• 대한한방내과학회지
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• 제22권4호
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• pp.683-689
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• 2001

In order to study the anti-stress effect of hyangbujapalmultang, several measures of stress, including body weight changes, organ weight changes and catecholamine changes. The following result have been obtained: 1. The weight loss of contol group was $28.5{\pm}1.8g$, that of sample group was $20.3{\pm}1.6g$. This differance was statistcally significant. 2.The organ weight(Liver,Spleen,Kidney,Adrenal gland) was the only significant change in the spleen, in sample group comparing to control group. 3. The norepinephrine contents of control group was $695.5{\pm}22.7pg/ml$, that of sample group was $607.4{\pm}21.7pg/ml$. This shows significant difference in sample group comparing to contol group. 4. The epinephrine contents of control group was $212.8{\pm}9.8pg/ml$, that of sample group was $182.6{\pm}8.4pg/ml$. This shows significant differance in sample group comparing to control group. 5. The dopamine contents of control group was $504.5{\pm}31.3$, that of sample group was $463.4{\pm}27.8pg/ml$. This shows the value decreased, but none of it is significant. Based on avove results, it may be conculed that hyangbujapalmultang has anti-stress effects.

• 사상체질의학회지
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• 제23권3호
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• pp.412-418
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• 2011

1. Objectives: The purpose of this study is to evaluate the effect of Hyangbujapalmul-tang(香附子八物湯) for hot flush on the palms and soles of the feet. 2. Methods: The patient was hospitalized from June 4. 2011 to June 18. 2011. The Patient Was treated with herbal medicine. The changes in symptoms can be diagnosed by the help of DITI(Digital Infrared Thermal Imaging) and VAS(Visual analogue Score). 3. Results By the use of Hyangbujapalmul-tang(香附子八物湯), this patient showed a positive response. We compared the temperature of palm with that of sole the feet on DITI. After the treatment, the symptoms and DITI, VAS results improved. The temperature of palms and soles of the feet after treatment were statistically lower than those before treatment. 4. Conclusions: We suggest that Hyangbujapalmul-tang(香附子八物湯) significantly has a curative effect on hot flush on the palms and soles of the feet patient with Soeumin.

• 동의신경정신과학회지
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• 제8권1호
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• pp.81-93
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• 1997

In order to investigate the anti-stress effect of Hyangbujapalmultnag in immobilization stress rats, the change of body weight, and, the humoral and cellular immune response were measured.The following results were obtained.1. The decrease of the body weight was significantly inhibited in test group, comparing with the control group.2 In the plaque fomation test, the number of the plaque in the control group was decreased but, the decreased in test group was significantly inhibited, comparing with the control group.3. In the hemagglutination titer, the control group was decreased on the serum antibody titer, but, the decreased in test group was significantly inhibited, comparing with the control group.4. In the footpad swelling response, the differences between the control and test group were not shown.

• 동의신경정신과학회지
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• 제17권1호
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• pp.79-105
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• 2006

Objective : This research aims to investigates the effects of CMT and HCMT on Dementia. and we also want to know the different effect of CMT, HCMT by drug types. Methods : The research is progressed by two types of experiment. one experiment is BV2 microglial cell line treated by LPS in vitro and another experiment is memory deficit mice induced by scopolamine in vivo. Results : The CMT and HCMT is effective in BV2 microglial cell line treated by LPS in vitro and in the serum of the memory deficit mice induced by scopolamine in vivo. But, there is no significant difference between CMT and HCMT extract&nano powder in experimental conclusion. Conclusions : These results suggest that the two drug types of CMT and HCMT may be effective for the prevention and treatment of Dementia. Investigation into the further study two drug types of the CMT and HCMT for Dementia is suggested for future research.

• 사상체질의학회지
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• 제17권2호
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• pp.107-114
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• 2005

I. Objectives - Hwabyung is anger syndrome due to prolonged, constrained feeling. In Sasang constitutional Medicine. Soeumin(소음인(少陰人))'s contancy is apprehension, so they tend to worry about little matters. And they are characterized by neurosis such as insomnia, headache and so on. This patient is classified Soeumin, and her main symptom is insomnia, diarrhea and flaring up. Refering to these symptom, she is suffering from Soeurnin interior disease bv psychological factor. This study is reported to evaluate the effect of Sasang prescription to Hwabyung patient with Soeumnin interior disease by psychological factor. 2. Methods - This patient was treated by Sibimigwanjoong-tang(십이미관중탕(十二味寬中湯)) mainly, and Hyangboojapalmool-tang( 향부자팔물탕(香附子八物湯)) subsequently to cure Hwabyung patient with Soeumin interiot disease by psychological factor 3. Results - By use of Sibimigwanjoong-tang mainly, this patient showed a positive response. 4. Conclusions - We suggest that Sibimigwanjoong-tang and Hyangboojapalmool-tang is effected significantly to Hwabyung patient with Soeumin interior disease by psychological factor.

• 생약학회지
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• 제43권1호
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• pp.79-84
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• 2012

A simple and reliable reverse phase HPLC method was developed to determine pharmacologically active marker compounds of Dipsaci Radix, Leonuri Herba and Cyperi Rhizoma. The stability test of water-extract of three natural medicines were examined for six months. However, no significant change in the content of the marker compounds of each extract observed during the time of investigation.

• 사상체질의학회지
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• 제20권3호
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• pp.199-207
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• 2008

1. Objectives Sasang Constitutional Medicine is Mind-Body medicine and it is based on difference of Nature & Emotion(性情) & real purpose(恒心). The purpose of this study is to evaluate the effect of Hyangbujapalmul-tang for somatoform disorders and is to drive the importance of psychiatric approach home. 2. Method The subject is about 49-year-old Soeumin patient presumed by Undifferentiated somatoform disorder based on his nature & emotion, physical characteristics, symptoms, and we have prescribed Soeumin Hyangsayangyui-tang, Ceongunggyegi-tang, Hyangbujapalmul-tang. Soeumin Hyangsayangyui-tang was prescribed based on oridinary symptoms(素症), Soeumin Ceongunggyegi-tang was prescribed based on real symptoms(病症), Soeumin Hyangsayangyui-tang was prescribed based on Nature & Emotion(性情) & real purpose(恒心). 3. Result and conclusions In result, Hyangbujapalmul-tang based on Nature & Emotion(性情) & real purpose(恒心) showed best positive response. It is necessary to approach to somatoform disorders not only in clinical view but also in psychiatric view based on Nature & Emotion(性情) & real purpose(恒心)

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2006년도 학술발표회 논문집
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• pp.1338-1342
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• 2006

수자원의 계획과 관리를 위해 정확한 유량 측정은 무엇보다 중요하다. 이를 위해 다양한 유량 측정방법이 개발, 적용되고 있다. 본 연구는 국내 하천에 적용 가능한 다양한 유량 측정방법을 시험하천에 동시에 적용하여 유량 측정 방법간 비교를 목적으로 수행되었다. 비교를 위해 적용된 방법은 유속면적법, 부자법, ADCP법 등의 비연속적 방법과 기존 보를 이용한 방법, 초음파 유량계를 이용한 방법, 유속지수법, 실시간 경사면적법 등의 연속적 방법이다. 평저수기에 주로 적용될 수 있는 비연속적 방법인 유속면적법과 ADCP법의 비교에서는 유속면적법이 방류량 대비 평균 ${\pm}4.7%$의 오차를 가지며, ADCP법의 경우 ${\pm}4.6%$의 오차를 갖는 것으로 나타났다. 비연속적 방법과 연속적 방법을 동시에 비교하기 위해 평저수 5회, 홍수 2회를 포함하는 총 7회의 동시 유량측정이 수행되었다. 유속면적법과 ADCP법은 부적절하게 적용된 경우를 제외하면 오차는 대체로 10% 이내로 나타났다. 부자법의 경우 홍수시에만 적용되었으나 오차가 방류량 대비 20% 이상으로 다소 크게 나타났다. 연속적 방법은 기존 보의 경우 개발된 수 위-유량 관계의 이하의 저유량에 적용할 경우 오차가 다소 크게 산정되었으나 그 이외에는 대체로 10% 이내의 오차를 나타내었으며, 일부 저수위의 유속지수법을 제외하면 연속적 방법은 모두 오차가 10% 이내로 조사되었다. 향후 보다 장기간에 걸쳐 다양한 유량 범위에서의 검증이 필요하지만, 시험하천에서의 유량 측정 방법간 비교는 국내 하천에 적용할 수 있는 다양한 방법의 적용성을 평가하는데 기여할 수 있을 것으로 생각된다.향 범위는 최대 $0.07km^2$ 면적에 그 효과를 기대할 수 있을 것으로 판단되어, 남조 수화현상이 심화될 경우 인공순환에 의한 저감효과가 크지는 않을 것으로 예측된다. 조사 기간중 H호의 현존 식물플랑크톤량의 $60%{\sim}87%$가 수심 10m 이내에 분포하였고, 녹조강과 남조강이 우점하는 하절기에는 5m 이내에 주로 분포하였다. 취수탑 지점의 수심이 연중 $25{\sim}35m$를 유지하는 H호의 경우 간헐식 폭기장치를 가동하는 기간은 물론 그 외 기간에도 취수구의 심도를 표층 10m 이하로 유지 할 경우 전체 조류 유입량을 60% 이상 저감할 수 있을 것으로 조사되었다.심볼 및 색채 디자인 등의 작업이 수반되어야 하며, 이들을 고려한 인터넷용 GIS기본도를 신규 제작한다. 상습침수지구와 관련된 각종 GIS데이타와 각 기관이 보유하고 있는 공공정보 가운데 공간정보와 연계되어야 하는 자료를 인터넷 GIS를 이용하여 효율적으로 관리하기 위해서는 단계별 구축전략이 필요하다. 따라서 본 논문에서는 인터넷 GIS를 이용하여 상습침수구역관련 정보를 검색, 처리 및 분석할 수 있는 상습침수 구역 종합정보화 시스템을 구축토록 하였다.N, 항목에서 보 상류가 높게 나타났으나, 철거되지 않은 검전보나 안양대교보에 비해 그 차이가 크지 않은 것으로 나타났다.의 기상변화가 자발성 기흉 발생에 영향을 미친다고 추론할 수 있었다. 향후 본 연구에서 추론된 기상변화와 기흉 발생과의 인과관계를 확인하고 좀 더 구체화하기 위한 연구가 필요할 것이다.게 이루어질 수 있을 것으로 기대된다.는 초과수익률이 상승하지만, 이후로는 감소하므로, 반전거래전략

• 동의신경정신과학회지
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• 제9권2호
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• pp.45-51
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• 1998

Purpose : This study has an experiment on finding how Hyangbujapamultang advanced the learning and memory of rat to find the method to improve the failure of memory which is the symptom of dementia.Method : In the experiment, rats were divided the control group (14 rat) which medicate the excipient into the sample group (17 rat) which medicates Hyangbujapalmutang. And the learning ability test and the memorv test was practiced to using the task of radial arm maze.The learning ability test had the presupposition that, when a rat which frequents 8 tracks makes am error not exceeding one time for 3 days without a break, it passes the test.First experiment compared total days when the control group passed the test with total days when the sample group it.The memory test practiced after 24 hours when the learning ability test was over. When a rat frequents 4 tracks, the gates is cut off during 30 seconds. Here the number of error at the control group with that of the sample group.Result: In the learning ability test, the sample group needed 5.82${\pm}$0.37 days to pass the test and the control group needed 6.43${\pm}$0.67 days. In the memory test, the sample group errored 0.29${\pm}$0.37 times and the control group errored 1.86${\pm}$0.78 times.Conclusion : In the learning ability test, the sample group passed the test earlier than the control group, but any statistical correlationship couldn't be found in it. In the memory test, the sample group had the pregnant reduction of the number of error in comparison with the control group.

• 대한한방부인과학회지
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• 제23권4호
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• pp.35-46
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• 2010

Purpose: This study was designed to investigate the effects of Cyperi Rhizoma (CR) on changes in weights morphological and histopathological observations in Polycystic Ovary(PCO) rats. Methods: PCO was induced by single intramuscular injection with EV(2mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for five weeks. PCO control group(n=8) were injected with EV and orally administrated distilled water for five weeks. CR treated group(n=8) were injected with EV and orally administrated CR for five weeks. Then we measured weight of body, ovaries. The histopathology changes of ovaries, and the expression of nerve growth factor(NGF) were also evaluated. Results: Single injection of EV induced suppression of weight gain, formation of cysts, increase of NGF expression. Oral administration of CR prevent suppression of weight gain shown in control group. In addition CR group showed upward tendency of ovarian size. Formation of cystic follicles induced by EV injection is suppressed by CR treatment. In additon, CR treatment lowered expression levels of nerve growth factor(NGF), which were elevated by induction of PCOS. Conclusion: These results suggest that CR can be used for patients with PCOS to prevent formation of cystic follicles and malfunction of ovary. And also suggest that the related mechanisms are involved in suppression of NGF expression.