• Title/Summary/Keyword: 14-3-$3{\beta}$

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Carotenoid Intake and Esophageal Cancer Risk: a Meta-analysis

  • Ge, Xiao-Xiao;Xing, Mei-Yuan;Yu, Lan-Fang;Shen, Peng
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.1911-1918
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    • 2013
  • This meta-analysis was conducted to evaluate the association between intake of carotenoids and risk of esophageal cancer. A systematic search using PubMed, Cochrane Library, Web of Science, Scopus, CNKI, and CBM (updated to 6 May 2012) identified ten articles meeting the inclusion criteria with 1,958 cases of esophageal cancer and 4,529 controls. Higher intake of beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin reduced esophageal cancer risk with pooled ORs of 0.58 (95% CI 0.44, 0.77), 0.81 (95% CI 0.70, 0.94), 0.75 (95% CI 0.64, 0.86), 0.80 (95% CI 0.66, 0.97), and 0.71 (95% CI 0.59, 0.87), respectively. In subgroup analyses, beta-carotene showed protective effects against esophageal adenocarcinoma in studies located in Europe and North America. Alpha-carotene, lycopene, and beta-cryptoxanthin showed protection against esophageal squamous cell cancer. This meta-analysis suggested that higher intake of carotenoids (beta-carotene, alpha-carotene, lycopene, beta-cryptoxanthin, lutein, and zeaxanthin) is associated with lower risk of esophageal cancer. Further research with large-sample studies need to be conducted to better clarify the potentially protective mechanisms of carotenoid associations risk of different types of esophageal cancer.

Reduced Interleukin-17 and Transforming Growth Factor Beta Levels in Peripheral Blood as Indicators for Following the Course of Bladder Cancer

  • Baharlou, Rasoul;Vasmehjani, Abbas Ahmadi;Dehghani, Ali;Ghobadifar, Mohamed Amin;Khoubyari, Mahshid
    • IMMUNE NETWORK
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    • v.14 no.3
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    • pp.156-163
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    • 2014
  • Interleukin (IL) 17 is produced by T-helper (Th) 17 with a vigorous effect on cells of the immune system playing important roles in pathogenesis of immune-mediated diseases, including autoimmune disorders and cancers. Therefore, the aim of current study was to determine the serum levels of IL-6, IL-17, and transforming growth factor beta (TGF-${\beta}$) in Iranian bladder cancer patients, and to correlate them with disease status. Blood samples were collected from 40 bladder cancer patients and 38 healthy individuals with no history of malignancies or autoimmune disorders. The serum levels of IL-6, IL-17, and TGF-${\beta}$ were measured by the enzyme-linked immunosorbent assay (ELISA). The results showed that the levels of IL-17 (p<0.0001) and TGF-${\beta}$ (p<0.0001) were significantly lower in the patients compared to the controls. No significant differences in the level of serum IL-6 (p=0.16) was observed between the patients and controls. In addition, demographic characteristics between control and patients groups were not significantly different. As most of the cases studied in this investigation were in stage I and II, it is concluded that reduced Th17-related cytokines can be used as indicators for following the course and clinical stages of bladder carcinoma progress and immune response to cancer.

Ionic Cluster Mimic Membranes Using Ionized Cyclodextrin

  • Won Jong-Ok;Yoo Ji-Young;Kang Moon-Sung;Kang Yong-Soo
    • Macromolecular Research
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    • v.14 no.4
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    • pp.449-455
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    • 2006
  • Ionic cluster mimic, polymer electrolyte membranes were prepared using polymer composites of crosslinked poly(vinyl alcohol) (PVA) with sulfated-${\beta}$-cyclodextrins (${\beta}-CDSO_3H$) or phosphated-${\beta}$-cyclodextrins (${\beta}-CDPO(OH)_2$). When Nafion, developed for a fuel cell using low temperature, polymer electrolyte membranes, is used in a direct methanol fuel cell, it has a methanol crossover problem. The ionic inverted micellar structure formed by micro-segregation in Nafion, known as ionic cluster, is distorted in methanol aqueous solution, resulting in the significant transport of methanol through the membrane. While the ionic structure formed by the ionic sites in either ${\beta}-CDSO_3H$ or ${\beta}-CDPO(OH)_2$ in this composite membrane is maintained in methanol solution, it is expected to reduce methanol transport. Proton conductivity was found to increase in PVA membranes upon addition of ionized cyclodextrins. Methanol permeability through the PVA composite membrane containing cyclodextrins was lower than that of Nafion. It is thus concluded that the structure and fixation of ionic clusters are significant barriers to methanol crossover in direct methanol fuel cells.

Factors Related to Stress, Coping, and Physical Symptom in High School Girls (일부 여고생의 스트레스와 스트레스 대처방식 및 신체증상 영향요인)

  • Yang, Kyung-Hee;Kim, Young-Hee;Park, Kum-Sook
    • Journal of Society of Preventive Korean Medicine
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    • v.17 no.1
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    • pp.13-25
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    • 2013
  • Objectives : This study was conducted to analyze the stress, coping and physical symptoms relevant to factors influencing physical symptoms on high school girls. Methods : The subjects were 521 high school girls in I city. The data was collected by using structured questionnaire. T-test, ANOVA, Pearson's correlation and Stepwise-multiple regression were performed by SPSS/PC 17.0. Results : Study-related stress were higher in the freshmen than sophomore (p=.001). The sophomore have highest level in family (F=5.32, p=.005), friends (F=3.13, p=.044), and appearance-related stress (F=5.49, p=.004). Poor grades in their studies were related to family-related stress (p=.010) and study-related stress (p=.009), They complained severe discomfort, displeasure, and G-I symptom in order. The more physical symptoms were, the more coping with their stress do (p=.001). Factors affecting physical symptoms are study-related stress (${\beta}$=.38), unhealthy (${\beta}$=.16), friends (${\beta}$=.14), active coping with stress (${\beta}$=.15) and sophomore (${\beta}$=.11), family (${\beta}$=.11), and they explained 33.3% of variables. Conclusions : Students have to learn how to cope with their stress. Therefore, it is needed program development to improve stress management for high school girls.

ATTITUDE DETERMINATION OF MICRO-SATELLITE USING GEOMAGNETISE AND MAGNETOMETER DATA (MAGNETOMETER 측정자료와 지구자기장을 이용한 소형 인공위성의 자세 결정)

  • 석재호;최규홍
    • Journal of Astronomy and Space Sciences
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    • v.9 no.2
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    • pp.203-212
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    • 1992
  • Geomagnetic data from 3-axis magnetometer and the IGRF model (tilite - eccentric dipole model) were used to determine the attitude of a satellite. We compared the values of the geomagnetic model with the magnetometer data and two attitude angles, called $\alpha$ -angle and $\beta$-angle respectively, were calculated. From these angles we calculated simple bounds, $\gamma1$ and $\gamma2$, on the true attitude angle $\gamma$, which is used to detemine attitude, between the z-axis and the local vertical. And then we investigated conditions of attitudes of UoSAT-11, 14, 22.

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Characterization of Three Extracellular β-Glucosidases Produced by a Fungal Isolate Aspergillus sp. YDJ14 and Their Hydrolyzing Activity for a Flavone Glycoside

  • Oh, Jong Min;Lee, Jae Pil;Baek, Seung Cheol;Jo, Yang Do;Kim, Hoon
    • Journal of Microbiology and Biotechnology
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    • v.28 no.5
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    • pp.757-764
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    • 2018
  • A cellulolytic fungus, YDJ14, was isolated from compost and identified as an Aspergillus sp. strain. Three extracellular ${\beta}$-glucosidases, BGL-A1, BGL-A2, and BGL-A3, were separated using ultrafiltration, ammonium sulfate fractionation, and High-Q chromatography. The molecular masses of the three enzymes were estimated to be 100, 45, and 40 kDa, respectively, by SDS-PAGE. The optimum pH and temperature of BGL-A3 were 5.0 and $50^{\circ}C$, respectively, whereas the optimum pH and temperature of BGL-A1 and BGL-A2 were identical (4.0 and $60^{\circ}C$, respectively). The half-life of BGL-A3 at $70^{\circ}C$ (2.8 min) was shorter than that of BGL-A1 and BGL-A2 (12.1 and 8.8 min, respectively). All three enzymes preferred p-nitrophenyl-${\beta}$-$\text\tiny{D}$-glucopyranoside (pNPG) and hardly hydrolyzed cellobiose, suggesting that these enzymes were aryl ${\beta}$-glucosidases. The $K_m$ of BGL-A3 (1.26 mM) for pNPG was much higher than that of BGL-A1 and BGL-A2 (0.25 and 0.27 mM, respectively). These results suggested that BGL-A1 and BGL-A2 were similar in their enzymatic properties, whereas BGL-A3 differed from the two enzymes. When tilianin (a flavone glycoside of acacetin) was reacted with the three enzymes, the inhibitory activity for monoamine oxidase, a target in the treatment of neurological disorders, was similar to that shown by acacetin. We conclude that these enzymes may be useful in the hydrolysis of flavone glycosides to improve their inhibitory activities.

Frangrance and Chemical Composition of Essential Oil in Cone of Metasequoia (Metasequoia glyptostroboides Hu et Cheng) (메타세콰이아 (Metasequoia glyptostroboides)구과(毬果) 정유의 향취 및 휘발성 화학성분)

  • Yeon, Bo-Ram;Cho, Hae-Me;Jeong, Mi-Soon;Kim, Song-Mun
    • Korean Journal of Weed Science
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    • v.31 no.2
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    • pp.146-151
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    • 2011
  • Essential oil was extracted from cones of metasequoia (Metasequoia glyptostroboides) by steam distillation, fragrance was determined by sensorial analysis and chemical compositions were analyzed by gas chromatography-mass spectrometry with solid-phase microextraction apparatus. Metasequia contained 0.40% of essential oil in the cone. Major impact fragrances of the essential oil were woody, coniferous and herbal, and minor impact fragrances were minty, spicy and oily. There were nine constituents in the essential oil : 8 hydrocarbons and 1 oxide. Constituents were limonene (66.18%), ${\delta}$-3-carene (11.11%), ${\beta}$-caryophyllene (6.66%), ${\beta}$-myrcene (5.92%), ${\beta}$-pinene (4.14%), caryophyllene oxide (2.39%), camphene (2.32%), ${\alpha}$-caryophyllene (0.85%), and tricyclene (0.43%). Herbal and minty frangrances could be due to limonene and ${\delta}$-3-carene, spicy frangrance to caryophyllene, woody and coniferous frangrances to ${\alpha}$-pinene and ${\beta}$-pinene, and oily fragrance to camphene.

Variation in Carotenoid Composition in Carrots during Storage and Cooking

  • Lim, Chae-Jin;Kim, Hyun-Young;Lee, Cheol-Ho;Kim, Yong-Ung;Back, Kyong-Whan;Bae, Jung-Myung;Lee, Shin-Woo;Ahn, Mi-Jeong
    • Preventive Nutrition and Food Science
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    • v.14 no.3
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    • pp.240-245
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    • 2009
  • High-performance liquid chromatography (HPLC) was applied to determine the carotenoid composition of carrots during storage and cooking. Analyses were conducted immediately after harvest and 1, 2, 4, and 8 weeks after harvest. During the course of the storage, the carotenoid levels generally decreased, and this decrease was found to be greater during the first week for $\beta$-carotene (all-trans-$\beta$-carotene) and lutein, and during the second week for $\alpha$-carotene. Additionally, the amount of the $\alpha-$ and $\beta$-carotenes in carrot leaves changed slightly within the first 2 weeks of harvest when stored at $4^{\circ}C$. Specifically, the level of lutein, the main component of carrot leaves, increased from 233.8$\pm$11.7 to $346.2\pm26.7{\mu}g$/g DW during the first 2 weeks. In addition, the change in carotenoid contents was observed during the home-processing of one Korean cultivar. Carrots fried in oil showed the highest amount of $\beta$-carotene ($164.3\pm6.6{\mu}g$/g DW) and $\alpha$-carotene ($50.1\pm0.4{\mu}g$/g DW), while carrots that were prepared by sauteing, pressure-cooking in water and microwaving had the second highest levels. The greatest loss of in carotenoids occurred in response to boiling in water containing 1% NaCl, braising and baking. The content of lutein increased slightly after boiling in water containing 1% NaCl ($9.3\pm0.4{\mu}g$/g DW), while a loss in lutein occurred after preparation using other home-processing methods. A cis-isomer of all-trans-$\beta$-carotene, 13-cis-$\beta$-carotene, was present in detectable amounts in all processed samples, but not in raw roots. Another isomer, 9-cis-$\beta$-carotene, was detected in carrots that were prepared by boiling, frying and pressure-cooking.

Optical and Electrical Properties of $\beta$-$FeSi_2$ Single Crystals ($\beta$-$FeSi_2$ 단결정의 전기적 광학적인 특성)

  • 김남오;김형곤;이우선
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.14 no.8
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    • pp.618-621
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    • 2001
  • Plate-type $\beta$-FeSi$_2$single crystals were grown using FeSi$_2$, Fe, and Si as starting materials by the chemical transport reaction method. The $\beta$-FeSi$_2$single crystal was an orthorhombic structure. The direct optical energy gap was found to be 0.87eV at 300K. Hall effect shows a n-type conductivity in the $\beta$-FeSi$_2$ single crystal. The electrical resistivity values was 1.608Ωcm and electron mobility was 3x10$^{-1}$ $\textrm{cm}^2$/V.sec at room temperature.

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Survey on the residual drugs (tetracyclines, ${\beta}$-lactams, chloramphenicol, sulfonamides) on beef and pork carcass at abattoir in Seoul (서울 시내 도축장의 소${\cdot}$돼지 지육에 대한 잔류물질 (tetracyclines, ${\beta}$-lactams, chloramphenicol, sulfonamides) 함량 조사)

  • Kim Doo-Hwan;Lee Jae-Shin;Ham Hee-Jin;Ki No-Joon;Lee Jung-Hark
    • Korean Journal of Veterinary Service
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    • v.27 no.3
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    • pp.265-272
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    • 2004
  • It was carried out to compare the residual materials by EEC 4-plate, Charm II and HPLC method in the muscles of cattle and pigs from slaughter-houses in Seoul from 2000 to 2003. Residual materials were detected from $1.10\%$(73/6,623) samples by EEC 4-plate method, and $10.93\%$(55/503) samples by Charm II method. The highest residual concentration(ppm) of oxytetracycline, tetracycline, chloramphenicol, chlortetracycline, sulfamethazine, sulfamerazine, sulfadimethoxine, penicillin and sulfamonomethoxine were 25.5, 3.46, 3.26, 1.5, 0.3, 0.2, 0.2, 0.14, and 0.07, respectively. Eighty nine samples were classified as 58($65.17\%$) only tetracyclines, 20($22.47\%$) only sulfonamides, 3($3.37\%$) only ${\beta}$-lactams, 2($2.25\%$) only chloramphenicol, 4($4.49\%$) tetracyclines and sulfonamides simultaneously, 1($1.12\%$) chloramphenicol and sulfonamides simultaneously, and 1($1.12\%$) chloramphenicol, sulfonamides and tetracyclines simultaneously.