• Smart Media Journal
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• v.5 no.1
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• pp.49-54
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• 2016

Medical image processing is a compulsory process to diagnose many kinds of disease. Therefore, an automatic algorithm for this task is highly demanded as an important part to construct a computer-aided diagnosis system. In this paper, we introduce an automatic method to segment the liver region from 3D abdominal CT images using Otsu method. First, we choose a 2D slice which has most liver information from the whole 3D image. Secondly, on the chosen slice, we enhanced the image based on its intensity using Otsu method with multiple thresholds and use the threshold to enhance the whole 3D image. Then, we apply a liver mask to mark the candidate liver region. After that, we execute the Otsu method again to segment the liver region from the chosen slice and propagate the result to the whole 3D image. Finally, we apply preprocessing on the frontal side of 3D images to crop only the liver region from the image.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.6
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• pp.475-482
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• 2019

Glioma is the most common brain tumor with a dismal prognosis. While temozolomide (TMZ) based chemotherapy significantly improves survival in glioma patients, resistance against this compound commonly leads to glioma treatment failure. Overexpression of long-noncoding RNA (LncRNA) FoxD2 adjacent opposite strand RNA 1 (FoxD2-AS1) was identified to promote glioma development, but the role in TMZ resistance remains unclear. In this paper, we found that FoxD2-AS1 was overexpressed in recurrent glioma, high FoxD2-AS1 expression was significantly correlated with poor patient outcome. Methylation of $O^6$-methylguanine-DNA methyltransferase (MGMT) is significantly less frequent in high FoxD2-AS1 expression patients. Knockdown of FoxD2-AS1 decreased the proliferation, metastatic ability of glioma cells and promote the sensitivity to TMZ in glioma cells. Furthermore, knockdown of FoxD2-AS1 induced hypermethylation of the promoter region of MGMT. Our data suggested that FoxD2-AS1 is a clinical relevance LncRNA and mediates TMZ resistance by regulating the methylation status of the MGMT promoter region.

• Animal cells and systems
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• v.2 no.1
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• pp.117-122
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• 1998

D-raf, a Drosophila homolog of the human c-raf-1, is known as a signal transducer in cell proliferation and differentiation. A previous study found that the D-raf gene expression is regulated by the DNA replication-related element (DRE)/DRE-binding factor (DREF) system. In this study, we found the sequences homologous to transcription factor C/EBP, MyoD, STAT and Myc recognition sites in the D-raf promoter. We have generated various base substitutional mutations in these recognition sites and subsequently examined their effects on D-raf promoter activity through transient CAT assays in Kc cells with reporter plasmids p5'-878DrafCAT carrying the mutations in these binding sites. Through gel mobility shift assay using nuclear extracts of Kc cells, we detected factors binding to these recognition sites. Our results show that transcription factor C/EBP, STAT and Myc binding sites in D-raf promoter region play a positive role in transcriptional regulation of the D-raf gene and the Myo D binding site plays a negative role.

• International Commerce and Information Review
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• v.16 no.4
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• pp.385-408
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• 2014

The purpose of this paper is to find the determinants of Korean FDI(1996~2012) in China using the spatial autoregressive model and four regions of China is analyzed respectively. Most previous studies ignored spatial interdependence to analyze the determinants of Korean outward FDI in China. Empirical results of total Chinese area shows per RGDP and spatial effects are positive and significant variables. Results of region A reveal that per RGDP is positive and spatial effects are negative and significant. Results of region B shows that both per GDP and spatial effects are positive. All variables of region C are insignificant but those of region D are significant and positive. This means that Korean companies to invest in region D should consider spatial characteristics of surrounding areas of D.

• Korean Journal of Agricultural Science
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• v.40 no.1
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• pp.27-34
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• 2013

To investigate the distribution of psychrotrophic bacteria, raw milk was collected from farms in nine different regions located around Kyunggi province in South Korea at four different seasons. Psychrotrophic counts were higher in winter than in other seasons as $3.0{\times}10^4$ CFU/mL (p<0.05). Among nine regions, the population in raw milk sampled from B region was in significantly greater numbers and those from C and D province were in significantly lower numbers than any other regions, $2.4{\times}10^5$ CFU/mL and $8.7{\times}10^3$ CFU/mL, respectively (p<0.05). In addition, among 706 bacterial isolates, the predominant class was Gamma-proteobacteria (81.02%) and genus was Pseudomonas (32.34%), especially Pseudomonas fluorescens (39.46%). Compared to the regional predominance, Acinetobacter johnsonii in A region, Pseudomonas fluorescens in B region, Enterobacter amnigenus in C region, Psychrobacter maritimus in D region, Acinetobacter johnsonii in E region, Acinetobacter haemolyticus in F region, Pseudomonas fluorescens in G region, Acinetobacter jounsonii in H region, and Pseudomonas mucidolens in I region were found.

• Journal of the HCI Society of Korea
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• v.2 no.2
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• pp.1-9
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• 2007

In this paper, we propose a reconstruction technique of the lost hair region for 3D human actor modeling. An active depth sensor system can simultaneously capture both color and geometry information of any objects in real-time. However, it cannot acquire some regions whose surfaces are shiny and dark. Therefore, to get a natural 3D human model, the lost region in depth image should be recovered, especially human hair region. The recovery is performed using both color and depth images. We find out the hair region using color image first. After the boundary of hair region is estimated, the inside of hair region is estimated using an interpolation technique and closing operation. A 3D mesh model is generated after performing a series of operations including adaptive sampling, triangulation, mesh smoothing, and texture mapping. The proposed method can generate recovered 3D mesh stream automatically. The final 3D human model allows the user view interaction or haptic interaction in realistic broadcasting system.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.22 no.10
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• pp.665-671
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• 2010

In the present study a 1D-3D numerical simulation was performed to analyze the fire safety in a rescue station of a long railroad tunnel equipped with a mechanical ventilation. The behavior of hot air was studied for the emergency operation mode of ventilation system in case of fire in the rescue station. The 1D simulation was carried out for entire tunnel region. Detailed 3D CFD simulation was performed for the rescue station area in the central region of the tunnel by using the result of the 1D simulation as the boundary condition of the 3D simulation. Various type of cross passage installation were evaluated for the prevention of smoke diffusion to suggest the optimized interval of the cross passages in the rescue tunnel.

• Korean Journal of Community Nutrition
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• v.25 no.1
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• pp.32-47
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• 2020

Objectives: Calcium (Ca) is an insufficiently consumed nutrient, whereas phosphorus (P) intake has exceeded the recommended intake level in Korea over the past decade. The purpose of this study was to analyze dietary Ca and P intakes and their contribution rate according to dish groups. Methods: A 24-hour dietary recall survey of 640 healthy adults (aged 19-69 years) was undertaken twice in four Korean provinces. Dietary Ca and P intakes and their rates of contribution from 31 major dish groups were analyzed and compared by gender, age group, and region. Results: The average Ca and P intakes of the subjects were 542.1 ± 222.2 mg/d and 1,068.3 ± 329.0 mg/d, respectively. The intakes of Ca and P as percentages of recommended nutrients intake (RNI%) were 71.7 ± 29.8% and 152.6 ± 47%, respectively, and the percentages under the estimated average requirement were 60.3% for Ca and 3.8% for P. The RNI% of Ca was not significantly different between males and females, but was significantly higher in subjects in the sixties age group than in other age groups and was significantly lower in the Korean capital than in other regions. The RNI% of P did not significantly differ by gender or age groups, but it was significantly higher in the capital than in Gyeong-sang. The five major dish groups contributing to Ca intake (contribution rate) were milks/dairy products 69.2 ± 109.2 mg/d (12.6%), soups 55.6 ± 69.6 mg/d (10.1%), stir-fried foods 53.1 ± 70.7 mg/d (9.7%), stews 43.4 ± 85.4 mg/d (7.9%), and kimchi 38.4 ± 31.8 mg/d (7.0%). The five major dish group contributing to P intake (contribution rate) were cooked rice 160.7 ± 107.1 mg/d (14.9%), stir-fried foods 88.5 ± 89.4 mg/d (8.2%), soups 76.7 ± 85.8 mg/d (7.1%), one-dish meals 63.3 ± 94.4 mg/d (5.9%), and stews 62.6 ± 89.3 mg/d (5.8%). The dish groups contributing to Ca and P intakes differed somewhat by gender, age group, and region. Conclusions: Programs to improve the nutritional status of Ca and P intakes should consider the differences in Ca and P contribution rates by dish groups as well as by gender, age group, and region.

• Animal Bioscience
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• v.35 no.7
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• pp.989-998
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• 2022

Objective: This study investigated the effects of intrauterine growth restriction (IUGR) during late pregnancy on the cell growth, proliferation, and differentiation in ovine fetal thymuses. Methods: Eighteen time-mated Mongolian ewes with singleton fetuses were allocated to three groups at d 90 of pregnancy: restricted group 1 (RG1, 0.18 MJ ME/body weight [BW]^0.75/d, n = 6), restricted group 2 (RG2, 0.33 MJ ME/BW^0.75/d, n = 6) and control group (CG, ad libitum, 0.67 MJ ME/BW^0.75/d, n = 6). Fetuses were recovered at slaughter on d 140. Results: The G0/G1 phase cell number in fetal thymus of the RG1 group was increased but the proliferation index and the expression of proliferating cell nuclear antigen (PCNA) were reduced compared with the CG group (p<0.05). Fetuses in the RG1 group exhibited decreased growth hormone receptor (GHR), insulin-like growth factor 2 receptor (IGF-2R), and their mRNA expressions (p<0.05). For the RG2 fetuses, there were no differences in the proliferation index and PCNA expression (p>0.05), but growth hormone (GH) and the mRNA expression of GHR were lower than those of the CG group (p<0.05). The thymic mRNA expressions of cyclin-dependent protein kinases (CDKs including CDK1, CDK2, and CDK4), CCNE, E2-factors (E2F1, E2F2, and E2F5) were reduced in the RG1 and RG2 groups (p<0.05), and decreased mRNA expressions of E2F4, CCNA, CCNB, and CCND were occurred in the RG1 fetuses (p<0.05). The decreased E-cadherin (E-cad) as a marker for epithelial-mesenchymal transition (EMT) was found in the RG1 and RG2 groups (p<0.05), but the OB-cadherin which is a marker for activated fibroblasts was increased in fetal thymus of the RG1 group (p<0.05). Conclusion: These results indicate that weakened GH/IGF signaling system repressed the cell cycle progression in G0/G1 phase in IUGR fetal thymus, but the switch from reduced E-cad to increased OB-cadherin suggests that transdifferentiation process of EMT associated with fibrogenesis was strengthened. The impaired cell growth, retarded proliferation and modified differentiation were responsible for impaired maturation of IUGR fetal thymus.

• Journal of Biomedical Engineering Research
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• v.44 no.1
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• pp.25-32
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• 2023

Recognizing the size and location of prostate cancer is critical for prostate cancer diagnosis, treatment, and predicting prognosis. This paper proposes a model to classify the tumor region and normal tissue with cross-sectional visual images of prostatectomy tissue. We used specimen images of 44 prostate cancer patients who received prostatectomy at Gachon University Gil Hospital. A total of 289 prostate slice images consist of 200 slices including tumor region and 89 slices not including tumor region. Images were divided based on the presence or absence of tumor, and a total of 93 features from each slice image were extracted using Radiomics: 18 first order, 24 GLCM, 16 GLRLM, 16 GLSZM, 5 NGTDM, and 14 GLDM. We compared feature selection techniques such as LASSO, ANOVA, SFS, Ridge and RF, LR, SVM classifiers for the model's high performances. We evaluated the model's performance with AUC of the ROC curve. The results showed that the combination of feature selection techniques LASSO, Ridge, and classifier RF could be best with an AUC of 0.99±0.005.