melanoma cells. 4. YMG increased the expression of ERK-1, ERK-2, and AKT-1 in B16F10 melanoma cells. 5. YMG decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, we suggest that YMG inhibit melanin synthesis via tyrosinase inhibition and regulation of the gene expression in B16F10 melanoma cells.

Reaction Properties of Dinuclear Metallocenes

  • Noh Seok-Kyun;Jeong Eung-Yeong;Qei Duang Huang Dan;Lyoo Won-Seok
    • Proceedings of the Polymer Society of Korea Conference
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    • 2006.10a
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    • pp.224-225
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    • 2006
  • The Ethylene polymerization behavior of a series of polymethylene bridged dinuclear CGC $[Zr({\eta}^{5}:{\eta}^{1}-C_{9}H_{5}SiMe_{2}NCMe_{3})Me_{2}]_{2}[(CH_{2})_{n}]\;[_{n}=6(1),\;9(2),\;12(3)]$ in the cocatalytic activation with $Ph_{3}C^{+}B^{-}(C_{6}F_{5})_{4}\;(B_{1})\;or\;Ph_{3}C^{+}(C_{6}F_{5})_{3}B^{-}C_{6}F_{4}B^{-}(C_{6}F_{5})_{3}Ph_{3}C^{+}\;(B_{2})\;or\;B(C_{6}F_{5})_{3}\;(B_{3})$ were investigated to study the nuclearity effects as well as the counteranion effects. The ethylene polymerization and ethylene/1-hexene copolymerization were conducted at $30^{\circ}C$ It was found that both in ethylene polymerization and ethylene/1-hexene copolymerization, activities increased in the order of 1 < 2 < 3, which indicates the presence of longer bridge between two active sites contributes more efficiently to facilitate the polymerization activity.

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The Deformation and Breaking Load of the Fishing Hook by the Tensile Test (인장시험에 의한 낚시의 변형과 파단하중)

  • KO Kwan-Soh;KIM Yong-Hae
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.14 no.4
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    • pp.269-275
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    • 1981
  • The fishing hooks were tested for breaking and unbending due to plastic deformation of the material. Study of tensile test is not complicated, but has not even worked out fully enough, especially when the test specimen is subjected to plastic deformation. The fishing hook is subjected to unbending stress and the critical section is a Point which is furthest from the line of action of the forces. The dynamic force of fish during jerks depends on their speed of movement and body weight, the kinetic energy corresponding to it and also on the rlastic displacement of the rigging which absorb the energy. Six kinds of hook were tested by the dynamometer under tensile speed 290mm/min (subscript s) and 780mm/min (subscript f). According to their results, the breaking load(B: kg) can be induced with the formula $B={\alpha}wd^2+\beta$ where w(mm) is the distance between the barb base and the lower shank and d(mm) is diameter. The coefficients of the formula for the round hooks(R) and the angular hooks(A) are approximately as follows: $$R:\;\alpha_{s}=0.5,\;\beta_{s}=1.6,\;\alpha_{f}=0.4,\;\beta_{f}=1.4$$ $$A:\;\alpha_{s}=1.1,\;\beta_{s}=2.0,\;\alpha_{f}=1.0,\;\beta_{f}=0.9$$ The ratio of $B_{f}\;to\;B_{s}$ is corresponding to 0.8. The ratio of deformation(X) that is moved distance of barb base at break to the distance(H) between head base and barb base is about $50\%$. Further study should be carried out on the subject of impact and fatigue test under the same condition which is exerted force by the hooked fish.

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A CHARACTERIZATION OF M-HARMONICITY

  • Lee, Jae-Sung
    • Bulletin of the Korean Mathematical Society
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    • v.47 no.1
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    • pp.113-119
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    • 2010
  • If f is M-harmonic and integrable with respect to a weighted radial measure $\upsilon_{\alpha}$ over the unit ball $B_n$ of $\mathbb{C}^n$, then $\int_{B_n}(f\circ\psi)d\upsilon_{\alpha}=f(\psi(0))$ for every $\psi{\in}Aut(B_n)$. Equivalently f is fixed by the weighted Berezin transform; $T_{\alpha}f = f$. In this paper, we show that if a function f defined on $B_n$ satisfies $R(f\circ\phi){\in}L^{\infty}(B_n)$ for every $\phi{\in}Aut(B_n)$ and Sf = rf for some |r|=1, where S is any convex combination of the iterations of $T_{\alpha}$'s, then f is M-harmonic.

CHARACTERIZING FUNCTIONS FIXED BY A WEIGHTED BEREZIN TRANSFORM IN THE BIDISC

  • Lee, Jaesung
    • Korean Journal of Mathematics
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    • v.27 no.2
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    • pp.437-444
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    • 2019
  • For c > -1, let ${\nu}_c$ denote a weighted radial measure on ${\mathbb{C}}$ normalized so that ${\nu}_c(D)=1$. For $c_1,c_2>-1$ and $f{\in}L^1(D^2,\;{\nu}_{c_1}{\times}{\nu}_{c_2})$, we define the weighted Berezin transform $B_{c_1,c_2}f$ on $D^2$ by $$(B_{c_1,c_2})f(z,w)={\displaystyle{\smashmargin2{\int\nolimits_D}{\int\nolimits_D}}}f({\varphi}_z(x),\;{\varphi}_w(y))\;d{\nu}_{c_1}(x)d{\upsilon}_{c_2}(y)$$. This paper is about the space $M^p_{c_1,c_2}$ of function $f{\in}L^p(D^2,\;{\nu}_{c_1}{\times}{\nu}_{c_2})$ ) satisfying $B_{c_1,c_2}f=f$ for $1{\leq}p<{\infty}$. We find the identity operator on $M^p_{c_1,c_2}$ by using invariant Laplacians and we characterize some special type of functions in $M^p_{c_1,c_2}$.