The Experimental Study on the Effects of Hangbujapalmultang on Enhancing Learning and Memory in Rats with Radial Arm Maze

향부자팔물탕(香附子八物湯)이 흰쥐의 방사형 미로학습(迷路學習)과 기억(記億)에 미치는 영향(影響)

  • Ryu Jae-Myun (Dept. of Neuropsychiatry College of Oriental Medicine, Kyung Hee University) ;
  • Kim Jong-Woo (Dept. of Neuropsychiatry College of Oriental Medicine, Kyung Hee University) ;
  • Whang Wei-Wan (Dept. of Neuropsychiatry College of Oriental Medicine, Kyung Hee University) ;
  • Kim Hyun-Taek (Department of Psycology, Korea University) ;
  • Lee Hong-Jae (Department of Psycology, Korea University)
  • 유재면 (경희대학교 한의과대학 신경정신과학교실) ;
  • 김종우 (경희대학교 한의과대학 신경정신과학교실) ;
  • 항의완 (경희대학교 한의과대학 신경정신과학교실) ;
  • 김현택 (고려대학교 심리학과) ;
  • 이홍재 (고려대학교 심리학과)
  • Published : 1998.12.30

Abstract

Purpose : This study has an experiment on finding how Hyangbujapamultang advanced the learning and memory of rat to find the method to improve the failure of memory which is the symptom of dementia.Method : In the experiment, rats were divided the control group (14 rat) which medicate the excipient into the sample group (17 rat) which medicates Hyangbujapalmutang. And the learning ability test and the memorv test was practiced to using the task of radial arm maze.The learning ability test had the presupposition that, when a rat which frequents 8 tracks makes am error not exceeding one time for 3 days without a break, it passes the test.First experiment compared total days when the control group passed the test with total days when the sample group it.The memory test practiced after 24 hours when the learning ability test was over. When a rat frequents 4 tracks, the gates is cut off during 30 seconds. Here the number of error at the control group with that of the sample group.Result: In the learning ability test, the sample group needed 5.82${\pm}$0.37 days to pass the test and the control group needed 6.43${\pm}$0.67 days. In the memory test, the sample group errored 0.29${\pm}$0.37 times and the control group errored 1.86${\pm}$0.78 times.Conclusion : In the learning ability test, the sample group passed the test earlier than the control group, but any statistical correlationship couldn't be found in it. In the memory test, the sample group had the pregnant reduction of the number of error in comparison with the control group.

Keywords

References

  1. 대한한의학회지 v.9 no.4 健忘의 原因,治法,治方에 대한 文獻的 考察 김세길;문병순;김연두
  2. 동의신경정신과학회지 v.9 no.1 Dementia of Alzheimer Type에 關한 韓醫學的 臨床硏究 김보균;현경철;김종우;황의완
  3. 대한신경과학회지 v.3 no.1 Alzheimer' disease의 神經 化學的 變化에 대한 考察 김진수
  4. 인지과학 v.7 no.3 學習과 記憶의 生理學的 基礎(I) : 神經心理學的 개관 문양호
  5. 계명의대논문집 v.16 no.3 老化에 관련된 認知機能 減退 박종한;김희철
  6. 동와신경정신과학회지 v.8 no.1 調胃升淸湯이 흰쥐의 방사형 미로 學習과 記憶에 미치는 影響 우주영;김종우;황의완;김현택;박순권
  7. 調胃升淪湯이 Alzheimer's disease 모델 白鼠의 學習과 記憶에 미치는 影響 李錐錫
  8. 한의대논문집 v.20 no.2 荊防地黃湯이 흰쥐의 Morris 水中미로 學習과 記憶에 미치는 影響 이재혁;김종우;황의완;김현택;박순권
  9. 동의생리학회지 v.6 no.1 記憶과 腎과의 關聯性에 대한 實驗的 硏究 李宰熙
  10. 동의신경정신과학회지 v.9 no.1 荊防地黃湯이 Alzheimer's disease 모델 白鼠의 學習과 記憶에 미치는 影響 조윤숙;황의완;김현택;박순권
  11. 경희의학 v.12 no.2 치매에 관한 한의학적 임상연구 황의완;김종우;이조희;엄효진;이승기
  12. Behvavioral and Neural Biology v.46 Exponential decay of spatial memory of rats in a radial maze Bolhuis JJ;Bijlsma S;Ansnlink P
  13. Alzheimer's disease : A handbook for caregivers(2nd ed.) Hamdy RC;Turnbull JM;Clark W;Lancaster MM
  14. Peptides v.10 no.1 TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats Horita A;Carino MA;Zabawska J;Lai H
  15. Psychophamacology v.106 Oxiracetam antagonizes the disruptive effects of scopolamine on memory in the radial maze Magnani M;Pozzi M;Biagetti R;Banfi S;Dorigotti L
  16. Neuroscience v.37 no.6 Dopaminergic drug reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway McGurk SR;Levin ED;Butcher LL
  17. Neurotoxicol Teratol v.17 no.6 Subchronic exposure to toluene and reference memory in rats Miyagawa M;Honma T;Sato M
  18. Animal Learning and behavior v.7 Intermaze cues and "Odor - trials" fail to direct choice behavior on an elevated maze Olton DS;Collison C
  19. American psychologist v.34 Maze, maps and memory Olton DS
  20. Brain Research v.494 no.2 The role of the hippocampal-nucleus accumbens pathway in radial-arm maze performance Schacter G.B;Yang CR;Innis NK;Mongenson GJ
  21. Behavior and Neural Biology v.47 Memory persistence of rats in a radial maze varies with training procedure Strujkstra AM;Bolhuis JJ
  22. Brain Research v.726 no.1;2 Injection of IgG 192-saporin into the medical septum produces cholinergic hypofunction and dose- dependent working memory deficits Walsh TJ;Herzog CD;Gandhi C;Stackman RW;Wilev RG
  23. Brain Research v.654 no.2 Enhancement of memory processing in an inhibitory avoidance and radial maze task by post-traininginfusion of bom-besin tinto the nucleus tractus solitairus Williams CL;McGaugh JL
  24. Physiology and Behavior v.35 Adrenalectomy fails to alter radial maze performance of rats at retention intervals of 24hours or less Youngue BG;Roy E