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The Safety Evaluation of a Potent Antioxidant, Fructose 1,6-diphosphate(FDP), for the Skin Application  

김배환 (태평양기술연구원 의약건강연구소)
이병석 (태평양기술연구원 의약건강연구소)
정경미 (태평양기술연구원 의약건강연구소)
안수미 (태평양기술연구원 의약건강연구소)
안수선 (태평양기술연구원 의약건강연구소)
심영철 (태평양기술연구원 의약건강연구소)
Publication Information
Toxicological Research / v.18, no.3, 2002 , pp. 267-273 More about this Journal
Abstract
Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E$_2$production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.
Keywords
Fructose 1,6-diphosphate(FDP); Antioxidant; Anti-inflammatory; Safety evaluation; Skin application;
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