• Information Systems Review
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• v.12 no.3
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• pp.1-17
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• 2010

IT Systems based on Global Single Instance (GSI) can manage a corporation's internal information, resources and assets effectively and raise business efficiency through consolidation of their business process and productivity. But, It has also dangerous factor that IT system fault failure can cause a state of paralysis of a business itself, followed by huge loss of money. Many of studies have been conducted about fault-tolerance based on using redundant component. The concept of fault tolerance is rather simple but, designing and adopting fault-tolerance system is not easy due to uncertainty of a type and frequency of faults. So, Operational fault management that working after developed IT system is important more and more along with technical fault management. This study proposes the fault management process that including a pre-estimation method using TRM (Technical Reference Model) check point and event rule engine. And also proposes a effect of fault-free process through built fault management system to representative company of Hi-tech industry. After adopting fault-free process, a number of failure decreased by 46%, a failure time decreased by 56% and the Opportunity loss costs decreased by 77%.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• autumn
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• pp.353-358
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• 2003

Recently there has been huge efforts to improve performance in construction process by applying emerging techniques such as the Lean principle, Just-in-time concept and so on. However, little achievement as we expected has come out in reality due to the lack of strategy to set a definite goal of the execution and differences of personal viewpoints on construction productivity. Accordingly, it is the most important to promote the circumstances for the construction process improvement by quantifying the goals of respective unit activity groups. This research explores feasible solutions for the improvement of construction projects performance by combining the six-sigma principle for the generic administrative innovation based on the idea of construction process performance. For this purpose, mutual comparisons of various current approaches are performed in an attempt to establish the advantages in applying six-sigma idea and to provide its fundamental strategy. Furthermore, through a case study with the simulation of applying six-sigma to a unit activity group in construction process, this paper verifies that the overall performance improves as the degree of sigma level gets advanced.

• Journal of Life Science
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• v.25 no.9
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• pp.1007-1013
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• 2015

A COG (Cluster of Orthologous Groups of proteins) algorithm was applied to detect conserved genes in 711 prokaryotes. Only COG0080 (ribosomal protein L11) was common among all the 711 prokaryotes analyzed and 58 COGs were common in more than 700 prokaryotes. Nine COGs among 58, including COG0197 (endonuclease III) and COG0088 (ribosomal protein L4), were conserved in a form of one gene per one organism. COG0008 represented 1356 genes in 709 of the prokaryotes and this was the highest number of genes among 58 COGs. Twenty-two COGs were conserved in more than 708 prokaryotes. Of these, two were transcription related, four were tRNA synthetases, eight were large ribosomal subunits, seven were small ribosomal subunits, and one was translation elongation factor. Among 58 conserved COGs in more than 700 prokaryotes, 50 (86.2%) were translation related, and four (6.9%) were transcription related, pointing to the importance of protein-synthesis in prokaryotes. Among these 58 COGs, the most conserved COG was COG0060 (isoleucyl tRNA synthetase), and the least conserved was COG0143 (methionyl tRNA synthetase). Archaea and eubacteria were discriminated in the genomic analysis by the average distance and variation in distance of common COGs. The identification of these conserved genes could be useful in basic and applied research, such as antibiotic development and cancer therapeutics.

• Journal of the Korea Institute of Building Construction
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• v.13 no.6
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• pp.530-540
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• 2013

The business environment that affects the management performance can be characterized by each Strategic Business Unit (SBU) since construction companies win overseas contracts due to the fairly good construction situations while experience a decline in the local housing market. Environmental changes can alter the strategic importance of the SBU when measuring the management performance. However, large construction companies apply BSC (Balanced Score Card) for collective calculation to determine the management performance, making it difficult to reflect the strategic importance of SBU. This method may create a distorted image of management performance that fails to take environmental changes into consideration, and as such it needs to be improved. Yet, there are no studies on the weight of each SBU considering environmental changes. Thus, the current study intends to analyze the weight of SBU for company-wide measurement of the performance of large construction companies. In addition, a model for analysis of SBU importance is proposed to respond to the constantly changing environmental situations and to modify the weight. For analysis of SBU weight, a questionnaire was conducted with 23 experts and hands-on workers, and the questionnaire result was quantitatively analyzed by applying the FD-AHP method. It is expected that the result will enable a model to be proposed to calculate the weight per division in a manner that reflects environmental changes and minimizes strategic distortion when measuring the management performance of large construction companies.

• KSBB Journal
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• v.21 no.2
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• pp.144-150
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• 2006

The exploitation of metagenome, the access to the natural extant of enormous potential resources, is the way for elucidating the functions of organism in environmental communities, for genomic analyses of uncultured microorganism, and also for the recovery of entirely novel natural products from microbial communities. The major breakthrough in metagenomics is opened by the construction of libraries with total DNAs directly isolated from environmental samples and screening of these libraries by activity and sequence-based approaches. Screening with activity-based approach is presumed as a plausible route for finding new catabolic genes under designed conditions without any prior sequence information. The main limitation of these approaches, however, is the very low positive hits in a single round of screening because transcription, translation and appropriate folding are not always possible in E. coli, a typical surrogate host. Thus, to obtain information about these obstacles, we studied the genetic organization of individual URF's(unidentified open reading frame from metagenome sequenced and deposited in GenBank), especially on the expression factors such as codon usage, promoter region and ribosome binding site(rbs), based on DNA sequence analyses using bioinformatics tools. And then we also investigated the above-mentioned properties for 4100 ORFs(Open Reading Frames) of E. coli K-12 generally used as a host cell for the screening of noble genes from metagenome. Finally, we analyzed the differences between the properties of URFs of metagenome and ORFs of E. coli. Information derived from these comparative metagenomic analyses can provide some specific features or environmental blueprint available to screen a novel biocatalyst efficiently.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.9 no.2
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• pp.259-269
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• 2019

The main purpose of this study is to explore the foreign students' learning experiences in natural science basic course at college of engineering in Korea. The subjects were 7 but 4 students took part in the semi-structured interview. All of the interviews were recorded, and the recorded material was transferred and kept. The transcripts were analyzed in a qualitative method. The researchers answered the questionnaire to 7 foreign students who voluntarily participated in the study, and 4 in-depth interviews were also conducted. The interview took 30 minutes to 1 hour, and semi - structured interviewing technique was used. The contents of the interviews were all recorded with the consent of the participants, and the recorded materials were transferred and managed with the interview notes. The transferred data were analyzed based on the coding and categorization process according to the step of the continuous comparison method. The results of this study is the following. There are four themes; problems due to lack of Korean language ability when taking basic courses; problems of terms and concept understanding in major courses; supplementary learning methods of basic courses; necessity of natural science basic education program and requirement of support of the university.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.8
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• pp.477-484
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• 2019

Several types of scavenger receptors, including the Collectin-Placenta 1 (CL-P1) receptorthat is present in mammals, are molecules that are expressed on the surfaces of endothelial cells, macrophages and smooth muscle cells. These molecules are cell surface glycoproteins that can be conjugated to oxidized low density lipoprotein (oxLDL). Among these molecules, the effect of quercetin on CL-P1 activation has been confirmed. Quercetin is known as an antioxidant that stops oxidation because it acts to remove free radicals that are responsible for the oxidation reaction. In this study, fragments from the transcription start site of the mouse CL-P1 gene promoter to the -500th base were cloned using DNA polymerase. These fragments were then introduced into macrophage like RAW264.7 cells and fibroblast-like NIH3T3 cells to study the effect of quercetin on the CL-P1 gene expression. As a result, we found that bases ranging from -250 to -350 in the anterior part where gene expression starts are important for producing CL-P1 protein. Among them, the DNA mutation experiments we performed confirmed that the E2F binding sites are critical for producing the CL-P1 protein? In addition, when quercetin was added to the RAW264.7 culture medium, which was a culture of adherent cells, observedthe phenomenon of the cells falling off from the surface of the culture container.

• Korean Journal of Heritage: History & Science
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• v.56 no.2
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• pp.124-133
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• 2023

Preservation processing for two combat boots was executed through application of 3-dimensional digital technology and with use of preservation materials providing outstanding reversibility and stability. The aim of this was to establish a method to preserve the relics of fallen Korean War soldiers that had been excavated by the soldiers remains excavation corps of the Ministry of National Defense. It was possible to estimate the foot size of the soldiers who would have worn the combat boots via 3-dimensional digital scanning and modeling of the boots. In this process, the original form of the combat boots was restored through the use of 3D-printed structures. The original form was restored through a process of removing contaminants from the excavated relics and performing a conditioning treatment, and through use of an antique-color treatment after bonding and filling in the sections that had been ripped or deteriorated. Following the aforementioned preservation processes, it was possible to confirm that both of the combat boots had soles and top sections made of rubber, and portions of the top section and ankle section of the boots were made of synthetic rubber. As such, it was confirmed that these were similar to the Shoe Pac(M-1944, 12-inch) winter boots that had been manufactured for the purposes of waterproofing and/or protection against cold, and introduced in 1944. Such results confirmed that it is possible to discover the manufacturing techniques, materials, and uses of relics excavated through application of preservation processing, thereby illustrating the importance of the convergent research of scientific preservation processing and 3-dimensional digital technology.

• Korean Journal of Construction Engineering and Management
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• v.16 no.3
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• pp.101-112
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• 2015

In the 1950s, the concept of configuration management (CM) was started by the US Department of Defense (DOD). Later, it has begun to be applied in aerospace, software, engineering, construction, and nuclear power industry. However, configuration management (CM) in the Korean nuclear industry was firstly utilized in 2006 only for selected parts of facilities, while the US nuclear industry has applied CM for the facilities' entire systems since 1990s. Furthermore, configuration management (CM) is in its conceptual stage in the Korean nuclear industry because of ambiguous CM concepts, lacks of CM professional manpower, non-computerization, and inadequacy of CM procedures and processes. In order to address this issues, seven industries (including defense, aerospace, software, engineering, architecture, civil engineering, nuclear power) that utilize the concept of configuration management (CM) were compared and analyzed based on the CM purpose, technique, and life-cycle perspectives. By an extensive literature review and expert interviews, this paper developed a framework of configuration management (CM) for the nuclear industry. And also, a list of functions based on life-cycle stages and CM techniques are developed for clarifying CM framework in order to promote practical applications.

• The korean journal of orthodontics
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• v.33 no.6 s.101
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• pp.485-497
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• 2003

The form and function of the craniofacial structure critically depend on genetic information. With recent advances in the molecular technology, genes that are important for normal growth and morphogenesis of the craniofacial skeleton are being rapidly uncovered, shaping up modem craniofacial biology. One of them is fibroblast growth factor receptor 2 (FGFR2). Specific point mutations in the. FGFR2 gene have been linked to Apert syndrome, which is characterized by premature closure of cranial sutures and craniofacial anomalies as well as limb deformities. To study pathogenic mechanisms underlying craniosynostosis phenotype of Apert syndrome, we used a transgenic approach; an FGFR2 minigene construct containing an Apert mutation (a point mutation that substitute proline at the position 253 to arginine; P253R) was introduced into fertilized mouse germ cells by DNA microinjection. The injected cells were then allowed to develop into transgenic mice. We used a bone-specific promoter (a DNA fragment from the type I collagen gene) to confine the expression of mutant FGFR2 gene to the bone tissue, and asked whether expression of mutant FGFR2 in bone is sufficient to cause the craniosynostosis phenotype in mice. Initial characterization of these mice shows prematurely closed cranial sutures with facial deformities expected from Apert patients. We also demonstrate that the transgene produces mutant FGFR2 protein with increased functional activities. Having this useful mouse model, we now can ask questions regarding the role of FGFR2 in normal and abnormal development of cranial bones and sutures.