• Journal of Korea Multimedia Society
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• v.14 no.5
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• pp.614-621
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• 2011

This paper presents design of a wide tuning range digitally controlled oscillator(DCO) for Mobile-DTV applications. DCO is the key element of the ADPLL block that generates oscillation frequencies. We proposed a binary delay chain(BDC) structure, for wide tuning range DCO, modifying conventional fixed delay chain. The proposed structure generates oscillation frequencies by delay cell combination which has a variable delay time of $2^i$ in the range of $0{\leq}i{\leq}n-1$. The BOC structure can reduce the number of delay cells because it make possible to select delay cell and resolution. We simulated the proposed DCO by Cadence's Spectre RF tool in 1.8V chartered $0.18{\mu}m$ CMOS process. The simulation results showed 77MHz~2.07GHz frequency range and 3ps resolution. The phase noise yields -101dBc/Hz@1MHz at Mobile-DTV maximum frequency 1675MHz and the power consumption is 5.87mW. The proposed DCO satisfies Mobile-DTV standards such as ATSC-M/H, DVB-H, ISDB-T, T-DMB.

• Bulletin of the Korean Chemical Society
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• v.34 no.12
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• pp.3749-3754
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• 2013

Two 3D isomorphous and isostructural complexes, namely, $[Zn(BDOA)(bpy)(H_2O)_2]_n$ (1) and $[Cd(BDOA)-(bpy)(H_2O)_2]_n$ (2); (BDOA = Benzene-1,4-dioxyacetic acid, bpy = 4,4'-bipyridine) were synthesized under hydrothermal conditions and characterized by means of elemental analyses, thermogravimetric (TG), infrared spectrometry, and single crystal X-ray diffraction. Complexes 1 and 2 crystallize in the triclinic system, space group P-1 and each metal ion in the complexes are six-coordinated with the same coordination environment. In the as-synthesized complexes, $BDOA^{2-}$ anions link central metal ions to form a 1D zigzag chain $[-BDOA^{2-}-Zn(Cd)-BDOA^{2-}-Zn(Cd)-]_{\infty}$, whereas bpy pillars connect metal ions to generate a 1D linear chain $[-bpy-Zn(Cd)-bpy-Zn(Cd)-]_{\infty}$. Both infinite chains are interweaved into 2D grid-like layers which are further constructed into a 3D open framework, where hydrogen bonds play as the bridges between the adjacent 2D layers. Luminescent properties of complex 1 showed selectivity for $Hg^{2+}$ ion.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.11a
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• pp.147-172
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• 1994

Aziridinylbenzoquinones such as 3, 6-diaziridinyl-1, 4-benzoquinone (DZQ) and its 2, 5-methyl analog (MeDZQ) require bioreductive activation in order to elicit their anticancer activities. To determine the involvement of DTD in the activation of these drugs, we have used a ligation-mediated polymerase chain reaction to map the intracellular alkylation sites in a sing1e copy gene at the nucleotide level. We have performed this analysis in two human colon carcinoma cells, one proficient (HT-29) and one deficient (BE) in DT-diaphorase (DTD) activity. In the DTD proficient HT-29 cell line, DZQ and MeDZQ were found to alkylate both 5'-(A/T)G(C)-3' and 5'-(A/T)A-3' sequences. This is consistent with the nucleotide preferences observed when DZQ and MeDZQ are activated by purified DTD to reactive metabolites capable of alkylating DNA in vitro [Lee, C. -S., Hartley, J. A., Berardini, M. D., Butler, J., Siegel., D., Ross, D., & Gibson, N. W. (1992) Biochemistry, 31: 3019-3025]. Surprisingly in the DTD-deficient BE cell line a pattern of alkylation induced by DZQ and MeDZQ similar to that observed in the DTD-proficient HT-29 cells was observed. This suggests that reductive enzymes other than DTD can be involved in activating DZQ and MeDZQ to DNA reactive species in vivo.

• Polymer(Korea)
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• v.34 no.2
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• pp.159-165
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• 2010

Dipyridine-terminated polystyrenes and polybutadienes were synthesized by the chain endfunctionalization reaction of polystyryllithium (PSLi) and polybutadienyllithium (PBDLi) with di(2-pyridyl) ketone(DPK) using a living anionic polymerization method in the Ar-glove box. Living polymeric lithiums with low molecular weights (Mw=1000~2000 g/mol) were used to investigate the chain end-functionalization yield with DPK and the degree of coupling reaction by the attack of organolithium to the pyridine ring in the presence of TMEDA using GPC, $^1H$-NMR, $^{13}C$ analysis. DPK-terminated PBD exhibited much higher functionalization yield and less amount of coupling reaction compared with DPK-terminated PS. 86% functionalization yield with 9% degree of coupling was obtained when the PBDLi was added dropwise to DPK solution at room temperature. The functionalization yield was increased as the reaction temperature decreased, however, no LiCl effect was observed in this chain end-functionalization reaction with DPK.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.15 no.2
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• pp.93-97
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• 2015

Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is an autosomal recessive hereditary metabolic disorder of mitochondrial fatty acid beta-oxidation. Mutations in the ACADS gene cause short-chain acyl-CoA dehydrogenase deficiency, which is characterized by developmental delay, hypotonia, seizure, and hypoglycemia. Here, we describe one Korean pediatric case of SCAD deficiency, which was diagnosed during newborn screening by tandem mass spectrometry and confirmed by molecular analysis. The level of C4 was typically elevated 5.23 mg/dL (reference range <1.5 mg/dL). This patient had a homozygous mutation [c.1031A>G, p. E344G] in ACADS. Therefore, we present a case of SCAD deficiency in an otherwise healthy neonate and her subsequent development and growth over four years.

• Korean Journal of Pharmacognosy
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• v.42 no.3
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• pp.246-252
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• 2011

Korean mistletoe Lectin (KML-C) is composed of A and B sub-chain. B chain binds to carbohydrates on cell surface and A chain hinders translation and induces an apoptosis as a RIP (ribosome inactivating protein). KML-C has very strong biological activities, it has seriously limits to use as a cancer therapy or adjuvant because of its toxicity to normal cells. This study is therefore conducted to see if B chain of KML-C might have immunological activity, especially adjuvant activities with less toxicity. We isolated B chain from KML-C using the lactose affinity chromatography, and examined their immunoadjuvant activity. The isolated B-chain did not show any cytotoxicity against tumor cell, RAW264.7, and P388D1 while KML-C had a very strong toxicity. This non-toxic effect was observed also by in-vivo study. Both humoral and cellular immunities were observed ; the antibody titer was increased when the mice were immunized with B-chain used as adjuvant like Freund's adjuvant, indicating that B chain of mistletoe lectin alone might be used for adjuvant; it also increased DTH in cellular immunity. These results suggest that B-chain of KML-C might be used for adjuvant used for the production of antibody or vaccine with less toxicity.

• Journal of KIISE:Software and Applications
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• v.28 no.1
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• pp.46-51
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• 2001

2D로 확장한 HMM은 다수 제안되었지만 엄밀한 의미에 있어서 2D HMM이라고 하기에 부족한 점이 많다. 본 논문에서는 기존의 랜덤 필드 모형이 아닌 새로운 2D HMM을 제안한다. 상하 및 좌우 방향의 causal chain 관계를 가정하고 완전한 격자 형성 조건을 두어 2D HMM의 평가, 매개 변수를 추정하는 알고리즘을 제시하였다. 각각의 알고리즘은 동적 프로그래밍과 최우 추정법에 근거한 것이다. 변수 추정 알고리즘은 반복적으로 이루어지며 국소 최적치에 수렴함을 보였다.

• Journal of applied mathematics & informatics
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• v.37 no.5_6
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• pp.469-480
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• 2019

A generalized tiling is defined as a generalization of the properties of tiling a region of ${\mathbb{Z}}^2$ with dominoes, and comprises tiling with rhombus and any other tilings that admits height functions which can be ordered into a distributive lattice. By using properties of the distributive lattice, we prove that the Markov chain consisting of moving from one height function to the next by a flip is fast mixing and the mixing time ${\tau}({\epsilon})$ is given by ${\tau}({\epsilon}){\leq}(kmn)^3(mn\;{\ln}\;k+{\ln}\;{\epsilon}^{-1})$, where mn is the area of the grid ${\Gamma}$ that is a k-regular polycell. This result generalizes the result of the authors (T-tetromino tiling Markov chain is fast mixing, Theor. Comp. Sci. (2018)) and improves on the mixing time obtained by using coupling arguments by N. Destainville and by M. Luby, D. Randall, A. Sinclair.

• Applied Chemistry for Engineering
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• v.30 no.2
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• pp.219-225
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• 2019

Side-chain liquid crystalline polymers with various compositions of azobenzene and cholesteryl functional groups as the mesogenic moiety were synthesized by direct polycondensation, and their properties were investigated. The inherent viscosity values of synthesized polymers were between 0.32 and 0.38 dL/g in 1,1,2,2-tetrachloroethane. All polymers except the SP-A10C0 polymer containing only the azobenzene group were amorphous or exhibited very low crystallinity due to the presence of bulky mesogenic side chains. All synthesized polymers exhibited enantiotropic liquid crystallinity; the SP-A10C0 polymer having only the azobenzene group exhibited a nematic phase, and all other polymers showed a cholesteric phase. In particular, it was found that when the content of cholesteryl groups in the side chain of the polymer increases, the liquid crystallinity decreases due to the bulkiness of cholesteryl groups.

• Journal of Biosystems Engineering
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• v.29 no.5 s.106
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• pp.441-450
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• 2004

This study was performed to estimate mid and long term demands of a tractor, a rice transplanter, a combine and a grain dryer by using logistic curve function and Markov chain model. Field survey was done to decide some parameters far logistic curve function and Markov chain model. Ceiling values of tractor and combine fer logistic curve function analysis were 209,280 and 85,607 respectively. Based on logistic curve function analysis, total number of tractors increased slightly during the period analysed. New demand for combine was found to be zero. Markov chain analysis was carried out with 2 scenarios. With the scenario 1(rice price $10\%$ down and current supporting policy by government), new demand for tractor was decreased gradually up to 700 unit in the year 2012. For combine, new demand was zero. Regardless of scenarios, the replacement demand was increased slightly after 2003. After then, the replacement demand is decreased after the certain time. Two analysis of logistic owe function and Markov chain model showed the similar trend in increase and decrease for total number of tractors and combines. However, the difference in numbers of tractors and combines between the results from 2 analysis got bigger as the time passed.