• Phonetics and Speech Sciences
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• v.12 no.2
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• pp.73-80
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• 2020

Breathing is the voice's driving force and also acts as a regulator of larynx function and efficiency. Respiratory distress is a side effect of general anesthesia in thyroid surgery. Therefore, this study's objective was to provide practical and complementary information for voice recovery after thyroid surgery, based on aerodynamic evaluation pre- and post-thyroidectomy. From May 2014 to July 2015, aerodynamic evaluations were performed on 34 female patients diagnosed with thyroid papillary cancer one week before surgery (PRE), one month after surgery (P1), and three months after surgery (P3). The Phonatory Aerodynamic System (model 6600, KayPENTAX, USA) was employed for this purpose, and a total of 29 analysis parameters were selected. The results showed statistically significant differences in peak expiratory airflow (p=0.004), mean pitch (p<0.01), expiration airflow duration (p=0.001), and expiratory volume (p=0.018), based on time factors. In the comparison of time factors, peak expiratory airflow and mean pitch parameters were different in PRE-P1 and PRE-P3. Expiration airflow duration and expiratory volume parameters were different in PRE-P3 and P1-P3. The interaction effect of time and surgical range was significant only for expiratory volume (p=0.024). Female patients who undergo thyroidectomy require post-operative breathing training, and exhalation improvement is considered to reflect a positive lifestyle after surgery.

• Tuberculosis and Respiratory Diseases
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• v.40 no.2
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• pp.123-134
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• 1993

Background: Tissue-type plasminogen activator is a physiologic activator, which has high affinity for fibrin and is activated by fibrin. Because of these properties, t-PA has the potential to induce effective thrombolysis without producing a systemic lytic state. In practice, however, therapeutically efficacious doses of t-PA has been associated with the development of a systemic lytic state. As experience with t-PA has accumulated, it has suggested that the fibrin selectivity is influenced by the dose and duration of t-PA infusion, and many studies have performed in an attempt to optimize the duration of t-PA regimen. Methods: This study was designed to assess the thrombolytic efficacy of t-PA and the differences of two dosing regimens of t-PA (infusion of 1 mg/kg t-PA over 15 or 180 minutes) in a canine model of pulmonary embolism, induced by injection of radioactive autologous blood clots. By continuously counting over both lung fields with a external gamma counter, we correlated rate and extent of pulmonary thrombolysis with corresponding pulmonary hemodynamics in addition to the gas analyses of arterial and mixed venous blood. Results: 1) While total clot lysis was similar ($36.2{\pm}3.3%$ and $39.6{\pm}2.3%$ respectively, p>0.05) when t-PA was infused over 15 or 180 minutes, the rate of lysis during infusion was markedly increased with the shorter infusion ($81.4{\pm}16.8%/hr$ vs $37.3{\pm}2.4%/hr$, p<0.05). 2) The duration of thrombolysis was $63.3{\pm}22.2$ minutes although t-PA was administered over 15 minutes, and it was only $148.5{\pm}14.0$ minutes in case of the infusion over 180 minutes (p<0.05). 3) The increased rate of thrombolysis with the shorter infusion was accompanied by a faster amelioration of cardiopulmonary impairment from pulmonary embolism (p<0.05). Conclusion: It is concluded that the shorter (15 minutes) infusion of t-PA is superior to the longer (180 minutes) infusion when the dose is equal, in consideration of the faster improvement in cardiopulmonary impairment from pulmonary embolism.

• Tuberculosis and Respiratory Diseases
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• v.45 no.5
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• pp.1039-1046
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• 1998

Background: Sleep-related breathing disorders(SRBD) and periodic leg movements disorder(PLMD) are both common, and are considered as separate sleep disorders. However, both disorders show high comorbidity. SRBD and PLMD can result in excessive daytime sleepiness and insomnia due to frequent sleep fragmentation. So, it is very important to consider the presence of PLMD, when we are dealing with the diagnosis and management of SRBD. The objectives of this study were to determine the incidence of PLMD in patients with SRBD, and to describe any differences between patients with and without PLMD. Method: The authors reviewed the sleep recordings of 106 patients with a final diagnosis of SRBD(obstructive sleep apnea or upper airway resistance syndrome), who underwent full nocturnal polysomnography, including the monitoring of the anterior tibialis electromyogram. All sleep records were recorded and scored using the standard criteria. The data was analyzed by the student t-test. Result: 106 patients(M=76, F=30) were included in the analysis. Data revealed a mean age of $49.5{\pm}13.6$ years, a respiratory disturbance index(RDI) of $22.3{\pm}25.4$/hour sleep, a lowest oxygen saturation of $84.9{\pm}11.3%$, a maximal esophageal pressure of $-41.0{\pm}19.1cmH_2O$, and PLM index(PLMI) of $13.1{\pm}22.4$movements/hour sleep. Forty four percent(47 of 106 patients) had a PLMI of greater than 5 on this study. The mean age of the patients with PLMD was significantly higher than that of the patients without PLMD(p<0.005). Female patients with SRBD accompanied more PLMD(p<0.05). The apnea index of the patients with PLMD was significantly lower than that of the patients without PLMD(p<0.01). The percentage of stage 1 sleep in the patients with PLMD was significantly lower than that of the patients without PLMD(p<0.05). Conclusion: The prevalence of PLMD in the patients with SRBD was high at 44.3%. The patients with PLMD were older and had more high RDI in comparison to the patients without PLMD, which was consistent with previous findings. The authors recommend that more careful consideration of PLMD is required when diagnosing and treating SRBD.

• Journal of Dental Rehabilitation and Applied Science
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• v.27 no.2
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• pp.141-147
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• 2011

The aim of this study was to evaluate histomorphometrically and compare the efficiency of various bone graft material and autogenous tooth bone graft material which were used in sinus bone graft procedure. Subjects were the 24 patients who had treated with sinus bone graft using lateral approach from October 2007 to September 2009 at SNUBH. The average age was $52.51{\pm}11.86$ years. All cases was taken after 4month of procedure and divided into 3 groups according to bone graft material. Group 1: autogenous tooth bone graft material, Group 2: OrthoblastII(integra lifescience corp. Irvine, US)+Biocera(Osscotec, seoul, korea), group 3: DBX(Synthes, USA)+BioOss(Geistlich Pharm AG, Wolhusen, Switzerland). Total 37 implant placement area were included and evaluated(7 in group 1, 10 in group 2, 20 in group 3). Evaluation of new bone formation, ratio of woven bone to lamellar bone, ratio of new bone to graft material were performed on each tissue section. Kruskal-Wallis test was used for statistical analysis(SPSS Ver. 12.0, USA). New bone formation were $52.5{\pm}10.7%$ in group 1, $52.0{\pm}23.4%$ in group 2, $51.0{\pm}18.3%$ in group 3. There were no statistical significant differences between each groups. Ratio of woven bone to lamella bone were $82.8{\pm}15.3%$ in group 1, $36.7{\pm}59.3%$ in group 2, $31.0{\pm} 51.2%$ in group 3. Ratio of new bone to graft material were $81.3{\pm}10.4%$ in group 1, $72.5{\pm}28.8%$ in group 2, $80.3{\pm}24.0%$ in group 3. After 4 month of healing period, all group showed favorable new bone formation and around graft material and implant. Within limitation of our study, it is suggested that autogenous tooth bone graft material might be used as novel bone graft material for sinus bone graft.

• Proceedings of the Korea Society for Simulation Conference
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• 1996.05a
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• pp.1-3
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• 1996

시뮬레이션 기법을 이용한 시스템의 분석에 있어서 실험의 자동화는 현재 많은 연구와 개발이 진행 중인 분야이다. 컴퓨터와 정보통신 시스템에 대한 시뮬레이션의 예를 들어 보면, 수많은 모델을 대한 시뮬레이션을 수행할 경우 자동화된 실험의 제어가 요구되고 있다. 시뮬레이션 수행회수, 수행길이, 데이터 수집방법 등과 관련하여 시뮬레이션 실험방법이 자동화가 되지 않으면, 시뮬레이션 실험에 필요한 시간과 인적 자원이 상당히 커지게 되며 출력데이터에 대한 분석에 있어서도 어려움이 따르게 된다. 시뮬레이션 실험방법을 자동화하면서 효율적인 시뮬레이션 출력분석을 위해서는 시뮬레이션을 수행하는 경우에 항상 발생하는 초기편의 (initial bias)를 제거하는 문제가 선결되어야 한다. 시뮬레이션 출력분석에 사용되는 데이터들이 초기편의를 반영하지 않는 안정상태에서 수집된 것이어야만 실제 시스템에 대한 올바른 해석이 가능하다. 실제로 시뮬레이션 출력분석과 관련하여 가장 중요하면서도 어려운 문제는 시뮬레이션의 출력데이터가 이루는 추계적 과정 (stochastic process)의 안정상태 평균과 이 평균에 대한 신뢰구간(confidence interval: c. i.)을 구하는 것이다. 한 신뢰구간에 포함되어 있는 정보는 의사결정자에게 얼마나 정확하게 평균을 추정할 구 있는지 알려 준다. 그러나, 신뢰구간을 구성하는 일은 하나의 시뮬레이션으로부터 얻어진 출력데이터가 일반적으로 비정체상태(nonstationary)이고 자동상관(autocorrelated)되어 있기 때문에, 전통적인 통계적인 기법을 직접적으로 이용할 수 없다. 이러한 문제를 해결하기 위해 시뮬레이션 출력데이터 분석기법이 사용된다.본 논문에서는 초기편의를 제거하기 위해서 필요한 출력데이터의 제거시점을 찾는 새로운 기법으로, 유클리드 거리(Euclidean distance: ED)를 이용한 방법과 현재 패턴 분류(pattern classification) 문제에 널리 사용 중인 역전파 신경망(backpropagation neural networks: BNN) 알고리듬을 이용하는 방법을 제시한다. 이 기법들은 대다수의 기존의 기법과는 달리 시험수행(pilot run)이 필요 없으며, 시뮬레이션의 단일수행(single run) 중에 제거시점을 결정할 수 있다. 제거시점과 관련된 기존 연구는 다음과 같다. 콘웨이방법은 현재의 데이터가 이후 데이터의 최대값이나 최소값이 아니면 이 데이터를 제거시점으로 결정하는데, 알고기듬 구조상 온라인으로 제거시점 결정이 불가능하다. 콘웨이방법이 알고리듬의 성격상 온라인이 불가능한 반면, 수정콘웨이방법 (Modified Conway Rule: MCR)은 현재의 데이터가 이전 데이터와 비교했을 때 최대값이나 최소값이 아닌 경우 현재의 데이터를 제거시점으로 결정하기 때문에 온라인이 가능하다. 평균교차방법(Crossings-of-the-Mean Rule: CMR)은 누적평균을 이용하면서 이 평균을 중심으로 관측치가 위에서 아래로, 또는 아래서 위로 교차하는 회수로 결정한다. 이 기법을 사용하려면 교차회수를 결정해야 하는데, 일반적으로 결정된 교차회수가 시스템에 상관없이 일반적으로 적용가능하지 않다는 문제점이 있다. 누적평균방법(Cumulative-Mean Rule: CMR2)은 여러 번의 시험수행을 통해서 얻어진 출력데이터에 대한 총누적평균(grand cumulative mean)을 그래프로 그린 다음, 안정상태인 점을 육안으로 결정한다. 이 방법은 여러 번의 시뮬레이션을 수행에서 얻어진 데이터들의 평균들에 대한 누적평균을 사용하기 매문에 온라인 제거시점 결정이 불가능하며, 작업자가 그래프를 보고 임의로 결정해야 하는 단점이 있다. Welch방법(Welch's Method: WM)은 브라운 브리지(Brownian bridge) 통계량()을 사용하는데, n이 무한에 가까워질 때, 이 브라운 브리지 분포(Brownian bridge distribution)에 수렴하는 성질을 이용한다. 시뮬레이션 출력데이터를 가지고 배치를 구성한 후 하나의 배치를 표본으로 사용한다. 이 기법은 알고리듬이 복잡하고, 값을 추정해야 하는 단점이 있다. Law-Kelton방법(Law-Kelton's Method: LKM)은 회귀 (regression)이론에 기초하는데, 시뮬레이션이 종료된 후 누적평균데이터에 대해서 회귀직선을 적합(fitting)시킨다. 회귀직선의 기울기가 0이라는 귀무가설이 채택되면 그 시점을 제거시점으로 결정한다. 일단 시뮬레이션이 종료된 다음, 데이터가 모아진 순서의 반대 순서로 데이터를 이용하기 때문에 온라인이 불가능하다. Welch절차(Welch's Procedure: WP)는 5회이상의 시뮬레이션수행을 통해 수집한 데이터의 이동평균을 이용해서 시각적으로 제거시점을 결정해야 하며, 반복제거방법을 사용해야 하기 때문에 온라인 제거시점의 결정이 불가능하다. 또한, 한번에 이동할 데이터의 크기(window size)를 결정해야 한다. 지금까지 알아 본 것처럼, 기존의 방법들은 시뮬레이션의 단일 수행 중의 온라인 제거시점 결정의 관점에서는 미약한 면이 있다. 또한, 현재의 시뮬레이션 상용소프트웨어는 작업자로 하여금 제거시점을 임의로 결정하도록 하기 때문에, 실험중인 시스템에 대해서 정확하고도 정량적으로 제거시점을 결정할 수 없게 되어 있다. 사용자가 임의로 제거시점을 결정하게 되면, 초기편의 문제를 효과적으로 해결하기 어려울 뿐만 아니라, 필요 이상으로 너무 많은 양을 제거하거나 초기편의를 해결하지 못할 만큼 너무 적은 양을 제거할 가능성이 커지게 된다. 또한, 기존의 방법들의 대부분은 제거시점을 찾기 위해서 시험수행이 필요하다. 즉, 안정상태 시점만을 찾기 위한 시뮬레이션 수행이 필요하며, 이렇게 사용된 시뮬레이션은 출력분석에 사용되지 않기 때문에 시간적인 손실이 크게 된다.

• Food Science and Preservation
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• v.15 no.1
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• pp.49-57
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• 2008

This study was conducted to develop an optimal composite recipe for a cookie including yam powder that would be attractive to all age groups. Wheat flour was partially substituted by yam powder to reduce the content of wheat flour. This study has produced the sensory optimal composite recipe by making cookies, respectively with each 5 level of yam powder $(X_1)$, Sugar$(X_2)$, butter$(X_3)$, by C.C.D (Central Composite Design) and conducting sensory evaluation and instrumental analysis by means of RSM (Response Surface Methodology). Sensory items showed very significant values in color, softness, overall quality (p<0.01), flavor (p<0.05) and those of instrumental analysis showed significant values in lightness, redness (p<0.05), spread ratio, hardness (p<0.01). Also sensory optimal ratio of yam cookie was calculated at yam powder 37.35 g, sugar 50.75 g, butter 78.40 g and it was revealed that the factors of influencing yam cookie aptitude were in older of yam powder, butter, sugar.

• Food Science and Preservation
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• v.24 no.6
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• pp.802-812
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• 2017

This study was conducted to investigate the quality properties depending on the cultivation methods (general, organic, pesticide-free) of yuza and its various parts (peel, pulp, seed). The contents of hesperidin were the highest in yuza feel grown by pesticide-free method (13.23 mg/g). The contents of naringin presented a higher content in the peel, especially which of the general (4.62 mg/g) showed the highest value. Vitamin C analysis showed the highest content in the peel, significantly varied according to the cultivation method and various parts (p<0.05). Vitamin C value was significantly highest in organic peel, which was 770.02 mg/100 g, whereas among the peel, the pulp and the seed were it the lowest in the seed. The content of total polyphenols were the highest in general peel (0.85 mg/g). Flavonoid content of pesticide-free seed was significantly higher than those of the other yuja samples which was 0.89 mg/g (p<0.05). The DPPH radical scavenging activity was relatively more active in the peel among the above-mentioned three parts, especially the pesticide-free peel was most active, which was 73.94%. The ABTS radical scavenging activity of organic peel was significantly active among the samples, which was 84.47% (p<0.05). Based on these results, it can be said that yuja has variety of useful components in the pulp and the seed as well as the peel: and thus it's hight recommended to develop more varied yuja products.

• Journal of The Korean Society of Grassland and Forage Science
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• v.24 no.1
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• pp.43-52
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• 2004

This study was carried out to determine the effect of corn silage and roughage feeding systems on milk yield and milk compositions. The experimental design was allotted into 3 treatments according to the feeding systems of rice straw(rice straw＋concentrate: T1), corn silage(corn silage ＋ concentrate: T2) and TMR treatment(Total mixed rate : roughage ＋ concentrate: T3). This research was carried out from Oct. 1988 to Mar. 1999 at Kimcheon Kyungbook. The results obtained were summarized as follows: 1. The milk yield increased upon T2(31.9$\pm$3.2kg) ＞ T3(29.6$\pm$3.8kg) ＞ T1 treatment(22.5$\pm$2.0kg)(P<0.05), but cows with T2 and T3 produced the highest at third parity while T1 at forth parity. 2. The milk fat percentage was the highest at T3 treatment(3.79$\pm$0.31%), and on the other hand T1 treatment appeared the lowest percentage. Cow at 2nd parity produced the highest milk fat contend over the other parity. 3. There was no significant difference in protein content between treatments and parity, but T2 and T3 were higher than T1 4. Treatment did not affact content of SNF even though T2 and T3 of the SNF revealed to higher than T1. T5 was T3(12.51$\pm$0.57%)>T1(11.71$\pm$0.62%)>T2 treatment(11.52$\pm$0.55%). These were not significant. 5. Somatic cell counts were the highest at T1(39.6 ${\times}$ $10^4$cell/ml), but T2 treatment was the lowest as 28.7 ${\times}$ $10^4$ cell/ml. These results indicates that com silage(T2) and TMR treatment(T3) could be recommended

• Korean Journal of Medicinal Crop Science
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• v.5 no.2
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• pp.95-101
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• 1997

This study was conducted to investigate how a labor saving for conventional hand sowing and respond to major agronomic traits under different planting density in 1993 and 1994. Each trial was a randomized block split plot with row spacing as the main plots and hill spacing as subplots. Sowing rate appeared lower in 20 or 25cm hill spacing using machine seeder than in hand sowing. Sowing time required reduced more 121 hours per hectare in 60cm row, 20cm hill spacings using machine seeder than in hand sowing. Increasing row and hill spacings reduced number of seedling stand per unit $area(m^2)$. Both number of pods per plant and grain weight per plant and showed highly increase in wide planting. Best yield obtained in 60cm row, 20cm hill spacing using machine seeder. Accumulative mean air temperature was positively correlated with stem height, number of pods per plant and yield, otherwise accumulative rainfall was negatively correlated with ones. A highly significant negative correlation was showed between number of seedling stand per unit $area(m^2)$ and number of branches, number of pods per plant, grain weight per plant and yield. Yield was positively correlated with number of branches, number of pods per plant and grain weight per plant.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.18 no.1 s.116
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• pp.62-75
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• 2007

This paper describes a shaped-beam antenna for increasing the antenna gain of a radiating element. The proposed antenna structure is composed of an exciting element and a multi-layered disk array structure(MDAS). The stack micro-strip patch elements were used as the exciter for effectively radiating the electromagnetic power to the MDAS over the broadband, and finite metallic disk array elements - which give the role of a director for shaping the antenna beam with the high gain - were finitely and periodically layered onto it. The efficient power coupling between the exciter and the MDAS should be carried out in such a way that the proposed antenna has a high gain characteristic. The design parameters of the exciter and the MDAS should be optimized together to meet the required specifications to meet the required specifications. In this study, a shaped-beam antenna with high gain was optimally designed under the operating conditions with a linear polarization and the frequency band of $9.6{\sim}10.4\;GHz$. Two methods constructed using thin dielectric film and dielectric foam materials respectively were also proposed in order to implement the MBAS of the antenna. In particular, through the computer simulation process, the electrical performance variations of the antenna with the MDAS realized by the thin dielectric film materials were shown according to the number of disk array elements in the stack layer. Two kinds of antenna breadboard with the MDAS realized with the thin dielectric film and dielectric foam materials were fabricated, but experimentation was conducted only on the antenna breadboard(Type 1) with the MDAS realized with the thin dielectric film materials according to the number of disk array elements in the stack layer in order to compare it with the electrical performance variations obtained during the simulation. The measured antenna gain performance was found to be in good agreement with the simulated one, and showed the periodicity of the antenna gain variations according to the stack layer number of the disk array elements. The electrical performance of the Type 1 antenna was measured at the center frequency of 10 GHz. As the disk away elements became the ten stacks, a maximum antenna gain of 15.65 dBi was obtained, and the measured return loss was not less than 11.4 dB within the operating band. Therefore, a 5 dB gain improvement of the Type 1 antenna can be obtained by the MDAS that is excited by the stack microstrip patch elements. As the disk array elements became the twelve stacks, the antenna gain of the Type 1 was measured to be 1.35 dB more than the antenna gain of the Type 2 by the outer dielectric ring effect, and the 3 dB beam widths measured from the two antenna breadboards were about $28^{\circ}$ and $36^{\circ}$ respectively.