• Journal of Chest Surgery
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• v.38 no.9 s.254
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• pp.595-600
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• 2005

Background: Colchicine with its immunosupressive properties has been used with benefcial effects in autoimmune disease, such as Gout, etc. Whether colchicine, by virtue of the above property, could attenuate the process of cardiac allograft rejection in the rats is investigated in this report. Material and Method: We compared the untreated group (Control, n=6), Cyclosporin A group (10 mg/kg, daily, n=20), and Colchicine derivative group (Colchicine 40 ${\mu}g$/kg, n=20) of cardiac allografts in the rats. Result: In the untreated control group (n=6), all of 6 rats showed rejection within 3 weeks after cardiac allograft. In the cyclosporin A group (n=20), cyclosporin A (10 mg daily oral dose) was administered at a 10 mg daily oral dose and promoted long-term survival (over 100 days). The cyclosporin A group had one mortality at the 18th post-operative day due to infection. Furthermore, in the Colchicine derivatives group (n=20) with a daily IP (Intra Peritoneum) dose (40 ug/kg/day), we observed long-term survival.(> 100 days), except for one rat that died of an anesthetic problem (respiratory failure) at the 9th post-operative day. Conclusion: Experiments have also been performed to evaluate whether the effect of colchicine derivatives allowed prolonged survival of cardiac allografts compared with the cyclosporin A administration group in the rats.

• Geotechnical Engineering
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• v.14 no.5
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• pp.129-142
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• 1998

This research is focused on the inducement of the constitutive equation considering the creep strain component and on the development of a finite element method program. The purpose of this research was to contribute to the design of construction structures or to the construction management in soft clay ground through predicting the long-term strain of construction structures reasonably bused on the above program. Modified Cam Clay model was adopted to describe the elastic-plastic behavior of clayey soil. And in the calculation of the creep sprain, the secondary coefficient of consolidation C. was applied for considering the volumetric creep element and the constants m, $\alpha$, A were rosed by the empirical creep equation proposed by Singh 8E Mitchell for considering the deviatoric creep element. To examine the reliability of the program which is developed in this study, the estimated values by this program were compared with the theoretical solution and the experimental results. And the applicability of the developed program was found to be reliable from the sensitive analysis of each parameters used in this study. According to the results obtained from the application of the program on the field measurement data, the estimated values by the program were found with be consistent with the actual values. And from the analysis of the displacement of embankments, the case of considering the creep behavior induced much fower errors than the case of neglecting it. But the results obtained from considering the volumetric creep behavior only were slightly underestimated the results from considering the deviator creep behavior showed the slightly overestimated values. Therefore, it remains the task of further studios to develop the laboratory test devices to obtain the reliable creep parameters, and to select the appropriate soil parameters, etc.

• Proceedings of the Korea Concrete Institute Conference
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• 2010.05a
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• pp.109-110
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• 2010

A pedestrian UHPC cable-stayed bridge(Super Bridge I) of the KICT was completed as a test bed. A long-term monitoring system has been installed on the UHPC bridge in order to acquire all types of long-term data such as strain, acceleration, tension force, wind direction and speed, temperature, etc. This system will provide valuable database enabling to assess the long-term behavior of the UHPC pedestrian hybrid cable-stayed bridge. This database will be exploited for the evaluation of the mechanical characteristics and serviceability of the UHPC members so as to estimate the behavioral features of long-span hybrid cable stayed bridges.

• 한국방재학회:학술대회논문집
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• 2010.02a
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• pp.90.2-90.2
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• 2010

흙막이 굴착 및 절취사면의 보강공법으로 많이 적용되고 있는 앵커의 장력을 측정하는 전기저항식 로드셀과 스트레인게이지, 바이브레이팅 와이어 (vibrating wire) 타입의 모니터링 방법은 안전관리를 위한 장기적인 모니터링에 한계를 가지고 있어 이를 개선할 수 있는 방안으로 광섬유 센서를 이용하여 강연선의 변형률을 측정할 수 있는 스마트 텐던이 개발되었다(김재민 등, 2007). 앵커를 구성하는 7연 강연선(텐던)의 중앙케이블에 삽입된 광섬유브래그격자(Fiber Bragg Grating ; FBG)센서는 기존 스트레인게이지 타입에 비해 크기가 작고 내구성이 우수하며 전자기파에 의한 노이즈 발생이 없고 하나의 리드선으로 다중점 측정(multiplexing)이 가능하여 장기모니터링에 효과적인 장점이 있다. 본 연구에서는 FBG센서를 내장한 스마트 텐던을 실대형(Prototype) 앵커(L=11.5m)에 적용하여 현장 인발실험에 의해 시공중 장력 모니터링을 수행하고 로드셀 측정결과와 비교하였고 정착부에 설치된 FBG 센서로부터 앵커의 하중전이 계측을 수행하였다.

• Proceedings of the Korea Concrete Institute Conference
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• 1997.04a
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• pp.308-314
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• 1997

Shrinkage and creep are the fundamental properties of concrete. These long term deformations can be seen as bothersome(increased deflection) or can be seen as reduction of compressive stress of prestressed concrete. Steel fibers advance the mechanical properties of concrete:tensile strength, ductility, flexural strength, fracture toughness, and post-cracking resistance, etc...Silica fume is pozzolanic material which combines with hydrated lime to generate silicate materials which increase the compressive strength and reduce somewhat the creep of concrete. This paper is the result of the long-term deformation by silica fume and steel fibers with varying percentages.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5D
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• pp.783-796
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• 2006

Rut-resistance pavement is adopted to prevent pavement from plastic deformation since 1998. The objective of this paper is to investigate performance and economic efficiency between rut-resistance pavement and conventional hot-mix asphalt(HMA) on national highway. The pavement deterioration models incorporated in HDM-4 have been calibrated and adapted to local road conditions based on observed pavement rut-depth data. Based on calibration result of HDM-4, the economic evaluation including road agency cost and user cost is performed for 34 road pavement sections. Furthermore, we presented optimal timing for maintenance and performance levels subject to different budget. We found that rut-resistance pavement is performing better than conventional hot-mix asphalt in most road sections. Furthermore, we confirmed that the application of HDM-4 is useful for pavement project planning and evaluation. More investigation is needed to enlarge the scope of the pavement data and to explore more deeply socio-environmental cost and delay cost.

• Journal of the Korea Concrete Institute
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• v.13 no.1
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• pp.77-85
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• 2001

Concrete filled steel tubular (CFT) columns are becoming popular in structural applications. The increased popularity comes from their excellent structural properties such as high strength, high ductility, and large energy absorption capacity. However, the disadvantage feature of CFT column is the difficulty in predicting its time dependant characteristic (i.e., creep and shrinkage) of inner concrete. The time dependent behavior of CFT column can cause serious serviceability problems. Therefore, it is necessary to investigate the long term behavior of CFT column. This paper presents analytical and experimental studies on long-term behavior of CFT-column under a central axial loading. Two loading cases are considered in the research; (1) the load applied only at the inner core concrete of CFT-column and (2) the load applied simultaneously on both concrete and steel tube. Analysis method using the bond strength model is proposed and conclusions on long-term properties of CFT-column can be derived from the results.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.1
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• pp.50-55
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• 2011

In this study, simultaneous aero-structural design was performed for HALE aircraft wing. The span and the shape of main spar were considered as design variables. To maximize aerodynamic performance and to minimize weight, multi-objective optimization was used. Nonlinear static aeroelastic analysis was performed to compute large deflection of wing. Design of experiment and response surface method were used to reduce computation cost in the design process. Also, aerodynamic performances of deformed wing and rigid wing were compared.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1993.04a
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• pp.103-103
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• 1993

목적: Estroge 결핍으로 나타나는 폐경기의 주요 증상을 경감 치료하기 위해, estrogen경구 투여시 위장장애, 위장에서의 대사, 간 초회효과, 자주 투여로 인한 환자의 불편 등의 단점이 있나, 이러한 점을 개선하기 위한 투여경로의 하나로 피부를 통해 일정약물을 장기간 일정속도로 송달시키는 경피 흡수 시스템의 개발이 필요하다. 따라서 (EE)의 장기제어방출을 위해 ethylene vinyl acetate (EVA)를 사용하여 장기 제어방출 및 경피 흡수의 최적화 조건을 설정하여 경피흡수 시스템을 위한 막의 개방을 목적으로 한다. 방법: VA 함량이 18-40％까지의 EVA를 사용하여 EE를 함유한 matrix를 casting 방법으로 제조하고 변형된 Keshary-Chien cell을 이용하여 방출실험을 실행하였다. 이때 방출에 미치는 여러 가지 인자로서 EVA 주의 VA함량, 막의 두께, receptor 중 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 량 등에 대해 검토하였다. 그리고 점개한 mouse skin에 대한 투과 실험을 행하고 이에 미치는 PEG 400과 자질층의 역할을 검토하였다. 결과: EE의 용해도는 saline so PEG 400의 용량 비율이 증가함에 따라 지수 함수적으로 증가하였다. 그리고 VA 함량이 증가될수록, PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 PEG 400의 용량비율, 방출 매개체의 온도, loading 된 약물의 양이 증가될수록 EE의 방출속도와 부과속도는 증가하였다. 또한 투과속도는 막두께의 역수와 직선상의 상관 관계를 보였다. 그리고 EVA matrix로부터 EE가 방출되는 양상은 diffusion-controlled model을 따랐으며 이때 단위면적당 방출된 총량은 T에 비례되었다. 절개한 mouse skin을 통한 EE의 permeation은 PEG 400의 첨가에 의해 상승되었다. 이와 같이 EVA 막이 EE의 부과 및 방출을 조절하는 것으로 보아 경피 흡수를 위해 사용될 수 있다고 사료된다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.4
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• pp.741-749
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• 1994

The purpose of the present study is to propose a realistic method to analyze the prestressed concrete members subjected to long term torsional loading. The present study devises a method to realistically take into account the tensile stiffness of concrete after cracking. The effects of biaxial compressive and tensile loadings on the compressive and tensile strengths of concrete are also taken into account in the present model. The salient feature of the present study lies in the fact that the cracking, creep, and shrinkage behavior of concrete and the relaxation of steel have been realistically considered. The comparison of the present theory with experimental data indicates that the proposed model dipicts reasonably well the actual behavior of prestressed concrete members under long-term torsional loadings.