• Korean Journal of Clinical Laboratory Science
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• v.56 no.1
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• pp.43-51
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• 2024

[⁶⁸Ga]Ga-FAPI-04 is a promising radiopharmaceutical that binds specifically to fibroblast activation protein, which is overexpressed in more than 90% of malignant epithelial tumors but not in normal healthy tissue. This study aimed to develop an efficient method for producing ⁶⁸Ga-labelled FAPI-04 using a cassette-based automated synthesizer. [⁶⁸Ga]GaCl₃ was eluted from an Eckert & Ziegler Medical germanium-68/gallium-68 generator using 2.5 mL of 0.1 M HCl. The synthesis of the [⁶⁸Ga]Ga-FAPI-04 was performed using different concentrations of HEPES (1~2.5 M; 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid) in 3~10 minutes; amounts of FAPI-04 precursor (5~50 ㎍) and reaction temperature (25℃~100℃) were optimized on the BIKBox^® synthesizer. The labeling efficiency of [⁶⁸Ga]Ga-FAPI-04 was greater than 96% (decay corrected) using 25 ㎍ FAPI-04 synthesized in 10 minutes at 100℃ in 2 M HEPES (pH 3.85), and its stability was greater than 99% at 6 hours. The total synthesis time of [⁶⁸Ga]Ga-FAPI-04 was 32.4 minutes, and the product met all quality control criteria. In this study, we developed and optimized a labeling method using [⁶⁸Ga]Ga-FAPI-04 using a cassette-based synthesizer. The devised method is expected to be useful for supplying [⁶⁸Ga]Ga-FAPI-04 for diagnosis in clinical practice.

• Journal of Navigation and Port Research
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• v.47 no.4
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• pp.220-230
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• 2023

Aids to Navigation (AtoN) is an important tool for safe navigation, and the variety of information provided by AtoN is invaluable. The demand for standardized AtoN information for efficient utilization is gradually increasing, and for this purpose, the International Association of Lighthouse Authorities (IALA) has developed S-201, a standard for the management of AtoN information, and recommends its application to member countries. Notably, since Korea defines AtoNs and manages the information according to the Aids to Navigation Act, the need for definition and information management according to the S-201 standard, an international standard, is even greater. Therefore, in this study, according to the recommendation of IALA, we aimed to suggest a way to manage AtoN information by applying the S-201 standard. To this end, after comparing the classification criteria of the AtoN information of the IALA, and that of Korea's classification standards, Korea's AtoN information management plan applying the S-201 standard was presented. The results of this study provide important basic data for managing standardized digital AtoN information that is easy to use worldwide.

• Journal of Korean Society for Geospatial Information Science
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• v.6 no.2 s.12
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• pp.35-44
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• 1998

Road guide sign is one of important traffic facility, which guides a driver a direction to go. A road is being newly built and/or an existing road can be temporarily closed very often at metropolitan area. Such information has to be linked to a road guide sign and to be updated in time. Otherwise, it might cause not only confusion to a driver but also traffic accident and/or traffic congestion. However, road guide signs are not properly managed at this time since the amounts of information are huge and they are being managed through paper maps manually. A decision-making framework has been developed to manage a variety of information of road guide signs based on the concept of GIS(Geographic Information Systems). Especially, it is designed on the fact that the existing national digital base maps under the NGIS(National Geographic Information Systems) program can be utilized. This framework has several functions such as the manipulation of statistics, landmark linkages along the selected traffic corridor and automatic design of signboard's content. This system is applied to the Kangnam district in Seoul Metropolitan area (SMA) for a case study.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2009.06a
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• pp.519-524
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• 2009

해양교통안전시설인 부표류에 대한 효율적인 관리 운영 방안을 마련하여 국제 기준 이상의 항로표지 운영률을 제고함으로서 통항 선박의 안전을 확보하는 데 목적이 있다.

• 한국공간정보시스템학회:학술대회논문집
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• 2005.05a
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• pp.47-52
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• 2005

본 논문에서는 4S-Van에 의하여 수집된 동영상으로부터 공간정보, 특히 도로 표지판을 구축하고 갱신할 수 있는 변화탐지 기술에 대하여 소개한다. 4S-Van은 차량의 위치/자세정보와 영상을 동기화하여 취득하고 이로부터 공간객체의 위치정보를 구축하는 시스템이다. 4S-Van에서 취득한 영상으로부터 표지판을 구축하고 갱신하는 작업은 수동 입력에 의한 많은 시간을 필요로 하며, 본 논문에서는 이를 해결하기 위하여 영상으로부터 표지판 정보를 구축 및 갱신할 때 수동 입력을 최소화하기 위한 방법을 제안하고 시스템을 구축한 결과를 제시한다. 4S-Van 데이터로부터 객체의 위치를 결정하는 사진측량기술과 영상처리기술을 결합하여 공간객체를 인식할 수 있는 기술을 제안하였으며, 새로 취득된 동영상에서 객체의 변화를 탐지함으로써 해당객체의 정보만을 새로 구축할 수 있도록 하였다. 개발된 시스템은 표지판 정보의 효율적 구축과 갱신을 지원할 수 있다.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.2
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• pp.100-109
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• 2008

Traffic accidents at night occur more than any other time because of improper road light facility and delineators. Therefore, cost-effective criteria of installing delineators are needed instead of expensive road light facility, especially, on rural road including light volume of traffic. This paper presents the criteria of installing 'Chevron Alignment Sign' considering driver's visual behavior characteristics and 'Raised Pavement Marker' considering critical encroachment angie of both straight section and curve one in order to reduce both the number of accidents on curve sections and the number of road encroachment accidents, respectively. The characteristics of visual behaviors can be expressed by visual angle involving curve radius and intersection angle. The estimated installing angles are $1^{\circ}{\sim}2.5^{\circ}$ by radii, which is based on changes in sensitivity across visual field by exogenous attention. Also, the raised pavement marker is installed every 2m, 3m, and 4m considering critical encroachment angles by radii.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2010.04a
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• pp.143-144
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• 2010

Recently, IALA has introduced AIS AtoN and standardized Aids to Navigation communication system and the World-wide IALA-Net has announced plans to build the system. Systematic beacon network may offer opportunities to make infrastructure for information service and upgrade AtoN service performance. This paper proposes Aids to Navigation information service network for e-NAV. Network based on AIS is consist of AIS AtoN channels as Real, Synthetic or Virtual AIS AtoN. And inner network is consist of Wireless networks as AIS, WCDMA, WIFI, WlBRO, USN or VSAT. Introducing of various network systems can lead to combine and design among land, beacon and service network infrastructures.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.3D
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• pp.199-204
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• 2010

The purpose of this study is to estimate the effectiveness of newly proposed guide sign system. Existing guide sign system on expressways in South Korea have point-based system with city, district names or land marks. They have also several problems as excessive amount of information, low use of exit number, and lack of lane designation arrows. Efficiency of existing guide sign system is deteriorated from these problems. The enhanced guide sign system is proposed to alleviate problems. The best alternative sign system is chosen from three different designs with preference survey and human factors evaluation. The new signs showed reduced time compared to existing signs with statical significance. The existing sign system conveys more information in farther distance and less information in nearer distance. Nevertheless new systems imparts more information i nearer distance. It is also suggested that lane designation signs should be established with overhead installation at 0m point for efficient direction choice.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2019.11a
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• pp.59-61
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• 2019

In unmanned lighthouse unmanned construction, it is necessary to establish a standardized system for efficient management and operation, and RTU standard protocols for condition monitoring and control are used to efficiently manage rotary lighters as the management system for the most important lighthouses. It is enacted to ensure the safety of maritime traffic through efficient management.

• The Korean Journal of Nuclear Medicine
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• v.36 no.2
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• pp.102-109
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• 2002

Purpose : In gene therapy, tumor cells expressing the herpes simplex virus thymidine kinase are sensitive to prodrugs. Potential prodrugs IVDU and IVFRU were synthesized and radiolabeled with radioiodine for noninvasive imaging of herpes simplex virus type 1 gene expression. Material and Methods : 5-(2-trimethysilyl) vinyl-2'-deoxyuridine and 5-(2-trimethylsilyl)vinyl-2'-fluoro-2'-deoxyuridine, precursors of 5-(2--iodo)viny l-2'-deoxy uridine(IVDU) and 5-(2-iodo)-2'-vinyl-2'-deoxy-2'-fluororibofuranosyl uracil(IVFRU), were synthesized from reaction of trans-1-trimethylsillyl-2-tri-n-butylstannylethylene with 5-iodo-2'-deoxyuridine and 5-iodo-2'-fluoro-2'-deoxyuridine, respectively, on the condition of Pd catalyst. These precursors were separated from reaction mixture by silica gel column chromatography method. Each precursor was radioiodinated with radioiodine by mixing with ICI oxidizing agent. These radioiodinated compounds were purified with HPLC. Radiohalogen exchange has been shown to be effective for the synthesis of products with lower specific activity. Similarly, carrier-added and high specific activity products have been isolated in respectable radiochemical yields using ICI method. Results : Synthetic yield of precursors, IVDU and IVFRU were 43% and 18%, respectively. Radiochemical purity of both compunds was over 98%. Conclusion : We synthesized precursors of IVDU and IVFRU for monitoring of HSV1-tk gene expression. Radiotracers were radioiodinated with high radiolabeling yield by ICI method.