• 한국ITS학회 논문지
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• 제12권6호
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• pp.37-43
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• 2013

본 논문에서는 SIR(Stepped Impedance Resonator) 구조를 이용한 초광대역(UWB:Ultra Wide Band) 개방형 스터브 대역통과 여파기를 제안한다. 제안한 개방형 스터브 대역통과 여파기는 초광대역을 구현하기 위해 스터브 위치에 SIR 구조를 적용하였으며 낮은 삽입손실을 갖는다. 제안된 대역통과 여파기의 대역폭은 중심 주파수 5.8GHz에서 103% 이고, 삽입 및 반사손실은 각각 0.17dB 및 13.1dB이며 전체의 크기는$21.6{\times}17.8mm^2$ 이다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 1999년도 하계종합학술대회 논문집
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• pp.914-917
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• 1999

The paper describes a 17 $\times$ 17-b multiplier using the Radix-4 Booth’s algorithm. which is suitable for 32-bit RISC/DSP microprocessors. To minimize design area and achieve improved speed, a 2-stage pipeline structure is adopted to achieve high clock frequency. Each part of circuit is modeled and optimized at the transistor level, verification of functionality and timing is performed using HSPICE simulations. After modeling and validating the circuit at transistor level, we lay it out in a 0.35 ${\mu}{\textrm}{m}$ 1-poly 4-metal CMOS technology and perform LVS test to compare the layout with the schematic. The simulation results show that maximum frequency is 330MHz under worst operating conditions at 55$^{\circ}C$ , 3V, The post simulation after layout results shows 187MHz under worst case conditions. It contains 9, 115 transistors and the area of layout is 0.72mm by 0.97mm.

• 한국버섯학회지
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• 제14권1호
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• pp.21-26
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• 2016

The mannanase-producing bacteria, designated YJ17, was isolated from spent mushroom (Flammulina velutipes) substrates. The isolate YJ17 was a facultative anaerobic and was grown at temperatures ranging from $20^{\circ}C$ to $50^{\circ}C$ with an optimal temperature of $40^{\circ}C$. The DNA G+C content of the YJ17 was 44 mol%. The major fatty acids were anteiso-15:0 (38.9%), 17:0 (7.6%), and iso-15:0 (36.5%). The 16S rRNA gene sequence similarity between the isolate YJ17 and other Bacillus strains was from 98% to 99%. In the phylogenetic analysis based on these sequences, the isolate YJ17 and Bacillus amyloliquefaciens clustered within a group together and separated from other species of Bacillus. Based on the physiological and molecular properties, the isolate YJ17 was classified within the genus Bacillus as B. amyloliquefaciens YJ17. The optimal pH and temperature for mannanase activity of B. amyloliquefaciens YJ17 were pH 7.0 and $50^{\circ}C$, respectively.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.873-876
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• 2005

A low noise amplifier(LNA) using electro-magnetic field simulator is designed in standard 0.25um CMOS process. Integrated spiral inductor is simulated using EM field solver. Then LNA is simulated with active device, capacitor and simulated inductor by EM field solver. A S11 and S21 of -15.45dB and 17.8dB at 2.3GHz as simulation results was achieved. A Noise Figure is 2.92dB. And Measurements show a S11 and S21 of -12.4dB and 17.8dB at 2.3GHz. A Noise Figure of 3.3dB was achieved.

• Journal of Magnetics
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• 제17권3호
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• pp.219-224
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• 2012

In the present study, changes in signal-to-noise ratio (SNR) and apparent diffusion coefficient (ADC) of the diffusion-weighted images in the normal livers were investigated using changes in b values in 1.5 T MR (magnetic resonance) instruments. Respective diffusion-weighted images and ADC map images were obtained from 20 healthy individuals by increasing b values from 50 to 400 and 800 $s/mm^2$ using 1.5T MR scanner between January 2011 and November 2011. At each ADC map image obtained at each b value, ADCs in the right hepatic lobe, spleen and kidney were measured. As a result, ADCs of the right hepatic lobe, spleen and kidney have gradually decreased in the diffusion-weighted images in accordance with the reduced b value. This outcome may be used as preliminary data for applications to various abdominal diseases.

• Biomolecules & Therapeutics
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• 제17권3호
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• pp.219-240
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• 2009

Since NF-${\kappa}B$ has been identified as a transcription factor associated with immune cell activation, groups of researchers have dedicated to reveal detailed mechanisms of nuclear factor of ${\kappa}B$ (NF-${\kappa}B$) in inflammatory signaling for decades. The various molecular components of NF-${\kappa}B$ transcription factor pathway have been being evaluated as important therapeutic targets due to their roles in diverse human diseases including inflammation, cystic fibrosis, sepsis, rheumatoid arthritis, cancer, atherosclerosis, ischemic injury, myocardial infarction, osteoporosis, transplantation rejection, and neurodegeneration. With regards to new drugs directly or indirectly modulating the NF-${\kappa}B$ pathway, FDA recently approved a proteasome inhibitor bortezomib for the treatment of multiple myeloma. Many pharmaceutical companies have been trying to develop new drugs to inhibit various kinases in the NF-${\kappa}B$ signaling pathway for many therapeutic applications. However, a gene knock-out study for $IKK{\beta}$ in the NF-${\kappa}B$ pathway has given rise to controversies associated with efficacy as therapeutics. Mice lacking hepatocyte $IKK{\beta}$ accelerated cancer instead of preventing progress of cancer. However, it is clear that pharmacological inhibition of $IKK{\beta}$ appears to be beneficial to reduce HCC. This article will update issues of the NF-${\kappa}B$ pathway and inhibitors regulating this pathway.

• Genomics & Informatics
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• 제17권3호
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• pp.27.1-27.9
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• 2019

Supernumerary B chromosomes were found in Lilium amabile (2n = 2x = 24), an endemic Korean lily that grows in the wild throughout the Korean Peninsula. The extra B chromosomes do not affect the host-plant morphology; therefore, whole transcriptome analysis was performed in 0B and 1B plants to identify differentially expressed genes. A total of 154,810 transcripts were obtained from over 10 Gbp data by de novo assembly. By mapping the raw reads to the de novo transcripts, we identified 7,852 differentially expressed genes (log₂FC > |10|), in which 4,059 and 3,794 were up-and down-regulated, respectively, in 1B plants compared to 0B plants. Functional enrichment analysis revealed that various differentially expressed genes were involved in cellular processes including the cell cycle, chromosome breakage and repair, and microtubule formation; all of which may be related to the occurrence and maintenance of B chromosomes. Our data provide insight into transcriptomic changes and evolution of plant B chromosomes and deliver an informative database for future study of B chromosome transcriptomes in the Korean lily.

• 한국산림과학회지
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• 제109권4호
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• pp.413-420
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• 2020

본 연구는 체세포배 발아 식물체의 세포 라인별, 순화용 기질별 생육 특성을 분석하여, 일본잎갈나무 조직 배양묘의 순화 중 생존율을 높이려는 방안을 마련하고자 실시하였다. 체세포배 발아 식물체는 라인 L14-66, L16-18, L17-B4를 사용하였으며, 순화용 기질은 낙엽송 전용 상토, 원예용 상토, 엘리포트, 피트플러그를 사용하였다. 평균 초기 신초와 뿌리 길이는 L14-66 라인이 가장 짧았고, L17-B4 라인이 가장 길었다. 세포 라인별 평균 생존율은 L17-B4 라인이 87.0%로 가장 높았고, L14-66 라인이 64.3%로 가장 낮았다. 순화용 기질별 생존율은 엘리포트와 피트플러그에서 각각 88.5%, 88.9%로 가장 높았다. L14-66 라인의 초기 신초 길이는 낙엽송 전용 상토(r = 0.852), 원예용 상토(r = 0.692), 엘리포트(r = 0.867)에서 생존율과 상관이 높았으나, 전 질소 함량이 높은 피트플러그에서는 상관이 없었다. L17-B4 라인의 초기 신초 길이는 모든 순화용 기질에서 생존율과 상관이 없었다. L14-66 라인의 초기 뿌리 길이는 낙엽송 전용 상토(r = 0.986), 엘리포트(r = 0.846), 피트플러그(r = 0.802)에서 생존율과 상관이 높았으며, 유식물체의 생존율은 초기 뿌리 길이가 길수록 높았다. L17-B4 라인의 초기 뿌리 길이는 낙엽송 전용 상토(r = 0.896)와 엘리포트(r = 0.696)에서만 생존율과 상관을 보였다. 결론적으로, 유식물체의 생존율을 높이기 위해서 신초 길이보다 뿌리 길이를 우선 고려해야 하며, 피트플러그와 같이 기질 내 질소 함량이 높은 재료를 사용하거나 순화 과정 중에 질소 시비를 높여 주는 것이 좋다. 또한, 생존율을 높이기 위해 초기 생장이 빠른 라인 개발도 함께 이루어져야 한다.

• Archives of Pharmacal Research
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• 제25권5호
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• pp.608-612
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• 2002

The twelve-protostane analogues were synthesized from alisol B 23-acetate and assessed for their in vitro antitumor activity against six different human and murine tumor cell lines. Of the compounds synthesized, 23S-acetoxy-24R(25)-epoxy-11$\beta$,23S-dihydroxyprotost-13(17)-en-3-hy-droxyimine (12) exhibited significant cytotoxic activities against A549, SK-OV3, B16-F10, and HT1080 tumor cells with $ED_{50}/$ values of 10.0, 8.7 ,5.2, and 3.1 ${\mu}g$/ml, respectively. Furthermore, 23S-acetoxy-13(17),24R(25)-diepoxy-11$\beta$-hydroxyprotost-3-one (5), 13(17),24R(25)-diepoxy-11$\beta$, 23S-dihydroxyprotostan-3-one (6), 24R,25-epoxy-11$\beta$,23S-dihydroxyprotost-13(17)-en-3-one (7), and 11$\beta$,23S,24R,25-tetrahydroxyprotost-13(17)-en-3-one (9) showed moderate cytotoxic activities against 816-F10 and HT1080 tumor cells. These results mean that a hydroxyimino group at C-3 position in the protostane-type terpene enhances cytotoxic activity.

• 한국산학기술학회논문지
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• 제17권4호
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• pp.440-447
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• 2016

장기적인 글로벌 경기침체의 여파로 소비재 기반의 B2C 시장 외에 산업재 기반의 B2B 시장이 새로운 성장 동력으로 주목받고 있다. 고객과의 관계가 중요한 B2B 시장에서는 고객과의 관계에서 발생하는 효용을 기반으로 하는 관계가치가 중요하고, 국가나 조직의 제도적 특수성도 관계 및 관계가치에 영향을 준다. 특히, 한국과 대만의 B2B 시장에서 창출되는 고객과의 관계가치들을 도출하여 국가별 특수성을 비교하고 글로벌 B2B 시장의 관계가치와 비교하였다. 순차적 탐색 설계에 기반한 혼합방법론을 적용하여 분석한 결과, 한국과 대만의 B2B 시장에서 요구되는 관계가치의 6가지 유형(공급자 노하우, 서비스 지원, 출시시기, 전달 성능, 개인 상호작용 및 제품의 품질)을 도출하였다. 한국은 대기업 기반의 시장 특성을 가져 '공급자의 노하우'가 가장 중요한 관계가치로 인식되었고, 반면 대만은 중소기업 기반의 시장 특성을 가져 '서비스 지원'이 가장 중요한 관계가치로 도출되었다. 본 연구결과는 다른 아시아 개발도상국들도 B2B 시장에서 비즈니스 관계 개선을 위해 집중해야할 관계가치로 시사점이 있으며, 아시아 B2B 시장에서의 성공사례로 글로벌 시장으로 역으로 적용될 수 있다는 점에 의의가 크다.