Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Basaloid Squamous Carcinoma of Unusual Sites

생소한 위치에 발생한 기저양 편평세포암종

  • Cho Yong-Mee (Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim Kyu-Rae (Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Ro Jae-Y. (Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Jang Se-J. (Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Kim Sang-Yoon (Department of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center) ;
  • Cho Kyung-Ja (Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center)
  • 조영미 (울산대학교 의과대학 병리학교실) ;
  • 김규래 (울산대학교 의과대학 병리학교실) ;
  • 노재윤 (울산대학교 의과대학 병리학교실) ;
  • 장세진 (울산대학교 의과대학 병리학교실) ;
  • 김상윤 (울산대학교 의과대학 이비인후과학교실) ;
  • 조경자 (울산대학교 의과대학 병리학교실)
  • Published : 2004.11.01
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Abstract

Basaloid squamous carcinoma (BSC) is an uncommon aggressive variant of squamous cell carcinoma with a predilection for hypopharynx, tongue base, and larynx. We present 5 cases of BSC of unusual sites, each from maxillary sinus, external auditory canal, submandibular gland, tonsil, and nasopharynx. Only a few cases arising in these sites have been reported to date. Patients included 3 men and 2 women with the age range of 45-69 years (mean, 56.4 years). Microscopically, the tumors were characterized by solid lobules and nests of ovoid basaloid cells with abundant desmoplastic stroma. Comedonecrosis, peripheral palisading of tumor cells, trabecular pattern, and rosette-like arrangement were commonly observed. Tumor cells had scanty cytoplasm and their nuclei were ovoid, relatively uniform, and hyperchromatic. In two cases, concomitant squamous cell carcinoma in situ was identified. Immunohistochemical stains revealed that tumor cells were strongly positive for pancytokeratin and negative or weakly positive for p63. Being aware of BSC that can arise from unusual sites would help diagnose correctly and treat properly this rare and distinct clinicopathologic entity.

Keywords

References

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