• Journal of the Society of Cosmetic Scientists of Korea
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• v.48 no.2
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• pp.157-167
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• 2022

In this study, we investigated the effects of heptapeptide on cellular activation and inhibition of cellular damage induced by photoaging condition in NIH3T3 fibroblasts. Cell proliferation and extracellular matrix (ECM) expression were induced by heptapeptide. The reduced cell viability under photoaging condition through ultraviolet A (UVA) irradiation was increased by heptapeptide. And UVA-induced apoptosis, matrix metalloproteinases-1 (MMP-1) expression, and reactive oxygen species (ROS) level were decreased by heptapeptide. In addition, the inhibition of transforming growth factor-β (TGF-β)/smad signaling under UVA irradiation which resulting in reduction of ECM expression was also recovered by heptapeptide. We also tested the effect of heptapeptide under another photoaging condition through heat shock, and pre-treatment of heptapeptide prevented the phosphorylation of mitogen-activated protein kinase (MAPK) and MMP-1 expression induced by heat shock. From these results, it has been shown that the heptapeptide has protective effects on fibroblasts through the up-regulation of cellular activity and through the decreasing of intracellular ROS level induced by UVA irradiation or heat shock. It is expected that the dermal protection effect of heptapeptide can be applied as a new cosmetic material in the future.

• Journal of the Korea Society of Computer and Information
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• v.27 no.5
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• pp.1-9
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• 2022

Localization systems can be used with various circumstances like measuring population movement and rescue technology, even in security technology (like infiltration detection system). Vision sensors such as camera often used for localization is susceptible with light and temperature, and can cause invasion of privacy. In this paper, we used ultra-wideband radar technology (which is not limited by aforementioned problems) and machine learning techniques to measure the number and location of occupants in other indoor spaces behind the wall. We used four different algorithms and compared their results, including extremely randomized tree for four different situations; detect the number of occupants in a classroom, split the classroom into 28 locations and check the position of occupant, select one out of the 28 locations, divide it into 16 fine-grained locations, and check the position of occupant, and checking the positions of two occupants (existing in different locations). Overall, four algorithms showed good results and we verified that detecting the number and location of occupants are possible with high accuracy using machine learning. Also we have considered the possibility of service expansion using the oneM2M standard platform and expect to develop more service and products if this technology is used in various fields.

• The Journal of the Korea Contents Association
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• v.22 no.2
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• pp.10-21
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• 2022

In order to improve formal presentation attitudes such as presentation of job interviews and presentation of project results at the company, there are few automated methods other than observation by colleagues or professors. In previous studies, it was reported that the speaker's stable speech and gaze processing affect the delivery power in the presentation. Also, there are studies that show that proper feedback on one's presentation has the effect of increasing the presenter's ability to present. In this paper, considering the positive aspects of correction, we developed a program that intelligently corrects the wrong presentation habits and attitudes of college students through facial analysis of videos and analyzed the proposed program's performance. The proposed program was developed through web-based verification of the use of redundant words and facial recognition and textualization of the presentation contents. To this end, an artificial intelligence model for classification was developed, and after extracting the video object, facial feature points were recognized based on the coordinates. Then, using 4000 facial data, the performance of the algorithm in this paper was compared and analyzed with the case of facial recognition using a Teachable Machine. Use the program to help presenters by correcting their presentation attitude.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.3
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• pp.97-103
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• 2021

Perilla frutescens (P. frutescens) is an important herb used for many purposes such as medicinal, aromatic, and functional food in Asian countries and has beneficial effects such as antioxidant activity, anti-inflammation activity, anti-depression activity, and anxiolytic activity. However, there have been no studies on the protective effect of P. frutescens extract (PFE) on amnesia in vivo. The present study aimed to investigate whether PFE protects memory deficit using a scopolamine-induced mice model and elucidate the underlying mechanisms involved. The protective effect of PFE against scopolamine-induced memory deficits was investigated using Y-maze, passive avoidance, and Morris water maze tests. Furthermore, the potential mechanisms of PFE in improving memory capabilities related to the cholinergic system and antioxidant activity were examined. PFE significantly increased spontaneous alternation in the Y-maze test, step-through latency in the passive avoidance test, and swimming time in the target quadrant in the probe test when compared to the scopolamine-treated group. Likewise, PFE significantly decreased escapes latency in the Morris water maze test. PFE could not regulate cholinergic function in acetylcholine level and acetylcholine esterase activity. However, PFE increased DPPH radical scavenging activity dose-dependently and total polyphenol content was 127.7±1.2 ㎍ GAE/mg. The results showed that the PFE could be a preventive and/or therapeutic candidate for memory and cognitive dysfunction in Alzheimer's disease.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.387-393
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• 2021

This study aimed to improve the software quality in weapon systems by applying ISO/IEC 25023 to the software engineering process. The software engineering process in weapon systems manages the Software Quality Requirement but has restrictively improved the software quality. Software quality items are already defined and used for software engineering processes in weapon systems, but they are defined inconsistently according to individual software development cases. Thus, the methods of quantifying software quality are different, even though the same software quality is defined. In addition, the software quality has been managed differently. The major problems of software engineering processes in weapon systems are the unclear definition of the software quality requirements and the absence of quantifying software quality standards. ISO/IEC 25023 is composed of eight quality characteristics and thirty-one sub-characteristics. ISO/IEC 25023 provides measurement functions that can quantify the software product quality based on its characteristics. To improve the software quality further, the measurement functions in ISO/IEC 25023 are suggested to quantify and manage software quality for software engineering processes in weapon systems. The expected effects of this study were analyzed.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.6
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• pp.1249-1258
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• 2022

Marine debris is defined as a substance that is intentionally or inadvertently left on the shore or is introduced or discharged into the ocean, which has or is likely to have a harmful effect on the marine environments. In this study, the detection of marine debris and the analysis of the amount of change on marine debris were performed using the object detection method for an efficient method of identifying the quantity of marine debris and analyzing the amount of change. The study area is Yuho Mongdol Beach in the northeastern part of Geoje Island, and the amount of change was analyzed through images collected at 15-minute intervals for 32 days from September 12 to October 14, 2022. Marine debris detection using YOLOv5x, a one-stage object detection model, derived the performance of plastic bottles mAP 0.869 and styrofoam buoys mAP 0.862. As a result, marine debris showed a large decrease at 8-day intervals, and it was found that the quantity of Styrofoam buoys was about three times larger and the range of change was also larger.

• The Korea Journal of Herbology
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• v.27 no.6
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• pp.107-114
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• 2012

Objectives : In this study, we investigated the anti-diabetic and anti-inflammatory effects of water extract from leaves of Ligustrum japonicum (WLJ) in db/db mouse. Methods : The db/db mice were treated orally with WLJ (300 mg/kg/day) for 10 weeks to examine the long-term effects on hyperglycemia and glomerular tissue as well as biochemical and functional abnormalities in the kidney. Results : WLJ treatment markedly reduced plasma levels of glucose, triglyceride, creatinine, and systolic blood pressure in diabetic db/db mouse. Treatment of WLJ significantly increased plasma level of high density lipoprotein (HDL)-cholesterol. We also found that overexpressions of vascular cellular adhesion molecule (VCAM)-1 and endothelin (ET)-1 were observed in aortic tissue of db/db mouse, whereas, WLJ suppressed both expression of VCAM-1 and ET-1 in aorta. In renal tissue, overexpressions of ICAM-1 and TGF-${\beta}1$ were found in untreated db/db mouse, however, significantly decreased those levels by WLJ treatment. The insulin immunoreactivity of the pancreatic islets remarkably increased in WLJ treated db/db mouse compared with untreated db/db mouse. Taken together, WLJ treatment ameliorated hyperglycemia and hyperlipidemia via improvement of insulin secretion and lipid metabolism, respectively. Furthermore, WLJ treatment also ameliorated hypertension via inhibition of inflammatory process in vascular and renal tissues. Conclusions : Ligustrum japonicum has an anti-diabetic and anti-inflammatory effects in db/db mouse. Thus, these results suggested a beneficial effect of Ligustrum japonicum in treatment with diabetes and diabetic vasculopathy.

• The Korea Journal of Herbology
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• v.27 no.6
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• pp.99-105
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• 2012

Objectives : Korean red ginseng and Morus alba L. are used as a traditional treatment for diabetes. This study was designed to elucidate whether combination with Korean red ginseng and Morus alba L. (MPM) ameliorates metabolic syndrome in fructose-fed rats. Methods : Animals were divided into four groups; Control receiving tap water, fructose-fed, rosiglitazone-treated fructose-fed rats, and MPM-treated fructose-fed rats both receiving supplemented with 60% fructose (n=10). The MPM or rosiglitazone groups initially received a high-fructose (HF) diet alone for 8 weeks, with supplementation with MPM or rosiglitazone occurring during the final 6 weeks. Results : MPM and rosiglitazone, synthetic $PPAR{\gamma}$ agonist, treatment significantly prevented the increase in fasting serum glucose, leptin, triglyceride, and low density lipoprotein in the HF group when comparing with the control group. MPM and rosiglitazone also led to an increase in high density lipoprotein level in the HF group. The administration of MPM and rosiglitazone prevented the development of the metabolic disturbances such as impaired glucose tolerance, and blood pressure. MPM suppressed increased expressions of endothelin-1 (ET-1) in HF rat aorta. In addition, MPM significantly increased IR-${\beta}$ and PPAR-${\gamma}$ expression in muscle. Conclusions : Based on these results, we suggest that the administration of MPM improves metabolic syndrome through the alteration in lipid profiles and suppression of insulin resistant and blood pressure.

• Korean Journal of Food Science and Technology
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• v.54 no.4
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• pp.391-397
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• 2022

This study aimed to verify the antidiabetic effects of the unripe black raspberry extract (UBRE) in obese diabetic mice. For the experiment, animal model mice were divided into six groups: normal control, diabetic control, three experimental groups (treated with 75, 150, and 300 mg/kg single dose of UBRE), and a positive control (200 mg/kg metformin). The groups treated with 300 mg/kg UBRE and metformin had significantly reduced blood glucose and triglyceride levels in the diabetic mice compared to those in the vehicle control group. In addition, histopathological evaluation showed that UBRE increased the Langerhans area, cell number, and insulin concentration in the pancreatic islets of db/db mice. Therefore, UBRE exerts significant antidiabetic effects by decreasing the blood glucose and lipid levels, suggesting that it can be consumed as a functional diet for diabetic patients.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.34 no.4
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• pp.128-134
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• 2022

Nakdong river estuary is being operated with the goal of expanding the period of seawater inflow from this year to 2022 every month and creating a brackish water area within 15 km of the upstream of the river bank. In this study, the deep learning algorithm Long Short-Term Memory (LSTM) was applied to predict the salinity of the Nakdong Bridge (about 5 km upstream of the river bank) for the purpose of rapid decision making for the target brackish water zone and prevention of salt water damage. Input data were constructed to reflect the temporal and spatial characteristics of the Nakdong River estuary, such as the amount of discharge from Changnyeong and Hamanbo, and an optimal model was constructed in consideration of the hydraulic characteristics of the Nakdong River Estuary by changing the degree according to the sequence length. For prediction accuracy, statistical analysis was performed using the coefficient of determination (R-squred) and RMSE (root mean square error). When the sequence length was 12, the R-squred 0.997 and RMSE 0.122 were the highest, and the prior prediction time showed a high degree of R-squred 0.93 or more until the 12-hour interval.