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http://dx.doi.org/10.3345/kjp.2009.52.1.87

The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease  

Lee, Hyo Jin (Department of Pediatrics, Sung-Ae General Hospital)
Lee, Myung Sook (Department of Pediatrics, Sung-Ae General Hospital)
Kim, Ji Sook (Department of Pediatrics, Sung-Ae General Hospital)
Kim, Eun Ryoung (Department of Pediatrics, Sung-Ae General Hospital)
Kang, Sung Wook (Kohwang Medical Research Institute, School of Medicine, Kyunghee University)
Kim, Soo Kang (Kohwang Medical Research Institute, School of Medicine, Kyunghee University)
Chung, Joo Ho (Kohwang Medical Research Institute, School of Medicine, Kyunghee University)
Yoon, Kyung Lim (Department of Pediatrics, East-West Neo-medical Center, Kyunghee University)
Han, Mi Young (Department of Pediatrics, College of Medicine, Kyunghee University)
Cha, Seong Ho (Department of Pediatrics, College of Medicine, Kyunghee University)
Publication Information
Clinical and Experimental Pediatrics / v.52, no.1, 2009 , pp. 87-92 More about this Journal
Abstract
Purpose : Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients. Methods : One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing. Results : There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P= 0.0077, dominant P=0.0021, recessive P=0.16). Conclusion : Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.
Keywords
Mucocutaneous lymph node syndrome; Kawasaki disease; Coronary artery disease; Genetic polymorphism; Catechol-O-Methyltransferase;
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