한국어병학회지 (Journal of fish pathology)

  • 제18권3호
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  • Pages.293-300
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  • 2005
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  • 1226-0819(pISSN)
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  • 2233-5412(eISSN)
한국어병학회 (The Korean Society of Fish Pathology)
권호 표지

Bisphenol A의 노출에 따른 조피볼락(Sebastes schlegeli)의 혈액학적 영향

In vivo effects of bisphenol A exposure on haematological parameters in Korean rockfish, Sebastes schlegeli

  • 금유화 (부경대학교 수산생명의학과) ;
  • 지정훈 (해양수산부 양식개발과) ;
  • 이옥현 (부경대학교 수산생명의학과) ;
  • 박수일 (부경대학교 수산생명의학과) ;
  • 강주찬 (부경대학교 수산생명의학과)
  • Keum, Yoo-Hwa (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Jee, Jung-Hoon (Aquaculture Development Division, MOMAF) ;
  • Lee, Ok-Hyun (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Park, Soo-Il (Department of Aquatic Life Medicine, Pukyong National University) ;
  • Kang, Ju-Chan (Department of Aquatic Life Medicine, Pukyong National University)
  • 발행 : 20051200
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초록

본 연구는 우리나라 주요 양식어류인 조피볼락을 대상으로 bisphenol A가 혈액에 어떠한 영향을 끼치는지를 조사하였다. 실험어를 대상으로 어체중 kg 당 0.1, 1 및 10 mg BPA를 0, 3, 7 및 12일째에 복강주사 한 후, 15일째에 그 영향을 조사하였다. BPA에 노출된 조피볼락은 적혈구수와 헤모글로빈의 농도가 유의한 감소를 나타내었고, 혈청 클로라이드, 칼슘, 혈당, 빌리루빈 및 요소질소의 농도는 증가하는 경향을 나타내었고, 콜레스테롤은 감소하였다. 또한, 혈청 전이효소와 젖산탈수소효소의 활성은 증가하였다.

This study was conducted to investigate the effect of bisphenol A (BPA; 4,4' -isopropylidenediphenol) on haematological parameters of Korean rockfish, Sebastes schlegeli in laboratory condition, Fish were randomly distributed into three treatment groups which were received of 0.1, 1 and 10 mg BPA $kg^{-1}$ body weight. They were injected four times intraperitoneally at days 0,3,7 and 12 with BPA. Control group was subjected to the same regime using an equal volume of 60% ethanol-mixed PBS carrier injection only. Fish from each group were sacrificed on day 15 after first injection for haematological assay. Observations on haematological parameters indicated BPA-treatment induced lower level of red blood cell counts and hemoglobin concentration. Serum chloride, calcium, glucose, bilirubin and blood urea nitrogen concentrations increased following exposure to BPA at 10 mg $kg^{-1}$ body weight. In contrast, serum cholesterol in fish exposed to BPA decreased. Serum transaminase and lactate dehydrogenase activities after the highest level of 10 mg $kg^{-1}$ PBA was significantly increased. These results demonstrate that BPA have induced adverse impact on haematological parameters in the Korean rockfish, Sebastes schlegeli.

키워드

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