• Journal of Acupuncture Research
• /
• v.22 no.3
• /
• pp.227-241
• /
• 2005

Objective & Methods : The purpose of this study is to observe the effects of Asari Herba Cum Radice herbal-acupuncture solution(AHCR-HAS) on arthritis of mice induced by Collagen II at Joksamni(ST36). The author performed several experimental items. First, it is the cell survival rate of mice lung fibroblasts and expression of TNF-${\alpha}$ in synovial cells. Second, it is the incidence rate of arthritis and the weight of spleen. Third, it is the levels of IL-6, TNF-${\alpha}$, INF-${\gamma}$, IgG, IgM and anti-collagen II in serum Fourth, it is histological analysis of the mice joint. Fifth, it is expression ratio of CD3e+ to CDl9+ cell, CD4+ to CD8+ cell, CD69+/CD3e+ cells, CD11+/CD19+ cells and CD11b+/Gr-1+ cells. Result : 1. The highest survival rate of mice lung fibroblasts were measured in the 1% AHCR-HAS, and the expression of TNF-${\alpha}$ in synovial cells were significantly decreased in the 1% AHCR-HAS. 2. In the AHCR-HA I & AHCR-HAII groups, the incidence of arthritis and the weight of spleen were significantly decreased. 3. In AHCR-HAI & AHCR-HAII groups, the levels of IL-6, INF-${\gamma}$, TNF-${\alpha}$, IgG, IgM and anti-collagen II in serum of CIA mice were significantly decreased. 4. In histology, the cartilage destruction and synovial cell proliferation were decreased in the AHCR-HA I & AHCR-HAII groups, and the collagen fiber expressions in the AHCR-HA I & AHCR-HAII groups were similar with that of the Normal group. 5. In the AHCR-HA I & AHCR-HA II groups, the expression ratio of CD3e+ to CD19+ cell and CD4+ to CD8+ cell were similarly maintained as Normal group in lymph nodes, and CD69+/CD3e+ cells and CD11a+/CD19+ cells were decreased in Iymph nodes, and CD11b+/Gr-1+ cells were decreased in synovium. Conclusion : Taking all these observations into account, AHCR-HA is considered to be effective in prophylaxis and treatment of rheumatoid arthritis, and then more effective in prophylaxis than treatment, so put to practical use in future rheumatoid arthritis clinic.

• Journal of Korean Medicine Rehabilitation
• /
• v.20 no.1
• /
• pp.141-152
• /
• 2010

Objectives : The purpose of this study is to compare with the effect of acupuncture treatment with or without indirect moxibustion treatment for acute ankle sprain. Methods : This study was carried out on the 48 patients who had been treated for acute ankle sprain from June 1st to November 30th 2009 in the Dept. of Oriental Rehabilitation, Pohang Oriental Medical Hospital, Daegu Hanny University. The patients were divided into 3 groups ; Group A took near acupuncture point_needling, Group B took remote acupuncture point needling, Group C took remote acupuncture point needling with indirect moxibustion. 3 Groups had been co-treated with rest, ice, compression and elevation(RICE) therapy, physical treatment and administered Ojeok-san(Wuji-san) extract granule. To evaluating the efficiency of each treatment, Ankle-Hindfoot Scale(AHS) and Visual Analogue Scale(VAS) were applied before treatment and after 3rd treatment. Results : In results, the AHS scores were increased and the VAS scores were decreased after 3rd treatment in all group. Also, AHS scores and the VAS scores of intergroup were showed no significant change. Conclusions : In this study, there is no significant effect between only acupuncture treatment and moxibustion co-treatment for acute ankle sprain.

• Journal of Acupuncture Research
• /
• v.28 no.6
• /
• pp.85-91
• /
• 2011

Objectives : The purpose of this study was to evaluate the clinical effect of indirect moxibustion treatment for patients with neck pain caused by whiplash injury. Methods : From October 2010 to October 2011, 85 patients with neck pain caused by whiplash injury who admitted to Semyung oriental medical hospital were divided into two groups. Group A was treated by general acupuncture, group B by indirect moxibustion and general acupuncture. The efficacy of treatment was measured by visual analog scale(VAS) scores and neck disability index(NDI) scores of before and after 5 days to start treatment. Results : 1. Both group A and B represented effective improvement in VAS and NDI of neck pain caused by whiplash injury. 2. Group B has more statistical effect than group A. Conclusions : Through this research, indirect moxibustion treatment is considered to be effective reducing pain for patients with neck pain caused by whiplash injury.

• Journal of Acupuncture Research
• /
• v.28 no.1
• /
• pp.85-92
• /
• 2011

Objectives : The purpose of this research was to compare remote and near acupuncture point needling with near acupuncture point needling acupuncture on posterior neck pain treatment. Methods : We divided 36 patients with posterior neck pain patient into two groups and treated Group A with near acupuncture and remote acupuncture point needling and Group B with near acupuncture point needling. The efficacy of treatment was measured by VAS scores and NDI scores of before and after 5 days to start treatment. Results : Both group A and B represented effective improvement in VAS and NDI of neck pain. And group A is more effective than B group statistically. Conclusions : It was suggested that near acupuncture and remote acupuncture point needling might have more effect compared with near acupuncture point needling acupuncture on posterior neck pain treatment.

• Science of Emotion and Sensibility
• /
• v.13 no.3
• /
• pp.551-558
• /
• 2010

Pain is very complex and multi-level experience that should be objective or subjective. Acupuncture is a traditional method to heal the pain and have been based on meridian theory. There have been many clinical evidences showing the pain-relieving effect of acupuncture but science-based understanding of it was poor. Furthermore in daily life, we feel huge gap between the source of pain and pain control by acupuncture stimulation. However, the underlying connection between pain control and acupuncture stimulation has been reported in many recent reports. In this paper, we briefly introduce the brain imaging techniques (functional magnetic resonance images, positron emission tomography, electroencephalograph, and magnetoencephalography) and review researches in pain and acupuncture. Through this, the brain areas that activated by pain and acupuncture will be verified, and compared each other regarding their specificity and similarity. In addition, detailed understanding of brain function which is related to pain and acupuncture analgesia through brain imaging techniques will be discussed.

• Journal of Acupuncture Research
• /
• v.27 no.3
• /
• pp.1-13
• /
• 2010

목적 : 이 연구는 봉약침의 봉독과 그 주요성분인 멜리틴이 NF-${\kappa}B$의 활성억제와 세포자멸사 관련 단백질의 발현 조절을 통하여 세포자멸사를 유도함으로써 전립선 암세포주인 PC-3 세포의 성장을 억제하는지를 확인하고 해당 기전을 살펴보고자 하였다. 방법 : 봉독이나 멜리틴을 처리한 후 PC-3의 성장억제를 관찰하기 위해 WST-1 assay, CCK-8 assay를 시행하였고, 세포자멸사 조절단백질의 변동 관찰에는 western blot analysis를 시행하였고, 세포자멸사와 연관된 NF-${\kappa}B$의 활성 변화를 관찰하기 위해 EMSA를 시행하였으며, PC-3에서 봉독이나 멜리틴과 NF-${\kappa}B$의 상호작용을 관찰하기 위해 transient transfection assay를 시행하여 세포생존율과 NF-${\kappa}B$의 활성 변동을 측정하였다. 결과 : PC-3 세포에 봉독이나 멜리틴을 처리한 후, 전립선암세포의 성장, 세포자멸사의 유발, 세포자멸사 관련 단백질의 발현, NF-${\kappa}B$의 활성, NF-${\kappa}B$의 p50, $IKK{\alpha}$, $IKK{\beta}$ 치환 후 NF-${\kappa}B$의 활성과 PC-3 세포 증식에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. PC-3 세포에서 봉독이나 멜리틴을 처리한 후 세포자멸사가 유도되어 세포성장이 억제되었고, 세포자멸사 관련 단백질 중 분리된 PARP, caspase-3, -9는 유의한 증가를, Bcl-2, XIAP, cXIAP2는 유의한 감소를 나타내었다. 2. PC-3 세포에서 봉독이나 멜리틴을 처리한 후 NF-${\kappa}B$의 활성은 유의한 감소를 나타내었다. 3. PC-3 세포에서 NF-${\kappa}B$의 p50, $IKK{\alpha}$, $IKK{\beta}$를 치환하여 작용기를 없애고 봉독이나 멜리틴을 처리하였을 경우에도 NF-${\kappa}B$의 활성이 유의한 감소를 나타내었다. 결론 : 이상의 결과는 봉독이나 멜리틴이 NF-${\kappa}B$의 활성 억제를 통하여 인간 전립선암세포주인 PC-3의 세포자멸사를 유발함으로써 증식억제 효과가 있음을 입증한 것으로, 전립선암의 예방과 치료에 대한 효과적인 치료제 개발에 도움이 될 것으로 기대된다.

• Journal of Acupuncture Research
• /
• v.28 no.2
• /
• pp.43-47
• /
• 2011

Objectives : The purpose of this study is to investigate the effectiveness of treating low back pain patients with Wan-Gwa acupuncture. Methods : Clinical study was conducted to 42 patients who were treated in Dept. of Acupuncture and Moxibusion, Woosuk University Hospital from March 1 to December 31, 2010. Subject were randomly divided into two groups. In one group(control group), patients were treated with acupuncture. And in the other group(test group), patients were treated with both acupuncture and Wan-Gwa acupuncture. To estimate the efficacy of treatments, visual analog scale(VAS) and Oswestry disability index(ODI) were checked. 13 patients were excluded and we investigated 14 patients of control group and 15 patients of test group entirely. Results : 1. In both two groups, VAS and ODI of patients were decreased significantly in the statistics 2. In test group, ODI of patients were decreased more significantly in the statistics than ODI of patients in control group. Conclusions : We suggest that cotreatment of acupuncture and Wan-Gwa acupuncture on low back pain patients can be recommended as a useful therapy.

• Journal of Acupuncture Research
• /
• v.27 no.6
• /
• pp.101-109
• /
• 2010

Objectives : This study was to compare effects of scalp acupuncture with usual acupuncture on peripheral facial palsy in comparison with usual acupuncture only. Methods : We investigated 40 cases of patients with peripheral facial palsy, and devided patients into two groups: We treated one group by scalp acupuncture with usual acupuncture and did the other group by usual acupuncture only. To evaluate the effectiveness of treatment applied for two groups, we used Gross Grading System of House-Brackmann(H-B grade), Yanagihara's Unweighed Grading System(Y system). Results : 1. In H-B grade group B(common acupuncture therapy and scalp acupuncture)'s score was reduced than group A(common acupuncture therapy), but there was no statistical significance. 2. In Y-system group B was higher than group A, but there was no statistical significance. Conclusions : There was no stastical significance between two groups : treated by scalp acupuncture with usual acupuncture and usual acupuncture therapy only, on peripheral facial palsy.

• Journal of Korean Physical Therapy Science
• /
• v.8 no.1
• /
• pp.907-915
• /
• 2001

The purpose of this study is to effectively treat low back pain for the out patients who have been treated at the oriental hospital. Sorting the low back pain patients into four types based on scapular and ilium tilting hyper/hypo mobility characteristics, it has used several kinds of acupuncture stimuli on the 4 motor points of limb skeletal muscles, analyzing the acupuncture treatment on the 12 acupuncture points with which oriental hospitals has given to the low back pain patients and comparing with this effect. It has been analyzed how effectively the acupuncture stimuli has been contributed to the low back pain patients who suffered from skeletal muscles of spinal limb thorax abdominal and spinal skeletal system. The results are as follows. 1. There has been changes after treatment in both the control and experimental groups for low back pain patients, but the latter has been more increased in changes than the former. 2. There were much effects on the balanced restorations for spinal skeletal muscle in both the control group and experimental one, but on terms of restoration degree, the degree of the experimental group was higher than that of the control group. 3. Both the contrastive treatment and the experimental one have been contributed to the balanced restoration for all of the limb thorax abdominal muscles, but there were a few differences in terms of the way for restoration and the effects for improvement according to body types. 4. On both the control and the experimental group, spinal skeletal system has been restored with balance, but the experimental group has been higher effective on the balanced restoration than the one of the control group. Considering these results both the control and the experimental treatments have been contributed to the balanced restorations for all of low back pain patients who were suffering from skeletal muscles of spinal limb thorax abdominal and spinal skeletal system, but the contribution degree for the experimental group has been higher than that of the control group.

• Journal of Acupuncture Research
• /
• v.21 no.1
• /
• pp.149-158
• /
• 2004

Objective: Herniation of Nucleus Pulpous(HNP) of L-spine is the most important reason that causes low back pain. The aim of this study is to investigate the effectiveness of Bee venom acua-acupuncture therapy for HNP. Methods: We divided HNP patient into 2 groups: Control group with acupuncture therapy only, and Experimental group with both acupuncture and bee venom acua-acupuncture therapy. To estimate the efficacy of treatment that applied for two groups, we used visual analog scale(VAS) and Oswestry disability index(ODI). We compared the VAS and ODI score of two groups statistically. Results & Conclusions: 1. In VAS, experimental group shows statitically significant improvement rate, but control group does not show statistical significance. 2. In ODI, both the experimental and control group shows statistically significant improvement. 3. By comparing the experimental and control group, there was more significant improvement in experimental group than control group of VAS and ODI. As a result, bee venom acua-acupuncture therapy can be used with acupuncture therapy for highly effective treatment for HNP.