• Title/Summary/Keyword: 합성 작용

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Bottlenecks of conventional approaches and complemental expectations of molecular biology in variental improvement of vegetable crops (채소 품종 개량에 있어서 전통기술의 한계 극복을 위한 분자유전학의 역할 기대)

  • 윤진영;오대근
    • Proceedings of the Botanical Society of Korea Conference
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    • 1995.07a
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    • pp.109-130
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    • 1995
  • 지난 반세기간에 우리나라에 채소 육종은 주요 채소의 주년공급을 가능하게 하였으며, 토지 생산성의 향상, 상품화율의 증대, 품질의 향상 등의 면에서도 괄목할 만한 성과를 거두었고 인공교잡은 물론이고 웅성불임성과 자가불화합성의 활용에 의한 1대잡종 품종의 일반화로 채소 산업의 발전에 크게 기여하였다. 앞으로는 기왕의 업적을 심화시키는 한편, 생산비를 절감하기 위한 생력화, 기계화 재배용 품종 및 내제초제성 품종의 개발 환경보호 및 식품안정성의 확보를 위한 내병층성 품종 개발, 수출시장과 다양화하는 국내의 시장기호에 대응하고 가공 식품의 표준화된 품질관리를 지원할 수 있도록 품질 면에서의 개량과 신작물 또는 신생태형 품종의 개발에도 더욱 노력이 필요하다. 이러한 육종목표를 달성하기 위한 유전자원의 확보는 더욱 어려워질 것이며 유전 양식이 복잡하고, 환경요인의 작용이 상대적으로 크기 때문에 전통적인 육종 방법만으로는 목표달성에 필요한 인적, 물적, 시간적 소요가 훨씬 증가될 전망이다. 유전변이의 창성 및 확대, 유용 대립인자의 도입, 동정 및 선발, 그리고 종자생산을 위한 자가 불화합성 및 웅성불임성과 개화·수정 관련 유전인자의 발현 조절에 분자유전학의 보완적 역할이 기대되며 이렇게 되면 전통육종과 분자유전학간의 잡종강세로 품종 개량의 효율은 크게 높아질 것이다.

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Ara - C유도체의 항암작용에 관한 연구 (2) : 암세포에 대한 Ara-C 유도체의 항암효과에 대한 in vitro 연구 및 독성연구

  • Lee, Hyung-Hwan;Cho, Dong-In;Ji, Yong-Hoon;Lee, Chul-Kyu;Kang, Heon;Choi, Hee-Baek;Lee, Hye-Yeol;Kim, Eun-Tae;Kanter, P.M.;Creaven, P.J.;West, C.R.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1994.04a
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    • pp.200-200
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    • 1994
  • Thioglycerol과 g1ycerol로부터 rac-1-S-octa-decyl-2-O-palmitoyl-1-S-thioglycerol-3-phosphate (DL -PTBA-P)와 rac -1-O-octadecyl -2-O-palmitoyl-g1ycerol-3-phosphate (DL-PBA-P)등을 합성하였고, 이들에 ara-C유도체인 ara-CMP morpholidate를 반응시켜 최종 산물인 ara-CDP-DL-PCA, ara-CDP-DL-PBA, ara-CDP-DL-PTCA 및 ara-CDP-DL-PTBA등을 합성하였다. 이들 최종 산물의 항암효과는 L1210 lymphoid leukemia, P388 leukemia등의 암세포주를 사용하여 실험하였다. 암세포인 L1210, P388 leukemia 세포의 성장에 대한ara-CDP-DL-PTBA의 시험관 내 세포성장 억제정도를 알아보기 위하여 비색법인 MTT방법을 시행하였으며, 검체의 세포성장 억제능을 비교하기 위하여 대조군으로 5-Fluorouracil (5-FU)을 사용하였다.

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A Study on the Synthesis of 2-Thiophenyltriisopropoxytitanium and its Reactivity to Carbonyl Compounds (2-Thiophenyltriisopropoxy titanium 의 합성 및 카르보닐 화합물에 대한 반응성)

  • Kyung, Suk-Hun;Joo, Hyun
    • Korean Journal of Environmental Agriculture
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    • v.13 no.2
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    • pp.191-198
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    • 1994
  • 2-Thiophenyltriisopropoxytitanium was prepared in situ by trans-metallization of 2-thiophenyllithium and chlorotitaniumtriisopropoxide. It could be isolated at room temperature and preserved at $-10{\circ}C$ for weeks. The reactivity of 2-thiophenyltriisopropoxytitanium to carbonyl compounds proved to be high. Complete aldehyde-selectivity was observed in competition reactions of 2-thiophenyl-triiso-propoxytitanium with a 1 : 1 mixture of aldehyde and ketone. In the competitive reaction of 2-thiophenyl-triisopropoxytitanium to ketone-ester function, ketone adduct was perfectly obtained.

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Regulation of Ferritin Synthesis by Iron-responsive Element in 5'-Untranslated Region (5'-Untranslated Region에 존재하는 Iron Responsive Element에 의한 Ferritin 합성조절)

  • Chung, In-Sik;Lee, Jung-Lim;Kim, Hae-Yeong
    • Applied Biological Chemistry
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    • v.41 no.3
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    • pp.224-227
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    • 1998
  • The expression of ferritin involved in iron metabolism is regulated at the translational level by the interaction of iron regulatory protein with iron-responsive element(IRE) in the 5'-untranslated region of ferritin transcript. To identify the role of structural element utilized for translational regulation of ferritin, we studied the effects of mutations in the ferritin IRE by measuring IRP binding activity and translational activity. Our data suggest that the cytosine at bulged position of IRE within ferritin is important for the formation of RNA secondary structure involved in translational regulation.

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Effects of Higher-order RNA Structure on Ribosomal Frameshifting Event for the Expression of pol Gene Products of Human T-cell Leukemia Virus Type I (HTLV-l) (Human T-cell leukemia Virus Type I (HTLV-I) 에서 RNA 고차구조가 pol 유전자의 발현에 필요한 Ribosomal Frameshifting 에 미치는 영향)

  • 남석현
    • Korean Journal of Microbiology
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    • v.30 no.6
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    • pp.472-478
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    • 1992
  • Synthesis of the pol gene products of HTLV-I requires rihosomes to shift frame twice in - I direction while translating genome-size mRNA. We havc made a lI1utagcni/cd RNA in which the gag and pro genes are aligned to allow synthe,.is of a largcr amount of the Gag-Pro-Pol polyproteins by a single frameshifting. Using this mutant, wc could examine the questions whether the predicted RNA secondary or tertiary structure downstream of the shift site is operative as a determinant for - I frameshifting. Deletion analysis showed that the stem-loop structure is essential for efficient frameshifting in the pro-pol overlap, but formation of a pseudoknot is less important.

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Synthesis of New Triazacrown Ion Exchanger and Its Ion Exchange Characteristics (새로운 트리아자크라운 이온교환체의 합성과 그의 이온교환 특성)

  • Kim, Dong Won;Chung, Yong Soon;Kim, Chang Suk;Choi, Ki Young;Lee, Yong Ill;Hong, Choon Pyo
    • Journal of the Korean Chemical Society
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    • v.39 no.5
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    • pp.371-378
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    • 1995
  • The triazacrown compound, 1,7-dioxa-4,10,13-triazacyclopentadecane trihydrobromide salt (Na3O2-3HBr) was synthesized. And this compound was used to synthesize the new ion exchanger, which combined with Merrifield peptide resin. This new ion exchanger had a capacity of 3.2 meq/g dry resin. And the distribution coefficients of alkali and alkaline earth metal ions on this ion exchanger in the various concentrations of hydrochloric acid were determined. The ion exchange behaviors of alkali and alkaline earth metal ions in the various hydrochloric acid concentrations are, also, discussed.

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Preparation and Rheological Properties of Alkali-Soluble Associative Thickener (알칼리 용해성 회합 증점제의 합성 및 유성학적 물성에 관한 연구)

  • Seo, Eun-Hyun;Lee, Doug-Youn;Lee, Jong-Kil;Kim, Jung-Hyun
    • Applied Chemistry for Engineering
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    • v.8 no.4
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    • pp.673-678
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    • 1997
  • Associative acrylic thickeners were prepared by emulsion copolymerization using nonionic vinyl surfactant esters as an associative macromonomer and their rheological properties were investigated. The thickening efficiency was shown to depend on the chain length of therminal hydrophobe and degree of ethoxylation of VSE. increasing the content of VSE enhanced the efficiency of the resulting polymers as a thickener. It was attributed to the intermolecular association of terminal hydrophobes of associative thickener in aqueous solution. The chain transfer agent caused to reduce the molecular weight of associative thickener, resulted in decrease of thickening efficiency.

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The User Interface of Button Type for Stereo Video-See-Through (Stereo Video-See-Through를 위한 버튼형 인터페이스)

  • Choi, Young-Ju;Seo, Young-Duek
    • Journal of the Korea Computer Graphics Society
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    • v.13 no.2
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    • pp.47-54
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    • 2007
  • This paper proposes a user interface based on video see-through environment which shows the images via stereo-cameras so that the user can control the computer systems or other various processes easily. We include an AR technology to synthesize virtual buttons; the graphic images are overlaid on the captured frames taken by the camera real-time. We search for the hand position in the frames to judge whether or not the user selects the button. The result of judgment is visualized through changing of the button color. The user can easily interact with the system by selecting the virtual button in the screen with watching the screen and moving her fingers at the air.

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Scaffold-Based Classification of Chemical Library in Korea Chemical Bank (한국화합물은행 화합물 라이브러리의 Scaffold 별 분류)

  • ;Choi, Yeon-Joo;Kim, Ju-Young;Heo, Mi-Young;Kim, Sun-Woo;Kim, Sun-Ho;Kim, Sung-Soo;Chae, Chong-Hak
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2004.11a
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    • pp.191-202
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    • 2004
  • 한국화합물은행(KCB)에서 보유중인 12만 개의 화합물을 주요 골격에 따라 분류하고, 4 가지 protease 작용점에 대한 활성도와 골격사이의 관계를 조사하였다. 화합물들은 합성기관의 합성 목적과 주요 고리골격 등을 고려하여 분류되었으며, 이를 이용하여 scaffold 분류를 위한 분류 계통도를 작성하였다. 화합물들은 이 계통도에 따라 7 가지의 race, 168 tribe, 493 parent, 439 child, 325 grandchild 등 1,087개의 scaffold로 분류되었으며, 각 race 및 scaffold 별 골격의 개수는 고르게 분포되었다. 골격별 분류 시스템을 이용하여 4 가지의 protease에 대한 활성도와 골격 간의 상관관계를 조사한 결과, Protease C에 대하여 몇 가지 골격이 활성이 뛰어남을 보였다.

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Structural Behavior of Newly Developed Cold-Formed Steel Sections(II) - Flexural Behavior (신형상 냉간성형 단면의 구조적 거동(II) - 휨거동)

  • Song, In Seop;Kim, Gap Deuk;Kwon, Young Bong
    • Journal of Korean Society of Steel Construction
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    • v.14 no.2
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    • pp.357-364
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    • 2002
  • The study performed a series of flexural tests on Closed Cold-Formed Steel Sections for stud, joist, and roof truss. Results were compared with analytical values. Each 2.4-m long and 0.9-m wide specimen consisted of two steel beams set at 0.46 m interval. The steel beams were attached to the specimens using either plaster board or ply wood. Another specimens did not use any attachment material. Positive and negative bending tests were conducted to investigate the composite behavior, including the effects of plaster board or ply wood on the buckling behavior of steel beam. Full-scale roof truss tests were also performed to study the buckling behavior and failure mode of the truss members.