Browse > Article

Skin Anti-aging Effect of Forsythia viridissima L. Extract  

Kim, Mi-Jin (R&D Center, Saimdang Cosmetics Co., Ltd.)
Kim, Ja-Young (R&D Center, Saimdang Cosmetics Co., Ltd.)
Jung, Teak-Kyu (R&D Center, Saimdang Cosmetics Co., Ltd.)
Choi, Sang-Won (Department of Food Science and Nutrition, Catholic University of Daegu)
Yoon, Kyung-Sup (R&D Center, Saimdang Cosmetics Co., Ltd.)
Publication Information
KSBB Journal / v.21, no.6, 2006 , pp. 444-450 More about this Journal
Abstract
Skin anti-aging effect of Forsythia viridissima L. extract was evaluated by using antioxidant assay, expression of type I procollagen, and UVA-induced matrix metalloproteinase-1 in human dermal fibroblasts. Matairesinol-rich Forsythia viridissima L. extract was showed the scavenging activity of radicals and reactive oxygen species with the $IC_{50}$ values of $4.50\;{\mu}m/ml$ against 1,1-diphenyl-2-picrylhydrazly radical and $542.43\;{mu}m/ml$ against superoxide radicals in the xanthine/xanthine oxidase system, respectively. The type I procollagen was increased 33.76% by treatment with matairesinol-rich Forsythia viridissima L. extract, and UVA-induced MMP-1 was reduced 35.78% in a dose dependent manner. In the human skin irritation test, 2% matairesinol-rich Forsythia viridissima L. extract did not show any adverse effect. Also, the clinical study indicated that a cream group treated with 0.2% matairesinol-rich Forsythia viridissima L. extract significantly reduced skin wrinkles, as compared with a non-treated cream group (p < 0.05). These results suggest that Forsythia viridissima L. extract may be useful as a potential source of functional anti-aging cosmetics.
Keywords
Anti-aging; Forsythia viridissima L. extract; type I procollagen; matrix metalloproteinase-1; cosmetics;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Chun, J. H., S. W. Kang, J. Varani, J. Lin, G. J. Fisher, and J. J. Voorhees (2000), Decreased extracellular signal regulated kinase and increased stress activated MAP kinase activities in aged human skin in vivo, J. Invest. Dermatol. 115, 177-182   DOI   ScienceOn
2 Thornton, M. J. (2002), The biological actions of estrogen on skin, Exp. Dermatol, 11, 487   DOI   ScienceOn
3 Franke A. A., L. J. Custer, C. M. Cerna, and K. Narala (1995), Rapid HPLC analysis of dietary phytoestrogens from legumes and from human urine, Proc. Soc. Exp. Biol. Med. 208, 18-26
4 Thompson, L. U. (1998), Experimental studies on lignans and cancer, Baillieres Clin. Endocrinol. Metab. 12, 691-705   DOI   ScienceOn
5 Mazur, W., T. Fotsis, K. Wahala, S. Ojala, A. Salakka, and H. Adlercreutz (1996), Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples, Anal. Biochem. 233, 169-180   DOI   ScienceOn
6 KP 2005-004354
7 In vivo, anti-wrinkles efficacy test, Dermapro Co. Ltd. (2006)
8 Vlietinck, A. J., T. De Bruyne, S. Apers, and L. A. Pieters (1998), Plant-derived leading compounds for chemotherapy of human immunodeficiency vims (HIV) infection, Planta. Med. 64, 97-109   DOI   ScienceOn
9 Schinella, G. R., H. A. Toumier, J. M. Prieto, D. Modujovich, and J. L. Rios (2002), Antioxidant activity of anti-inflammatory plant extracts, Life Sci. 70, 1023-1033   DOI   ScienceOn
10 Ozaki, Y., J. Rui, and Y. T. Tang (2000), Antiinflammatory effect of Forsythia suspensa V (AHL) and its active principle, Biol. Pharm. Bull. 23, 365-367   DOI   ScienceOn
11 WO 02/080702
12 Lim, D. K., U. Choi, and D. H. Shin (2000), Antioxidative activity of ethanol extract from Korean medicinal plants, Korean J. Food Sci. Technol. 8, 342-350
13 Kim, T. J. (1991), Korean resources plants, p262, Seoul National University Pub. Seoul
14 Matthews, K., A. E. Meilahn, and L. H. Kuller (1989), Menopause and risk factors for coronary heart disese, The New England J. of Med. 321, 641-646   DOI   ScienceOn
15 KP 2002-0046614
16 Beauregard, S. and B. A. Gilchrest (1987), A snrvey of skin problems and skin care regimens in the elderly, Archives. of Dermtol. 123, 1638-1643   DOI
17 KP 2002-0080660
18 Lee, E. B. and H. J. Keum (1988), Pharmacological studies on Forsythia Fructus, Kor. J. Pharmacogen. 19, 262-269   과학기술학회마을
19 Nora, T., O. Yasushi, M. Toshio, U. Akira, and S. Fukushima (1983), Inhibition of xanthine oxidase from the flowers and buds of Daphne genkwa, Chem. Pharm. Bull. 31, 3984-3987   DOI   ScienceOn
20 Lee, E. B. and H. J. Keum (1998), Pharmacological studies on Forsythia Fructus, Kor. J. Pharmacogen 19, 262-269
21 Blois, M. S. (1958), Antioxidant determinations by the use of a stable free radical, Nature 181, 1199-1200   DOI   ScienceOn
22 Rim, Y. S., Y. M. Park, M. S. Park, K. Y. Kim, M. J. Kim, and Y. H. Choi (2000), Screening of antioxidant and antimicrobial activity in native plants, Korean J. Medicinal Crop Sci. 8, 342-350   과학기술학회마을
23 Li, Z. X., X. H. Wang, J. H. Zhao, J. F. Yang, and X. Wang (2000), Investigation on antibacterial activity of Forsythia suspense Vahl in vitro with Mueller-Hinton agar, Zhongguo Zhong. Yao. Za. Zhi. 25, 742-745
24 Seo, J. Y., G. E. Hrie, and J. H. Chung (2001), The effect of ultraviolet irradiation on the expression of type I procollagen and MMP-1 in human dermal fibroblast and human skin in vivo, Kor. J. Invest. Dermatol. 8, 116-122
25 JP 1989-031717
26 Mosmann, T. (1983), Rapid colorimetric assay for the cellular growth and snrvival : application to proliferation and cytotoxic assay, J. Immun. Methods 65, 55-63   DOI   ScienceOn
27 Brincat, M. P. (2000), Hormone replacement therapy and the skin, Maturitas 29, 107
28 JP 1999-255639
29 Shah, M. G. and H. I. Maibach (2001), Estrogen and skin, Am. J. Clin. Dermatol. 2, 143   DOI   ScienceOn
30 WO 03/047608