• Korean Journal of Biological Psychiatry
• /
• v.24 no.2
• /
• pp.68-74
• /
• 2017

Objectives It is well known that problem drinking is associated with alterations of brain structures and functions. Brain functions related to alcohol consumption can be determined by the resting state functional connectivity in various resting state networks (RSNs). This study aims to ascertain the alcohol effect on the structures forming predetermined RSNs by assessing their cortical thickness. Methods Twenty-six abstinent male patients with alcohol dependence and the same number of age-matched healthy control were recruited from an inpatient mental hospital and community. All participants underwent a 3T MRI scan. Averaged cortical thickness of areas constituting 7 RSNs were determined by using FreeSurfer with Yeo atlas derived from cortical parcellation estimated by intrinsic functional connectivity. Results There were significant group differences of mean cortical thicknesses (Cohen's d, corrected p) in ventral attention (1.01, < 0.01), dorsal attention (0.93, 0.01), somatomotor (0.90, 0.01), and visual (0.88, 0.02) networks. We could not find significant group differences in the default mode network. There were also significant group differences of gray matter volumes corrected by head size across the all networks. However, there were no group differences of surface area in each network. Conclusions There are differences in degree and pattern of structural recovery after abstinence across areas forming RSNs. Considering the previous observation that group differences of functional connectivity were significant only in networks related to task-positive networks such as dorsal attention and cognitive control networks, we can explain recovery pattern of cognition and emotion related to the default mode network and the mechanisms for craving and relapse associated with task-positive networks.

• Investigative Magnetic Resonance Imaging
• /
• v.7 no.1
• /
• pp.47-55
• /
• 2003

Purpose : Cortical dysplasia is known to be of variety of MR imaging findings. We attempted to classify MR imaging findings of cortical dysplasia into several types and to correlate those with histopathologic grades and subtypes. Materials and Methods : Preoperative MR images of 97 patients with pathologically-proven cortical dysplasia were retrospectively reviewed with knowledge of the diagnosis and operative sites. The patients were divided into MR-positive and MR-negative groups based on the presence or absence of MR imaging abnormalities. In MR-positive group, MR imaging features were arbitrarily classified into four types (atrophic, cortical-band, inward-rounding, and nonspecific types) on the basis of size of the gyrus and adjacent CSF space, cortical thickness, signal intensity of the subcortical white matter, and blurring of the gray-white matter junction. The pathologic findings were also retrospectively reviewed without knowledge of MR imaging findings and divided into three grades (mild, moderate, and severe) and two subtypes (nonballoon-cell and balloon-cell). Pathologic grades and subtypes we re compared between MR-positive and MR-negative groups. Four MR types of the MR-positive group were correlated with the pathologic grades and subtypes. Results : MR-positive and MR-negative groups consisted of 39 (40%) and 58 (60%) patients, respectively. Of the MR-positive group, atrophic type was seen in 13 patients (33 %), cortical-band type in 9 (23%), inward-rounding type in 9 (23%), and nonspecific type in 8 (21%). There was no significant difference in the pathologic grades between MR-positive and MR-negative groups, although MR-positive group tended to have higher pathologic grades than MR-negative group did. Balloon-cell subtype was found significantly higher in MR-positive group than in MR-negative group (p<0 .05): 21% (8/39) versus 5% (3/58). The inward-rounding type corresponded to the pathologically severe grade and balloon-cell subtype in 78% (7/9) and 56% (5/9) of the patients, respectively, while the atrophic type to the mild grade and nonballoon-cell subtype in 77% (10/13) and 100% (13/13), respectively. Conclusion : A variety of MR imaging abnormalities were found in 40% of the patients with cortical dysplasia and those were classified into four types (atrophic, cortical-band, inward-rounding, and nonspecific types), of which the inward-rounding type correlated well with the pathologically severe grade and balloon-cell subtype, whereas the atrophic type with the mild grade and nonballoon-cell subtype.

• The korean journal of orthodontics
• /
• v.36 no.3 s.116
• /
• pp.178-187
• /
• 2006

The present study was performed to evaluate the stress distribution on the diameter of the mini-implant and insertion angle to the bone surface. To perform three dimensional finite element analysis, a hexadron of $15{\times}15{\times}20mm^3$ was used, with a 1.0 mm width of cortical bone. Mini-implants of 8 mm length and 1.2 mm, 1.6 mm, and 2.0 mm in diameter were inserted at $90^{\circ},\;75^{\circ},\;60^{\circ},\;45^{\circ},\;and\;30^{\circ}$ to the bone surface. Two hundred grams of horizontal force was applied to the center of the mini-implant head and stress distribution and its magnitude were analyzed by ANSYS, a three dimensional finite element analysis program. The findings of this study showed that maximum von Mises stresses in the mini-implant and cortical and cancellous bone were decreased as the diameter increased from 1.2 mm to 2.0 mm with no relation to the insertion angle. Analysis of the stress distribution in the cortical and cancellous bone showed that the stress was absorbed mostly in the cortical bone, and little was transmitted to the cancellous bone. The contact area increased according to the increased diameter and decreased insertion angle to the bone surface, but maximum von Mises stress in cortical bone was more significantly related with the contact point of the mini-implant into the cortical bone surface than the insertion angle to the bone surface. The above results suggest that the maintenance of the mini-implant is more closely related with the diameter and contact point of the mini-implant into the cortical bone surface rather than the insertion angle.

• The korean journal of orthodontics
• /
• v.39 no.4
• /
• pp.203-212
• /
• 2009

Objective: The aim of this study was to evaluate the strain induced in the cortical bone surrounding an orthodontic microimplant during insertion in a self-drilling manner. Methods: A 3D finite element method was used to simulate the insertion of a microimplant (AbsoAnchor SH1312-7, Dentos Co., Daegu, Korea) into 1 mm thick cortical bone. The shape and dimension of thread groove in the center of the cortical bone produced by the cutting flute at the apical of the microimplant was obtained from animal test using rabbit tibias. A total of 3,600 analysis steps was used to calculate the 10 turns and 5 mm advancement of the microimplant. A series of remesh in the cortical bone was allowed to accommodate the change in the geometry accompanied by the implant insertion. Results: Bone strains of well higher than 4,000 microstrain, the reported upper limit for normal bone remodeling, were observed in the peri-implant bone along the whole length of the microimplant. Level of strains in the vicinity of either the screw tip or the valley part were similar. Conclusions: Bone strains from a microimplant insertion in a self-drilling manner might have a negative impact on the physiological remodeling of cortical bone.

• Applied Microscopy
• /
• v.38 no.3
• /
• pp.265-273
• /
• 2008

We investigated the morphological differences of the ethnic hairs using scanning electron microscopy and transmission electron microscopy, sampled from African, Asian and Caucasian women. Transverse section of African hair had a highly elliptical type whereas those of Asian and Caucasian hairs had circular and elliptical types, respectively. The diameter of African hair showed wide variations from 90 to 115 ${\mu}m$. The diameter of Asian hair was 100 ${\mu}m$ and Caucasian hair had a lesser diameter of 80 ${\mu}m$ on average. African hair were much more damaged in cuticle layer compared with Asian or Caucasian hairs. In particular, endocuticle of cuticle cell had a lot of holes in it, which resulted that it tends to be easily broken. Phaeomelanin in the cortex of Caucasian hair had a concentrically helical structure in it.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.11
• /
• pp.323-326
• /
• 1996

Dental implant is increasingly used to recover the mastication function of tooth. Several types of implant were designed to give an optimal stress distribution in surrounding bony regions. In this study, six types of implant were investigated using finite element method and it was studied i) how the variation of cortical bone thickness affects the stress distribution in surrounding bony regions depending upon implant types, ii) which type gives the best characteristics in the sence of stress distribution and stability. The hybrid-type implant with cylinder and screw gave the optimum properties in view of stability and response to the variation of cortical bone thickness.

• Korean Journal of Biological Psychiatry
• /
• v.25 no.3
• /
• pp.60-71
• /
• 2018

Objectives A growing body of evidence has suggested that morphologic changes in cerebellum may be implicated with pathophysiology of major depressive disorder (MDD). The aim of this study is to investigate a difference in the volume and cortical thickness of the specific region of cerebellum between patients with MDD and healthy controls (HC). Methods A total of 127 patients with MDD and 105 HC participated in this study and underwent T1-weighted structural magnetic resonance imaging. We analyzed volume and cortical thickness of each twelve cerebellum regions divided by left and right and the volume and cortical thickness of the whole cerebellum from T1-weigted image of participants. One-way analysis of covariance was used to investigate the volume and cortical thickness difference of total and specific regions between two groups adjusting for age, gender, medication, and total intracranial cavity volume. Results We found that the patients with MDD had significantly greater volume in the left cerebellum lobule III region [false discovery rate (FDR)-corrected p = 0.034] compared to HC. Also, our findings indicate that cortical thickness of left lobule VIIB (FDR-corrected p = 0.032) and lobule VIIIB (FDR-corrected p = 0.032) are significantly thinner in the patients with MDD compared with the HC. No significant volume and cortical thickness differences were observed in other sub-regions of the cerebellum. The volumes and cortical thickness of whole cerebellum between patients with MDD and HC did not differ significantly. Conclusions We observed the region-specific volume and cortical thickness difference in cerebellum between the patients with MDD and HC. The results of our study implicate that the information about structural alterations in cerebellum with further replicative studies might provide a stepping stone toward a specific marker to diagnose MDD.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.26 no.1
• /
• pp.47-57
• /
• 2010

An undisturbed healing process without micromotion at the implant-bone interface is essential for achievement of osseointegration of dental implant. Therefore, initial stability was advocated as prerequisite for successful clinical outcome. Adequate bone quality and quantity were important to achieve initial stability and to prevent early failures. However there were few published data available regarding the effect of design change in implant geometry on initial stability of the implants. The purpose of the current study was to assess the initial stability of various designs of implants when placed into artificial bone materials of varying qualities and shapes of insertion holes. Within the scope of this study, the following results were drawn. Bone quality was major importance to achieve initial stability. Initial stability was higher on GS II which had additional design feature of double thread. With a tapered design of implant such as GS III showed a higher initial stability than straight one. An insertion hole with the similar shape of implant would lead to reduce a compression force on cortical bone and enhance a bone anchorage on cancellous bone.

• Journal of the Korea Convergence Society
• /
• v.8 no.7
• /
• pp.123-129
• /
• 2017

Morphological and ultrastructural characteristics of human hair medulla was investigated with scanning electron microscopy and transmission electron microscopy. The medulla is located in the central position of hair shaft and appear greatly variable forms which discontinuous shape arranged from hair root to apical portion according to longitudinal axis. The thickness of medulla from a single hair presented as very variable in size. The diameter of cross section of human hair medulla measured as $21{\mu}m$ and longitudinal section showed $27{\mu}m$. It grows up to 1/3 from 1/4 in diameter of human hair shaft. It appears emptied hole during separating of macrofibrils in the keratinocyte. The empty space measured $6.5{\mu}m$ in diameter as maximum size and it was filled with air.

• Proceedings of the Korean Vacuum Society Conference
• /
• 2016.02a
• /
• pp.373-373
• /
• 2016

파푸아뉴기니 열대 우림에 서식하는 극락조의 가슴깃은 독특한 나노 구조를 가지고 있다. 이 독특한 구조에 의해 구조색이 발현된다. 또한 이 구조색은 입사하는 빛의 각도에 따라 색이 변화 하며 아름다운 색을 낸다. 극락조의 가슴깃의 구조는 keratin과 melanin으로 구성 되어 있는데 keratin과 melanin이 한 층씩 교대로 위치하여 multi layer 구조를 가진다. 가슴깃의 단면의 형태는 부메랑 모양의 구조로 되어 있는데 물질은 주로 keratin 으로 이루어져 있고 keratin 내부에 melanin rodlet이 층층이 박혀서 multi layer를 형성한다. 부메랑 모양의 단면에서 keratin 피질의 각도는 약 $30^{\circ}$ 정도로 이루어져 있고 내부의 melanin 기둥이 이루는 층은 약 $11.3^{\circ}$ 정도로 이루어져 있다. 본 연구에서는 극락조 가슴깃의 구조를 도식화 하여 입사하는 빛의 각도에 따라 나타나는 구조색을 FDTD simulation을 통해 계산하였고 실제 구조에 의해 측정된 reflectance spectra와 비교하여 특성이 유사하게 나타남을 확인 하였다. 실제 극락조 가슴깃의 반사 특성은 부메랑 모양 구조의 가운데 부분에서는 파장이 610 nm 정도인 주황빛이 주로 반사가 되고, 부메랑 모양 구조의 양옆 부분에서는 파장이 420 nm 정도인 파란빛이 주로 반사되어 나타난다. 그리고 각도에 따른 구조색의 변화는 보통의 multi layer의 특징과 다르게 나타난다. 입사하는 빛의 각도가 커질수록 reflectance peak가 나타나는 파장이 점점 짧아지는 특징은 일반적인 multi layer와 일치하지만 일반적인 multi layer가 입사 각도가 커질수록 reflectance가 커지는데 반해 극락조 가슴깃의 반사특성은 입사 각도가 커질수록 reflectance는 오히려 작아진다. 우리가 도식화한 구조를 FDTD simulation한 결과는 이러한 특징이 실제 구조의 측정 결과와 일치하게 잘 나타났다. 또한 keratin과 melanin층의 각도 및 두께변화에 따른 reflectance를 FDTD simulation을 통해 계산 해보았고 구조변화에 따른 특징들을 확인해 보았다.