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In vivo effects of bisphenol A exposure on haematological parameters in Korean rockfish, Sebastes schlegeli  

Keum, Yoo-Hwa (Department of Aquatic Life Medicine, Pukyong National University)
Jee, Jung-Hoon (Aquaculture Development Division, MOMAF)
Lee, Ok-Hyun (Department of Aquatic Life Medicine, Pukyong National University)
Park, Soo-Il (Department of Aquatic Life Medicine, Pukyong National University)
Kang, Ju-Chan (Department of Aquatic Life Medicine, Pukyong National University)
Publication Information
Journal of fish pathology / v.18, no.3, 2005 , pp. 293-300 More about this Journal
Abstract
This study was conducted to investigate the effect of bisphenol A (BPA; 4,4' -isopropylidenediphenol) on haematological parameters of Korean rockfish, Sebastes schlegeli in laboratory condition, Fish were randomly distributed into three treatment groups which were received of 0.1, 1 and 10 mg BPA $kg^{-1}$ body weight. They were injected four times intraperitoneally at days 0,3,7 and 12 with BPA. Control group was subjected to the same regime using an equal volume of 60% ethanol-mixed PBS carrier injection only. Fish from each group were sacrificed on day 15 after first injection for haematological assay. Observations on haematological parameters indicated BPA-treatment induced lower level of red blood cell counts and hemoglobin concentration. Serum chloride, calcium, glucose, bilirubin and blood urea nitrogen concentrations increased following exposure to BPA at 10 mg $kg^{-1}$ body weight. In contrast, serum cholesterol in fish exposed to BPA decreased. Serum transaminase and lactate dehydrogenase activities after the highest level of 10 mg $kg^{-1}$ PBA was significantly increased. These results demonstrate that BPA have induced adverse impact on haematological parameters in the Korean rockfish, Sebastes schlegeli.
Keywords
Bisphenol A; 4,4'-isopropylidenediphenol; Haematological parameters; sebates schelgeli;
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