• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.6 no.1
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• pp.116-122
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• 1995

목적 : 다음과 같은 fluoxetine으로 유발된 조증 증례를 보고한다. 이와 함께 fluoxetine사용이후 보고된 조증 증례보고를 모아서 정리하고 함께 문헌고찰을 하였다. 증례요약 : 가족력상 기분장애의 병력이 없었으며, 다른 주요 정신과적 질환의 병력은 없었다. 환아는 개인력상 5세경에 주의력 결핍, 과잉행동의 양상을 보였던 병력이 있었고, 13세때에 피해 망상, 환청이 지속되어 haloperidol로 치료받기 시작하였다. 이후 피해 망상의 내용을 언급하거나 환청에 영향받는 행동은 없어졌고 간혹 우울감을 호소하였다. 이후 정신분열증의 진단 하에 haloperidol만으로 3년간 유지하였다. 1994년 환아는 18세때 고3이 되면서 대입에 대한 걱정과 신체적인 허약감을 자주 호소하며, 우울증상이 두드려져 fluoxetine 20mg를 3일간 투여하던 중 갑자기 조증의 임상적 양상을 보이기 시작하여 본원의 입원치료를 받게 되었는데, 입원당시 보인 임상양상은 앙양된 기분, 이자극성(irritability), 사고의 비약, 연상의 이완과 지리멸렬, 과대망상, 피해망상, 관계망상, 환청 등이었고 사람, 장소, 시간에 대한 지남력까지 일시적으로 상실되는 심헌 정신병적 조증상태였다. 토의 : fluoxetine 사용이후 현재까지 세계적으로 문헌상 보고된 14개의 증례보고를 모아서 정리하였다. fluoxetine-induced mania의 병태생리학적인 기전은 명확하지 않지만 가능한 기전에 대해 토론하였다. 이 약물의 중대한 부작용중의 하나인 조증을 예방하기 위해, 이 약물을 다루는 의사는 가능한 조증 발병의 위험인자들에 대하여 인식하고, 약물의 용량조절시에도 주의를 하여야 한다. 가능한 발병 위험인자들에 관해서도 검토하였다.

• Journal of Sasang Constitutional Medicine
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• v.27 no.1
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• pp.171-177
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• 2015

Objectives The purpose of this study is to give an account of the effects of the Traditional Korean herbal medicine therapy which is based on the Sasang constitutional medicine on psoriasis Methods We diagnosed her as Soyangin(少陽人) based on her nature and emotion, physical chracteristics, symptoms. We thought Leaky Gut Syndrome is related to Soyangin Food Stagnation, stuffiness and fullness(食滯痞滿). So we applied Dokhwaljihwang-tang(獨活地黃湯) which is used to Soyangin Food Stagnation, stuffiness and fullness because her symptoms recurred as a result of Food Stagnation(食滯) after eating meat. The improvement of the skin condition was observed by Psoriasis Area and Severity Index (PASI) score Results Psoriasis patient who was treated with Soyangin Dokhwaljihwang-tang showed improvement in Psoriasis symptom. This case study describes the effectivenss on psoriasis symptoms by using Soyangin Dokhwaljihwang-tang. Conclusions The PASI score of the patient reduced from 10.8 to 1.2 after three months of treatment. According to the result, we concluded that Dokhwaljihwang-tang had a good effect on psoriasis.

• Korean Journal of Psychosomatic Medicine
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• v.24 no.2
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• pp.174-183
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• 2016

Objectives : The aim of this study is to evaluate difference of somatic symptoms of anxiety disorder and major depressive disorder and domainal association with suicidal idealization, plan, and attempts. Methods : A total of 359 adults diagnosed with major depressive disorder and anxiety disorder of last one year participated. Participants interviewed with certain sections of Korean version of Composite International Diagnostic interview of CIDI. Sections of interests includes questionnaires regarding somatic symptoms and suicidal idea, plan and attempts of last one year. Results : Chest pain shows more prevalence in major depressive disorder. Symptoms of Headache and loose stool are more prevalent in anxiety disorder. Difficulty in equilibrium and fainting spells are more common somatic complaints of co-diagnosis states of anxiety disorder and major depressive disorder. Comparing 3 domains of pain symptoms, gastrointestinal symptoms and pseudo-neurological symptoms, pain symptom domains, gastrointestinal symptoms domain shows significant statistic difference between diagnosis. Average somatic symptom numbers of each symptom domains increase through suicidal idealization, plan and attempt, accordingly. Conclusions : Our finding shows some of somatic symptoms are more prevalent at certain diagnosis. Since increasing numbers of somatic complaints of each symptom domains goes with the suicidal idealization to suicidal attempts, proper psychiatric evaluation and consultations are crucial for patients with numerous somatic complaints in non-psychiatric clinical settings.

• Tuberculosis and Respiratory Diseases
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• v.39 no.5
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• pp.392-399
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• 1992

Background: Despite dyspnea is a predominant complaint of patients with respiratory disease, the mechanisms contributing to the sensation of breathlessness are poorly understood. Traditionally, physicians have measured objective pulmonary function to assess severity of dyspnea. But it will be also useful to measure subjective dyspnea index because dyspnea probably depends on a complex interplay of mechanical, experimental, emotional and other factors. Method: We measured breathlessness at rest, after Methacholine challenge and then bronchodilator inhalation using a Visual Analogue Scale (VAS) and Borg Scale Dyspnea Index (BSDI) in stable asthmatic patients. Spirometry was performed concomittently. Results: There was no correlation between dyspnea index and FEV1. There was also no correlation between the change in dyspnea index and change in FEV1. The change in dyspnea index after methacholine and bronchodilator was greater in clinically mild asthmatic patients than clinically severe symptomatic group. Conclusion: In asthmatic patients, there was a wide variation in sensory response for any given FEV1, and the change in perception of dyspnea was greater in those with clinically mild symptoms. The measurement of dyspnea index may yield information complementary to that obtained by spirometry.

• Journal of agricultural medicine and community health
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• v.29 no.2
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• pp.265-285
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• 2004

Objectives: The acute toxic effects of pesticide are well known. Concern has also been expressed that long-term exposure may result in damage to the central nervous system. This study was conducted to test the hypothesis that central nervous system symptoms might occur due to pesticide exposure. Methods: In a cross-sectional study, first, cumulative exposure index (CEI) was estimated. Neurologic symptoms (Q-16 questionnaire) for 541 farmers (exposed to pesticides) were compared with 119 non-exposed persons in spraying season nine rural areas in Korea. Results: The pesticides poisoning rates for last 3 months were 67.2% for orchard farmers, 55.3%for dry field farmers, and 20.5% for husbandry farmers, respectively, showing significant difference (p<0.001). Compared with non-exposure group, exposure groups (especially, orchard farmers) reported significantly more neurologic symptoms and had a higher overall neurological symptoms score (p<0.001). Factors related to the positive neurological symptoms (answers "yes" to six or more of Q-16 questionnaire) adjusted for age, sex, education level, smoking and alcohol drinking were type of farming (OR 3.08, 95% CI 1.50-6.30 in orchard farmers vs non-exposure group), CEI (OR 2.75, 95% CI 1.12-6.78 in Q3 vs Q1), past poisoning (OR 1.97, 95% CI 1.21-3.20 vs normal), current mild poisoning (OR 3.03, 9500 CI 1.47-6.22 vs normal) and current moderate poisoning (OR 6.34, 95% CI 3.03-13.25 vs normal), respectively. Conclusions: These results suggest that long-term exposure to pesticides appears to be associated with subtle changes in the central nervous system.

• Journal of Korean Library and Information Science Society
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• v.42 no.4
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• pp.243-262
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• 2011

The aim of this study was to investigate musculo-skeletal symtoms and working conditions of university library's librarians to search for the risk factors related to musculo-skeletal symptoms. The study subjects were 266 librarians who were working at 20 university libraries. A self-recording questionnaire was used to investigate the general characteristics, working conditions, job intensity, job satisfaction and stress, education of musculoskeletal disorders and nature of musculoskeletal symptom. Statistical analysis was done by using t-test and multiple regression analysis. The complaint proportion of self-reported positive musculoskeletal symptoms was 62.5% and that of severe musculoskeletal symptoms was 26.1%. Multiple regression analysis showed that low satisfaction of working conditions, high job intensity, irregular mealtime, job stress were closely related to the positive rate of musculoskeletal symptoms. Therefore, it will be necessary to make efforts to reduce the prevalence of musculoskeletal disorders improving working conditions and mitigating the job intensity.

• Journal of Oral Medicine and Pain
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• v.26 no.4
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• pp.345-353
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• 2001

Thermography는 신체 체표면에서 발생되는 온도를 정량화하는 다양한 방법에 대한 일반적인 표현이다. Electrothermography는 의학분야에서 사용이 증가되고 있는 술식이다. 인체를 포함한 모든 물체는 적외선을 방출한다. 그래서, Wien의 법칙에 따르면, 방출되는 최대에너지에서의 주파수는 체온에 의존한다는 것을 알 수 있다. 따라서, 피부 표면에서 방출되는 적외선을 측정하는 것에 의해 온도가 측정될 수 있다. 최근에는, electrothermography가 만성 구강안면동통 환자의 진단에 있어서 새로운 진단 기기로서 각광을 받고 있다. 본 연구에서는 측두하악관절장애의 증상이 있는 교근, 측두근, 그리고 측두하악관절의 발통점의 피부 온도와 증상이 없는 대측의 피부 온도를 디지틀 적외선 체열 촬영으로 비교하고자 하였다. 측두하악관절장애를 주소로 하고 편측성의 구강안면동통을 호소하는 21명의 내원환자를 선택하였다. 디지틀적외선 체열촬영은 DTI-16-DOREX21(Dorex Inc., U.S.A) 기기를 사용하였다. 발통점 피부에 marker를 부착하고, 좌측과 우측의 color thermogram을 $0.1^{\circ}C$ 해상도로 측정하였다. 본 실험에서 측정한 발통점은 masseter inferior, masseter anterior, temporalis anterior 그리고 TMJ이었다. 증상이 있는 부위와 증상이 없는 대측의 피부온도 차이를 알아보기 위해 paired t-test를 사용하였으며, 실험 결과는 다음과 같다. 1. 급성 근육장애 환자에 있어서는 증상이 있는 부위와 증상이 없는 대측과의 피부온도 차이가 통계학적으로 유의한 차이가 있었다(p<0.0075). 2. 만성 근육장애 환자에 있어서는 증상이 있는 부위와 증상이 없는 대측과의 피부온도 차이가 통계학적으로 유의한 차이를 볼 수 없었다. 3. 측두하악관절 내장증 환자에 있어서는 증상이 있는 부위와 증상이 없는 대측과의 피부온도 차이가 통계학적으로 유의한 차이를 볼 수 없었다. 결론적으로 적외선 체열촬영은 급성저작근장애의 진단에 있어서 유용한 진단방법의 한가지로 사료되며, 앞으로 임상적으로 더욱더 심화된 연구가 필요할 것으로 사료된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.1928-1936
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• 2015

This study is to identify the related factors of musculoskeletal symptoms in university hospital workers. The subjects were 313 workers who were working at a university hospital. The data was analyzed by descriptive statistics, logistic regretion using the SPSS/PC 21.0 program. The results showed that 201 respondents(64.2%) had musculoskelectal pain. According to a survey of musculoskeletal pain in body parts, the shoulder was the most common region; 37% of the health-workers(116 respondents). Musculoskeletal pain are more common in health-workers under 35 years old or work more than 6 years, or have more physical burden. In conclusion, health-workers need more active health care such as planning a preventive activity and stretching during work in order to prevent the deterioration of musculoskeletal symptoms into diseases.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1982.05a
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• pp.16.3-17
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• 1982

Nasal polyps were apparently common in many parts of the world and treated for nearly three thousand years. Nasal polyps are round, smooth, soft, semi-translucent, yellow or pale glistening structures, usually attached to the nasal or sinus mucosa by a relatively narrow stalk or pedicle. The incidence of nasal polyps is increased in patients with atopic diseases; it varies from 15% to 25% and now increased using allergy therapy for nasal polyposis treatment. Sinusitis is an inflammation of the mucous membranes of the sinuses. Many agents can cause an inflammatory response, including organisms such as bacteria and viruses, physical and chemical trauma, and antigen antibody reactions. The role of antigen antibody interactions (allergy) in simusitis is not completely understood ; however, patients with allergic rhinitis and nasal polyps have a high incidence of sinusitis. Recently authors have experienced two cured cases of nasal polyposis combined with chronic sinusitis by allergy therapy, that cases were treated only allergy thereapy after Caldwell Luc operation with ethmoidectomy and polypectomy. At now cases were not recur of nasal polyps and nasal symptoms. So the cases were reported with a brief review of literature.

• Tuberculosis and Respiratory Diseases
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• v.49 no.2
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• pp.237-245
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• 2000

Tuberculomas in the spine are estimated to be 15 to 50 times less common than those occurring in the cranium. We experienced a case of intramedullary spinal tuberculoma and brain tuberculoma associated with pulmonary tuberculosis. A 39-year-old male was referred to the National Medical Center via emergency room because of urinary difficulty lower limb weakness for 3 days. He had been treated with anti-tuberculosis regimens against pulmonary tuberculosis for 20 days. Spinal MRI revealed intradural intramedullary tuberculoma at T5. On the 21st day at the hospital, a generalized seizure attacked him. Brain MRI revealed multiple tuberculoma in both hemispheres, brainstem and cerebellum. He was treated anti-tuberculosis regimens and corticosteroids for 9 months. His condition improved clinically and radiologically. We report this case with a review of the literature.