• 한국방사선학회논문지
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• 제13권3호
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• pp.339-348
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• 2019

본 연구는 건강검진을 목적으로 내원하여 경동맥초음파를 실시한 113명을 대상으로 하였다. 경동맥의 내중막 두께는 심혈관 질환 및 뇌혈관 질환과 유의한 상관관계를 보이는 것으로 알려져 있다. 임상에서 선별 검사로 많이 이용되고 있는 경동맥 초음파를 이용하여 경동맥 내중막 두께와 체질량지수, 허리둘레, 혈청지질수치, 공복 혈당, 당화혈색소, 혈압등이 갖는 연관 관계에 대하여 알아보고자 하였다. 경동맥초음파상 IMT두께가 0.8 mm 이상을 비정상으로 간주하고 죽상경화증(atherosclerosis)의 유무를 평가하였으며, 혈청검사를 통하여 지질학적 수치 및 공복혈당수치, 당화혈색소를 분류하여 상관관계를 알아보았다. 그 결과 허리둘레(p=.022), 저밀도 콜레스테롤(p=.004), 공복혈당수치(p=.019), 당화혈색소 수치(p=.002)가 죽상경화증(atherosclerosis을 일으키는 예측인자로 분석되었다. ROC 곡선 분석에서 허리둘레에서 민감도 87.80%(95% CI : 73.8-95.9), 특이도 41.67%(95% CI : 30.2-53.9), 저밀도 콜레스테롤에서 민감도 78.05%(95% CI : 62.4-89.4), 특이도 50.00%(95% CI : 38.0-62.0 공복혈당에서 민감도 73.11%(95% CI : 57.1-85.8), 특이도 61.11 (95% CI : 48.9-72.4)), 당화혈색소에서 민감도 82.93%(67.9-91.8), 특이도 43.06%(31.4-55.3)를 나타내었다. 로지스틱 회귀분석에서 죽상경화증(atherosclerosis) 발생위험성은 허리둘레(WC)>76 cm에서 0.248배, 저밀도 콜레스테롤(LDL-C)${\geq}124mg/dL$에서 3.475배, 당화혈색소(HbA1C)>5.4%에서 0.618배로 나타났다. 향후 심뇌혈관질환의 효과적인 일차예방 역할을 위해 다수의 대상자를 대상으로 혈액검사수치를 고려하여 혈관의 추적관찰이 용이한 경동맥초음파를 통한 전향적연구가 필요할 것으로 사료 된다.

• 월간당뇨
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• 통권134호
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• pp.72-73
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• 2001

당뇨병 환자에서 고혈압의 빈도는 일반인에 비해 2배 이상 높고, 대개 환자의 약 40$\~$60$\%$에서 고혈압을 동반한다. 고혈압이 당뇨병과 같이 있는 경우는 대혈관 및 미세혈관 질환의 위험인자로서 작용하여 심장사, 관상동맥 질환, 울혈성 심부전, 뇌혈관질환, 그리고 말초혈관 질환의 발생 위험을 높여 당뇨병 환자 사망원인의 대부분을 차지하며, 고혈압이 동반되어 있지 않을 경우에는 장기생존률이 높다. 또한 당뇨병에서 확장기 및 수축기 혈압은 당뇨병성 신증과 망막증의 발생 및 경과 악화에도 영향을 미친다. 당뇨병에서 고혈압이 예후에 중대한 영향을 미치는 만큼, 고혈압을 동반한 당뇨병 환자에서, 혈당의 조절뿐 아니라 죽상경화증의 예방 및 고혈압의 치료가 당뇨병에 의한 혈관 합병증의 발생과 진행을 지연시키고 사망률을 감소시키는데 결정적이라 할 수 있다.

• 한국산학기술학회논문지
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• 제19권7호
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• pp.239-244
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• 2018

뇌경색의 주요 원인인 동맥 박리와 죽상경화증으로 인한 동맥 폐색 모두 고식적 자기공명혈관조영술이나 컴퓨터단층혈관조영술에서 혈관이 막힌 것처럼 보이지만, 발생 기전이 다르기 때문에 치료 방향에 차이가 생길 수 있다. 최근 고해상도MRI가 발달하면서 비침습적으로 혈관벽의 영상을 확인할 수 있게 되었다. 임상적으로 혹은 영상학적으로 동맥 박리가 의심되는 환자에게 고해상도MRI는 매우 유용한 검사방법으로 자리 잡고 있으나, 아직 두 질환의 감별점이 완전히 적립 되지는 않았다. 저자들은 컴퓨터단층혈관조영술에서 척추동맥폐색이 관찰된 두 환자에서 고해상도MRI를 통해 척추동맥박리와 죽상경화증의 차이점을 찾아보았고, 이를 추적 관찰하였다. 지금까지 알려진 혈관벽의 형태, 내막 판, 이중 내막, 혈관벽내 혈종, 가성 동맥류, 동맥벽의 초승달 모양 고신호 강도와 같은 동맥박리의 특징뿐만 아니라 저자들이 경험한 증례와 같이 긴 협착 길이, 폐쇄 부위 혈관의 재개통도 동맥 박리를 시사하는 소견이라고 판단하였다. 고해상도MRI를 통해 확인된 추가적인 동맥박리의 특징과 함께 향후 다양한 연구들을 통해 진단 기준이 명확해 진다면 치료에 많은 도움을 줄 수 있을 것으로 생각한다.

• 대한기계학회논문집B
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• 제29권9호
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• pp.1042-1048
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• 2005

Numerical investigation has been made on the stent design to minimize the neointimal hyperplasia. Computational fluid dynamics is applied to investigate the flow distributions in the immediate vicinity of the given idealized stent implanted in the blood vessel. Parametric study on the variations of the number of stouts, stent diameters, stent spacings and Reynolds numbers has been conducted using axi-symmetric Navier-Stokes equations. An initial difficulty in the study is to determine the optimal stent design to understand the flow physics of the flow disturbance induced by stent. The size of recirculation zone around stent is depend on the stent diameter, number of stent wire and Reynolds number but is insensitive to the stent wire spacing. It is also found that when the flow is in acceleration, the flow sees a more favorable pressure gradient, and the separation zones are smaller than the steady flow case. When the flow is in deceleration and the flow sees a more adverse pressure gradient so that the separation zones are larger.

• 한국정밀공학회지
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• 제22권9호
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• pp.179-187
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• 2005

The characteristics of blood flow and the interaction between the blood vessel and blood flow play important roles in plaque cap rupture and the growth of atherosclerosis which may lead directly to a heart attack or a stroke. In this study, carotid arteries with different stenoses have been numerically simulated to investigate the wall shear stress(WSS) and the elastic motion of the vessel. Blood flow has been treated as physiological, laminar and incompressible flow. To model the shear thining behavior of the blood, the Carreau-Yasuda model has been employed but the viscoelasticity of blood has not been considered. The results show that the WSS of $severe(75\%)$ stenosis is much higher than those of $25\%\;and\;50\%$ stenosis in the region of stenosis. With the increase in the stenosis thickness, the expansion ratio of the center of the stenosis decreases while the expansion ratio of the upstream region of the stenosis increases.

• 대한기계학회논문집B
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• 제31권1호
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• pp.21-28
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• 2007

The use of drug-eluting stents has dramatically reduced the incidence of restenosis however, much remains to be teamed about the performance of these stouts. In the present study, we tested the hypothesis that the design of drug-eluting stents influences the efficacy of local drug delivery to the arterial wall and that this effect depends on both arterial geometry and the prevailing flow conditions. We performed computational simulations in which the coupled Navier-Stokes and advection-diffusion equations were solved to determine the flow field and drug concentration in the vicinity of model drug-eluting stouts It is found that the characteristics of flow phenomena can be influenced greatly by the ratio of stent diameter to vessel diameter. The presence of drug-eluting stent may have profound effect on wall shear stresses, recirculation sizes and drug distributions. The results show that recirculation zone is influenced by the imposed flow conditions and stent diameter. In pulsatile flow, the low wall shear stress and high drug concentration occur along the arterial wall during the decelerating flow conditions. These results could provide the guideline for future drug-eluting stent designs toward reducing restenosis by affecting local wall shear stress distributions associated with neointimal hyperplasia.

• 한방재활의학과학회지
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• 제23권2호
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• pp.193-199
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• 2013

This study was performed to report the effect of coffee enema among detoxification Therapy on atherosclerosis. Russian patient was treated by coffee enema, acupuncture, herbal medicines, exercise, cupping, korean physical therapy, chuna manipulation treatment and moxibustion. The state of patient was measured by Infrared Thermography, Blood Vessel Stasis Test and Minnesota Nicotine Withdrawal Scale. After treatments, both feet temperature were increased. And index of indicating the occlusion of the lower body was improved. Also, Minnesota Nicotine Withdrawal Scale scores were improved. It means the patient was successful at non-smoking during hospitalization. These results suggests that atherosclerosis was improved. According to above results, coffee enema was effective to improve the atherosclerosis. More studies should be followed.

• 대한본초학회지
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• 제31권2호
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• pp.13-19
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• 2016

Objectives : The present study was designed to evaluate the protective effect of Allium tuberosum (AT) extract on atherosclerosis in LDL receptor knockout (LDLr KO) mouse fed western diet.Methods : The AT was extracted 70% ethanol. The experimental groups were divided with four groups of LDLr KO mice, one group fed a normal diet and the others fed a Western diets for 8weeks. Two Western diet groups were orally administered AT extract at dosage of 100 and 300 mg/kg body weight. The body weight and food intake were measured every day. We measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Glucose in serum. Also, effect of AT extract performed using H&E staining.Results : The AT treatment groups showed decrease in body weight and food efficiency in comparison with control group. Blood biochemistry parameters such as TG, TC, LDL, and glucose levels were increased in control group, while AT treatment groups were reduced. Also, the increased levels of ALT and AST were improved by AT extract. We confirmed that the weights of liver, kidney, subcutaneous fat, epididymal fat, kidney leaf fat, and intraabdominal fat were change in LDLr KO mice treated AT extract. In addition, histopathological changes in liver and aorta were similar to normal group.Conclusions : Based on these results, the AT extract is considered to make prevention of atherosclerosis through reduction and functional improvement of the liver and vascular endothelial cells in the body fat accumulation and lipid content in LDLr ko mouse model.

• Journal of Chest Surgery
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• 제43권6호
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• pp.785-789
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• 2010

만성동맥폐색증 환자의 혈관내 시술 시 발생되는 기술적 실패의 가장 많은 이유 중의 하나는 폐색부위를 내막하 진행 후 진강내 재진입의 실패에 기인한다. 진강내 재진입 카테터는 유도철사의 진강내 재진입을 용이하게 하여, 대부분 수술로 전환될 만성폐색질환에서 성공적인 혈관내 시술을 가능하게 한다. 본원에서는 표재성 대퇴동맥의 만성동맥폐색증의 혈관내 시술 시 기존의 장비로 진강내 재진입이 실패한 3예에서 $Outback^{(R)}$ $LTD^{TM}$ catheter를 이용하여 성공적으로 치료하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한본초학회지
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• 제31권1호
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• pp.17-23
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• 2016

Objectives : This study was designed to protect effect on atherosclerosis through regulation of low density lipoprotein(LDL) by 70 % ethanol extract Ganoderma lucidum (GL) in LDL receptor knockout mouse (LDLr ko mice) fed Western diet.Methods : The LDLr ko mice were divided into 3 groups ; Control, GL100, and GL300. After grouping, LDLr ko mice were fed Western diet. The GL (100 or 300 mg/kg body weight/day, p.o.) was administered every day for 8 weeks. The body weight and food intake were measured every day. The changes in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, triglyceride (TG), total cholesterol (TC), and high-density lipoprotein (HDL) in serum were analyzed after experiment.Results : The LDLr ko mice fed Western diet were increased body weight gain and blood biochemistry parameters such as ALT, AST, TG, TC, and LDL. However GL300 group significantly reduced the body weight. Also TG, TC, and LDL level did not increase. The levels of ALT, AST, HDL were not changed. Also, LDLr ko mice model liver were observed lipid drop, but GL groups did not appear. Futhermore, histological analysis of GL groups aorta tissue were similar to NOR groups.Conclusions : We confirmed that whether GL administration is protect atherosclerosis or not. As the results, blood biochemistry and histological analysis did not changed much in GL administration groups. This study provides scientific evidence that GL protect the atherosclerosis through the reduction of LDL cholesterol. Therefore GL has potential medicine inhibition of atherosclerosis.