• Clinical and Experimental Pediatrics
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• v.50 no.10
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• pp.976-981
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• 2007

Purpose : Aortic valve or aortic root (AoRo) replacement is occasionally required because of AoRo dilatation and aortic regurgitation (AR) in repaired tetralogy of Fallot (TOF). We evaluated AoRo size and possible factors associated with its hemodynamic nature in patients with repaired TOF. Methods : We investigated 130 repaired TOF patients more than 15 years of age who followed-up by echocardiography from January 2002 to December 2003. Of 130 patients, we identified 17 patients with AoRo dilatation, which was defined as ratio of expected AoRo size by standard nomogram (AoRo ratio) >1.5 (dilator group), and 113 TOF controls, with AoRo ratio <1.5 (non-dilator group). Results : Mean indexed AoRo size ($mm/m^2$) in the first echo was $24{\pm}3.2$ in the dilator group and $18{\pm}3.4$ in the non-dilator group (P<0.0001). AoRo rate of change (mm/year) from the first to latest echo study was $1.6{\pm}3.8$ in dilator group and $0.05{\pm}1.6$ in the non dilator group (P=0.0021). Patients from the dilator group showed a higher prevalence of pulmonary atresia (P=0.031) and a history of aortopulmonary shunt before repair (P=0.048), moderate to severe AR (P=0.0065), and increased left ventricular end-diastolic dimensions (P=0.003). Conclusions : A subset of patients late after TOF repair may show progressive dilatation of AoRo. To identify and prevent long-term sequelae in this patient group, regular follow-up and speculation about AoRo after TOF repair is recommended.

• Journal of the Korean Institute of Landscape Architecture
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• v.46 no.5
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• pp.22-35
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• 2018

The purpose of this study is to understand the idea of the ideal garden, pursued by Dasan, by analyzing the production process of his writing and the location of his dwelling, and the characteristics of the garden in the writings of Dasan (茶山) Jeong Yag-Yong (丁若鏞)'s "Jaehwangsangyuincheop (題黃裳幽人帖)" is concerned with his writings on an imaginary garden (意園). This paper assumed that "Jaehwangsangyuincheop" served as a blueprint for his ideal dwelling. The main research subjects are the external scenes described in the "Jaehwangsangyuincheop", and the garden elements and spatial construction that were visualized as a Korean Ink Painting (水墨畵) through the analysis of related works. The results are as follows. First, Hwang Sang was Dasan's favorite pupil, and "Jaehwangsangyuincheop" was written by Dasan while at Boeunsanbang in the winter of 1805 as an answer to a question that Hwang Sang posed about the residence of a hermit. By referring to this response, Hwang Sang established Ilsoksanbang (一粟山房) under Mt. Cheongae in Daegu-myeon, Gangjin. Secondly, the residence in "Jaehwangsangyuincheop" has mountains behind it and water in front of it (背山臨水). The residence was used as a place to combine life and leisure. It was an ideal residence that secluded the scholar(隱士). Thirdly, Dasan's ideal garden was shown as operation of natural geography in a residential location, practically using various plant materials, expanding physical boundaries of garden, pursuing synesthetic aesthetics while enjoying garden elements, and having an active experience of the taste for the arts in the extended garden. "Jaehwangsangyuincheop" depicted the life of a scholar with the taste of elegance (雅趣), who live in reclusiveness (隱逸), which was wanted by Dasan after exile. It was realized as Ilsoksanbang. "Jaehwangsangyuincheop" was interpreted as the ideal of a feasible dwelling that faithfully reflects Dasan's conceptual thoughts on the garden.

• Tuberculosis and Respiratory Diseases
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• v.61 no.2
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• pp.143-149
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• 2006

Background: Irinotecan (topoisomerase I inhibitor) is effective as a monotherapy against small-cell lung cancer(SCLC). Cisplatin is also an important drug against SCLC. A phase II study of irinotecan combined with cisplatin was carried out to evaluate the efficacy and toxicity of this combined regimen as a first line treatment in patients with extensive SCLC. Methods: Thirty-nine patients with previously untreated extensive SCLC were enrolled in this study. Irinotecan $60mg/m^2$ was administered intravenously on days 1, 8 and 15, and in combination with cisplatin $60mg/m^2$ on day 1 and every 28 days thereafter. Four cycles of chemotherapy were given to the patients. Results: The overall response rate was 77% with a complete response (CR) rate of 8%. The median survival time, 1- and 2-year survival rate were 14.8 months, 60.9% and 27.6%, respectively. The median progression free survival time, 6-and 12-month progression free survival rate were 8.4 months, 75% and 18.8%, respectively. The WHO grade 3 or more toxicity encountered were leukopenia (23%), diarrhea (26%). Two patients changed their chemotherapeutic regimen and one patient died from severe diarrhea. Conclusion: The combination of irinotecan and cisplatin is effective as a first line therapy in extensive SCLC is effective, but has severe or fatal diarrhea as toxicity.

• The korean journal of orthodontics
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• v.38 no.1
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• pp.13-30
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• 2008

Objective: The objective of this study was to evaluate the displacement pattern and the stress distribution of the finite element model 3-D visualization during symphyseal widening according to the osteotomy position, osteotomy type, and distraction device. Methods: The kinds of distraction devices used were tooth-borne type, hybrid type, bone-borne type and tooth-borne type $30^{\circ}$ angulated, and the kinds of osteotomy design were vertical osteotomy line between the central incisors and step osteotomy line through the symphysis. Results: All reference points of the mandible including the condyles were displaced laterally irrespective of the osteotomy position, osteotomy method and distraction device. The anteroposterior or vertical displacements showed small differences between the groups. The widening pattern of the osteotomy line in the tooth-borne type of device was v shaped, and that of bone-borne type was a reverse v shape. However, the pattern in the hybrid type was parallel. The lateral displacement of the mandibular angle by the bone-borne device was more remarkable than the other types of devices. The displacement by the $30^{\circ}$ angulated tooth-borne type was different between the left and right sides in both the transverse and anteroposterior aspects. Conclusion: The design of the distraction devices and osteotomy line can influence the displacement pattern and the stress distribution during mandibular symphyseal distraction osteogenesis procedures.

• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.87-92
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• 2009

Purpose : Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients. Methods : One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing. Results : There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P= 0.0077, dominant P=0.0021, recessive P=0.16). Conclusion : Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.

• Journal of Korean Society of Transportation
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• v.20 no.1
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• pp.19-38
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• 2002

To evaluate the effects of transportation system operation, usually measures of effectiveness(MOE) such as travel time, space mean speed, stop/delay ratio have been used. But, energy consumption as well as the existing MOE in transportation receives more attention as an alternative MOE in transportation operation. The purpose of this study is a development of procedure, which could measure the relative energy consumption for each alternative and compare the results. A mesoscopic simulator called INTEGRATION is used to evaluate the operation of high occupancy vehicle lane, signal optimization, lane expansion, and the application of ITS. Among those, the application of ITS shows the greatest effectiveness in energy reduction, and then lane expansion, signal optimization, and the operation of high occupancy vehicle lane in the order named. Because we don't consider the characteristics of vehicle class, Potential demand and the simulation time is just for an hour. it is recommended that a procedure for precise economic analysis and an improvement in methodology are needed in the future for the expanded application of this study.

• The Transactions of the Korea Information Processing Society
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• v.3 no.7
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• pp.1680-1686
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• 1996

The deterministic update method of intensional predicates in a parallel deductive database that deductive database is distributed in a parallel computer architecture in needed. Using updated data from the deterministic update method, a strategy for parallel evaluation of intensional predicates is required. The paper is concerned with an approach to updating parallel deductive database in which very insertion or deletion can be performed in a deterministic way, and an extended parallel semi-naive evaluation algorithm in a parallel computer architecture. After presenting an approach to updating intensional predicates and strategy for parallel evaluation, its implementation is discussed. A parallel deductive database consists of the set of facts being the extensional database and the set of rules being the intensional database. We assume that these sets are distributed in each processor, research how to update intensional predicates and evaluate using the update method. The parallel architecture for the deductive database consists of a set of processors and a message passing network to interconnect these processors.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.40 no.5
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• pp.497-503
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• 2016

In this study, we formulate an acoustical topology optimization problem to optimally design a partition layout inside the expansion chamber of a muffler. The lower-limit insertion loss value at a target frequency is constrained, and the partition volume is selected as an object function. In this study, we calculate the insertion loss outside the duct, while to determine the noise-attenuation performance, we use the insertion loss value calculated inside the duct or transmission loss value obtained in a previous study. We employ the finite-element model for acoustical analysis, and we determine the transmission of an incident acoustic wave through each finite element using the functions of design variables that change continuously between "0" and "1." The rigid body elements, which totally reflect incident waves, build up partitions. Finally, we compare optimal topologies that depend on the target frequency and the allowed lower-limit value of insertion loss.

• The korean journal of orthodontics
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• v.27 no.3 s.62
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• pp.445-456
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• 1997

This study was designed to examine the dental asymmetry in person with facial asymmetry and to examine the relationship between the degree of mandibular deviation and asymmetry of maxillary dental arch. The sample!, were divided to asymmetry group and normal group. The asymmetry group consisted of 21 subjects(6 males and 15 females) and their mean age was 23.5 years. The normal group consisted of 20 subjects(10 males and 10 females) and their mean age was 18.6 years. Anteroposterior, transverse position of all maxillary teeth except 3rd molars, vortical position of maxillary 1st molars, and angulation of central incisors were measured. The anterioposterior and transverse positions of teeth were measured on the maxillary dental casts, the vertical position of maxillary 1st molars and angulation of maxillary incisors were measured on posteroanterior cephalometric radiographs. The data were analyzed to examine whether significant asymmetries existed in each of the asymmetry and normal groups. The results of this study were as follows : 1. In the asymmetry group, the correlation between the degree of mandibular deviation and that of 3-dimensional dental asymmetry was not so high. 2. In the asymmetry group, the teeth in deviated side were more laterally positioned than that of undeviated side. There were differences in the anteroposterior position of maxillary 1st and 2nd molars and the angulation of maxillary central incisors. 3. In the asymmetry group, the transverse asymmetry was larger in the posterior teeth rather than in the anterior teeth and larger than the anteroposterior asymmetry.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1994.04a
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• pp.94-99
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• 1994

최근 인구의 과밀화와 이에 따른 지가의 상승 등으로 대표적인 주거용 빌딩인 아파트의 고층화가 급속하게 진행되고 있고 아파트에 설치되는 엘리베이터도 점차 대형화, 고속화 되고 있다. 실례로 15층 아파트의 경우 11인승, 60m/min의 엘리베이터가 일반적으로 사용되는 반면, 20층 아파트의 경우 17인승, 90m/min이 주로 사용된다. 이와 같이 엘리베이터의 용량과 운행 속도가 증가함에 따라 필연적으로 소음 및 진동 문제가 발생하게 된다. 특히 아파트의 경우 침실, 공부방 등 고도의 정숙을 요하는 생활 공간이 많고, 내부 공간의 활용도를 높이기 위하여 이들 방들이 엘리베이터 기계실 또는 운행 통로와 직접 접하여 있는 경우도 있어 이 경우 소음, 진동 문제는 아주 심각한 문제로 대두된다. 본 연구소가 측정한 방에 의하면 S신도시 L아파트의 경우 아파트 최상층 방에서 실내 소음도가 46dB(A), 벽의 진동가속도가 3.4mm/s$^{2}$(RMS)으로 나타났다. 진동의 경우 생활에 직접적인 악영향을 미칠 수준은 아니지만 소음의 경우 ASHRAE 권장 주택소음 기준치가 35dB(A) 이하임ㅇㄹ 감안하면 주거에 곤란한 수준이다. 수년전, 고층 아파트가 보급될 초기에는 아파트에 엘리베이터가 설치되어있다는 그 자체만으로 충분한 장점이 되어 다소음 소음, 진동문제는 큰 불만거리가 되지 않았지만 엘리베이터가 보편화된 지금에는 엘리베이터의 편리성만으로는 점점더 크게 요구되는 정숙성이 보상되지 않는다. 따라서 전반적인 아파트의 소음, 진동 문제에 큰 비중을 차지하는 엘리베이터에 의한 소음, 진동에 관하여 체계적인 연구가 필요하다. 이에 본고에서는 엘리베이터에 의한 아파트의 소음 및 진동에 관하여 그 현황, 원인 그리고 대책에 관한여 논하고자 한다.감 방법을 연구하였고, T.Sakai는 5자유도 모델을 이용하여 엔진 공회전시 발생하는 치타음에 대해 이론과 실험을 통해 해석하고, 엔진 회전수 변동, 클러치 특성, 변속기의 드래그(drag) 토크의 영향과 치타음 저감을 위한 개선된 클러치 특성을 제시하였다. 이 외에도 Thomas C.T.와 E.P.Petkus는 특정 차량에 대한 동력전달계의 비틀림 진동 현상에 대해 연구하였다. 이러한 연구들로 볼 때, 자동차 동력전달계에서 발생하는 진동은 이론과 실험을 통해 그 해석이 가능하며 설계에 매우 유용하게 이용되고 있음을 알 수 있다. 따라서, 본 연구는 4 실린더 4 싸이클 1.5 L 엔진을 장착한 경승용차의 실차 주행실험을 통해 가속 페달의 급조작에 따른 차체의 종진동 현상을 측정하고, 엔진-변속기-타이어-차체의 반환정계 4자유도 진동모델로 시뮬레이션을 수행하여 실차 주행실험의 결과치와 비교, 분석한 후 클러치 비틀림 특성을 비롯한 자동차 동력전달계의 각 설계인자들이 차체의 종진동에 어떠한 영향을 미치는가를 해석하고자 한다.be presented.LIFO, 우선 순위 방식등을 선택할 수 있도록 확장하였다. SIMPLE는 자료구조 및 프로그램이 공개되어 있으므로 프로그래머가 원하는 기능을 쉽게 추가할 수 있는 장점도 있다. 아울러 SMPLE에서 새로이 추가된 자료구조와 함수 및 설비제어 방식등을 활용하여 실제 중형급 시스템에 대한 시뮬레이션 구현과 시스템 분석의 예를 보인다._3$", chain segment, with the activation energy of carriers from the shallow trap with 0.4[eV], in he amorphous regions.의 증발산율은 우기의 기상자료를 이용하여 구한 결과 0.05 - 0.1