• Title/Summary/Keyword: 1-dimensional heat analysis

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Proteomic Analysis of the Triglyceride-Rich Lipoprotein-Laden Foam Cells

  • Lu, Yanjun;Guo, Jianli;Di, Yong;Zong, Yiqiang;Qu, Shen;Tian, Jun
    • Molecules and Cells
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    • v.28 no.3
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    • pp.175-181
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    • 2009
  • In hypertriglyceridaemic individuals, atherosclerogenesis is associated with the increased concentrations of very low density lipoprotein (VLDL) and VLDL-associated remnant particles. In vitro studies have suggested that VLDL induces foam cells formation. To reveal the changes of the proteins expression in the process of foam cells formation induced by VLDL, we performed a proteomic analysis of the foam cells based on the stimulation of differentiated THP-1 cells with VLDL. Using two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser-desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis, 14 differentially expressed proteins, containing 8 up-regulated proteins and 6 down-regulated proteins were identified. The proteins are involved in energy metabolism, oxidative stress, cell growth, differentiation and apoptosis, such as adipose differentiation-related protein (ADRP), enolase, S100A11, heat shock protein 27 and so on. In addition, the expression of some selected proteins was confirmed by Western blot and RT-PCR analysis. The results suggest that VLDL not only induces lipid accumulation, but also brings about foam cells diverse characteristics by altering the expression of various proteins.

Recent Progress in Air-Conditioning and Refrigeration Research : A Review of Papers Published in the Korean Journal of Air-Conditioning and Refrigeration Engineering in 2016 (설비공학 분야의 최근 연구 동향 : 2016년 학회지 논문에 대한 종합적 고찰)

  • Lee, Dae-Young;Kim, Sa Ryang;Kim, Hyun-Jung;Kim, Dong-Seon;Park, Jun-Seok;Ihm, Pyeong Chan
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.29 no.6
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    • pp.327-340
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    • 2017
  • This article reviews the papers published in the Korean Journal of Air-Conditioning and Refrigeration Engineering during 2016. It is intended to understand the status of current research in the areas of heating, cooling, ventilation, sanitation, and indoor environments of buildings and plant facilities. Conclusions are as follows. (1) The research works on the thermal and fluid engineering have been reviewed as groups of flow, heat and mass transfer, the reduction of pollutant exhaust gas, cooling and heating, the renewable energy system and the flow around buildings. CFD schemes were used more for all research areas. (2) Research works on heat transfer area have been reviewed in the categories of heat transfer characteristics, pool boiling and condensing heat transfer and industrial heat exchangers. Researches on heat transfer characteristics included the results of the long-term performance variation of the plate-type enthalpy exchange element made of paper, design optimization of an extruded-type cooling structure for reducing the weight of LED street lights, and hot plate welding of thermoplastic elastomer packing. In the area of pool boiling and condensing, the heat transfer characteristics of a finned-tube heat exchanger in a PCM (phase change material) thermal energy storage system, influence of flow boiling heat transfer on fouling phenomenon in nanofluids, and PCM at the simultaneous charging and discharging condition were studied. In the area of industrial heat exchangers, one-dimensional flow network model and porous-media model, and R245fa in a plate-shell heat exchanger were studied. (3) Various studies were published in the categories of refrigeration cycle, alternative refrigeration/energy system, system control. In the refrigeration cycle category, subjects include mobile cold storage heat exchanger, compressor reliability, indirect refrigeration system with $CO_2$ as secondary fluid, heat pump for fuel-cell vehicle, heat recovery from hybrid drier and heat exchangers with two-port and flat tubes. In the alternative refrigeration/energy system category, subjects include membrane module for dehumidification refrigeration, desiccant-assisted low-temperature drying, regenerative evaporative cooler and ejector-assisted multi-stage evaporation. In the system control category, subjects include multi-refrigeration system control, emergency cooling of data center and variable-speed compressor control. (4) In building mechanical system research fields, fifteenth studies were reported for achieving effective design of the mechanical systems, and also for maximizing the energy efficiency of buildings. The topics of the studies included energy performance, HVAC system, ventilation, renewable energies, etc. Proposed designs, performance tests using numerical methods and experiments provide useful information and key data which could be help for improving the energy efficiency of the buildings. (5) The field of architectural environment was mostly focused on indoor environment and building energy. The main researches of indoor environment were related to the analyses of indoor thermal environments controlled by portable cooler, the effects of outdoor wind pressure in airflow at high-rise buildings, window air tightness related to the filling piece shapes, stack effect in core type's office building and the development of a movable drawer-type light shelf with adjustable depth of the reflector. The subjects of building energy were worked on the energy consumption analysis in office building, the prediction of exit air temperature of horizontal geothermal heat exchanger, LS-SVM based modeling of hot water supply load for district heating system, the energy saving effect of ERV system using night purge control method and the effect of strengthened insulation level to the building heating and cooling load.

A study on the stress and strain during welding of plate-to-pipe joint (평판-관 구조물 용접시 발생하는 응력 및 변형율에 관한 연구)

  • 나석주;김형완
    • Journal of Welding and Joining
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    • v.4 no.2
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    • pp.30-39
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    • 1986
  • In manufacturing of pipe walls for boiler units, distortion can result in pipe-web-pipe joints from the nonuniform expansion and contraction of the weld metal and the adjacent base metal during heating and cooling cycle of the welding process. In this study, the stresses and strains during longitudinal welding of the plate-to-pipe joint were investigated. Using the method of successive elastic solution, longitudinal stresses and strains during and after welding were calculated from the information of temperature distributions obtained by Rosenthal's equations. In order to confirm the validity of the numerical results, the temperature and residual stress distributions were measured and compared with the calculated results. In spite of some assumptions, the one-dimensional analytical results of residual stresses were in fairly good agreement with the experimental ones. The residual stresses due to welding of plate-to-pipe joints are tensile near the weld line and compressive in the base metal as in the welding of plates. the amount and distribution of residual stresses were deeply dependent on the heat input ratio of the plate and pipe.

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Performance Modeling of a Pyrotechnically Actuated Pin Puller

  • Jang, Seung-Gyo;Lee, Hyo-Nam;Oh, Jong-Yun
    • International Journal of Aeronautical and Space Sciences
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    • v.15 no.1
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    • pp.102-111
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    • 2014
  • An analytical model was developed to understand the physics and predict the functional performance of a pin puller. The formulated model is based on one-dimensional gas dynamics for an ideal gas. Resistive forces against pin shaft movement were measured in quasi-static mechanical tests, the results of which were incorporated into the model. The expansion chamber pressure and the pin shaft displacement were measured from an actual firing test and compared to the model prediction. The gas generation rate was adjusted by a correction factor, and the heat transfer rate was obtained through parametric analysis. The validity of the model is assessed for additional firing tests with different amounts of pyrotechnic charge. This model can provide knowledge on how the pin puller functions, and on which design parameters contribute the most to the actuation of the pin puller. Using this model, we estimate the functional safety factor by comparing the energy generated by the pyrotechnic charge to the energy required to accomplish the function.

Numerical Evaluation of the Cooling Performance of a Core Catcher Test Facility

  • Lee, Dong Hun;Park, Ik Kyu;Yoon, Han Young;Ha, Kwang Soon;Jeong, Jae Jun
    • Journal of Energy Engineering
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    • v.22 no.1
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    • pp.8-16
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    • 2013
  • A core catcher is considered as a promising engineered system to stabilize the molten corium in the containment during a postulated severe accident in a nuclear power plant. Conceptually, the core catcher consists of a carbon steel body, sacrificial material, protection material, and engineered cooling channel. The cooling capacity of the engineered cooling channel should be guaranteed to remove the decay heat of the molten corium. The flow in ex-vessel core catcher is a combined problem of a two-phase flow in the engineered cooling channel and a single-phase natural circulation in the whole core catcher system. In this study, the analysis of the test facility for the core catcher using the CUPID code, which is a three-dimensional thermal-hydraulic code for the simulation of two-phase flows, was carried out to evaluate its cooling capacity.

Relative Analysis between Fertility and Protein Changes in Semen of Different Species in Pigs (돼지 품종간 정액 내에서 수정 능력과 단백질 변화와의 관계 분석)

  • Lee, Yeon-Ju;Lee, Sang-Hee;Kim, Yu-Jin;Cheong, Hee-Tae;Yang, Boo-Keun;Park, Choon-Keun
    • Reproductive and Developmental Biology
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    • v.38 no.1
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    • pp.53-62
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    • 2014
  • The objective of this study was to investigate the relationship between fertility and protein pattern change using in vitro fertilization, analysis of sperm characteristics and two-dimensional gel electrophoresis in different pig types. In results, the viability and mitochondria integrity of sperm were higher significantly (p<0.05) but the portions of acrosome reaction was lower significantly (p<0.05) in Duroc and $F_1$ (potbellied ${\times}$ PWG miniature pig) than PWG miniature. On in vitro fertilization to investigate fertility, the fertility of $F_1$ semen war higher significantly (p<0.05) than in Duroc and PWG miniature pig. On the other hand, protein patterns showed similar function among the different boar semen. Especially, the heat shock 70 kDa 1-like and G patch domain-containing protein 4 were significantly (p<0.05) higher expressed in $F_1$ than in Duroc and PWG miniature pig. The proteins associated with mitochondria in Duroc were significantly (p<0.05) higher expressed than in $F_1$ and PWG miniature pig. The developmental rates to blastocyst stage of oocytes fertilized with sperm of $F_1$ pig were significantly (p<0.05) higher than in PWG miniature pig. However, phosphoglycerate kinase 2 and zinc finger protein 431 were significantly (p<0.05) higher expressed in PWG miniature pig than in $F_1$ and Duroc pigs. In conclusion, the results of the present study indicate that different proteins were expressed in different pig types, and were associated with a sperm functions and embryo development.

Validation of a New Design of Tellurium Dioxide-Irradiated Target

  • Fllaoui, Aziz;Ghamad, Younes;Zoubir, Brahim;Ayaz, Zinel Abidine;Morabiti, Aissam El;Amayoud, Hafid;Chakir, El Mahjoub
    • Nuclear Engineering and Technology
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    • v.48 no.5
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    • pp.1273-1279
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    • 2016
  • Production of iodine-131 by neutron activation of tellurium in tellurium dioxide ($TeO_2$) material requires a target that meets the safety requirements. In a radiopharmaceutical production unit, a new lid for a can was designed, which permits tight sealing of the target by using tungsten inert gaswelding. The leakage rate of all prepared targets was assessed using a helium mass spectrometer. The accepted leakage rate is ${\leq}10^{-4}mbr.L/s$, according to the approved safety report related to iodine-131 production in the TRIGA Mark II research reactor (TRIGA: Training, Research, Isotopes, General Atomics). To confirm the resistance of the new design to the irradiation conditions in the TRIGA Mark II research reactor's central thimble, a study of heat effect on the sealed targets for 7 hours in an oven was conducted and the leakage rates were evaluated. The results show that the tightness of the targets is ensured up to $600^{\circ}C$ with the appearance of deformations on lids beyond $450^{\circ}C$. The study of heat transfer through the target was conducted by adopting a one-dimensional approximation, under consideration of the three transfer modes-convection, conduction, and radiation. The quantities of heat generated by gamma and neutron heating were calculated by a validated computational model for the neutronic simulation of the TRIGA Mark II research reactor using the Monte Carlo N-Particle transport code. Using the heat transfer equations according to the three modes of heat transfer, the thermal study of I-131 production by irradiation of the target in the central thimble showed that the temperatures of materials do not exceed the corresponding melting points. To validate this new design, several targets have been irradiated in the central thimble according to a preplanned irradiation program, going from4 hours of irradiation at a power level of 0.5MWup to 35 hours (7 h/d for 5 days a week) at 1.5MW. The results showthat the irradiated targets are tight because no iodine-131 was released in the atmosphere of the reactor building and in the reactor cooling water of the primary circuit.

Thermal Energy Balance Analysis of a Packed Bed for Rock Cavern Thermal Energy Storage (충전층을 이용한 암반공동 열에너지저장시스템의 열에너지 수지 분석)

  • Park, Jung-Wook;Ryu, Dongwoo;Park, Dohyun;Choi, Byung-Hee;Synn, Joong-Ho;Sunwoo, Choon
    • Tunnel and Underground Space
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    • v.23 no.3
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    • pp.241-259
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    • 2013
  • A packed bed thermal energy storage (TES) consisting of solid storage medium of rock or concrete through which the heat transfer fluid is circulated is considered as an attractive alternative for high temperature sensible heat storage, because of the economical viability and chemical stability of storage medium and the simplicity of operation. This study introduces the technologies of packed bed thermal energy storage, and presents a numerical model to analyze the thermal energy balance and the performance efficiency of the storage system. In this model, one dimensional transient heat transfer problem in the storage tank is solved using finite difference method, and temperature distribution in a storage tank and thermal energy loss from the tank wall can be calculated during the repeated thermal charging and discharging modes. In this study, a high temperature thermal energy storage connected with AA-CAES (advanced adiabatic compressed air energy storage) was modeled and analyzed for the temperature and the energy balance in the storage tank. Rock cavern type TES and above-ground type TES were both simulated and their results were compared in terms of the discharging efficiency and heat loss ratio.

Numerical Analysis of Integrated Fuel Processing System Considering Thermo-Chemical Energy Balance (열/화학적 에너지 평형을 고려한 통합 연료 개질 시스템의 수치적 연구)

  • Noh, Junghun;Jung, Hye-Mi;Jung, Un-Ho;Yoon, Wang-Lai;Um, Sukkee
    • 한국신재생에너지학회:학술대회논문집
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    • 2010.11a
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    • pp.111.1-111.1
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    • 2010
  • This paper focuses on a systematic configuration of steam reforming fuel processor, particularly designed for small and medium sized hydrogen production application. In a typical integration of the fuel processor, there exist significant temperature gradients over the entire system which has negative effect on both catalyst life-time and system performance. Also, the volumetric inefficiency should be avoided to obtain the possible compactness for the commercial purpose. In the present work, the computational analysis will be performed to gain the fundamental insight on the transport phenomena and chemical reactions in the reformer consisting of preheating, steam reforming (SR), and water gas shift (WGS) reaction beds in the flow direction. Also, the fuel processing system includes a top-fired burner providing necessary thermal energy for endothermic catalytic reactor. A fully two-dimensional numerical modeling for a integrated fuel processing system is introduced for in-depth analysis of the heat and mass transport phenomena based on surface kinetics and catalytic process. In the model, water gas shift reaction and decomposition reaction were assumed to be at equilibrium. A kinetic model was developed and then computational results were compared with the experimental data available in the literature. Finally, the case study was done by considering the key parameters, i.e. steam to carbon (S/C) ratio and temperature. The computer-aided models developed in this study can be greatly utilized for the design of advanced fast-paced compact fuel processors research.

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Development of stability maps for flashing-induced instability in a passive containment cooling system for iPOWER

  • Lim, Sang Gyu;No, Hee Cheon;Lee, Sang Won;Kim, Han Gon;Cheon, Jong;Lee, Jae Min;Ohk, Seung Min
    • Nuclear Engineering and Technology
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    • v.52 no.1
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    • pp.37-50
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    • 2020
  • A passive containment cooling system (PCCS) has been developed as advanced safety feature for innovative power reactor (iPOWER). Passive systems are inherently less stable than active systems and the PCCS encountered the flashing-induced instability previously identified. The objective of this study is to develop stability maps for flashing-induced instability using MARS (Multi-dimensional Analysis of Reactor Safety) code. Firstly, we conducted a series of sensitivity analysis to see the effects of time step size, nodalization, and alternative MARS user options on the onset of flashing-induced instability. The riser nodalization strongly affects the prediction of flashing in a long riser of the PCCS, while time step size and alternative user options do not. Based on the sensitivity analysis, a standard input and an analysis methodology were set up to develop the stability maps of PCCS. We found out that the calculated equilibrium quality at the exit of the riser as a stability boundary above 5 kW/㎡ was approximately 1.2%, which was in good agreement with Furuya's results. However, in case of a very low heat flux condition, the onset of instability occurred at the lower equilibrium quality. In addition, it was confirmed that inlet throttling reduces the unstable region.