• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.369-375
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• 2012

Loess-sulfur complex has been widely used as an environmental friendly organic materials for insecticides and fungicides in crop cultivation. However, there are high concerns about skin and eye irritation for farm workers due to the high alkaline properties of loess-sulfur complex. The acute toxicity evaluation was conducted with three samples of loess-sulfur complex in different pH (pH 9, 10, 11) in order to supply the evidentiary data for selecting the optimal product among the test materials. The results of acute oral toxicity using rats showed $LD_{50}$ of over 2,000 mg/kg b.w. for all three samples of loess-sulfur complex. The calculated acute dermal $LD_{50}$ of all tested materials was over 4,000 mg/kg b.w.. The Skin and eye irritation indicated that all tested materials have no irritation. Consequently, it was suggested that loess-sulfur complex be low in acute toxicity at all different pH values (pH 9~11).

• Toxicological Research
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• v.18 no.3
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• pp.267-273
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• 2002

Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E$_2$production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.

• Proceedings of the ESK Conference
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• 1997.10a
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• pp.220-225
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• 1997

졸음에 의한 순간적 과오는 자동차운전을 비롯한 각종 산업안전에 인명피해를 포함하는 치명적 손실 을 수반한다. 따라서 이분야에 대한 연구가 국내를 포함한 전세계에서 활발히 진행되어 상업화가 추진 중이다. 그러나 이러한 연구는 실용적 차원에서 주로 피부전기활동(Electrodermal Activity: EDA)과 눈 깜박임 등의 측정방법에 의존하고 있으며 졸음의 첫 지시치로서 중요하고 객관적인 각성-졸음 과도기 뇌파를 포함하는 수면 다원생리신호 측정에 관한 연구는 이 방법이 피험자에게 구속성을 주고 측정 자체가 까다로워서 현실적으로어려운 실정이다. 본 연구에서는 그 동안 Medilog SAC847 Polysomnography를 이용한 수면에 관련된 종합적 생리신호를 측정.분석 연구해온 경험을 토대로 정상적인 성인의 각성-졸음 과도기 생리신호특징으로서 뇌전도(Electroencephalogram:EEG), 턱 및 다리근전도(Electromyogram:EMG), 심전도( Electrocardiogram:ECG), 안전도(Electrooculogram:EOG) 등을 종합적으로 분석한 결과 졸음상태가 각성상 태에 비하여 EEG의 주파수는 감소하고, EMG와 ECG의 진폭은 줄어들고, EOG에서는 느린 안구운동의 특징을 갖는 것을 알 수 있었다.

• Journal of Auto-vehicle Safety Association
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• v.15 no.1
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• pp.63-68
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• 2023

A study on the need for a safety system using driver's biometric information, vehicle automatic emergency braking system, and the e-call system that in the event of an unexpected situation such as loss of driving ability due to sudden physical abnormality of elderly drivers and drivers with health problems, and the improvement of laws for the spread of this system were studied.

• Applied Chemistry for Engineering
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• v.27 no.3
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• pp.299-306
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• 2016

In this study, new hydroxyapatite powder surface composites were investigated for protective effects against ultraviolet rays. Hydroxyapatite (HAp) is biocompatible and does not cause nebula phenomenon on skin. We investigated the surface modification of hydroxyapatite to improve UV block and skin usage. Dimethicone, lauroyl lysine, triethoxycaprylylsilane and silica were used as coating agents for the surface modification of HAp. To prepare the composite complex of the modified surface, the dimethicone, lauroyl lysine and triethoxycaprylylsilane were prepared by a dry process, and silica by a hydrothermal synthesis method. The HAp-silica was chosen as the best composite powder when measuring its sun protection levels. We investigated the characteristics of the surface of HAp-silica by SEM, particle size analyzer and energy dispersive spectrometry (EDS). Additionally, the stability in the formulation, UV block effect, and safety in BB creams were investigated. In conclusion, HAp-silica prepared by the modification of HAp complex surface improved the skin usage and UV block effect by enhancing the white cloudy phenomenon. These results indicate that HAp-silica may be used for UV block cosmetics.

• The Journal of the Convergence on Culture Technology
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• v.5 no.4
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• pp.445-450
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• 2019

Recently, consumers using cosmetics have a great interest in raw material safety. Among them, interest in natural preservatives is increasing, and as the demand for cosmetics excluding paraben preservatives increases, a method of replacing synthetic preservatives with antibacterial essential oils is being considered. The antibacterial effect of essential oils depends on the components, concentrations and interactions between the main active compounds. Effective preservatives should have antimicrobial activity against a wide range of strains even at minimal concentrations. All preservatives should be considered to increase skin concentration and cause skin irritation and allergic reactions. Consumers recognize that essential oils from nature are safe, but some should be careful because they can cause contact allergies or phototoxic reactions. As such, it is important to balance natural preservatives with maximum preservative effects and low toxicity. This paper describes the characteristics of essential oils focused on antibacterial properties, efficacy and safety as cosmetic preservatives.

• Journal of Food Hygiene and Safety
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• v.18 no.3
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• pp.153-160
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• 2003

This study was performed to determine the urinary metabolites of methidathion in rats. Urine samples were collected for 24 hours in metabolic cages following after oral administration and dermal application of methidation to rats. The urinary metabolites were identified by GC/MS and the excretion time courses of urinary dialkyl phosphate metabolites were analyzed by CG/FPD. The results obtained are summarized as follows: Three dialkyl phosphate metabolites, DMP, DMTP. and DMDTP, were detected in the rat urine. Urinary dialkyl phosphate metabolites were identified on the basis of their mass spectra by GC/MS. The molecular ions of DMP, DMTP,and DMDTP, were identified at m/z 198, and m/z 158, respectively. A comparison of excretion time courses of urinary dialkyl phosphate metabolites between the orally administrated and dermally applicated rats were also established, After oral administration, 79.2% of DMP, 93.9% of DMTP, and 83.0% of DMDTP were excreted into the urine by 12, 24, and 12 hours, respectively. After dermal application, 71.1% of DMP, 82.8% of DMTP 87.7% of DMDTP were excreted into the urine by 24, 48, 48 hours, respectively. Consequently, almost all of the dialkyl phosphates in oral administration were excreted within 48 hours. However, the metabolites in dermal application were excreted up to 168 hours. In the study, three urinary metabolites of methidation, DMP, DMTP and DMDTP, were detected in the rat both after oral administraion and dermal application with methidathion. And the urinary excretion in dermal application was more delayed than that in oral administration. Based on the results, it tis suggested that three urinary dealkyl phosphates, DMP, DMTP, and DMDTP, could be used as the biomarkers of exposure for methidathion.

• KSBB Journal
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• v.21 no.6 s.101
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• pp.444-450
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• 2006

Skin anti-aging effect of Forsythia viridissima L. extract was evaluated by using antioxidant assay, expression of type I procollagen, and UVA-induced matrix metalloproteinase-1 in human dermal fibroblasts. Matairesinol-rich Forsythia viridissima L. extract was showed the scavenging activity of radicals and reactive oxygen species with the $IC_{50}$ values of $4.50\;{\mu}m/ml$ against 1,1-diphenyl-2-picrylhydrazly radical and $542.43\;{mu}m/ml$ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. The type I procollagen was increased 33.76% by treatment with matairesinol-rich Forsythia viridissima L. extract, and UVA-induced MMP-1 was reduced 35.78% in a dose dependent manner. In the human skin irritation test, 2% matairesinol-rich Forsythia viridissima L. extract did not show any adverse effect. Also, the clinical study indicated that a cream group treated with 0.2% matairesinol-rich Forsythia viridissima L. extract significantly reduced skin wrinkles, as compared with a non-treated cream group (p < 0.05). These results suggest that Forsythia viridissima L. extract may be useful as a potential source of functional anti-aging cosmetics.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.3
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• pp.211-216
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• 2016

Micronucleus test is genotoxicity assay for detection of micronuclei in the cytoplasm of interphase cells. The reduction and replacement of in vivo toxicity testing on animals require the development of in vitro models to predict the genotoxicity or other tests for cosmetic products. In this study, we evaluated a genotoxicity assay for topically applied chemicals using a three-dimensional human reconstructed skin model, KeraSkin$^{TM}$. Two genotoxins, mitomycin C (MMC) and methyl methanesulfonate (MMS), induced significant dose-related increases in cytotoxicity and micronuclei induction in the skin model. In contrast, two non-genotoxins, 4-nitrophenol (4-NP) and trichloroethylene (TCE), induced cytotoxicity but not micronucleus formation. In conclusion, micronucleus test using human skin model may be useful for predicting in vitro genotoxic potentials of cosmetic products.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.363-371
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• 2019

In this study, 340 Korean women were surveyed to analyze the impact of the type of sunscreen and use status on the satisfaction of products and resale. Studies have shown that indoor activity is higher than outdoor activity, and both simple and complex sunscreen is often used to compensate for skin tone. Out of single sunscreen, sun cream was used and air cushion was used a lot. Although product usability and UV protection indices were important factors in purchasing, 30% experienced side effects while product satisfaction and willingness to repurchase were high. The recognition of safety, Effectiveness, convenience, usability, satisfaction, and repurchase were all higher than that of composite UV-blocking products, and among subcomponents of product usage recognition, the level of convenience, efficacy, usability, and safety affected satisfaction and repurchase in order. Consequently, the perception of simple UV protection products was higher when using products for UV protection, and its convenience had a significant impact on satisfaction and resale.