• Journal of Chest Surgery
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• v.35 no.11
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• pp.799-806
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• 2002

In spite of the establishment of chemotherapy and the gradual decrease in prevalence, pulmonary tuberculosis is still mainly treated with an operation. Through analyzing and examining some cases of surgical treatment, we hope to provide some help in treating of pulmonary tuberculosis in the future. Material and Method: By comparing four journals previously published in our department with 144 cases of lung surgery during ten years from January of 1991 to December of 2000 performed by the department of thoracic and cardiovascular surgery of the National Medical Center, we analyzed and reviewed the most recent trends and the results of the surgical treatment. Annual frequency of the operation, distribution of age, examination of sputum, adaptability and types of techniques, complications, and results of the postoperative follow-up were used as methods. Result: It was found that the annual frequency of operations had decreased. The ratio of men to women, 2:1 indicates that there are more incidences in men. Aging of patients could be speculated by the .results that the decrease in the incidence rate in the 20s age range and increase rate in the 50s age range. The range of preoperative lesions belonged mostly to far advanced and moderately advanced tuberculosis. By monitoring the period of use in preoperative antituberculosis drugs, cases for more than 3 years remarkably increased from 16.0 % to 55.6 %. The positive reactive rate for preoperative sputum examinations were drastically decreased from 91 % to 27 %. Total pulmonary destruction and partial destruction were the most common cases in terms of adaptability to the operations and there were significant increases in forming empyema accompanied by parenchymal lesions from 4.0 % to 20.1 %. Pneumonectomy and pulmonary lobectomy were the major type of operations. Especially, there were increases in the incident rate of empyema and recurrence of tuberculosis resulted. Post operative follow-up indicates that the rate of complete recovery was more than 70 % and the rate of gradual increase in treating with persistent antituberculosis drug was from 5.8 % to 18.0 %. Conclusion: In recent cases, there is an increasing number of patients showing tolerance to chemotherapy. Patients with pleural tuberculosis and severe lesions were typically increased. It is important to accurately analyze those complaints accurately that are mostly difficult to be treated medically. Surgical treatment is strongly recommended Before multiple drug resistance occurs.

• Journal of Chest Surgery
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• v.36 no.11
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• pp.839-845
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• 2003

Background: Even today when chemotherapy has been established as a treatment for tuberculosis and the prevalence of tuberculosis is gradually decreasing, multi-drug resistance tuberculosis still results in poor treatment performance and lowered survival periods. This research sought to analyze the surgery of multi-drug resistance tuberculosis, and determine the usefulness and danger of surgery in connection with this disease. Material and Method: Starting from February 1990 to February 2002, retrospective surveys were conducted targeted at 21 cases involving 20 patients who underwent surgery due to multi-drug resistance tuberculosis. The survey included 14 males cases and 6 females cases with the age averaging 42.8$\pm$12.1 years. 10.3$\pm$7.6 years on average passed after patients were initially diagnosed with tuberculosis. 13 patients (65%) tested positive in the pre-operative sputum AFB test, and all showed resistance against an average of 3.5 anti-tuberculosis agents including INH and RFP. Pre-operative radiologic examinations revealed cavitary lesions in 15 patients (75%), and three patients had lesions in the both lung fields, with the major lesions existing in the unilateral area. 13 patients (75%) failed negative conversion with medical treatment, while two patients (10%) with recurrent hemoptysis and five patients (25%) with lesions involving high recurrence-rate received the operation. Operations included nine cases (40%) of pneumonectomy, nine cases (45%) of lobectomy, and three cases of lobectomy with segmentectomy. The average follow-up period of patients stood at 23 months. Result: There was no post-operative death, and found were a total of eleven cases involving complications were found: three cases of long-term air leakage, three cases of bleeding requiring re-operation, two cases of empyemas due to broncho-pleural fistula, and one case of atelectasis, wound infection and chest wall fistula each. Eleven cases (85%) of negative conversion were completed immediately after the operation, and two cases failed negative conversion. Eleven months after the operation, the disease recurred in one case of negative conversion patients, and the patient was cured by completion pneumonectomy. Conclusion: If patients' lung function was sufficient and appropriate resection was possible, multi-drug resistance tuberculosis could achieve high-rate negative conversion and cure using combination of surgical and medical treatment, and also there were not many serious complications.

• Journal of Life Science
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• v.28 no.8
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• pp.992-998
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• 2018

Cancer cells grow in an environment composed of various components that supports tumor growth. Major cell types in the tumor microenvironment are fibroblast, endothelial cells and immune cells. All of these cells communicate with cancer cells. Among infiltrating immune cells as an abundant component of solid tumors, macrophages are a major component of the tumor microenvironment and orchestrates various aspects of immunity. The complex balance between pro-tumoral and anti-tumoral effects of immune cell infiltration can create a chronic inflammatory microenvironment essential for tumor growth and progression. Macrophages express different functional programs in response to microenvironmental signals, defined as M1 and M2 polarization. Tumor-associated macrophages (TAM) secret many cytokines, chemokines and proteases, which also promote tumor angiogenesis, growth, metastasis and immunosuppression. TAM have multifaceted roles in the development of many tumor types. TAM also interact with cancer stem cells. This interaction leads to tumorigenesis, metastasis, and drug resistance. TAM obtain various immunosuppressive functions to maintain the tumor microenvironment. TAM are characterized by their heterogeneity and plasticity, as they can be functionally reprogrammed to polarized phenotypes by exposure to cancer-related factors, stromal factors, infections, or even drug interventions. Because TAMs produce tumor-specific chemokines by the stimulation of stromal factors, chemokines might serve as biomarkers that reflect disease activity. The evidence has shown that cancer tissues with high infiltration of TAM are associated with poor patient prognosis and resistance to therapies. Targeting of TAM in tumors is considered a promising therapeutic strategy for anti-cancer treatment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.6
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• pp.37-43
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• 2017

This review investigates the basic principle of physical interactions and failure mechanisms introduced in the materials and inner parts of semiconducting components under electromagnetic pulses (EMPs). The transfer process of EMPs at the semiconducting component level can be explained based on three layer structures (air, dielectric, and conductor layers). The theoretically absorbed energy can be predicted by the complex reflection coefficient. The main failure mechanisms of semiconductor components are also described based on the Joule heating energy generated by the coupling between materials and the applied EMPs. Breakdown of the P-N junction, burnout of the circuit pattern in the semiconductor chip, and damage to connecting wires between the lead frame and semiconducting chips can result from dielectric heating and eddy current loss due to electric and magnetic fields. To summarize, the EMPs transferred to the semiconductor components interact with the chip material in a semiconductor, and dipolar polarization and ionic conduction happen at the same time. Destruction of the P-N junction can result from excessive reverse voltage. Further EMP research at the semiconducting component level is needed to improve the reliability and susceptibility of electric and electronic systems.

• Korean Journal of Soil Science and Fertilizer
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• v.30 no.2
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• pp.168-177
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• 1997

This study was carried out to find the physico-chemical properties of soils and the rice growth at the pilot project rice farm of Buchanan city, Liberia. The results were as follows. Soils were classified as Plinthic Ferralsols. Real tropical soils had an oxic B horizon of 30cm thick with diffused horizon boundaries. The surface soils have Ochric A horizon with low organic matter. Plinthite was distributed throughout the whole soil profile unevenly. Exposed to sun light, Plinthite was dried out, hardened, and developed irreversibly into ironstone. There were 286 termite hills in 20ha in the project area. The pH value of the termite hills was higher than that of the ordinary soil two units. Soils of the termite hills had higher contents of carbon, nitrogen, available phosphate and exchangeable bases, especially calcium(2,000mg/kg). Available Fe contents was 230~330mg/kg in the surface soil, and 2,200mg/kg in the subsoil. This caused bronzing of rice in a few days after transplanting. The tolerance of Fe toxicity was lower in Korean cultivars than in Liberian cultivars. The tolerant cultivar was Hangang among Korean cultivars and Nizersail and Suakoko 8 among Liberian cultivars. Area weighted average percolation rate was 8.3mm/day and infiltration rate was 2~2.5mm/hr.

• Korean Journal of Ichthyology
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• v.28 no.1
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• pp.1-8
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• 2016

This study was conducted to investigate the physiological responses of sevenband grouper, Epinephelus septemfasciatus at low temperature condition in winter season. Water temperature was dropped from $12^{\circ}C$ to $5^{\circ}C$ by two different interval (interval I: $-1^{\circ}C/24h$ and interval II: $-1^{\circ}C/8h$). The experimental fishes were exposed for 9 days at each water temperature condition, and were observed survival rate. The blood sample was collected from fishes for analysis of cortisol, glucose, total protein (TP), and electrolytes ($Na^+$, $Cl^-$, $K^+$). Mortality of fish was not observed until $5^{\circ}C$. The mortality (12 individuals) began after 170 h and all fish were death after 174 h in interval I case, whereas the mortality (9 individuals) began after 72 h and all fish were death after 76 h in interval II case. Little different was observed in the physiological responses, but trend was similar between two intervals. The physiological metabolism of plasma cortisol and glucose were increased rapidly, and swimming ability and respiration response was faster at $7^{\circ}C$. This result means that the critical temperature of sevenband grouper was $7^{\circ}C$ at low water temperature condition.

• The Korean Journal of Ecology
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• v.25 no.2
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• pp.101-107
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• 2002

Three species of Chenopodiaceae, i.e. Suaeda japonica, Salicomia herbacea, Beta vulgaris var. cicla, were investigated to compare the physiological characteristics through inoic balances and osmoregulations under different environmental salt gradients. Plats were harvested in two weeks from treatments with salt gradients (0, 50, 100, 200 and 400 mM NaCl) and mineral nutrition gradients(1/1, 1/5, 1/10 dilutions of Hoagland solution). Plants were analyzed for growth responses, ionic balances, osmolalities, conductivities, glycinebetaine and proline contents quantitatively. Three plants of Chenopodiaceae accumulated slats into tissues unlike some salt sensitive species, and showed unique adaptation patterns to overcome saline environments, i.e. strong growth stimulation for Salicomia herbacea, growth negative tolerance for Suaeda japonica, and growth positive tolerance for Beta vulgaris var. cicla. The absorption of inorganic Ca/sup 2+/ ions was inhibited remarkably due to the excess uptake of Na+ with increasing salinity. The K+ content in plants was significantly reduced with increasing salinity. Total nitrogen content was reduced as mineral nutritions and salinity increased. Conductivity and osmolality increased with increasing salinity regardless of mineral nutritions. The ranges of glycinebetaine and proline contents were 0.2∼2.5 μM/g plant water and 0.1∼0.6μM/g plant water, respectively.

• Proceedings of the Korea Water Resources Association Conference
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• 2011.05a
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• pp.85-85
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• 2011

홍수기에 안전하고 정확한 유량측정을 통하여 물관리에 필요한 기초수문자료를 확보하고자 한국수자원공사에서 1993년도부터 홍수유량측정기술 확보를 위한 연구를 시작하였다. 그간의 연구성과를 바탕으로 1999년도에 하천의 유속을 비접촉식으로 측정할 수 있는 홍수용 전자파표면유속계를 개발하여 특허등록하였고 그와 동시에 이의 상품화를 추진하여 2010년도까지 75대를 보급하여 실무에서 이용하고 있다. 이동식인 홍수용 전자파표면유속계를 바탕으로 2001년도에는 고정식 실시간 홍수유량측정측정시스템을 개발하여 특허등록하였고, 이 시제품을 현재 용담 수자원시험유역의 동향지점에서 시험운영하고 있다. 또한, 현장 유량측정실무자들의 홍수용 전자파표면유속계 개선요구에 따라 편각용 전자파표면유속계 시제품을 개발하였으며, 이는 임의의 한 지점에 설치한 한 대의 장비로 좌우 여러 측선의 유속을 동시에 측정할 수 있는 다점 측정기능을 갖도록 성능을 개선하였다. 이에 따라 홍수시 유량측정에 소요되는 시간이 줄어들어 신속하게 유량측정을 완료할 수 있는 계기를 마련하였다. 이와 더불어 유속측정 범위를 확장하여 홍수시의 고유속 뿐만 아니라 0.5 m/s 이하의 저유속까지 측정할 수 있는 범용 전자파표면유속계의 시제품을 추가로 개발하였다. 이 장비는 최저유속 0.03 m/s의 측정을 실내시험을 통하여 입증하였다. 범용 전자파표면유속계는 상품화 시제품의 개발을 목표로 기존 시제품의 현장시험을 통하여 현장적용상의 문제점에 대한 해결에 주력하였다. 첫째, 평갈수용 전자파표면유속계의 사용편의를 개선하기 위하여 소형화 및 경량화를 추진하였고, 이를 위하여 사용주파수를 기존의 10 GHz에서 24 GHz로 변경함으로써 $35{\times}35\;cm$ 크기의 기존안테나를 $22{\times}22\;cm$ 크기로 소형화하였으며 송수신부의 무게는 기존 18 kg에서 3.3 kg으로 혁신적으로 줄이는데 성공하였다. 이를 위하여 안테나는 기존의 반사형안테나에서 도파관슬롯배열안테나로 변경하였다. 둘째, 측정값의 안정화를 위하여 안테나의 특성을 개선하여 부엽(side-lobe) 레벨 30 dB 이하 그리고 전후방비(front-back ratio) 50 dB 이하로 개선하여 안테나가 지향하는 방향 이외의 위치에서 반사되는 불필요한 신호를 줄였다. 또한 적응형 이득제어(adaptive gain control)기법의 채택으로 미소 신호에 대한 안정적 측정 및 과다 신호에 대한 능동적 감쇄를 할 수 있도록 시스템을 구성하여 전 유속범위에 대한 안정적 측정을 가능토록 설계 및 제작하였다. 셋째, 자가점검 기능을 탑재하여 유속측정 전에 기기의 상태에 대한 self test기능을 통하여 측정자가 기기의 상태를 사전에 파악 가능토록함으로써, 기기 오작동에 대한 능동 대처할 수 있도록 하였다. 이외에도 저전력 회로설계를 통하여 배터리 사용시간을 확장하였고, 기존의 전자파표면유속계가 가지고 있던 방습 및 방수에도 내성을 갖는 제품으로 설계하였으며 스마트기기를 이용한 무선측정 및 세련된 디자인 등 사용자의 요구사항을 충분히 반영하였다.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.56 no.3
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• pp.183-191
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• 2011

This study was undertaken to collect basic knowledge of Jatropha which is one of bio-energy crops, based on the understanding of physiological and molecular aspects under salt and drought conditions. The treatments were followed as: 100, 200 and 300 mM NaCl for salt stress and 5, 10, 20 and 30% PEG for drought stress for 8 days, respectively. Leaf growth, stomatal conductance, chlorophyll fluorescence and gene expression of aquaporin (JcPIP2) of Jatropha were investigated. From 2 days after treatments, plants treated with higher than 100 mM NaCl and 10% PEG respectively were significantly suppressed in leaf length, width, and stomatal conductance, but 5% PEG treatment showed that plant growth was improved more than control plant. Semi-quantitative RT-PCR analyses revealed that the JcPIP2 gene was expressed in root, stem, cotyledon and leaves. It was not detected in leaves at 200 and 300 mM NaCl treatments. However, transcripts of JcPIP2 were induced in roots and stems under salt and drought conditions compared to those of healthy plants. Therefore, it was concluded that JcPIP2 plays an important role in improving drought tolerance.

• Food Science of Animal Resources
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• v.25 no.1
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• pp.92-97
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• 2005

This study was carried out to determine the storage, cryotolerance, heat and drying resistance, when Lactobacillus acidophilus CT 01 isolated from preweaned piglet feces growing at suboptimal temperature. L. acidophilus CT 01 suboptimal temperature incubated for 48 hours had the slowest growth rate at 22℃ but the highest viable cell number after 36 hours at 22℃, with 1.3×10/sup 9/ CFU/mL. In case of 4 and 20℃ storage, the suboptimal temperature incubated groups had a viability higher than the control (p<0.01). The cryotolerance of suboptimal temperature incubated L. acidophilus CT 01 was a higher than the control (p<0.01). When L. acidophilus CT 01 was heat treated at 60℃ for 15 minutes and 30 minutes, the suboptimal temperature incubated L. acidophilus CT 01 at 22℃ had a viability higher more than the control (p<0.01). L. acidophilus CT 01 incubated suboptimal temperature was inoculated by 30% to the carrier, and dried at 50℃ for 12 hours had the highest viability in the suboptimal temperature incubated L. acidophilus CT 01 at 28℃.