Transactions of the Korean Society of Mechanical Engineers B (대한기계학회논문집B)

The Korean Society of Mechanical Engineers (대한기계학회)
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Numerical Analysis on the Effect of Wall Shear Stress Around the Ring Drug-Eluting Stent

고리형 약물분출 스텐트 주위 벽전단응력의 영향에 대한 수치해석

  • 서태원 (국립안동대학교 기계공학부) ;
  • Published : 2007.01.01
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Abstract

The use of drug-eluting stents has dramatically reduced the incidence of restenosis however, much remains to be teamed about the performance of these stouts. In the present study, we tested the hypothesis that the design of drug-eluting stents influences the efficacy of local drug delivery to the arterial wall and that this effect depends on both arterial geometry and the prevailing flow conditions. We performed computational simulations in which the coupled Navier-Stokes and advection-diffusion equations were solved to determine the flow field and drug concentration in the vicinity of model drug-eluting stouts It is found that the characteristics of flow phenomena can be influenced greatly by the ratio of stent diameter to vessel diameter. The presence of drug-eluting stent may have profound effect on wall shear stresses, recirculation sizes and drug distributions. The results show that recirculation zone is influenced by the imposed flow conditions and stent diameter. In pulsatile flow, the low wall shear stress and high drug concentration occur along the arterial wall during the decelerating flow conditions. These results could provide the guideline for future drug-eluting stent designs toward reducing restenosis by affecting local wall shear stress distributions associated with neointimal hyperplasia.

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References

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Cited by

  1. Numerical Study of Flow Pattern and Drug Deposition in Drug-Eluting Stent vol.35, pp.10, 2011, https://doi.org/10.3795/KSME-B.2011.35.10.1053
  2. Performance of Various Drug-Eluting Stent Geometries Measured Using Computational Analysis vol.36, pp.6, 2012, https://doi.org/10.3795/KSME-B.2012.36.6.601