• Tuberculosis and Respiratory Diseases
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• v.58 no.5
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• pp.490-497
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• 2005

Background : The paraoxonase enzyme plays a significant role in the detoxification of various organophosphorous compounds in mammals, and paraoxonase (PON) 1 is one of the endogenous free-radical scavenging systems in the human body. In this study, we investigated the interaction between cigarette smoking and the genetic polymorphism of PON1 with lung cancer in Korean males. Methods : Three hundred thirty five patients with lung cancer and an equal number of age-matched controls were enrolled in this study. Every subject was asked to complete a questionnaire concerning their smoking habits and alcohol drinking habits. A 5' exonuclease assay (TaqMan) was used to genotype the PON1 Q192R polymorphism. The effects of smoking habits and drinking habits, the PON1 Q192R polymorphism and their interactions were statistically analyzed. Results : Cigarette smoking and the Q/Q genotype of PON1 were significant risk factors for lung cancer. Individuals carrying the Q/Q genotype of PON1 were at a higher risk for lung cancer as compared with those individuals carrying the Q/R or R/R genotype (odds ratio, 2.84; 95% confidence interval, 1.69 - 4.79). When the groups were further stratified by the smoking status, the Q/Q PON1 was associated with lung cancer among the current or ex-smokers (odds ratio, 2.56; 95% confidence interval, 1.52 - 4.31). Current smokers or ex-smokers who had the Q/Q genotype showed an elevated risk for lung cancer (odds ratio: 15.50, 95% confidence interval: 6.76 - 35.54) as compared with the group of subjects who never smoked, and had the Q/R or R/R genotype. The odds ratios (95% confidence interval) of smokers with the PON1 Q/Q type compared to the nonsmokers with the PON1 Q/R or R/R type were 53.77 (6.55 - 441.14) for squamous cell carcinoma, 6.25 (1.38 - 28.32) for adenocarcinoma, and 59.94 (4.66 - 770.39) for small cell carcinoma, and these results were statistically significant. Conclusion : These results suggest that cigarette smoking and the PON1 Q/Q genotype are risk factors for lung cancer. The combination of cigarette smoking and the PON1 Q/Q genotype significantly increased the lung cancer risk irrespective of the histologic type of cancer.

• Korean Journal of Adult Nursing
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• v.20 no.1
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• pp.77-90
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• 2008

Purpose: This study attempted to identify influential variables on types of smoking in adult smokers, which have been derived from Q-study. Methods: A survey was conducted with 328 adult smokers at community settings in Seoul, South Korea from April 2006 to July 2006. To identify the influential variables related to smoking, variables from the Trans-theoretical model(i.e., self-efficacy for smoking abstinence, smoking temptation, process of change, decisional balance(pros and cons)) and nicotine dependency were analysed by ANOVA. Post-comparison tests were also done. Results: The scores of nicotine dependency and smoking temptation were higher in habitual craving types than any other types, while the scores of self-liberation and self-efficacy for smoking abstinence were higher in self control types than any other types. Conclusion: Specific smoking intervention methods for each of the smoking types needs to be developed, based on how different groups of individuals gets into a decisions to quit smoking within their contexts.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.2
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• pp.93-104
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• 2023

This study aimed to identify new markers that cause lung adenocarcinoma by analyzing mutation hotspots for the top five genes with high mutation frequency in lung adenocarcinoma in Koreans by next generation sequencing (NGS) analysis. The association between TP53 mutation types and patterns with smoking, a major cause of lung cancer, was examined. The clinicopathological characteristics of lung adenocarcinoma patients with TP53 P72R SNPs were analyzed. In Korean lung adenocarcinoma cases, regardless of the smoking status, the TP53 P72R SNP was the most frequently occurring mutational hotspot, in which the nucleotide base was transversed from C to G, and the amino acid was substituted from proline to arginine at codon 72 of TP53. An analysis of the clinicopathological characteristics of lung adenocarcinoma cases with TP53 P72R SNP revealed no significant correlation with the patient's age, gender, smoking status, and tumor differentiation, but a significant correlation with low stage (P-value =0.026). This study confirmed an increase in TP53 rather than EGFR, which was reported as the most frequent mutations in lung adenocarcinoma in Koreans through NGS. Among them, TP53 P72R SNP is the most frequent regardless of smoking status.

• Proceedings of the Korean Society of Tobacco Science Conference
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• 2001.05a
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• pp.44-54
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• 2001

담배는 오랜 과거부터 규제의 주요 대상이 되어 왔다. 1950년대 이전까지만 해도 담배관련 규제는 담배의 생산 및 제조활동과 함께 윤리 또는 규범적 차원에서 주로 이루어져 왔으나, 1950년대 초 이후부터 흡연의 건강 위해성에 관한 연구가 본격화되고 건강에 대한 공중의 관심이 확산되면서 담배와 흡연에 대한 사회적·법적 규제가 크게 강화되어 왔다고 할 수 있다. 담배산업이 그 동안 지속적인 성장을 하는 가운데에서도 담배와 흡연에 대해 강도 높은 규제가 가해져 온 이유는 담배가 성인들의 기호품으로써 보편화 된데 반해 건강 위해적 요소들을 내재하고 있고, 담배의 높은 수익가치로 인해 담배의 생산 및 판매가 정부의 재정사업으로 관할됨에 따라 정보에 의한 강력한 통제가 불가피했기 때문이라 할 수 있다. 세계 각 국에서 적용되고 있는 담배에 대한 일반적인 규제유형으로는 크게 흡연(smoking) 규제와 판매 및 촉진활동(sales & promotion) 규제, 경고문 부착(labeling)에 관한 규제, 그리고 진입 및 무역(entry & trade) 규제 등으로 구분될 수 있다. 한국의 경우는 전통적으로 흡연에 대해 매우 관대한 태도가 유지되어 왔으나, 95년도 중반 이후 국민건강 증진법 등의 규제법률이 제정·시행되면서 제도적·정책적 규제가 크게 강화되어 현재는 세계 최상위 수준을 유지하고 있다고 할 수 있다. 이러한 가운데 99년 5월 이후, 담배에 대한 표준화된 규제지침의 설정과 강화를 통해 궁극적으로 세상에서 담배를 근절시키고자 하는 목적 하에서 세계보건기구(WHO)의 주 역점사업으로서 추진되고 있는 담배규제협약(FCTC)은 담배에 대한 규제가 초국가적 차원으로 발전되는 계기를 제공하고 있다. 향후, 담배규제협약안의 세부사안들에 대한 합의과정에서 각 국별로 상당한 이견과 반발이 예상되고 있지만, 협약안의 전체 회원국 투표에서 승인될 경우 각 국가들뿐만 아니라 담배산업과 담배기업들에게 미치는 파급효과가 매우 클 것으로 예상된다. 대부분의 국제협약들이 그러하듯이, 담배규제협약도 그 적용 범위와 수준이 어느 정도로 결정되는지에 따라 각 국가와 기업별 이해관계가 크게 달라지게 되기 때문에 신중한 대응전략이 요구된다고 하겠다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.252-266
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• 2019

The purpose of this study was to identify the type of health behaviors in Korean adults and to identify related factors. The data used in the analysis was the Korea Health and Nutrition Examination Survey 2014., which was representative of the Korean population. Cluster analysis was used to find the pattern of clustering of smoking, drinking, exercising and nutrition. Differences in the pattern of clustering was examined, first by bivariate chi-square test, and then by multinomial logit regression. Lastly, the association between the clusters of health behaviors and other behavioral risk factors was tested by chi-square test and logistic regression. The distribution of the clusters varied not only across socioeconomic characteristics and local size, but also between individuals with certain chronic diseases and those without. The results of this study can be used as a basis for the usefulness of approaching the cluster rather than individually approaching the health behavior.

• Journal of Korean Public Health Nursing
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• v.30 no.3
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• pp.495-511
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• 2016

Purpose: The present study was performed to describe the prevalence of various types of smoking statuses and to identify factors associated with different types among Korean wageworkers. Methods: The prevalence of hardcore smoking, daily smoking, and intermittent smoking was assessed in 2,126 wage workers from the Sixth Korea National Health and Nutrition Examination Survey. The associations of these three types of smoking statuses with sociodemographic characteristics, health conditions, and occupation-related characteristics were also examined in a multinomial logistic regression. Results: In men, the prevalence of hardcore smoking and daily smoking were 11.4% and 30.2%, respectively; and in women, the daily smoking prevalence was 5.6%. The education level was strongly associated with men's hardcore smoking and women's daily smoking. The household income and marital status were associated with women's daily smoking. Among occupation-related characteristics, the regularity of work and night work were associated with men's intermittent smoking. Night work was also associated with women's daily smoking. Employment condition was associated with women's intermittent smoking. Conclusion: The socioeconomic status and health conditions, compared with occupation-related factors, were found to have more influence on smoking. Therefore, antismoking programs that focus on individual characteristics should be developed for Korean wageworkers.

• The Journal of Korean Society for School & Community Health Education
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• v.21 no.1
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• pp.1-14
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• 2020

Objectives: The purpose of this study is to analyze the relationship between dual smoking and mental health. Methods: This study was conducted on 5,879 Korean adults, and a logistic regression analysis was conducted to investigate the relationship between smoking type and mental health. Results: The types of smoking were surveyed as 'dual smoking' 6.1%, 'electronic cigarette' 1.7%, 'general smoking' 12.1%, and 'non-smoking' 80.1%.. The risk of diagnosing depression in the dual smoking group was 2.87 times higher than in the non-smoking group, the risk of depression was 1.66 times higher than in the non-smoking group, and the risk of stress was 1.62 times higher. Conclusion: Even in adulthood, health education such as smoking prevention education and smoking cessation education should be conducted.

• The Journal of Korean Society for School & Community Health Education
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• v.23 no.2
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• pp.65-76
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• 2022

Objectives: The purpose of this study is to investigate the factors that affect the smoking type among those who have used regular cigarettes, liquid or cigarette-type e-cigarettes. Methods: The subjects of analysis were 6,081 people who had smoked regular cigarettes or e-cigarettes. For data analysis, SPSS ver.25.0 statistical package program was used. Multinomial logistic regression analysis was performed to find out the factors affecting smoking type. Results: Factors affecting the experience of using e-cigarettes compared to regular cigarette smoking are gender and class. Academic performance, living with family members, drinking experience, and secondhand smoke in school. The factors influencing dual use compared to regular cigarette smoking were gender, class, academic performance, economic status, living with family, drinking experience, and experience of secondhand smoke in school. Smoking cessation attempts had an effect on dual use compared to regular cigarette smoking. Conclusion: Smoking cessation experience had a greater effect on e-cigarette use than regular cigarette smoking.

• Research in Community and Public Health Nursing
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• v.13 no.3
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• pp.481-492
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• 2002

The purpose of this study was to understand and analyze the subjective structure of attitude The method was based on a Q-Methodological approach. The results of this study, there were four categories of smoking middle school students' attitude about smoking. The first type named Self Belief type that this type didn't sensible of their surrounding persons when they were smoking and they also were responsible for strong opinion at their behavior. The second type named Other's Awareness type that they were seen the behaviors they always have to see other person when they were smoked, but if they didn't smoke or have tobaccos they feel heavy and are restless. The third type named Solving of Anxiety type. They first used to smoke when they wanted to solve their anxiety, stress, awkwardness and angry. The fourth type named A Sense of Belonging Group type. This type followed if their friends were smoking they also did it with them. As to grasping of their motivation to smoking of middle school of students with smoking, they felt some intimacy and same quality each other. In consideration of various types of attitude about smoking, it was very necessary important to grasp the meaning because we were known about attitude, belief etc. And then Through getting hold of the meaning, we could understand with their thought and value of Students in middle school. Besides, as a substitute for the students were depending on smoking purposelessly will fix right self-confidence.

• Journal of agricultural medicine and community health
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• v.29 no.1
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• pp.43-63
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• 2004

Objectives: The purpose of this study was to classify the patterns of health behaviors of some rural residents in Korea by sub-grouping them into populations with similar patterns of diet quality, physical activity, alcohol consumption and cigarette smoking, and then to investigate the relationship between these health behavior patterns and health status or health management of them. Methods: The study subjects were 722 rural residents above 20 years old on a typical rural district in Korea, and the data used in this study was from the survey data for health planning of a health center. Study questionnaire for this survey was developed from modifying the questionnaire for 'National Nutrition and Health Study' conducted in 1998. To classify health behavior patterns, cluster analysis was conducted. And to test the association of health behavior patterns with health status or health management, multiple logistic regression analysis were conducted. Results: The results and their implications of this study were as follows: 1. We identified six health behavior typologies : 67.8% of the sample had a good diet quality but showed sedentary activity level(good diet lifestyle) and 10.9% had heavy smoking behavior(smoking lifestyle). Individuals included in fitness lifestyle cluster(6.2%) had high physical activity level and those in drinking life style(2.6%) had had mainly large amount of alcohol. Zero point six percent of sample were included in hedonic lifestyle cluster, who showed poor health behaviors in all. Those included in passive lifestyle(11.9%) had no active health promoting activities but tended to avoid risk taking health behavior such as cigarette smoking and alcohol drinking. 2. As a result of logistic regression analysis, to compare with the individuals in good diet lifestyle, the prevalence of chronic diseases of those in fitness lifestyle showed higher and that of those in smoking lifestyle, drinking lifestyle, hedonic lifestyle, passive lifestyle showed lower than them, retrospectively. 3. Adjusting with general characteristics and health status, to compare with the individuals in good diet lifestyle, the proportion of those who had good health management practices in fitness lifestyle was higher, and the proportion of those who had health check in past 2 years was lower than them, retrospectively. Conclusions: There were some differences in health behavior patterns between rural population and national population, which influenced significantly on health status and health management practice of them. We suggested that the health promotion program for them be developed with considering these points.