• Journal of Korean Society of Forest Science
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• v.98 no.1
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• pp.1-7
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• 2009

We investigated the genetic variation and structure in Korean Arborvitae (Thuja koraiensis Nak.), by 29 examining I-SSR polymorphic loci in 84 individuals distributed among four natural populations in Korea. The level of population genetic diversity ($A_e$=1.44, P=72.42, $H_e$=0.258, S.I.=0.385) was similar to or slightly higher than that of plants with similar ecological traits and life history (Cupressaceae). Most genetic diversity was allocated among individuals within populations (${\Phi}_{ST}$=0.13). The UPGMA dendrogram based on genetic distance failed in showing decisive geographic relationship. The Mt. Bangtae population had the lowest level of genetic diversity and was the most distinctive from the other populations. Mt. Jang population which is possessed of the highest level of genetic variation and Mt. Bangtae population which is consisted of heterogeneous was considered to be a prime candidate for the conservation studies.

• Journal of Life Science
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• v.17 no.3 s.83
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• pp.402-406
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• 2007

This study was performed to develop the molecular marker for sex determination of hare (Lepus coreanus) distributed in Korea which focused on sexual dimorphism between X and Y chromosomal homologous genes, zinc finger-X (ZFX) and -Y (ZFY). The intron 7 regions of ZFX and ZFY genes exhibited differential amplification patterns between male and female hares. The lengths of intron 7 region of ZFX and ZFY genes were 538 and 233-bp, respectively. Especially, the ZFX intron 7 contained a repetitive sequence identified as member of RNA-mediated transposable elements which was similar to CSINE2 commonly found in the rabbit genome. However, it was not present in intron 7 of ZFY gene. The molecular sex typing by polymerase chain reaction (PCR) was also carried out to determine the sex of hare based on difference in lengths between the intron 7 regions of ZFX and ZFY genes. All DNA samples tested had common band amplified from ZFX. However, the male hare DNAs had two distinct bands which amplified from ZFX and ZFY genes, respectively. The results from ZFX-ZFY PCR sex typing were identical to those from phenotypic investigation and from amplification patterns using male-specific sex determining region Y (SRY) gene as well. Finally, this study suggested that the sexual dimorphism between intron 7 regions of ZFX and ZFY could be useful genetic marker to determine sex of hare.

• Journal of the Korean Society of Radiology
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• v.16 no.3
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• pp.309-317
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• 2022

It is reported that social distancing caused by the corona pandemic has resulted in a decrease in physical activity, and a decrease in muscle mass due to this increases the risk of vascular disease. Therefore, in this study, the risk of carotid intima media thickness was evaluated by measuring the thickness of CIMT, and the differences in variables according to gender were analyzed. From January 2022 to May 2022, a total of 220 people (121 males, 99 females) who performed blood tests, carotid ultrasound, and body composition analysis among those who visited the health check-up center of Busan H Hospital were included in this study. Significant differences in risk factors according to gender were analyzed using the chi-square test. The cut-off values of variables that can predict the risk of carotid intima media thickness were calculated, and the accuracy was evaluated by calculating the area under the curve, sensitivity, and specificity. As a result of the difference analysis, the higher the total cholesterol in men and the appendicular skeletal muscle index in women, the higher the risk of carotid intima media thickness. The cut-off value for predicting the risk of carotid intima media thickness was calculated to be greater than 199 mg/dL of total cholesterol in the male group and less than 5.9 kg/m² of the appendicular skeletal muscle index in the female group. As a result of this study, the higher the total cholesterol in men and the lower the appendicular skeletal muscle index in women, the higher the risk of increased CIMT. Therefore, in women, the appendicular skeletal muscle index is expected to serve as an indicator to predict and prevent vascular changes at an early stage.

• International Journal of Highway Engineering
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• v.12 no.4
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• pp.197-202
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• 2010

Post release mechanism is generally used to reduce the severity of the occupant of an errant vehicle impacting a roadside posts. The 820kg-50km/h head-on impact simulations were made using LS-DYNA program for the posts of 101.6mm Dia(t=4.0mm) with and without clip-type release mechanism. The simulation result was compared with impact test result to enhance the credibility of simulation model. The study shows that the high impact severity (THIV, PHD) and excessive deformation threatens the safety of the occupant when a car impacts a rigidly connected posts, while a post with clip-type slip base reduce the impact severity to a safe level.

• Development and Reproduction
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• v.9 no.2
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• pp.65-83
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• 2005

The three important phases in the development of ligand immunoassays are identified and summarized. The competitive radiolabelled hormone measurement had been developed in the first and early in the second generations(1950s to 1960s), such as radioimmunoassays(RIA) or immunoradiometric(saturation) assays(IRMA), and used in all most of the hormone and also analyte in biological samples. In the second generation, ultrasensitive non-isotopic immunoassays(NIA) were developed using monoclonal antibodies(McAb), labelling the McAb and high specific activity non-isotopic labels. After their usefulness, advantages and disadvantages has been evaluated and non-competitive methods are discussed. The chip/microarray based multianalyte ligand assays(microspot or genechip methods) are developed and known as alternative ones in the third generation. We summarize the developments of NIAs and its usefulness, and then introduce briefly the new ligand assays.

• Journal of Korean Society of Transportation
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• v.26 no.6
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• pp.71-80
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• 2008

Typically uncontrolled intersections are characterized by the absence of signal, stop and yield sign, and by very light traffic volume. In this study, a gap acceptance model for such uncontrolled intersections has been modeled. The motivation is to identify the behavior of drivers so that the traffic flow phenomena can be easily understood. For this, actual traffic survey was accomplished at intersections in Suwon and the data have been fed into modeling process. The logit model was used and the results showed that total delay experienced by drivers, turning right movement, age, sex, and the existence of passenger affected gap acceptance. For example, male drivers, with experiencing longer delay and having passenger(s) with them, accepted shorter gaps. These identified characteristics regarding gap acceptance could be used for facility design and/or safety oriented traffic information dissemination near uncontrolled intersections.

• Proceedings of the KOR-KST Conference
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• 1998.10a
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• pp.161-170
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• 1998

기존에 건설된 교통시설의 운영효율을 극대화하기 위한 지능형 교통체계의 한 분야인 ATIS는 도로를 이용하는 통행자에게 편리성을 제공하는 동시에 도로를 효율적으로 운영할 수 있는 정보체계이다. ATIS 체계하에서 통행자에게 신뢰성 있는 정보를 제공하기 위해서는 교차로서의 회전에 의한 지체를 정확하게 반영함은 물론이고 실시간으로 변화하는 교통상황을 반영할 수 있는 동적인 최단경로 탐색 알고리즘이 요구된다. 하지만 기존에 발표된 동적인 최단경로 탐색 알고리즘은 회전에 대한 정보를 반영하지 못하며 정적인 최단경로 탐색 알고리즘은 회전에 대한 정보를 반영하지 못하며 정적인 탐색알고리즘 조차 회전에 대한 정보를 정확히 반영하지 못한다. 본 연구에서는 이러한 이유에서 알고리즘 내부에서 회전을 반영하기 위해 수정형 덩굴망 알고리즘의 표지기법을 이용하여 동적인 최단경로 탐색알고리즘을 개발하였다. 본 연구에서 개발한 동적 최단경로 탐색 알고리즘은 정적인 상태의 수정형 덩굴망 알고리즘에 시간에 따라 변화하는 교통상황을 반영하기 위해 시간에 대한 변수를 추가하였다. 이렇게 해서 알고리즘은 시간대별로 변화하는 통행시간을 고려하여 최단 경로를 탐색하게 되며 출발시점을 기준으로 표지를 설정하여 모든 앞선 시간에 대해 경로를 고려하도록 하였다. 매 단계에서 전 노드를 추적하여 회전에 관한 정보를 반영하도록 하였다. 따라서 본 연구에서 개발한 최단경로 탐색 알고리즘은 교차로에서의 회전에 대한 정보와 통행금지 등을 정확히 반영하며 실시간으로 변화하는 통행시간을 반영함으로써 신뢰성 있는 노선 정보를 ATIS를 이용하는 통행자들에게 제공하는데 활용될 수 있는 기법이다.적으로 세부적 차종분류로 접근한다.의 영향들을 고려함으로써 가로망 설계 과정에서 가로망의 상반된 역할인 이동성과 접근성의 비교가 가능한 보다 현실적인 가로망 설계 모형을 구축하고자 한다. 지금까지 소개된 가로망 설계모형들은 용량변화에 대한 설계변수의 형태에 따라 이산적 가로망 설계 모형과 연속적 가로망 설계모형으로 나뉘어지게 된다. 본 논문의 경우, 계산속도의 향상 측면에서는 연속적 가로망 설계 모형을 도입할 수 있지만, 이때 요구되는 도로용량이 이산적인 변수(차선 수)로 결정되어야만 신호제어 변수를 결정할 수 있기 때문에, 이산적 가로망 설계 모형이 사용된다. 하지만, 이산적 설계모형의 경우 조합최적화 문제이므로 정확한 최적해를 구하기 위해서는 상당한 시간이 소요되며, 경우에 따라서는 국부 최적해에 빠지게 된다. 이러한 문제를 극복하기 위해, 우선 이상적 모형의 근사화, 혹은 조합최적화문제를 위해 개발된 Simulated Annealing기법의 적용, 연속적 모형의 변수를 이산화하는 방법 등 다양한 모형들을 고려해 본 뒤, 적절한 모형을 적용할 것이다. 가로망 설계 모형에서 신호제어를 고려하기 위해서는 주어진 가로망에 대한 통행 배정과정에서 고려되는 통행시간을 링크통행시간과 교차로 지체시간을 동시에 고려해야 하는데, 이러한 문제의 해결을 위해서 최근 활발히 논의되고 있는 교차로에서의 신호제어에 대응하는 통행배정 모형을 도입하여 고려하고자 한다. 이를 위해서 지금까지 연구되어온 Global Solution Approach와 Iterative Approach를 비교, 검토한 뒤 모형에 보다 알맞은 방법을 선택한다. 차량의 교차로 통행을 고려하는 perf

• Biomedical Science Letters
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• v.1 no.1
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• pp.27-35
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• 1995

Several studies showed that the immunological factors such as CD4+ cell number, CD4%, CD8+ cell number and CD4/CD8 ratio and the serological factors such as, ${\beta}^2$-microglobulin(${\beta}^2$-MG), neopterin, soluble CD4, and soluble CD8 are related to the risk of development of AIDS. Especially, the CD4+ cell counts have been used to monitor progresson of HIV disease, to stratify, and to follow patients in clinical trials. Recently, the Centers for Disease Control and Prevention(CDCP) in USA has made the CD4+ cell count as a part of the classification of HIV disease. It is composed of 3 categories such as 1, 2, and 3 which asr $\geq$ 500/$mm^3$, 200/$mm^{3} $\geq$ and < 500/$mm^3$, and < 200/$mm^3$, respectively. In this study, to estimate the differences of immunological factors between HIV-infected and normal human groups in Korea, CD4+ T and CD8+ T cells, and the CD4/CD8 ratio were measured in 185 HIV-infected subjects and 140 healthy adult subjects. The lymphocyte subsets such as CD4+ T and CD8+ T were analysed by flow cytometer(FACStar) with two-color immunofluorescent stain using monoclonal antibodies such as anti-CD4 and anti-CD8 antibodies. The absolute numbers and percentages of CD4+ T and CD8+ T and the CD4/CD8 ratio of HIV infected persons were $462\pm{277}/mm^3$, $18.2\pm7.7%$, $1,170\pm{534}/mm^3$, $47.0\pm10.6%$ and $0,43\pm0.26 whereas those of uninfected persons were $886\pm{299}mm^3$, $32.9\pm{7.0%}, 730{\pm}259/mm^3$, $26.8\pm6.4%$ and $1.31\pm0.46$(P<0.01). In addition, estimating the reference values of peripheral blood lymphocyte subsets of Korean, the absolute numbers and percentages of CD4+ T and CD8+ T and the CD4/CD8 ratio of 140 healthy adults persons were measured and compared with those of foreigners. The reference ranges of CD4+ T cells, CD8+ T cells, CD4％, CD8%, and the CD4/CD8 ratio and 1.31$\pm$0.46, respectively. The significant differences were not observed when compared with those of foreigners. However a little difference was observed in the percentages of CD4+ T and the absolute numbers of CD8+ T between the normal values of Korean and those of foreigners were $43.6\pm8.9%$, $560\pm{230}/mm^3$. This result can also be useful as a basic data for the treatment and surveillance of HIV-infected patients in Korea.

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2008.10a
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• pp.299-300
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• 2008

• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2003.05a
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• pp.121-128
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• 2003

화재가 발생했을 때 많은 사람이 연기에 질식하여 사망하는 피해가 거의 해마다 일어나고 있다. 특히 올해 2월18일 190여명이 사망한 대구 지하철 중앙로역 화재참사에서는 다량의 유독성 가스를 효과적으로 배출하지 못해 더 많은 사망자가 발생하였다. 당시 지하철역에는 화재가 발생하면 환기용 배기장치가 급기장치로 전환되는 급기방식의 제연설비가 설치되어 있었고, 시계 불량으로 피난 표지판과 유도등이 잘 보이지 않은 것으로 밝혀졌다.(중략)