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Phase II Study of Irinotecan Plus Cisplatin as First Line therapy in Extensive Small-Cell Lung Cancer  

Hwang, Ki Eun (Department of Internal Medicine, College of Medicine, Wonkwang University)
Kim, So Young (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jung, Jong Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University)
Park, Seong Hoon (Department of Radiology, College of Medicine, Wonkwang University)
Park, Jung Hyun (Department of Internal Medicine, College of Medicine, Wonkwang University)
Kim, Hwi Jung (Department of Internal Medicine, College of Medicine, Wonkwang University)
Kim, Hak Ryul (Department of Internal Medicine, College of Medicine, Wonkwang University)
Yang, Sei Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University)
Jeong, Eun Taik (Department of Internal Medicine, College of Medicine, Wonkwang University)
Publication Information
Tuberculosis and Respiratory Diseases / v.61, no.2, 2006 , pp. 143-149 More about this Journal
Abstract
Background: Irinotecan (topoisomerase I inhibitor) is effective as a monotherapy against small-cell lung cancer(SCLC). Cisplatin is also an important drug against SCLC. A phase II study of irinotecan combined with cisplatin was carried out to evaluate the efficacy and toxicity of this combined regimen as a first line treatment in patients with extensive SCLC. Methods: Thirty-nine patients with previously untreated extensive SCLC were enrolled in this study. Irinotecan $60mg/m^2$ was administered intravenously on days 1, 8 and 15, and in combination with cisplatin $60mg/m^2$ on day 1 and every 28 days thereafter. Four cycles of chemotherapy were given to the patients. Results: The overall response rate was 77% with a complete response (CR) rate of 8%. The median survival time, 1- and 2-year survival rate were 14.8 months, 60.9% and 27.6%, respectively. The median progression free survival time, 6-and 12-month progression free survival rate were 8.4 months, 75% and 18.8%, respectively. The WHO grade 3 or more toxicity encountered were leukopenia (23%), diarrhea (26%). Two patients changed their chemotherapeutic regimen and one patient died from severe diarrhea. Conclusion: The combination of irinotecan and cisplatin is effective as a first line therapy in extensive SCLC is effective, but has severe or fatal diarrhea as toxicity.
Keywords
Small-cell lung cancer; Irinotecan; Cisplatin;
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