• Title/Summary/Keyword: 헤모글로빈

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A Study on Carbon Monoxide and Other Gases During the Fire Test (A-class:1st Rating & B-class:1st Rating) (한국 A급, B급 1단위 화재 시험시 발생하는 일산화탄소 등의 정량적 연구)

  • Jeong, Incheon;Chung, Yeong-Jin
    • Fire Science and Engineering
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    • v.27 no.5
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    • pp.44-56
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    • 2013
  • This research is to identify how much toxic combustion gases are produced from Korea standardized real fire test (Class A&B) by using Room Corner Tester (RCT) and how much those gases are possibly dangerous to testing personnel by estimating the level of carboxyhemoglobin (% COHb). It is confirmed that testing personnel can be affected as more than 40% COHb from Class A 9th and 10th rating in respiration minute volume (RMV) 2 and from Class A 5th to Class A 10th rating in RMV 3 during the time for initial three minutes. Also, in the case of Class B real fire tests, although it is considered rather safe for the initial 1 minute, testing personnel can be affected as more than 20% COHb from Class B 16th to 20th rating in RMV 3 during total test time. Currently, the Korea standard is only focusing on the protection measures against the heat, but the it is neglecting the protection measures against toxic combustion gases. Therefore, according to this study, it is strongly recommended that testing personnel should wear a self-contained breathing apparatus, or the equivalence depending on the real fire test rating.

In vivo effects of bisphenol A exposure on haematological parameters in Korean rockfish, Sebastes schlegeli (Bisphenol A의 노출에 따른 조피볼락(Sebastes schlegeli)의 혈액학적 영향)

  • Keum, Yoo-Hwa;Jee, Jung-Hoon;Lee, Ok-Hyun;Park, Soo-Il;Kang, Ju-Chan
    • Journal of fish pathology
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    • v.18 no.3
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    • pp.293-300
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    • 2005
  • This study was conducted to investigate the effect of bisphenol A (BPA; 4,4' -isopropylidenediphenol) on haematological parameters of Korean rockfish, Sebastes schlegeli in laboratory condition, Fish were randomly distributed into three treatment groups which were received of 0.1, 1 and 10 mg BPA $kg^{-1}$ body weight. They were injected four times intraperitoneally at days 0,3,7 and 12 with BPA. Control group was subjected to the same regime using an equal volume of 60% ethanol-mixed PBS carrier injection only. Fish from each group were sacrificed on day 15 after first injection for haematological assay. Observations on haematological parameters indicated BPA-treatment induced lower level of red blood cell counts and hemoglobin concentration. Serum chloride, calcium, glucose, bilirubin and blood urea nitrogen concentrations increased following exposure to BPA at 10 mg $kg^{-1}$ body weight. In contrast, serum cholesterol in fish exposed to BPA decreased. Serum transaminase and lactate dehydrogenase activities after the highest level of 10 mg $kg^{-1}$ PBA was significantly increased. These results demonstrate that BPA have induced adverse impact on haematological parameters in the Korean rockfish, Sebastes schlegeli.

The Changes of Dietary Intakes in the Defectors from North Korea (탈북 귀순자들의 영양소 섭취변화에 관한 연구)

  • 조여원;홍주영;임정은
    • Korean Journal of Community Nutrition
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    • v.2 no.4
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    • pp.470-476
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    • 1997
  • 본 연구는 북한 식량사정의 실상과 탈북자들의 북한에서의 영양상태 및 남한에서의 정착 후 영양섭취 변화와 이에 따른 건강상태의 변화를 파악하기 위해 탈북한 일가족 10명을 대상으로 하여, 식이섭취 조사를 실시하였다. 또한 탈북직후와 4개월 후 의료기관에서 검진한 결과를 이용하여 분석한 결과는 다음과 같다. 일반적으로 이들의 체위는 남한의 평균 체위보다 매우 왜소하였으며. 4개월동안 평균 4.5kg 정도의 체중이 증가하였다. 이들의 식생활은 북한에서 주로 감자, 강냉이밥, 강냉이로 만든 국수, 산나물등 식물성 식품위주의 식사였으나 남한에서는 동물성 식품의 섭취가 급격히 증가하였다. 이북에서 이들의 평균 열량섭취량은 한국인 영양권장량에 비교할 때 50% 정도로 매우 낮은 수준을 보였으며, 남한에서도 열량섭취는 증가하지 않았다. 그러나 대부분의 영양소의 섭취는 북한과 비교할 때 남한에서 증가를 보였고, 특히 콜레스테롤 섭취는 급격한 증가를 보였다. 탈북직후의 이들 혈중 알부민, 포토당, 헤모글로빈, 헤마토크리트 농도는 대부분 정상이었으며, 혈액의 지질농도도 정상범위에 속하는 것으로 나타났다. 현재 북한 식량난은 더욱 심각할 것으로 추측할 수 있으나 이들의 거주할 당시의 북한에서는 하루 2끼 식사에 강냉이를 주로 하는밥이나 죽, 그리고 나물 등을 주로 먹은 것으로 나타났다. 명절은 김일성 생일, 김정일 생일, 8.15해방절, 조국 해방전쟁 승리일등이 있고, 이런 명절에서는 설탕, 밀가루등 특별배급이 추가되나 특별한 명절음식은 없는 것으로 조사되었다. 북한에는 양념이 매우 귀하며, 특히 고춧가루가 귀해서 주로 백김치를 담가서 먹고 있었다. 현재 북한에서 가장 필요로 하는 것으로 쌀, 잡곡류, 고기 그리고 참깨 등의 양념류와 의약품 및 비누 등을 제시하였다. 현재 자료수집이 극도로 제한된 상황에서 북한 주민들의 정확한 식이섭취 상태와 영양상태 판정은 불가능한 것으로 사료된다. 본 연구의 대상자가 극히 소수이고, 실제로 이들이 북한에서 소외된 계층이었으므로 본 연구결과가 북한의 사정을 정확히 대표한다고 할 수는 없으나 이들의 조사가 앞으로 북한주민의 영양상태를 판정하는데 중요한 자료가 되었으면 한다. 앞으로 통일에 대비하여 북한 주민들의 식생활의 양상과 정확한 영양상태에 대해 많은 연구가 시도되어야 할 것이다.

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Comparative Tissue Ablation Study between 532 and 980 nm (가시광선과 근적외선 파장을 이용한 조직 제거 연구)

  • Kang, Hyun Wook;Oh, Junghwan
    • Korean Journal of Optics and Photonics
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    • v.23 no.3
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    • pp.108-112
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    • 2012
  • In this paper, two wavelengths mainly used for laser prostatectomy have been quantitatively compared: 532 and 980 nm. Two lasers at 40 W were employed to ablate bovine liver in vitro. Ablation performance was evaluated in light of number of sweeps, ablation volume, and coagulative necrosis. 532 nm yielded up to four times higher ablation efficiency than 980 nm. Regardless of wavelength, ablation rate per sweep decreased with the number of sweeps. 532 nm generated relatively deeper ablation craters along with thinner coagulation whereas 980 nm created superficial tissue ablation with up to 2 mm thick coagulative necrosis. Due to higher light absorption and effective thermal confinement, 532 nm induced more efficient tissue ablation with a smaller coagulative necrotic zone. The current study demonstrated that 532 nm could be a more ideal wavelength for laser prostatectomy, and the future in vivo investigations will confirm these findings.

Personal Carbon Monoxide Exposures and Carboxyhemoglobin Levels of the Traffic Policemen (일부 도시 교통경찰관의 일산화탄소 개인 노출과 혈중 카르복실헤모글로빈에 관한 연구)

  • Chung, Yong;Shin, Dong-Chun;Park, Seong-Eun;Lee, Ki-Young
    • Journal of Korean Society for Atmospheric Environment
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    • v.11 no.4
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    • pp.323-329
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    • 1995
  • The number of motor vehicles in Korea has increased to about 4 million, and the exhaust gases of these vehicles have become a more threatening factor to public health. Traffic policemen are one of the highest health risk groups since they work on roadsides where they are exposed to high levels of air pollutants. The health effects on them due to air pollution were determined by measuring personal carbon monoxide(CO) exposure and carboxyhemoglobin(COHb) level in blood. Thirty-one traffic policemen in Seoul volunteered to be subjects of the study. In October 1992, personal CO exposure was measured by a CO passive sampler. The subjects wore the CO passive sampler for 8 hours while on duty. The exposed samples were analyzed by gas chromatography. Blood samples from each subject were collected just after the exposure sampling, and were analyzed within 3 hours of blood collection by a CO-oximeter. The activities of the subjects were recorded by the subject in 30 minute intervals using an activity log sheet containing location and time spent. Personal CO exposure were ranged between 0.1 and 14.5ppm, eith an average of 5.9ppm. Carboxyhemoglobin levels ranged from 1.1% to 6.9%, with an average of 3.6%. policemen on duty outdoors had significantly higher CO exposures and COHb levels than policemen on duty indoors(p<0.01). Personal CO exposure and COHb were positively correlated, although the coefficient was not significant. The relationship between CO level and COHb level was confounded by smoking status. Among smokers, COHb level was significantly higher as CO exposure and hours worked outdoors increased.

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Effects of Dietary Protein and Calcium Levels on Hematological Properties and Renal Functions of the Pb-administered Rats. (식이내 단백질과 칼슘의 수준이 납중독된 흰쥐에 혈액학적 성상 및 신기능에 미치는 영향)

  • 이정숙;조수열
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.20 no.4
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    • pp.337-345
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    • 1991
  • This study was designed to investigate the effects of dietary protein ana calcium levels on hematological properties and renal functions of the Pb-administered rats. Male Sprague-Dawley rats were assigned to a 3$\times$3$\times$2 factorial design with 3 levels of protein (40%, 16%, 6%), 3 levels of Ca (1.2%, 0.6%, 0.12%) and 2 feeding Periods (3 and 7 Weeks). The Control group was included separately, The rats were exposed to the drinking water containing 2, 000ppm of lead. Hematocrit, hemoglobin content and RBC count were lower in the Pb-added groups than in the control group and were reduced with decreasing dietary protein and Ca levels. Urinary-aminolevulinic acid was higher in the Pb-added groups than in the control group and increased with decreasing dietary Ca level. However, urinary glucose was higher in the Pb-added groups than in the control group and enhanced with decreasing dietary protein and Ca levels. Creatinine celarance was not affected by the Pb administration when the rats fed the diet containing sufficient protein and Ca.

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Effect of Dietary Iron and Exercise on Heme Biosynthesis and Lipid Metabolism of Rats (철분과 운동이 흰쥐의 헴 생합성과 지질 대사에 미치는 영향)

  • Choi, Jee-Young;Kim, Hye-Young P.
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.34 no.5
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    • pp.638-643
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    • 2005
  • This study was peformed to investigate the effect of dietary iron and exercise on heme biosynthesis and lipid metabolism of rats. Rats were divided into 4 groups according to dietary iron supplement (Fe-,5 ppm vs. Fe+, 50 ppm) and exercise status (control us exercise). The experiment continued for 8 weeks. Regular treadmill exercise ($6^{\circ}$, 28 m/min, 30 min duration, 5 days/week) was given to exercise groups. The aminolevulinate dehydrase activity of red blood cell, the marker of heme biosynthesis, was significantly increased in the exercise group. Regular aerobic exercise reduced body weight and epidydimal fat pad gain. Regular exercise also significantly decreased the plasma triglyceride, cholesterol and HDL-cholesterol of the rats. Meanwhile, the iron deficiency decreased the hematocrit and hemoglobin concentration and increased the accumulation of liver cholesterol.

Comparison of the Effects of Danjeon Breathing and Walking to Blood Lipids, Physical Symptoms and Hemoglobin in Middle Aged Women (중년여성의 혈중 지질농도, 신체증상, 헤모글로빈에 미치는 단전호흡운동과 걷기운동의 효과 비교)

  • Hyun, Kyung-Sun
    • Journal of East-West Nursing Research
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    • v.10 no.1
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    • pp.41-52
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    • 2004
  • Purpose: The purpose of this research was to compare the effects of Danjeon Breathing exercise and walking exercise on blood lipids, physical symptoms and hemoglobin of middle-aged women to determine which of these two exercises was more beneficial. Methods: The Danjeon breathing exercise group(20) took health management counseling and performed an eighty-minute Danjeon breathing exercise three times a week for 12 weeks while the walking exercise group(25) took health management counseling and performed a walking exercise seven hours per week for 12 weeks. The control group(20) received only health management counseling. The groups were homogeneous on age, religion, marital status, education, profession, monthly income per household, menopause, smoking, drinking, fat intake and cholesterol intake. Likewise, the groups were homogeneous on total cholesterol, HDL-cholesterol,atherogenic index, hemoglobin and physical symptoms. The collected data were analyzed by using the SPSS PC program and $x^2$-test, ANOVA, repeated measures of ANOVA and LSD. Results: 1. Total cholesterol of the Danjeon breathing exercise group and the walking exercise group were lower than that of the control group. 2. HDL- cholesterol of the Danjeon breathing exercise group and the walking exercise group were not higher than that of the control group. 3. Atherogenic index of the Danjeon breathing exercise group was lower than that of the control group, but atherogenic index of the walking exercise group was not lower than that of the control group. 4. Hemoglobin of the Danjeon breathing exercise group and the walking exercise group were not higher than that of the control group. 5. Physical symptom score of the Danjeon breathing exercise group was lower than those of the walking exercise group and the control group, but Physical symptom score of the walking exercise group was not lower than that of the control group. Conclusion: Danjeon breathing exercise and walking exercise are effective for decreasing total cholesterol of middle-aged women. Danjeon breathing exercise is more effective for decreasing atherogenic index and physical symptoms of middle-aged women than walking exercise.

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Production and Characterization of a Monoclonal Antibody against Surface Glycoprotein, gp6 1, on K562 Erythroleukemia Cells (K562 적혈구암 세포주의 표면 당단백질에 대한 단클론항체의 생성 및 특성)

  • 김한도;정재훈;홍선화;김정락;한규형;임운기;유미애;이경희;강호성
    • The Korean Journal of Zoology
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    • v.39 no.1
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    • pp.12-20
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    • 1996
  • A multipotential hematopojetic cell line, 1(562 cell, was differentiated into megakaryocyte by a chemical inducer, PMA, with an enhanced expression of gpIlla accompaning with a distinct morphological change. On the other hand, 1(562 cells were differentiated into erythrocytes by other chemical inducers, DMSO or butyrate, with a concomitant increase in hemoglobin accumulation. An antigen of apparent molecular weight of 61 kDa was identified on the surface of 1(562 cells by using monoclonal antibody raised against 1(562 cells. The antigen was considered to be a glycoprotein molecule rich in sialic acids and the epitope of antigen was sensitive to neuraminidase digestion or peroxidase oxidation, but resistant to heat treatment. The 61 kDa surface antigen was increased or decreased in its expression along differentiation of 1(562 cells into megakaryocytes or erythrocytes, respedively.

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Comparison of Hemoglobin Activity of Angelica gigas, Angelica sinensis and Angelica acutiloba roots (참당귀, 중국당귀, 일당귀의 헤모글로빈 활성도 비교)

  • Lee, Jang-Cheon;Cho, Suin;Kim, Hyungwoo;Kim, Jung-Hoon;Sung, Dae Dong;Lee, Boo-Kyun
    • The Korea Journal of Herbology
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    • v.35 no.4
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    • pp.1-8
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    • 2020
  • Objectives : Angelicae gigas, A. sinensis and A. acutiloba are three types of plants used as Angelicae Radix (Dang-Gui). Many doctors of Korean medicine want to know the difference in clinical use of these three species. This study aimed to compare the hemoglobin-related activity of the extracts of Angelicae gigas, A. sinensis and A. acutiloba roots by measuring the intensity of binding oxygen to hemoglobin using Raman spectroscopy. Methods : Hemoglobin activity was measured by chemical analysis and Raman spectroscopy to compare the pharmaceutical efficacy of three Angelica root extracts. The oxygenated hemoglobin intensity, blood decursinol and acetylcholinestrase(AChE) concentration in mice were measured. In addition, the effects of three Angelica root extracts on oxygenated hemoglobin intensity, decursinol and AChE concentration in red blood cells (RBC) from human were also investigated. Results : The contents of decursin, decursinol and decursinol angelate, which affected physiological activity and RBC properties, were higher in the extract of A. gigas root than in those of A. sinensis and A. acutiloba roots. Moreover, oxygenated hemoglobin intensity in the A. gigas extract was higher than that of other two species in the blood of mice and human RBCs. Also, the blood decursinol and AChE concentrations of A. gigas root extract were higher than that of A. sinensis and A. acutiloba roots. Conclusions : These results suggest that A. gigas is more effective in treating disease related oxygen deficiency in RBC deformation under oxidative stress.