• Journal of the Korean Applied Science and Technology
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• v.41 no.1
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• pp.69-82
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• 2024

The purpose of this study was to systematically evaluate and compare the effects of 640 nm LED irradiation and aromatherapy on the skin condition of the neck. Twenty female participants were divided into Group A (640 nm LED irradiation + aromatherapy) and Group B (640 nm LED irradiation only). Total of 8 experiments were conducted on the 2 groups twice a week. As a result of the experiment, moisture content was significantly improved in both group A (p<0.01) and group B (p<0.001), and wrinkle index was significantly improved in both group A (p<0.01) and group B (p<0.05). Additionally, the change in skin density was significantly improved in both group A (p<0.001) and group B (p<0.05), and the change in elasticity was significantly improved in both group A (p<0.001) and group B (p<0.001) as well. However, the change in skin tone was not significant in group A (p>0.05), but the change was drastically improved in group B (p<0.05). Blemishes and pigmentation changes were significantly improved in group A (p<0.05), but was not significant in group B (p>0.05). These results conclude that combining aromatherapy with 640 nm LED irradiation can be highly effective in improving skin condition of the neck.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.46 no.1
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• pp.73-80
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• 2020

Psychological stress can affect the physiological condition of the skin and cause various cutaneous disorders. The stress hormone cortisol is secreted by various skin cells such as fibroblasts, keratinocytes, and melanocytes. Tight junctions (TJs) are cell-cell junctions that form a barrier in the stratum granulosum of mammalian skin. TJs can also affect other skin barriers and are affected by chemical, microbial, or immunological barriers. Stress can cause damage to the skin barrier. Interestingly, to our knowledge, there has not been any research demonstrating the involvement of TJs in this process. In this study, cortisol was used to treat keratinocytes to determine its role in regulating TJs. We found that cortisol damaged skin barrier function by regulating the gene expression and structure of TJ components. Cortisol also inhibited the development of the granular layer in a skin equivalent model. These results suggest that cortisol affects the skin barrier function by the regulation of TJs.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.271-271
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• 1996

PG의 농도가 AM의 경피투과에 미치는 영향은 용해도곡선과 유수분배곡선의 교점인 40% 농도에서 투과극대를 보였다. 지방산 및 지방산 알코올의 촉진효과는 리놀레인산＞올에인산＞올레일알코올＞ DHA=EPA=라우린산의 순이었고 PG에 리놀레인산 또는 올레인산을 첨가한 경우는 PG 단독에 비해 129.9 및 43.0배의 투과를 나타냈다. 또, 리놀레인산의 농도증가 (2,5,10%)에 따라 피부/매질 간의 분배계수가 가장 큰 5% 농도의 리놀레인산을 사용했을 때 투과효과가 최대로 나타났다. 한편, AM의 농도증가에 따른 투과효과에 있어서는 포화용해상태인 2% 약물농도에서 투과 flux가 가장 컸다. 라우릴황산타트륨의 첨가는 유의성 있는 효과를 발현하지 못했고 지방산과 병용시에도 지방산 단독 사용시에 비해 오히려 투과를 감소시켰다. 종차에 따른 AM의 피부투과에 있어서는 리놀레인산을 투과촉진제로 사용한 결과 흰주와 무모마우스의 투과 flux가 각각 23.78 및 213.29 $\mu\textrm{g}$/$\textrm{cm}^2$/hr로 무모마우스가 8.97배 높았다. 흰주의 추출액 및 호모지네이트 중에서의 AM의 대사에 있어서는 겉보기 1차 분해속도정수가 표피측추출액, 장막측추출액, 호모지네이트에서 각각 0.0105, 0.572 및 6.153$hr^{-1}$로 호모지네이트 중의 분해속도가 가장 빨라 AM은 피부투과 중에 가장 많이 분해됨을 알았다.

• Proceedings of the KIEE Conference
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• 2008.10b
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• pp.203-204
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• 2008

한의학 진단의 중요 요소인 맥진을 자동화한 맥진기에서뿐만 아니라 비관혈적 심혈관 기능 평가를 위해서 요골동맥 맥파 측정이 널리 활용되고 있다. 요골동맥 맥파는 피험자의 생리적, 병리적 원인을 통제하더라도 가압력이 변함에 따라 형태가 달라지며, 어느 시점 맥파를 피험자의 상태를 대표하는 맥파로 해야 할지에 대한 명확한 기준이 없어 맥압이 최대가 되는 시점의 맥파를 사용하고 있다. 그러나, 맥파가 측정되는 가압력 범위뿐만 아니라 맥압이 최대가 되는 시점이 피험자마다 다르기 때문에 정확한 대표 맥파를 획득하기 위해서는 보다 가압력 단계를 늘려야 하며, 결과적으로 측정시간이 보다 길어지게 될 것이다. 본 논문에서는 최소한의 가압단계로도 보다 정확히 대표 맥파를 획득할 수 있는 방법을 개발할 수 있도록, 정밀 제어가 가능한 가압 로봇 축, 가압에 의해 눌리는 피부이동 거리 측정을 위한 레이저 센서, 가압에 따른 피부 반발력과 맥파를 측정할 수 있는 압력 센서로 구성된 테스트 지그를 개발하였다. 이를 통해 모터 이동 스텝 수에 따른 피부 이동 거리 특성, 피부 이동 거리에 따른 맥파 변화 특성 등을 관찰할 수 있었으며, 향후 효과적인 대표 맥파 획득 방법을 개발할 수 있을 것으로 기대한다.

• Journal of fish pathology
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• v.5 no.2
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• pp.159-164
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• 1992

The skin of fishes is also the important external barrier against a variety of the environmental detrimental agents, allowing normal internal physiological function, so its condition is very important in many disease processes. Since fishes are aquatic, morphologically and physiologically they posses specific characteristics lacking in terrestial animals. Thus, it is necessary to keep in mind various specific histologic characteristics for a precise interpretation of the histopathological lesions. In the normal environment the fish skin is more subtly adapted for its physiological requirements as a limiting barrier than the skin of higher terrestial vertebrates. However, its delicacy makes it high vulnerable to damage in fish culture facilities or polluted waters. Although changes in the skin of fish such as discoloration, ulcerative lesions, are the the most readily observed clinical features of fish, there is a wide variety of possible responses, which are best considered in terms of their site within the skin. Up to now, there are relatively few sytematically described information on the histological structure of the teleost skin as well as integrated reviews of the range of pathological processes that can occur in teleost skin. Therefore it was tried in this article to rearrange the information already described by other investigators on the histological structure and histopathological changes of teleost skin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.31 no.1 s.49
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• pp.35-41
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• 2005

We investigated the effects of skin hydration and anti-irritation of exopolysaceharide (GF-glucan) produced from submerged culture of Grifola frondosa. The moisturizing effects and trans-epidermal water loss (TEWL) of GF-glucan in cosmetic products (O/W emulsion) were clinically studied. GF-glucan showed good skin hydration effects when compared with sodium hyaluronate which is a commonly using moisturizer. The skin protective effects of GF-glucan against sodium lauryl sulfate (SLS) were also found. Twice a day application of the CF-glucan to skin reduced local inflammation remarkably. Irritant reactions were assessed by various aspects of skin function, erythema (skin color reflectance), hydration (electrical capacitance) and TEWL. In the human skin test, 5-day treatment of the GF-glucan was found to reduce SLS-induced skin erythema and Improve bier regeneration. Taken all together, GF-glucan should be a very useful cosmetic ingredient, as a moisturizer, and a protecting agent for various skin irritations.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.41 no.4
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• pp.413-420
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• 2015

The skin is one of the largest organs in our body and participates in many of the human organism's physiological and pathological events. Skin function were known for self-maintenance and self-repair, mechanical and chemical stress protection, protection against UV and environmental pathogenic micro-organisms, production of vitamin D, and social and psychological function through the physical aspect. The aim of this study was to evaluate the variation of biophysical parameters and to find relation with skin biomarkers in different anatomical site and age in Korean women. About 70 healthy volunteers in age range 20 to 49 were participated in this test. Test areas were the forearms and the cheek. Investigation to determine biophysical parameters on human skin, was carried out using various non-invasive methods. For analysis to skin biomarkers, we studied to examine various biomarkers for the quantitative determination of cortisol, fibronectin, keratin-1, 10, and 11, involucrin, and keratin-6 in human face and forearm. And we measured to skin biophysical parameters for skin anatomical site and age difference with non-invasive methods. As results of measuring site, some parameters were have following significant difference, stratum corneum hydration, trans epidermal water loss and skin color (L and a value). As results of age difference, skin colors were had only significant difference with age. For cortisol, keratin-6, fibronectin, keratin-1, 10, 11 contents, there were no significant difference in age and site. However, involucrin level in the cheeks were the highest for age group 30 ~ 39 compared to other age groups. These results suggest that in individual skin condition may explain detailed skin state variation.

• Journal of the Korean Applied Science and Technology
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• v.41 no.2
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• pp.459-471
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• 2024

In modern society, where tension and stress are ubiquitous, individuals often experience psychological imbalances. These stressors not only affect mental well-being but also manifest physically, through the skin. Consequently, a new term psychodermatology combining psychiatry and dermatology, has emerged, garnerning attention and research focus. In this study, we aimed to develop materials improving chronic skin conditions caused by stress by utilizing a compound of Cucurbita moschata, Paeonia japonica, and Prunus cerasus known to alleviate skin disorders. We sought to develop and validate the efficacy of materials alleviating chronic skin conditions induced by stress in keratinocytes..Therefore, in this study we analyzed the effects of a complex extract using Cucurbita moschata, Paeonia japonica, and Prunus cerasus on HaCaT keratinocyte cells to understand how it influences them. The complex extract on HaCaT keratinocyte cells showed a concentration-dependent decrease in the expression levels of TNF-α, IL-1β, IL-6, MDC, and TARC at concentrations of 12.5, 25, 50 and 100 ㎍/mL. Particularly noteworthy was the efficacy observed in inhibiting IL-1β, with a reduction of over 40% at a concentration of 100 ㎍/mL. Additionally, the production levels of AQP-3, HA, and filaggrin exhibited a significant concentration-dependent increase. The protein expression of p-ERK, p-JNK, and p-p38, which were elevated by TNF-α/IFN-γ, was significantly decreased with the treatment of the complex extract. These findings suggest that the compound extract may be utilized as a material for treating and preventing skin conditions, potentially mitigating the adverse effects of the mutual relationship between skin disorders and stress.

• Proceedings of the ESK Conference
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• 1997.04a
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• pp.203-211
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• 1997

본 연구는 기온$15^{\circ}C{\pm}1^{\circ}C$ $26^{\circ}C{\pm}1^{\circ}C$,습도$55%{\pm}5%$ 환경조건에서 손가락 끝마디 부분을 얼음물에 침지시킨후 구강온과 4부위 피부온, 손가락끝 피부온, 전신온냉감, 전신쾌적감, 손가락 끝 동통감의 변화를 젊은 남자 피험자와 노인남자 피험자를 대상으로 비교측정하고자 하였다. 본 학회에서는 젊은 남자피험자 그룹에 대하여 보고하고자 한다. 결과는 다 음과 같다. $15^{\circ}C{\pm}1^{\circ}C$에서 4부위 피부온을 보면 가슴과 상완은 손가락끝 침지시 약간 하강하고 다시 상승하지만 대퇴와 하퇴에서는 하강하고 그 상태가 유지된다. 특히 하퇴의 경우는 급격히 하강하는 경향을 보이고 있다. 손가락끝 피부온은 손가락 침지와 동시에 급격한 하강을 나타내나 손가락을 꺼낸후에 손가락 침지전의 온도로 회복되지는 않았다. 평균피부온을 보면 손가락 침지시 하강하는 경향을 보이고 있다. 전신 쾌적감은 약간 불쾌하게 나타났고, 전신온냉감은 서늘하다고나타났고 손가락끝의 동통 감은 매우 아프다고 나타났다. $26^{\circ}C{\pm}1^{\circ}C$에서 4부위 피부온을 보면 가슴 상완대퇴 하퇴 모두 손가락끝 침지시 약간 하강하고 낮은 상태로 유지되는 경향을 보이고 있다. 손가락끝 피부온은 손가락 침지시 급격한 하강을 나타내었고 손가락을 꺼낸후에도 침지의 온도로 회복이 되었다. 평균피부온은 손가락 침지후에 약간 하강하였지만 큰 차이는 없었다. 전신쾌적감은 약간 쾌적하게 나타났고 전신온냉감은 약간 따뜻하다라고 나타났으며 손가락끝의 동통감은 약간 아프다고쪽으로 나타났다.때문에 이를 디자인에 곧바로 적용시키기 어려운 점이 있다. 이에 본 연구는 기존의 바용성 평가를 위한 분석도구들이 갖는 문제 점들 해결하여 제품의 사용자 인터페이스 디자인 개발과정에서 활용할 수 있는 평가 분석도구를 개발하는 것을 목표로 한다. 이를 위해 첫째, 다양한 유형의 정보를 포함하는 비디오 정보를 선정하였따. 둘째, 데이터를 다양한 측면에서 추출할 수 있는 Data logger를 개발하였다. 셋째, 데이터를 시각적으로 정리하고 분석할 수 있는 도구를 제안한다. 마지막으로 인터페이스 디자인에서 여러 가지 디자인안을 도출해 내는 작업에 이용할 수 있는 종합화과정을 개발한다. 이러한 일련의 과정이 통합된 컴퓨터 시스템 안에서 이루어지도록 프로그램을 개발하여 정보의 유용성을 높일 수 있도록 한다.at the entropy index as a measurement of inter-business relatedness is not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI (Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an depende

• Korean Journal of Ichthyology
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• v.23 no.1
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• pp.70-74
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• 2011

During the winter, the rice field-dwelling muddy loach Misgurnus mizolepis is buried in burrows constructed of mud and are subjected to exposure to air at times of shortage of water. To investigate the environmental factors that lead to changes of the skin mucus cells of the muddy loach in rice fields, we carried out an experiment where we artificially exposure the fish to air, duplicating as close as possible winter conditions in nature. During the summer, a water tank containing M. mizolepis was filled with mud, and the water was allowed to evaporate. After a month of evaporation, the loach constructed burrows similar to those in a winter rice field. The epidermis in the experimental fish was mostly occupied by large elongated mucus cells, whose numbers drastically increased in all observed regions of the dorsum, lateral region, and the occiput. Such features are typically seen in fishes in wild habitats during the winter season.