• Journal of the Korean Society of Food Science and Nutrition
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• v.32 no.2
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• pp.181-184
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• 2003

We investigated the effect of ethanol on the production of cellulose and acetic acid fermentation by Gluconacetobacter persimmonensis KJ145. Results showed that bacterial cellulose productivity was highest when 2% ethyl alcohol was added to apple-juice medium. For acetic acid production, 7% ethyl alcohol was needed. Optimal concentration of ethyl alcohol was 5% for simultaneous production of bacterial cellulose and acetic acid. For simultaneous production of bacterial cellulose and acetic acid, optimal nitrogen source and optimal concentration were corn steep liquor and 15% (w/v), respectively Optimal culture time for simultaneous production of bacterial cellulose and acetic acid was 14 days. At the optimal condition, Cluconacetobacter persimmonenis KJ145 produced 7.55 g/L of bacterial cellulose (dry weight).

• Journal of the Korean Chemical Society
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• v.9 no.4
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• pp.215-221
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• 1965

The significant liquid structure theory is extended to binary mixture, benzene-ethylenechloride system. The partition function, applicable throughout the temperature range in which Raoult's law is satisfied is derived. The thermodynamic quantities such as total and partial pressures, molar volumes and mixing entropies are calculated from the partition function at the temperatures $293.15^{\circ},\;323.14^{\circ}\;and\;357.15^{\circ}K.$ The theoretical values, thus calculated, are found to agree with the experimental data in the literatures.

• Korean Journal of Head & Neck Oncology
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• v.20 no.2
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• pp.189-193
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• 2004

Basaloid squamous carcinoma (BSC) is an uncommon aggressive variant of squamous cell carcinoma with a predilection for hypopharynx, tongue base, and larynx. We present 5 cases of BSC of unusual sites, each from maxillary sinus, external auditory canal, submandibular gland, tonsil, and nasopharynx. Only a few cases arising in these sites have been reported to date. Patients included 3 men and 2 women with the age range of 45-69 years (mean, 56.4 years). Microscopically, the tumors were characterized by solid lobules and nests of ovoid basaloid cells with abundant desmoplastic stroma. Comedonecrosis, peripheral palisading of tumor cells, trabecular pattern, and rosette-like arrangement were commonly observed. Tumor cells had scanty cytoplasm and their nuclei were ovoid, relatively uniform, and hyperchromatic. In two cases, concomitant squamous cell carcinoma in situ was identified. Immunohistochemical stains revealed that tumor cells were strongly positive for pancytokeratin and negative or weakly positive for p63. Being aware of BSC that can arise from unusual sites would help diagnose correctly and treat properly this rare and distinct clinicopathologic entity.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.13 no.1
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• pp.104-109
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• 1991

Loss of mandibular continuity due to neoplasm, trauma, or infection results in major esthetic and biologic compromise. The use of costochondral grafts for reconstruction of temporomandibular joint, described first by Gillies in 1920, has been accepted as a suitable method for replacing the mandibular condyle, especially in growing children. Autogenous iliac bone graft has been a satisfactory source of mandibular reconstruction since Sykoffs report in 1900. Autogenous bone grafts from the posterior aspects of the ilium provide large amount of PMCB with acceptable donor site morbidity. In timing of reconstruction, initial disease, age, medical history, growth and development, esthetic and psychologic factors should be considered. We present a case of osteosarcoma in the mandible that was treated by a hemimandibulectomy and the defect was reconstructed 20 months later with composite method of costochondral and posterior iliac bone graft.

• Journal of the Korean Society of Propulsion Engineers
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• v.18 no.5
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• pp.35-42
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• 2014

Thermal analysis properties and adhesive properties of self-healing agents were evaluated through differential scanning calorimetry, reaction heat measurement, and adhesive shear test. D1E0, D3E1, D1E1, D1E3, and D0E1, depending on the mixing ratio of DCPD and ENB, were considered as self-healing agents. The amount of Grubbs' catalyst, depending on the type of self-healing agents, was varied from 0.1 wt% to 1.5 wt%. In the case of DCPD, the polymerization reaction occurred faster and the stabilized adhesive strength increased as the amount of catalyst increased; however, a large amount of catalyst was required. ENB had excellent reactivity with a small amount of the catalyst; however, high reaction heat was observed at the early stage of polymerization. Thermal analysis properties and adhesive properties of self-healing agents can be controlled by varying a mixing ratio of DCPD and ENB. Among the self-healing agents used for this study, the D3E1 would be one of the most preferable candidates with regard to maximum adhesive strength, reaching time to maximum adhesive strength, stabilized adhesive strength, and reaction heat.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.4
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• pp.572-577
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• 2002

We investigated the optimal condition for production of bacterial cellulose with Gluconacetobacter persimmonus KJ145. For bacterial cellulose production, optimal medium composition and culture conditions were conducted to determine. Apple juice (10$^{\circ}$Brix) medium was suitable than Hestrin & Schramm medium which is generally used for the bacterial cellulose production. When 1% pyruvate as carbon source was added to apple juice, bacterial cellulose production rose to high level. The effect of various nitrogen sources was investigated: CSL was found to be essential to high cellulose yields and the optimal CSL concentration was 10%. Optimal temperature and culture time for the bacterial cellulose production was 35$^{\circ}C$ and 16 days, respectively At the optimal condition Gluconacetobacter persimmonus KJ145 produced 8.96g/L of bacterial cellulose (dry weight), which was much higher than reported values.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.40 no.6
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• pp.515-522
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• 2012

CFIT(Controlled Flight Into Terrain) is one of the major causes of aircraft accidents. In order to solve this problem, GPWS(Ground Proximity Warning System) is used to generate terrain collision warning using the distance between the aircraft and the underneath ground. Since the GPWS uses the vertical clearance only, it frequently generates false warnings. In this study, a terrain/obstacle collision avoidance warning algorithm was developed for fast flying and highly maneuvering fighters using the flight status and the geographic information. This algorithm condsiders the overall delay in the aircraft reactive motion including the pilot's reaction time. The paper presents a detailed logic and test methods.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.233-233
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• 2022

최근 기후변화로 인해 집중호우 및 돌발홍수의 증가로 침수피해가 빈번하게 발생하고 있다. 마찬가지로 해안지역의 피해 또한 증가하고 있으나, 해안지역의 특성을 고려한 연구가 미비한 실정이다. 따라서 본 연구에서 해안지역의 특성을 고려해 폭풍해일로 인한 월파뿐만 아니라 강우도 고려하여 해안지역의 범람 양상을 확인하고자 하였다. 본 연구에서는 국내 해안지역에 대한 빈도별 폭풍해일과 강우로인한 범람 모의를 진행하였다. 우선, 수치해석 모형의 경계조건을 산정하기 위해 EurOtop(2018)의 경험식을 이용하여 월파량을 산정하였다. EurOtop의 월파량 산정 시 암석 옹벽이 아닌 콘크리트 옹벽으로된 경사식 단면으로 고려하여 계산하였고 산책로와 벽까지 고려하여 계산하였다. 경험식 계산을 위해 매개변수(유의파고, 여유고, 구조물의 조도계수, 구조물의 기울기 및 경사 등)를 조정하여 계산하였다. 이 중, 계산에 사용된 유의파고는 시나리오별 강우에 대해 SWAN(Simulating WAves Nearshore)으로 계산된 값을 활용하였고, 해안선을 두 부분으로 나누어 해안지역 각 지점별 파고값의 평균을 사용해 월파량 계산을 진행했다. 이때, 파고의 종류로 5% 확률의 파고, 평균 파고, 중앙값 파고, 95% 확률의 파고로 분류해 월파량 계산을 진행했고, 그 중, 평균 파고를 이용해 계산한 월파량을 수치해석 모델의 입력자료로 활용하였다. 시나리오별로 계산된 월파량만을 이용해 2차원 침수모형인 FLO-2D의 경계조건 입력값으로 사용하여 침수 양상을 표출하기 위해 Mapper와 ArcGIS를 이용하여 침수와 범람 양상을 확인하였다. 또, 다른 조건으로 시나리오별 계산된 월파량, 연구유역 해안 반대편에 위치한 산으로부터 유입되는 물의 양 그리고 해안지역 전체에 내리는 강우를 입력자료로 사용해 모의를 진행한 후 Mapper와 ArcGIS로 표출하여 침수 및 범람 양상을 확인하였다.

• Radiation Oncology Journal
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• v.18 no.4
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• pp.321-328
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• 2000

Purpose :NOS2 induce NO Production and NO activate TGF-${\beta}$. The TGF-${\beta}$ is a inhibitor of NOS2. If this negative feedback mechanism operating in radiation pneumonitis model, NOS2 inhibitor may play a role in TGF-${\beta}$ suppression. We planned this study to evaluate the expression patterns of NO, NOS2 and TGF-${\beta}$ in vivo radiation pneumonitis model. Materials and Methods : Sixty sprague-Dawley rat were irradiated 5 Gy or 20 Gy. They were sacrificed 3, 7, 14, 28 and 56 days after irradiation. During sacrifice, we peformed broncho-alveolar lavage (BAL). The BAL fluids were centrifuged and supernatents were used for measure NO and TGF-${\beta}$, and the cells were used for RT-PCR. Results : After 5 Gy of radiation, NO in BAL fluid increased at 28 days in both lung and TGF-${\beta}$ in left lung at 56 days. NO increased in BAL fluid at 28 days in both lung after irradiation and TGF-${\beta}$ in right lung at 28-56 days after 20 Gy of radiation. After 5 Gy of radiation, NOS2 expression was increased in right lung at 14 days, in both lung at 28 days and in left lung at 56 days. TGF-${\beta}$ expression was reduced in both lung at 28 days and increased in left lung at 56 days. Conclusions :The Proposed feedback mechanism of NO, NOS2 and TGF-${\beta}$ was operated in vivo radiation pneumonitis model. At 56 days, however, NOS2 and TGF-${\beta}$ expressed concurrently in left lung after 5 Gy and in both lung after 20 Gy of radiation.

• Journal of Nutrition and Health
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• v.51 no.6
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• pp.498-506
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• 2018

Purpose: Lycopene, a carotenoid with anti-oxidant properties, occurs naturally in tomatoes and pink grapefruit. Although the beneficial effects of lycopene on various disorders have been established, little attention has been paid to the possible anti-diabetic effects of lycopene focusing on ${\beta}$-cells. Therefore, this study investigated the potential of lycopene to protect ${\beta}$-cells against apoptosis induced by a cytokine mixture. Methods: For toxicity experiments, the cells were treated with 0.1 ~ 10 nM of lycopene, and the cell viability in INS-1 cells (a rat ${\beta}$-cell line) was measured using a MTT assay. To induce cytokine toxicity, the cells were treated with a cytokine mixture (20 ng/mL of $TNF{\alpha}$ + 20 ng/mL of IL-$1{\beta}$) for 24 h, and the effects of lycopene (0.1 nM) on the cytokine toxicity were measured using the MTT assay. The expression levels of the apoptotic proteins were analyzed by Western blotting, and the level of intracellular reactive oxidative stress (ROS) was monitored using a DCFDA fluorescent probe. The intracellular ATP levels were determined using a luminescence kit, and mRNA expression of the genes coding for anti-oxidative stress response and mitochondrial function were analyzed by quantitative reverse-transcriptase PCR. Results: Exposure of INS-1 cells to 0.1 nM of lycopene increased the cell viability significantly, and protected the cells from cytokine-induced death. Lycopene upregulated the mRNA and protein expression of B-cell lymphoma-2 (Bcl-2) and reduced the expression of the Bcl-2 associated X (Bax) protein. Lycopene inhibited apoptotic signaling via a reduction of the ROS, and this effect correlated with the upregulation of anti-oxidative stress response genes, such as GCLC, NQO1, and HO-1. Lycopene increased the mRNA expression of mitochondrial function-related genes and increased the cellular ATP level. Conclusion: These results suggest that lycopene reduces the level of oxidative stress and improves the mitochondrial function, contributing to the prevention of cytokine-induced ${\beta}$-cell apoptosis. Therefore, lycopene could potentially serve as a preventive and therapeutic agent for the treatment of type 2 diabetes.