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Single Oral Dose Toxicity Study of an Alcohol Extract of Bumblebee, Bombus ignitus Larvae in Rats

  • Ahn, Mi-Young;Han, Jea-Woong;Yoon, Hyung-Joo;Park, Hae-Chul;Chung, Wan-Tae
    • Toxicological Research
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    • v.25 no.2
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    • pp.107-111
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    • 2009
  • The alcohol extract of the larvae of Bombus ignitus, otherwise known as the Bumblebee, was orally administered to rats at doses of 0, 0.04, 0.2, 1 or 2 g/kg as a single oral dose. There were no observed clinical signs or deaths related to treatment in all the groups tested. Therefore, the approximate lethal dose of the alcohol extract of B. ignitus was considered to be higher than 2 g/kg in rats. Mild decreases in body weight gain in male rats were observed dose-dependently within the B. ignitus treated groups over 2 weeks. Throughout the administration periods, no significant changes in diet consumption, ophthalmologic findings, clinical pathology (hematology, clinical chemistry and coagulation) or gross pathology were detected. Minor changes in male rats were found with in the hematological parameters in groups treated with the 0.04 g/kg, 1 g/kg or 2 g/kg of B. ignitus larvae extract, however, all the changes observed were within the physiological range. From these results, it was concluded that there was no evidence of specific toxicity related to the ingestion of alcohol extract of B. ignitus larvae.

Piezoelectric and Dielectric Properties of Non-stochiometric(K0.5Na0.5)0.97(Nb0.96-xTaxSb0.04)O3 Ceramics (비화학양론적인 (K0.5Na0.5)0.97(Nb0.96-xTaxSb0.04)O3 세라믹스의 유전 및 압전특성)

  • Sin, Sang-Hoon;Noh, Jung-Rae;Yoo, Ju-Hyun
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.25 no.8
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    • pp.611-615
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    • 2012
  • In this study non-stoichiometric $(K_{0.5}Na_{0.5})_{0.97}(Nb_{0.96-x}Ta_xSb_{0.04})O_3$ ceramics were prepared by the conventional soild-state teaction method. The effect of Ta-substitution on the dielectric and piezoelectric properties were investigated. X-ray diffraction analysis of all the specimens less than x= 15 mol% indicated orthorhombic phase. Thereafter, the specimens showed orthorhombic phase near to pseudo-cubic. Sinterablity of all the specimens was improved due to secondary products such as KCT and KCN. The ceramics with x= 5 mol% showed the optimum velues of pizoelectric constant($d_{33}$)= 150 pC/N, electromechanical coupling factor (kp)= 0.45, electromechanical quality factor (Qm)= 418.9 and dielectric constant(${\varepsilon}_r$)= 567. Accordingly, These results indicate that the composition ceramics is a promising candidate for lead-free material.

Curriculum of IoT by IPC Code Analysis of Patents (특허문헌의 IPC 코드 분석에 의한 사물인터넷 분야 교육과정에 관한 연구)

  • Shim, Jaeruen;Choi, Jin-Ho
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.25 no.11
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    • pp.1642-1648
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    • 2021
  • We analyzes representative technologies of IoT patents and reflects these results in the curriculum of IoT. In order to identify the representative technologies, the IPC codes of the patents were analyzed. Among the main category IPC codes, the most used IPC codes were H04L in Single IPC Patent with 974 cases(32.0%) and G06Q in Multiple IPC Patent with 710 cases(29.2%). As a result of classifying the IPC code into the WIPO technology classification system, the most emphasized technologies are Digital Communication, accounting for about 60.5% in the Single IPC Patent and IT Methods for Management(710 cases, 29.2%) in Multiple IPC Patent. The main points to be considered when organizing the curriculum of IoT are: ∇Emphasis on Digital Communication, ∇Expansion of Education related to IT Methods for Management(Including entrepreneurship and patent application), and ∇Consideration of subjects related to the Convergence of IoT. This research can contribute to the curriculum design of new industrial technologies such as AI and Fintech.

Studies on the Chemical Characteristics of Korean Propolis (국내산 프로폴리스의 화학적 특성에 관한 연구)

  • 이수원;김희재;황보식
    • Food Science of Animal Resources
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    • v.21 no.4
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    • pp.383-388
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    • 2001
  • This study was conducted to analyzed the chemical compositions of Korean propolis. In proximate analysis, the moisture, crude protein. crude fat. ash and carbohydrate content of Yecheon and Youngwol propolis were 3.25 and 3.97%, 9.82 anti 7.04%, 48.25 and 50.7%, 3.91 and 5.89%, 34.77 and 32.4%, respectively. The highest level of P, Ca and Cu were revealed at Youngwol propolis as much as 184.15, 128.32 and 1.77ppm. As a harmful heavy meta1s, the Cr. AS, Cd, find Pb level of Australian propolis were revealed 2.2888, 0.9534, 0.2611 find 2.5595ppm. However, Korean propolis was not detected the Cd. The benzoic acid content of Yecheon and Youngwol propolis were 1,130.6 ppm and 1,049.1 ppm. And than Chinese product revealed the highest levee of benzoic acrid content. The linoleic and linolenic acid content of Yecheon and Youngwol propolis were 47.6:70.0 and 37.3:47.0mg/100g, respectively.

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Distribution of Heavy Metals in Sediments, Seawater and Oysters (Crassostrea gigas) in the Jinhae Bay (진해만의 퇴적물, 해수 및 참굴 내의 중금속 분포)

  • 이인숙;김은정
    • The Korean Journal of Ecology
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    • v.23 no.1
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    • pp.59-64
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    • 2000
  • Heavy metal concentrations in surface sediments, seawater and oysters (Crassostrea gigas) were determined to assess heavy metal contamination in the Jinhae Bay. The ranges of cadmium, cobalt, copper, nickel, lead and zinc concentration in surface sediments were 0.1∼2.4, 12.6∼14.4, 25.3∼ 92.3, 32.4∼ 93.5, 24. 1∼81.2, 124∼477 ㎍/g, respectively. The concentrations of cadmium, copper, lead and zinc which were influenced by industrial activity were the highest in the inside of Masan Bay. Dissolved concentrations of cadmium, cobalt, copper, nickel, lead and zinc in seawater were <0.010∼0.043, 0.008∼0.120, 0.31∼0.90, 0.25∼3.10, 0.010∼0.142, 0.27∼9.04 ㎍/L, respectively. The concentrations of cadmium, cobalt, copper, nickel, lead and zinc in seawater were also the highest inside of Masan Bay, suggesting that Masan Bay is the major source of heavy metal input to the Jinhae Bay. Bioconcentration factors (BCF) of zinc, copper, cadmium, lead, cobalt and nickel in C. gigas were 647373, 280861, 145069, 44559, 13524, 2745, respectively, showing C gigas is a stronger accumulator than other bivalves.

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Effects of Water Temperature and Salinity on the Growth and Survival of Larvae and Juvenile of Platycephalus indicus (수온과 염분이 양태 자치어의 성장과 생존에 미치는 영향)

  • Jin Lee;Ji-Won Yun;Sung-Hoon Lee;Kyeong Ho Han
    • Korean Journal of Ichthyology
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    • v.35 no.1
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    • pp.39-43
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    • 2023
  • The water temperature and salinity have an important effect on the growth and survival of rearing fish. This study investigates the effect of water temperature and salinity on larvae and juveniles of Platycephalus indicus. The experimental water temperature was set to 13, 16, 19, 22, and 25℃, respectively, and the salinity was set to 7, 14, 21, 28, and 32 psu, respectively. Ten individuals were randomly collected daily and measured the total length using a stereo microscope. The growth rate was the highest at 25℃ (21.62±0.14 mm), 28 psu (15.02±0.05 mm) and the lowest at 13℃ (7.04±0.05 mm), 7 psu. The survival rate was the highest at 22℃ (69.2%), 32 psu (84.1%) and the lowest at 13℃ (15.1%), 7 psu. This study demonstrates that the water temperature and salinity affected the survival and growth of Platycephalus indicus larvae and the juvenile.

Changes in metabolic rate and hematological parameters of black rockfish (Sebastes schlegeli) in relation to temperature and hypoxia (수온과 저산소에 따른 조피볼락(Sebastes schlegeli)의 호흡대사와 혈액성상의 변화)

  • Kim, Heung-Yun
    • Journal of fish pathology
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    • v.34 no.2
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    • pp.213-224
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    • 2021
  • Experiments were performed to investigate changes in metabolic rate (MO2), critical oxygen saturation (Scrit) and hematological parameters of black rockfish, Sebastes schlegeli exposed to hypoxia at 15, 20 and 25℃. The MO2 was measured at an interval of 10 min using intermittent-flow respirometry. The normoxic standard metabolic rate (SMR) was 116.5±5.5, 188.6±4.2 and 237.4±6.8 mg O2/kg/hr, and Scrit was 22.1±1.2, 30.6±1.5 and 41.9±1.4% air saturation at 15, 20 and 25℃, respectively. Q10 values were 2.62 between 15 and 20℃, 1.58 between 20 and 25℃, and 2.04 over the full temperature range. In the investigation of blood (hematocrit and hemoglobin) and biochemical parameters (plasma cortisol, glucose, electrolyte and osmolality), the rockfish were subjected to Scrit for each temperature during 4 hr. All of hematological parameters of the rockfish exposed to hypoxic water were significantly higher than those of normoxic control. Moreover, blood and biochemical parameters of the rockfish maintained to normoxic water showed the tendency of increase with temperature, and were significantly higher at 25C. As a result of this experiment, it was found that physiological stress due to hypoxia increased at high temperature.

A Study on the Measurements of Total Body Fat in Korean Women Worker (여성근로자(女性勤勞者)의 피하지방측정(皮下脂肪測定)에 의(衣)한 총지방량(總脂肪量))

  • Bin, Soon-Duk;Ryu, Tcheong-Kun
    • Journal of Preventive Medicine and Public Health
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    • v.6 no.1
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    • pp.17-25
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    • 1973
  • For purpose of understanding of women worker's nutritional status in Korea, the author had studied oil 668 workers who are working in textile industry, chemical industry, manufacture of electrical machinery and supplies, manufacture of rubber and transportation (bus-guider). Skin-fold caliper was applicated and measured five positions. As a results of this study the following conclusions were obtained; 1. The mean skin-fold thickness were; arm: $$9.08{\pm}3.40\;mm\;(7.23{\sim}10.50\;mm)$$ back: $$16.23{\pm}5.25\;mm\;(13.18{\sim}17.20\;mm)$$ waist : $$17.86{\pm}5.82\;mm\;(13.27{\sim}19.31\;mm)$$ abdomen : $$15.45{\pm}5.04\;mm\;(10.82{\sim}16.43\;mm)$$ knee: $$13.49{\pm}4.16\;mm\;(10.80{\sim}14.04\;mm)$$ The lowest mean skin-fold thickness by age was $12.26{\pm}3.50\;mm$ at 16 year-old and the highest mean skin-fold thickness was $14.57{\pm}5.55\;mm$ at 19 yesr-old respectively. 2. Fat amounts The lowest body fat weight was 10.77 kg at 16 year-old and the highest was 12.09kg at 19 year-old, respectively. The mean body fat weight was 11.76 kg. The lowest %Fat was 20.67% at 26 year-old, the highest was 23.89% at 18 year-old and the average was 22.76%, respectively. The mean FFW was 39.94 kg and the lowest was 37.91 kg at 17 year-old, the highest was 41.64 kg at 27 year-old. The ratio of fat weight and total body mass (FW/TBM) were 21.04% at 27 year-old 23.75% at 19 year-old and average was 22.75%, respectively. The ratio of fat free weight and total body mass (FFW/TBM) were 76.25% at 19 year-old and 78.96% at 27 year-old, respectively. The average was 77.25%. The ratio of fat weight and fat free weight (FW/FFW) were 27.31% at 27 year-old and 31.15% at 19 year-old. The average was 29.44%.

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Effects of Group Rehabilitation Gymnastics for Stroke Patients

  • Kim, Sun-Houng;Moon, Nam-Eun;Jeon, Mi-Yang;Jeong, Hyeon-Cheol
    • Physical Therapy Rehabilitation Science
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    • v.11 no.2
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    • pp.207-214
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    • 2022
  • Objective: This study is an experimental study to investigate the effect of group rehabilitation gymnastics on stroke patients. Design: A randomized controlled trial. Methods: From August 1, 2017, to February 30, 2018, 49 subjects hospitalized after being diagnosed with a stroke at K Rehabilitation Hospital had at least 8 weeks (more than 3 times a week) in the group rehabilitation exercise experimental group (25 patients), and the control group (24 patients) did not attend. Data analysis was performed using paired t-test for dependent variables before and after the experiment using SPSS 25. Results: In the experimental group, daily activities were statistically significantly increased from 59.04±25.19 points before treatment to 66.96±24.35 points after treatment (t=2.24, p=0.035). Lung capacity also significantly increased from 280.00±86.99 points to 334.40±93.23 points (t=4.21, p<0.001), and hospital reuse intention also significantly increased from 8.04±1.57 points to 8.88±1.16 points (t=2.67, p=0.013). In the case of the control group, although the MBI, lung capacity, stress, hospital reuse intention, and hospital use satisfaction increased after the experiment compared to before the experiment, there was no significant difference. Conclusions: In conclusion, group rehabilitation gymnastics for stroke patients is effective for daily living movements, lung capacity, and hospital re-use intention. Therefore, if it is continuously applied to stroke patients, it can be used as an intervention to improve the quality of nursing by enhancing physical function.

Therapeutic Approach by Traditional Veterinary Medicine in a Case with Canine Myleomalacia: Case Report (척수연화증 개에서 전통 수의학적 방법을 이용한 치료 시도: 증례 보고)

  • Jun, Hyung-Kyou;Oh, Hyun-Uk;Lee, Hyun-Hwa;Han, Ji-Won;Lee, Byung-Kon;Park, Jin-Ho;Lee, Young-Won;Jeong, Seong-Mok;Kim, Duck-Hwan
    • Journal of Veterinary Clinics
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    • v.24 no.4
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    • pp.608-612
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    • 2007
  • A 4-year-old castrated male Cocker spaniel was referred with chief complaint of pelvic limbs paralysis and trembling. This dog was diagnosed as a case of myelomalacia complicated with intervertebral disc disease(IVDD) by radiography and magnetic resonance imaging(MRI). This patient was treated by injection-AP with apitoxin, herbal medicine and moxibustion. The acupoints such as GV02-1, GV04, GV11, GV12, GV13, GV14, BL11, BL18, BL23, BL25, BL28, GB21, HT07, KI03, LI04, LU07, SI03, SI06, ST36, ST38, ST39, ST40, ST41, GB30, GB31, GB34, Liv03, SP06 and trigger points($T1{\sim}T4\;and\;T9{\sim}L1$) were used for treatment. At the session 1, the dog could not stand and move the limbs. However, gradual improvement of clinical signs was observed after 7, 14 and 21 session of treatment. Although the clinical signs related to pelvic paralysis were not completely abolished with TVM methods, this case showed the marked improvement of clinical signs after 21 sessions of treatment. In conclusion, the present patient was a case with canine myelomalacia complicated with IVDD which showed not so complete but somewhat improvement by TVM method.