• Journal of Life Science
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• v.19 no.9
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• pp.1294-1298
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• 2009

To investigate whether isoflavone genistein and daidzein could affect cancer cell viability, human colorectal HCT116 cells were incubated with genistein or daidzein in a dose-dependent manner. Genistein decreased cancer cell viability in a dose-dependent manner, whereas daidzein did not show dramatic cytotoxic effects. We also found that 71 genes were up-regulated more than 2-fold, whereas 64 genes were down-regulated more than 2-fold with 24 hr of $50{\mu}M$ genistein treatment by our previous microarray data. Among the up-regulated genes, we selected 3 genes (DKK1, ATF3 and NAG-1) and performed RT-PCR to confirm microarray data. The results of RT-PCR were highly correlated with those of the microarray experiment. In addition, we investigated whether a combination treatment of genistein and daidzein could affect cancer cell viability. Surprisingly, the combination treatment did show synergistic cytotoxic effects detected by MTS assay. The results of RT-PCR and real-time PCR indicate that a combination of genistein and daidzein can synergistically induce NAG-1 expression in HCT116 cells. This result implies that NAG-1 induction is highly associated with synergistic cytotoxic effects induced by a combination treatment of genistein and daidzein. Overall, these results may provide a clue in explaining the anti-cancer activity of soy bean in human colorectal cancer.

• Information Systems Review
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• v.18 no.1
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• pp.141-155
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• 2016

This study identified terminologies related to the proximity and frequency of disaster by social network analysis (SNA) and text mining, and then expressed the outcome into a mind map. The termdocument matrix of text mining was utilized for the terminology proximity analysis, and the SNA closeness centrality was calculated to organically express the relationship of the terminologies through a mind map. By analyzing terminology proximity and selecting disaster response-related terminologies, this study identified the closest field among all the disaster response fields to disaster response and the core terms in each disaster response field. This disaster response terminology analysis could be utilized in future core term-based terminology standardization, disaster-related knowledge accumulation and research, and application of various response scenario compositions, among others.

• Journal of Music and Human Behavior
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• v.17 no.1
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• pp.71-96
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• 2020

The purpose of this study was to identify research that included the rhythmic auditory stimulation (RAS) technique and to compare this body of research within the field of music therapy with that in physical therapy. Forty-five studies were identified that were published from January 1999 through November 2018, and these were analyzed in terms of intervention procedure, type of rhythmic cueing, and therapeutic basis described by the researcher. While research in both fields used rhythmic cueing as the primary therapeutic agent, differences were found in the area targeted by training and specific type of rhythmic cueing used. Research conducted in the field of music therapy focused primarily on gait function, while research in the field of physical therapy tended to address gait-related physical issues, such as balance, muscle strength, and proprioceptive sensation as well as gait. While all of the identified studies from the field of music therapy used music for cueing, a metronome was used more often for cueing in physical therapy research. In terms of description of theoretical basis, theory of entrainment was more sufficiently described in music therapy research. These results indicate that while music therapy research maximized the role of various elements of music in intervening in gait function, physical therapy research addressed gait in relation to other physical functions. Considering that both aspects are essential for gait training, this study supports the need for a multidisciplinary approach to neurological rehabilitation with RAS.

• Applied Biological Chemistry
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• v.40 no.3
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• pp.215-219
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• 1997

As a part of basic investigation for utilizing by-products derived from marine food processing more effectively as a food source, lipid contents, fatty acid compositions and lipid compositions in viscera and head of conger eel and hair tail, viscera of mackerel pike, and squids caught off Newzealand and off Falkland island were determined. The lipid contents in marine by-products showed $40.5{\sim}48.0%$ on a dry weight basis and it consisted of $92.1{\sim}99.0%$ neutral lipid and $1.0{\sim}7.9%$ polar lipid such as phospholipid and glycolipid. The neutral lipids mainly consisted of triglyceride$(50.0{\sim}69.9%)$ and had free fatty acid, free sterol, esterified sterol and hydrocarbon, diglyceride, and monoglyceride in less quantity. Squid viscera oil showed higher content in polyenes such as 20:5 and 22:6 than by-product oil derived from fish processing. Viscera oil of squid caught off Newzealand(21.1%) was the highest on DHA composition, followed by that of squid caught off Falkland island(16.3%), hair tail by-product oil(13.9%), conger eel by-product oil(11.7%) and mackerel pike by-product oil(10.7%), in the order named. The major fatty acids in total lipid and neutral lipid of byproducts were generally 16:0, 18: 1n-9, 20:5n-3 and 22:6n-3.

• Applied Chemistry for Engineering
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• v.20 no.2
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• pp.145-153
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• 2009

The acute oral and genetic toxicity of ASCO EAQ80 was established in this study. ASCO EAQ80, a novel cationic surfactant produced by Aekyung Speciality Chemicals Co. LTD. is currently commercialized as a clear fabric softener. In acute oral toxicity study, the 50% lethal dose $(LD_{50})$ of ASCO EAQ80 was determined to be higher than 5000 mg/kg and this product could be classified as Category 5 or Unclassified by Globally Harmonized Classification System. Also, to establish the gene-toxicity of ASCO EAQ80, we performed bacterial reversion assay against Salmonella typhimurium TA98, TA100, TA1535, TA1537, Escherichia coli WP2uvrA, and in vitro chromosomal aberration assay against Chinese hamster lung cells in the presence and absence of S-9 metabolic activation system. From these experiments, ASCO EAQ80 revealed nonmutagenic potential in S. typhimurium TA98, TA100, TA1535, TA1537, and Escherichia coli WP2uvrA both in the absence and presence of metabolic activation system. No clastogenicity of ASCO EAQ80 was observed in chromosomal aberration assay in vitro.

• Applied Biological Chemistry
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• v.25 no.3
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• pp.189-196
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• 1982

Seventy two samples of feedstuff were collected from commercial channels all over Korea. As a study on the moisture contents, microflora and mycotoxin production of each sample investigated. Moisture content of the samples was $11.2{\sim}15%$. Total counts of the samples were $1.8{\times}10^{2}{\sim}2.4{\times}10^{6}$ per gram. The Coli-form group were counted from 9 to $6.3{\times}10^{5}$ per gram which composed mainly of Enterobacter and Klebsiella, whereas Escherichia coli was minor ones. The contamination of many feeds was not remarkable, and only some broiler feeds was contaminated largely with Escherchia coli. Fungi were below detectable limit in 45% of the samples and the most contaminated sample had $4.5imes}10^{5}/g fungi counts.

• Archives of design research
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• v.14 no.3
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• pp.87-96
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• 2001

If we look at Korea's urbanization since 1960, only the urban communities like buildings have developed, yet the resting places for human itself have been ignored. Many people continuously felt alienated especially after the mechanization and started to demand for better living space. For that reason, it is essential for us to develop the resting places for human among the buildings in urban areas and these resting places could form the basis of new community. We have researched on street furniture and citizen's behavior pattern in resting places through references and internet surfing to propose a design concept for a new resting place and street furniture, Therefore, we would like to design a resting place in urban area considering human, community and environment. As a result, we have designed a resting place where citizens could interact with surrounding environment and let office workers enjoy the nature among the buildings in this resting place. People could always stop by and take some rose by enjoying the surrounding nature. The resting place consists of 5 zones- public square, environmental zone, communication zone, technology zone, and entertainment zone. Each zone has its own design motif to lead systematic street furniture and site planning. The resting place is formed in a specific region which is a prototype of a resting environment in urban areas in the future and it could be reassigned according to its regional condition.

• Journal of Korea Spatial Information System Society
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• v.7 no.2 s.14
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• pp.47-56
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• 2005

Recently, with the rapid development of mobile computing, wireless positioning technologies, and the generalization of wireless internet, LBS (Location Based Service) which utilizes location information of moving objects is serving in many fields. In order to serve LBS efficiently, the location data server that periodically stores location data of moving objects is required. Formerly, GIS servers have been used to store location data of moving objects. However, GIS servers are not suitable to store location data of moving objects because it was designed to store static data. Therefore, in this paper, we designed and implemented an extended SLDS(Short-term Location Data Subsystem) for real-time Location Based Services. The extended SLDS is extended from the SLDS which is a subsystem of the GALIS(Gracefully Aging Location Information System) architecture that was proposed as a cluster-based distributed computing system architecture for managing location data of moving objects. The extended SLDS guarantees real-time service capabilities using the TMO(Time-triggered Message-triggered Object) programming scheme and efficiently manages large volume of location data through distributing moving object data over multiple nodes. The extended SLDS also has a little search and update overhead because of managing location data in main memory. In addition, we proved that the extended SLDS stores location data and performs load distribution more efficiently than the original SLDS through the performance evaluation.

• The Korean Journal of Archival Studies
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• no.64
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• pp.157-186
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• 2020

RRecords management has focused largely on public records in south korea with a relatively low progress in the collection and management of private records with the enactment of Public Records Act in 1999. This study set out to categorize the records of the Coalition for Democratic Reunification and the People's Movement(DRPM) and develop them into a group collection. For this study, literature reviews, analysis and reorganization of records content, development of a classification system, and expert evaluation were carried out. The findings of this study will contribute to greater efficiency in the search of records about the DRPM by developing a classification system to recategorize its records of various sources and enable their easy access and utilization in a digital archive. In addition, the basic structure of producer-oriented classification can be suggested as an example of the organization of a group collection.

• Journal of Digital Convergence
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• v.14 no.2
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• pp.183-190
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• 2016

This paper proposes algorithm to reduce the computing time in a neural network that reduces transmission of data for tracking mobile objects in surveillance networks in terms of detection and communication load. Object Detection can be defined as follows : Given image sequence, which can forom a digitalized image, the goal of object detection is to determine whether or not there is any object in the image, and if present, returns its location, direction, size, and so on. But object in an given image is considerably difficult because location, size, light conditions, obstacle and so on change the overall appearance of objects, thereby making it difficult to detect them rapidly and exactly. Therefore, this paper proposes fast and exact object detection which overcomes some restrictions by using neural network. Proposed system can be object detection irrelevant to obstacle, background and pose rapidly. And neural network calculation time is decreased by reducing input vector size of neural network. Principle Component Analysis can reduce the dimension of data. In the video input in real time from a CCTV was experimented and in case of color segment, the result shows different success rate depending on camera settings. Experimental results show proposed method attains 30% higher recognition performance than the conventional method.