• Title/Summary/Keyword: 제약사

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Protective effect of Caryophylli Flos on apoptosis caused by oxidative stress in HaCaT cells (HaCaT 세포의 산화 스트레스로 인한 세포자멸사에서 정향의 보호효과)

  • Park, Sook Jahr
    • The Korea Journal of Herbology
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    • v.36 no.5
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    • pp.93-99
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    • 2021
  • Objective : Caryophylli Flos has been used in Korean medicine to relieve vomiting and pains caused by chills that make fluid circulation difficult. This study was designed to investigate the protective effect of ethanol extract of Caryophylli Flos (CF) in hydrogen peroxide (H2O2)-induced apoptotic cell death in human keratinocyte HaCaT cells. Methods : CF was prepared by extracting 200 g of Caryophylli Flos in 2 L of ethanol for 48 h. Cell viability was measured by MTT assay, and the protein expression was monitored by Western blot analysis. Apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Reactive oxygen species (ROS) was measured using fluorescent dye, and reduced glutathione (GSH) was determined with a colorimetric commercial kit. Results : CF protected HaCaT cells from cell death caused by oxidative stress after H2O2 treatment. H2O2 amplified generation of ROS and induced depletion of GSH, whereas these changes in ROS and GSH were inhibited by GF treatment. In addition, H2O2 resulted in apoptosis as assessed by TUNEL assay and the expression of apoptosis regulator proteins. However, cells treated with CF showed a decrease in TUNEL-positive cells and restored the reduced expression of procaspase-9, -3 and PARP. Conclusion : This study showed cytoprotective effects of CF by anti-apoptotic activity while exerting antioxidative activity in H2O2-treated HaCaT cells. These results suggest that CF could be beneficial in skin damage caused by oxidative stress.

Study on Problem and Improvement of Legal and Policy Framework for Smartphone Electronic Finance Transaction - Focused on Electronic Financial Transaction Act - (스마트폰 전자금융거래 보호를 위한 법제적 문제점 분석 - 전자금융거래법(안)을 중심으로 -)

  • Choi, Seung-Hyeon;Kim, Kang-Seok;Seol, Hee-Kyung;Yang, Dae-Wook;Lee, Dong-Hoon
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.20 no.6
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    • pp.67-81
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    • 2010
  • As wide propagation of smartphones, e-commerce with smartphones increases rapidly. Such as transfer or stock trade systems. It has prospect that most of financial companies going to offer e-commerce systems via smartphones. And e-commerce via smartphones will be increased, hence the nature of smartphone that can be used whenever, wherever. However, legislation of e-commerce in Korea does not reflect these characteristics of smartphones, because it has set standards in regular PC. So that this study is security threat and feature of smartphones considering that the current legal system will use Certificate constraints, ensuring the safety of e-commerce and install security programs for protection of users, e-commerce responsible for the accident analysis has focused on the issues presented for this improvement.

A Study on the Design of Test Item Framework for the Reliability of Frozen and Refrigerated Products with IoT Function (IoT 기능을 보유한 냉동·냉장 제품의 신뢰성 확보를 위한 시험항목 프레임워크 설계에 관한 연구)

  • Cho, Kyoung Rok;Lee, Jung Jae;Lee, Eun-Ser
    • KIPS Transactions on Software and Data Engineering
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    • v.10 no.6
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    • pp.211-222
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    • 2021
  • Recently, frozen and refrigerated appliances on the market are being released with additional IoT functions, but there are few tests on IoT functions. In particular, the existing test system does not have IoT test items for IoT-based frozen and refrigerated appliances, making it difficult for companies to find the cause even if defects occur, and test institutions are also restricted from selecting IoT-related test items and conducting correct performance tests. In this paper, we design a test item framework that can identify product defects and identify causes in the performance test process of frozen and refrigerated products with IoT functions among products in the home appliance field, and propose test methods and management measures using them. Through the proposed research, manufacturers and testing institutions can test the correct performance of IoT-based frozen and refrigerated products, thereby enhancing the completeness and securing reliability of the products.

Game-bot Detection based on Analysis of Harvest Coordinate

  • Choi, Jae Woong;Kang, Ah Reum
    • Journal of the Korea Society of Computer and Information
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    • v.27 no.5
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    • pp.157-163
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    • 2022
  • As the online game market grows, the use of game bots is causing the most serious problem for game services. We propose a harvest coordinate analysis model to detect harvesting bots among game bots of the Massively Multiplayer Online Role-Playing Games(MMORPGs) genre. The proposed model analyzes the player's harvesting behavior using the coordinate data. Game bots can obtain in-game goods and items more easily than normal players and are not affected by realistic restrictions such as sleep time and character manipulation fatigue. As a result, there is a difference in harvesting coordinates between normal players and game bots. We divided the coordinate zones and used these coordinate zone differences to distinguish between game bot players and normal players. We created a dataset with NCSoft's AION log and applied it to a random forest model to detect game bots, and as a result, we derived performance with a recall of 0.72 and a precision of 0.92.

Porphyra tenera induces apoptosis of oral cancer cells (구강암 세포주에서 김 추출물에 의한 세포자멸사 유도)

  • Kim, Sang Chan;Lee, Jong Rok;Park, Sook Jahr
    • The Korea Journal of Herbology
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    • v.30 no.2
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    • pp.25-30
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    • 2015
  • Objectives : Laver (Porphyra tenera), a red algae species, is one of the most widely consumed edible seaweed in Korea. Laver contains various substances such as essential amino acid, fiber, minerals and polyphenols that benefit human health. In the present study, we prepared ethanol extracts from commercially processed product of Porphyra tenera, and evaluated the growth inhibitory effect against human oral squamous carcinoma YD-10B cells. Methods : Cell viability was measured by MTT assay. Apoptosis was confirmed by TUNEL assay and flow cytometry with the green fluorescent dye FITC annexin V entering apoptotic cells and the red fluorescent dye PI not entering. The expression of the relevant proteins was detected using Western blot. Results : Ethanol extracts of Porphyra tenera (PTE, $50-200{\mu}g/m{\ell}$) caused a significant decrease of cell viability in a dose dependant manner. The cell death occurred as a result of apoptotic process as determined by TUNEL assay and flow cytometric analysis. In line with this observation, decrease in procaspase proteins and increase in cytosolic cytochrome c were observed in cells treated with PTE. In addition, exposure to PTE decreased the expression levels of Bcl-2, and induced PARP cleavage and AIF translocation from mitochondria to nucleus. Conclusions : In conclusion, PTE exerts anti-cancer effects by inducing apoptosis via caspase activation and AIF nuclear translocation in YD-10B cells. These results provide evidence for the possible therapeutic effect of Porphyra tenera in oral cancer cells.

A Study on Personal Environment Service on the Smartphone (스마트폰 중심의 개인환경서비스 연구)

  • Yun, Ho-Young;Kim, Jong-Ho;Park, Sun-Hwa;Jung, So-Hee;Ro, Kwang-Hyun
    • Annual Conference of KIPS
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    • 2011.04a
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    • pp.1169-1172
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    • 2011
  • 본 연구는 고가의 인프라 구축이라는 제약 때문에 현재까지 기초적인 수준에 머물러있는 홈 네트워크의 문제점을 극복하고자 제안된 스마트폰 중심의 개인환경서비스(PES : Personal Environment Service)를 연구하였다. 개인환경서비스는 스마트폰과 무선랜, 블루투스 등의 모듈이 탑재된 가전기기와 근거리 무선통신으로 사용자의 선호도를 저장하고 있는 프로파일을 교환하여 가전기기를 자동으로 설정해 주며 프로파일은 서비스 서버에도 전송되어 지속적으로 갱신, 사용자에게 편리한 생활을 제공해 준다. 본 연구는 이러한 스마트폰 중심의 개인환경서비스의 데모 시스템 구조 및 시연 시스템을 구축하였다. 데모시스템의 스마트폰 플랫폼은 구글 사의 안드로이드 2.2 (Froyo) 버전이며, 지능형 가전기기와는 블루투스 통신을 통해 사용자와 서비스 프로파일을 교환한다. 가전기기는 PC, 난방기기, 가스렌지, TV, 라디오 총 5가지를 구현하였는데 실제 가전기기를 구현할 수 없는 한계로 인해 PC를 제외한 가전기기는 블루투스 임베디드 보드에 LCD 디스플레이를 설치한 모의(pseudo) 가전기기로 대체하였다. 스마트폰에 저장되어 있는 사용자 프로파일은 각각의 가전기기별 선호도를 환경설정을 통해 설정할 수 있게 하였고, 선호도를 설정하면 가전기기는 블루투스 통신으로 스마트폰의 사용자 프로파일을 전송받아 자동 설정해 준다. 서비스 서버는 스마트폰과 가전기기의 모든 로그를 전송받아 패턴분석 과정을 거쳐 사용자의 프로파일을 자동으로 설정해주어서 사용자는 개인에게 최적화된 생활환경을 제공받게 된다. 개인환경서비스는 현재 표준화 규격 개발을 위해 제조업체, 이동통신사, 연구소, 대학교 등에서 활발히 연구 중에 있으며, 향후에는 현재까지 개발된 데모 시스템을 토대로 프로토콜을 연구, 수립하여 표준화 규격 개발에 기여할 예정이다.

The Value of Peace and the Acts of Women of the Old Testament from the Migrational Perspective (이주의 관점으로 본 구약성서의 여성들의 행동과 평화의 가치)

  • Choi, Eunyoung
    • Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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    • v.6 no.7
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    • pp.321-328
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    • 2016
  • This study seeks the applicable value for contemporary multiculturalism based on the women (Hagar, Tamar, Rahab, Ruth, A great woman who lives in Shunem, A nameless servant girl) of the Old Testament who experienced migration. The article critiques uses of scripture that emphasize the roles of the women in the household. It provides a new interpretation through the perspective of feminist criticism, narrative criticism, and reader-response criticism. The article introduces the examples of six migrant women who created peace with people around them through their positive roles despite the fact that women had limited function under patriarchal society at that time. It suggests, while recognizing the difference regarding race, gender, and class between migrants and non-migrants, women and men, that they should not be used as the tools of discrimination. Furthermore, through these women from the Bible, the reader may find role models of independent women who are working for peace and social justice.

A Study of Awareness and Implementation of OBP(Occupation-Based Practice) (작업기반 중재(Occupation-Based Practice)에 대한 인식 및 실행 조사연구)

  • Chang, ki-yeon
    • The Journal of Korean society of community based occupational therapy
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    • v.7 no.2
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    • pp.19-31
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    • 2017
  • Objective : This study was to learn the Korean Occupational Therapists' awareness and current state of implement of Occupation-Based Practice and to use it as a baseline data. Methods : After 300 Korean clinical occupational therapists were conveniently sampled, the structured 293 questionnaires were released, the answered 293 questionnaires were analyzed. Results : Awareness of OBP was 5.7 points on average and the awareness, increased with age and clinical experience. The opportunity that Occupational Therapists know OBP was through major subjects, articles & seminars, through peers and so on. The differences depended on age, level of education, location of work, clinical experience. 152 Occupational therapists(52.8%) answered that they apply OBP in their clinical work. There was no significant difference in the use of OBP based on gender, age, clinical experience, education background with exception of work location. It was shown that during practice,The most frequently used OBP was as follow in order: interview, practice, goal setting, assessment and documentation. The goal of using OBP was to find out a meaningful occupation for client's living, to promote client's participation in family or community, to treat for function recovery of clients. The biggest difficulty faced during OBP was lack of understanding of OBP for the clients and their guardian. Other difficulties were limitations of treatment environment, lack of occupational instruments, related knowledge, utilization method, preparation time and difficulty in handling insurance and medical expenses in order. Conclusion : Level of awareness of OBP was at intermediate level and it was related to education level and treatment environment. Based on this result, it is need to support institutional and academical discusstion in order to promote OBP.

An Exploratory Study on the Possibility of Using Next-Generation Technology in Long-term Care Facilities : Focusing on the Perception of the Workforce of in Long-term Care Facilities (노인장기요양시설의 차세대 기술 활용가능성에 대한 탐색적 연구 : 노인장기요양시설 인력의 인식을 중심으로 -)

  • Lee, Sun Hyung;Lim, Choon Hee;Kim, Weon Cheon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.5
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    • pp.191-205
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    • 2020
  • This study examined the possibility of utilizing next-generation technology, such as Virtual Reality or AI robots, in the long-term care facilities for the elderly. For the study, the Focus Group Interview was conducted in three different groups of 14 participants (care workers, social workers, and directors of long-term care facilities for the elderly). The analysis revealed a total of three topics, eight categories, and 26 sub-categories. The main results of the study showed that the use of next-generation technology could assist the psychological and emotional stability, provide curiosity and interest, and relieve the desire for physical activity for the elderly. In addition, for long-term care services staff, it could provide useful services for the elderly with physical constraints, facilitate effective management of the elderly roaming around, and enhance emotional support services. Finally, it could also help directors of long-term care facilities promote their services, educate staff, and keep up with current trends. Participants expressed concerns about the introduction of new technologies, but they generally expected that the application of next-generation technology would be positive for the elderly as well as for care workers and directors of long-term care facilities. Therefore, the use of next-generation technology in long-term care facilities for the elderly will also help develop gerontechnology.

A Plan for Introduction of New Performance-Enhancing Underwriting Technique (언더라이팅 기능 강화를 위한 신기법 도입방안)

  • Park, Sang-Jun
    • The Journal of the Korean life insurance medical association
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    • v.22
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    • pp.99-120
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    • 2003
  • 그 동안 지속적인 경제성장을 바탕으로 한국의 생명보험산업은 양적으로 성장하였다. 그러나 내면을 살펴보면 외형을 떠받칠 만큼 내실있게 성장했는지에 대해서는 많으 의구심을 갖게 한다. 현실적으로 경제성장을 바탕으로 한 외형성장은 한계를 맞을 수 밖에 없으며, 이제는 질적인 내실을 기하기 위해 그 동안 소홀히 했던 보함산업의 전반의 체질개선이 필요하다. IMF이후 경영이 부실한 보험사들이 퇴출되면서 전면적인 개편이 이루어졌고, 또한 보험사 내부에서도 전반적인 개혁의 필요성을 인식하여 여러 방면으로 방안을 구체화하고 있다. 본 논문은 이러한 상황하에서 생명보험산업의 기존 문제점 개선방안의 일환으로, 보험산업의 가장 핵심분야라 할 수 있는 언더라이팅 분야의 국내현황을 살펴보면서 보험선진국의 제도 및 운영현황과 비교 분석하여 부문별 문제점을 도출하고, 그에 따른 개선방안을 제안하게 되었으며, 본 논문에서 제시된 개선방안을 요약해 보면 다음과 같다. 첫째, 언더라이팅을 신속 정확하게 수행하고 도덕적 위험을 배제하기 위하여 개선된 정보교환시스템 제도를 구축해야 하며, 사정자료의 수집업무를 전문기관에게 아웃소싱함으로써 비용절감을 기하여야 한다. 이와 아울러 모집인의 전문성을 제고시켜 보험계약 청약서와 모집인 보고서가 정확하게 작성되도록 하고 언더라이팅 실적과 연계한 인센티브제도에 의하여 모집수당이 지급되도록 하여 언더라이팅이 효과적으로 수행되도록해야 할 것이다. 둘째, 언더라이팅기법의 선진화를 기함으로써 위험에 상응하는 보험료를 부가하여 위험에 노출되어 있는 가망고객의 보험가입율을 높이고, 보험사고 발생시 실질적인 보험혜택을 누리도록 하여야 한다. 이를 위한 실천방안으로 의적 직업적 재정적 언더라이팅 선진기법을 도입하여 각 부문의 역량을 강화해야 할 것이다. 특히 제도적으로 개인신용정보의 언더라이팅 활용이 제한되어 있는 현실에서 이를 법제도 내로 흡수하면서 개인의 사생활 유지라는 목적을 동시에 달성되도록 하는 재정적 언더라이팅 기법의 강화가 특히 중요하리라 생각된다. 아울러 언더라이팅 업무를 효과적 효율적 수행을 통해 일관성 있는 의사결정이 이루어질 수 있도록 지원하는 언더라이팅 시스템구축을 통해 정형화된 인수과정은 결정시스템화하고, 복잡한 위험의 경우 자문 시스템으로 운영하여 간단한 언더라이팅 업무는 구축된 시스템을 통해 즉각 해결함으로써 시간을 절약할 수 있고, 언더라이팅 인력은 보다 전문적인 부문에 집중하도록 해야 할 것이다. 마지막으로, 비표준위험시장의 활성화를 위해서는 현재의 제약조건인 생명보험 상품개발을 세트형에서 조립형으로 전환하고, 재보험으로 위험을 분산하여 비표준위험의 인수를 증대하여야 할 것이다. 이와 더불어 언더라이팅 과정에서 얻어진 피보험자의 사정자료를 활용하여 고객에게 필요한 의료정보 등을 제공함으로써, 피보험자와 유대관계를 돈독히 하여 기존계약이 계속 유지되도록 하며, 추가계약이 이루어지도록 해야 할 것이다. 이상과 같은 비표준위험의 언더라이팅 개선방안이 보다 효과적으로 수행되고 발전하기 위해서는 통계축적 및 관리, 전문 언더라이터 양성, 전산을 이용한 언더라이팅 확대 등이 이루어져야 하므로 향후 이에 대한 집중적인 연구가 있어야 할 것이다.

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