• Journal of Pharmacopuncture
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• 제13권1호
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• pp.15-35
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• 2010

연구목적 : 이 연구는 봉약침의 봉독이 NF-${\kappa}B$ 활성억제와 안드로겐 수용체 조절 단백질 및 세포자멸사 조절 단백질의 발현을 통하여 세포자멸사를 유도하고, 전립선 암세포를 이식한 쥐에서의 세포자멸사 유도 효과를 확인함으로써, 봉약침의 봉독이 생체 내에서도 세포자멸사를 유도하여 전립선암에 효과를 나타냄을 확인하고자 하였다. 실험방법 : 세포자멸사의 관찰에는 DAPI, TUNEL staining assay를 시행하였으며, 세포자멸사 조절 단백질의 변동 관찰에는 western blot analysis를 시행하였고, 세포자멸사와 연관된 NF-${\kappa}B$의 활성 변화를 관찰하기 위해 EMSA를 시행하였다. 결과 : 1. DAPI, TUNEL staining assay 결과 봉독 및 melittin을 처리한 LNCaP 세포 모두에서 세포자멸사 유도율이 유의한 증가를 나타내었다. 2. LNCaP 세포에 봉독이나 melittin을 처리한 결과, 안드로겐 수용체 조절 단백질 중 p-Akt, COX-2, calpain은 봉독과 melittin 모두에서 유의한 감소를 나타내었고, Akt는 melittin에서 유의한 감소를 나타냈으며, 봉독에서 증가하는 경향을 보였고, MMP-9은 증가하였다. 3. 생체 내에서의 봉독의 항암효과를 확인하기 위해 전립선암세포가 이식된 쥐에 봉독을 처리한 후 암세포의 부피와 무게, 쥐의 체중을 측정한 결과, 봉독을 처리한 군에서 암 세포 부피비율 및 무게는 감소하였고, 쥐의 체중은 증가하였다. 4. 전립선암세포가 이식된 쥐에 봉독을 처리한 결과, NF-${\kappa}B$ 활성에서 유의한 감소를 나타내었다. 5. 전립선암세포가 이식된 쥐에 봉독을 처리한 결과, 세포자멸사 조절 단백질 중 Bax/Bcl-2, p53, caspase-3, caspase-9, calpain은 유의한 증가를, COX-2는 유의한 감소를 나타냈으며, MMP-9는 증가를 나타내었다. 결론 : 이상의 결과는 봉독이 시험관 내에서 뿐만 아니라 생체 내에서도 NF-${\kappa}B$의 활성을 억제하고 안드로겐 수용체 조절 단백질 및 세포자멸사 조절 단백질의 조절을 통하여 인간 전립선암 세포주인 LNCaP의 세포자멸사를 유도함으로써 전립선암 세포 증식억제 효과 및 호르몬 비의존적인 전립선암으로의 전이를 지연시키는 경향이 있을 것으로 사료되고, 봉독이 전립선암의 예방과 치료에 효과적으로 활용될 수 있을 것으로 기대된다.

• The Journal of the Korea Contents Association
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• 제21권11호
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• pp.450-463
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• 2021

The purpose of this study was to examine the moderated mediating effect of self-compassion on the relationship between socially prescribed perfectionism, internalized shame, and interpersonal problems among university students. For this purpose, survey data of 327 domestic university students were obtained, and the collected data were analyzed using SPSS 25.0 and Macro 3.4 programs. The results of this study are as follows. First, it was found that internalized shame partially mediates the relationship between socially prescribed perfectionism and interpersonal problems. Second, it was found that self-compassion moderate the relationship between internalized shame and interpersonal problems. Third, it was found that there was a moderated mediating effect of self-compassion mediating the effect of socially prescribed perfectionism on interpersonal problems through internalized shame. Finally, the significance of this study and suggestions for follow-up studies were discussed.

• The Journal of the Korea Contents Association
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• 제15권7호
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• pp.216-227
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• 2015

The purpose of this study is to investigate the moderating effect of interpersonal relationship skills in adapting military life and stress in the army. For this purpose, 453 soldiers in Chungnam and Daejeon were surveyed. First, the main result of this study is the difference in interpersonal skills and group life adjustment in accordance with the rank and class of the soldiers. Second, too much stress can cause difficulty to adapt military life and interpersonal skills. Also high interpersonal skills can help to adjust well to military life. Third, according to the survey, it was confirmed that the openness in the sub-factors of military life and military life stress was effective. This study suggests that it is important to help control the stress of military life to improve the ability of the openness of interpersonal skills in order to increase the adaptability military life.

• Journal of Digital Convergence
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• 제13권7호
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• pp.117-124
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• 2015

Recently the concept of authenticity has made an issue on the study of transformational leadership. Without authenticity of leader the effect of leadership nullifies the effectiveness of leadership for the followers. This study examines convergently the effect of transformational leadership on trust, organizational devotion, and team performance with the moderating effect of authenticity focusing 232 hotel team members in Busan using structural equation model. The results are as follows: First, transformational leadership has shown significantly effective toward trust and organizational devotion. Second, trust toward team leader has shown significantly effective toward team performance, while devotion has not shown dignificantly effective. Third, authenticity has shown significantly effective for moderating effect between leadership and trust, but not effective between leadership and devotion. This paper make significant contribution by testing the concept of authenticity.

• Journal of Digital Convergence
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• 제15권2호
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• pp.89-98
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• 2017

This study analyzed empirically the same data through SPSS statistics(regression analysis) and AMOS program(structural equation model) used for cause and effect analysis. The result of empirical analysis of moderation effect was as follows. Meanwhile, SPSS statistics(regression analysis) did not pictured moderation effect in the categorical data(sex) and continous data(satisfaction of consunting), AMOS program(structural equation model) pictured partial moderation effect about the effecting of consultant's capability and attitude on the consulting repurchase within 10% level of significant. Eventually, This study showed that AMOS program and SPSS statistics used different methology in moderation effect, thus the different outcomes appeared although using the same data.

• Journal of the Korean Society of Child Welfare
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• 제32호
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• pp.99-127
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• 2010

This study is aimed to test the moderating effects of social support networks of parents and children on the relationships between poverty, marital discord, and child abuse. This study utilized the first wave of the Korea Welfare Panel Study, conducted in 2006. Multiple regression analysis was conducted to examine the effects of poverty, marital discord, and social support networks of parents and children on child abuse. The results show that poverty and marital discord have positive(+) effects on child abuse and that social support networks of parents and children have negative (-) effects on child abuse. This study also tested the moderating effects of social support networks of parents and children on the relationships between poverty, marital discord, and child abuse. The results confirm that social support networks of both parents and children can moderate the effects of poverty and marital discord on child abuse. That is, when the level of social support networks of parents and children are high, the influences of poverty and marital discord on child abuse becomes smaller or insignificant. Implications of study findings, which includes child protection strategies through improvements in supports for parents and their children are discussed.

• Journal of the korean veterinary medical association
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• 제29권11호
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• pp.641-645
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• 1993

소 유방염에서 cytokine의 역할연구는 이제 시작단계이다. 근래 시험에서는 재결합 cytokine은 실세포 증가와 염증반응의 조절에 의하여 강화된 세균의 정화능력을 유방에 준다. 그리고 효과인자 세포의 보충결합 효과를 통하여 유방염의 결과를 조절하는 능력이 있다는 것을 제시한다. 현재 앞서가는 연구자들의 도전은 세균의 병원성 증가, 숙주반응이 유선에서 병원균 제거 요구 그리고 cytokine이 이들 반응을 조절할 수 있는 기전, 이들 사이의 상호기전을 더 이해하기 위한 것이다. 이 분야에서 앞으로의 발전은 시험보다 야외상태에서 전달되어지는 것이다. 그리고 효과적인 정보의 증가를 위하여 우리의 관심이 더 많아야 하는 것이고, 유선면역기능 조절이 소 유방염 관리를 위하여 앞으로 cytoki-ne의 치료응용에 큰 잠재력을 제시하는 것이다.

• The Journal of the Korea Contents Association
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• 제22권8호
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• pp.557-569
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• 2022

The purpose of this study is intended to identify the mediated moderating effect including the mediating effect of job satisfaction and moderating effect of job expectations in the relation between work value, job satisfaction, In this study, the mediating effect of job satisfaction and job preference on the relationship between job value and quality of life were investigated. In this study, questions to measure job value, job satisfaction, and job preference were examined using GOMS data, and data analysis was performed using SPSS 23.0 and SPSS Macro. Since the mediated moderation model is an integrated model that includes mediating and moderating effects, the mediating effect, the moderating effect, and the mediated moderation effect were sequentially verified. As a result of the study, first, it was confirmed that the mediating effect model through job satisfaction was statistically significant. Next, it was confirmed that job value had a statistically significant effect on life satisfaction through the direct path and the indirect path through job satisfaction as a mediating variable. Third, it was confirmed that the moderated mediating effect model of job preference through job satisfaction was statistically significant. In detail, job value as an independent variables and job satisfaction as a mediating variable were found to have a statistically significant positive (+) effect on the dependent variable, quality of life.

• Korean Journal of Culture and Social Issue
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• 제23권3호
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• pp.333-359
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• 2017

We examined the moderator roles of negative belief in emotional expression and emotional clarity between work-life balance and psychological symptoms (depression, anxiety and somatization). Also we identified gender differences in their moderating effects. This study was based on a sample of 869 married working employees (man: 424, women: 445). Hierarchical moderated regression analyses showed that work-life balance, negative belief in emotional expression and emotional clarity were strongly associated with depression, anxiety and somatization. While negative belief in emotional expression significantly moderated the relationship between work-life balance and depression and anxiety, emotional clarity showed no significance. We found gender differences in moderating effects of two moderators. In specific, the only women who had more negative belief in emotional expression were more psychological symptoms in a low work-life balance situation. On the other hand, the only men who had higher emotional clarity were less depressive and anxious under the conditions of high work-life balance. We discussed about implications of these results.

• 한국벤처창업학회:학술대회논문집
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• 한국벤처창업학회 2018년도 추계학술대회
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• pp.195-199
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• 2018

OECD 국가들과 마찬가지로 한국의 청년실업문제는 매우 심각하다. 높은 청년실업문제는 경제성장에 영향을 미칠 뿐만 아니라 출산, 범죄 등의 심각한 사회적 문제를 초래할 수 있다. 창업은 단순히 청년들의 단기적 직업을 제공할 뿐만 아니라 미래 사회가 필요로 하는 인적자원을 개발시키는 역할을 담당하고 있다. 즉, 청년층인 대학생들의 창업을 북돋울 수 있는 방안과 연관된 연구는 매우 중요하다. 본 연구의 목적은 대학생의 기업가정신이 창업동기에 미치는 영향을 분석하고 이들 관계에서조절초점성향의 조절효과를 검증하는 것이다. 본 연구를 위해 강원지역 대학생들을 대상으로 한 342부의 설문지가 최종분석에 사용되었다. 연구 분석을 통해 확인된 결과는 다음과 같다. 첫째, 대학생의 기업가정신은 창업의도에 영향을 미칠 것이라는 가설을 설정했으며 실증연구에서 이를 확인할 수 있었다. 둘째, 기업가 정신이 창업의도에 미치는 영향에 있어서 성별의 조절효과를 확인하였다. 기업가정신이 남녀 모두에 있어 창업의도에 정(+)의 상관관계를 가지며 그 영향력은 남성에 비해 여성이 더 크다는 것을 확인하였다. 셋째, 대학생의 촉진초점이 남녀 모두에 있어서 창업의도에 정(+)의 상관관계를 가지며 그 영향력은 남성에 비해 여성이 크다는 것을 확인하였다.