Depression has a negative impact on social functioning due to its high prevalence and increased suicide rate, and is a disease with a high economic burden. Depression is related to diverse brain-related phenomena, such as neuroinflammation, synaptic dysfunction, and cognitive deficit. As antidepressant drugs used in clinical trials have shown poor therapeutic effects, antidepressant drugs that show rapid efficacy urgently need to be developed. Although studies on various genes, proteins, and signaling pathways related to depression have been conducted, the pathogenesis of depression has not been clearly elucidated. Sirtuin 1 is a nicotinamide-adenine dinucleotide- (NAD+-) dependent histone deacetylase and is involved in cell differentiation, apoptosis, autophagy, and cancer metabolism. Recent genetic studies found that sirtuin 1 is a potential target gene for depression. In addition, preclinical studies reported that sirtuin 1 signaling affects depression-like behavior. In this review, we attempt to present up-to-date knowledge of depression and sirtuin 1. We describe the various roles of sirtuin 1 in the regulation of glial activation, circadian rhythm, neurogenesis, and cognitive function and the effects of its expression on depression. Further, we discuss the effect of sirtuin 1 on the impairment of neural plasticity, one of the key mechanisms of depression, and the associated mechanisms of sirtuin 1.
The energy harvesting device is known to be promising as an alternative to solve the resource shortage caused by the depletion of petroleum resources. In order to overcome the limitations (environmental pollution and low mechanical properties) of piezoelectric elements capable of converting mechanical motion into electrical energy, many studies have been conducted on a polymer matrix-based composite piezoelectric energy harvesting device. In this paper, the output performance and related applications of the reported piezoelectric composites are reviewed based on the applied materials and processes. As for the piezoelectric fillers, zinc oxide, which is advantageous in terms of eco-friendliness, biocompatibility, and flexibility, as well as ceramic fillers based on lead zirconate titanate and barium titanate, were reviewed. The polymer matrix was classified into piezoelectric polymers composed of polyvinylidene fluoride and copolymers, and flexible polymers based on epoxy and polydimethylsiloxane, to discuss piezoelectric synergy of composite materials and improvement of piezoelectric output by high external force application, respectively. In addition, the effect of improving the conductivity or the mechanical properties of composite material by the application of a metal or carbon-based secondary filler on the output performance of the piezoelectric harvesting device was explained in terms of the structure of the composite material. Composite material-based piezoelectric harvesting devices, which can be applied to small electronic devices, smart sensors, and medicine with improved performance, can provide potential insights as a power source for wireless electronic devices expected to be encountered in future daily life.
Recently, Japanese cultural contents are being evaluated as a worldwide content. Among them, the animation takes an overwhelming place in the world market as a Japanese representative content. We need to understand that Japanese animation is being recognized world wide, because Japanese culture was grafted in to and it's very important to apply that to our situation. Cultural content to dominate the world has a fundamentally characteristics derived from regional culture. Cultural content includes elements of particular culture prototype. To investigate into cultural content that has globally used and is valuable, in-depth and systematic research for local (country) culture prototype showed be carried out. Our research aim to provide basic data so Korean animation can be developed as axis of Korean Wave. This compares and analyzes the Culture prototype from Korea and Japanese modern civilized media animation. Specifically for the animation shown in the culture prototype, we aim to - Analyze the content of culture prototype shown in Korea's animation: 'Hopi and Chadol Bawi', 'Heung-Bu and Nol-Bu', 'A Admiral's Diary', and 'Oseam'. - Analyze the content of culture prototype shown in Japan's animation: 'Genji', 'The Spiriting away of Sen and Chihiro', 'The Princess Mononoke', and 'Raccoon War Pom Poko'. - Compare and analyze the content of culture prototype depending on classifying criteria shown between Korea and Japan. We finally want to provide the basic data to develop the creation material for the global animation content based on these two countries throughout this research.
The outlook for Korea's consumer price inflation rate has a profound impact not only on the Bank of Korea's operation of the inflation target system but also on the overall economy, including the bond market and private consumption and investment. This study presents the prediction results of consumer price inflation in Korea for the next three years. To this end, first, model selection is performed based on the out-of-sample predictive power of autoregressive distributed lag (ADL) models, AR models, small-scale vector autoregressive (VAR) models, and large-scale VAR models. Since there are many potential predictors of inflation, a Bayesian variable selection technique was introduced for 12 macro variables, and a precise tuning process was performed to improve predictive power. In the case of the VAR model, the Minnesota prior distribution was applied to solve the dimensional curse problem. Looking at the results of long-term and short-term out-of-sample predictions for the last five years, the ADL model was generally superior to other competing models in both point and distribution prediction. As a result of forecasting through the combination of predictions from the above models, the inflation rate is expected to maintain the current level of around 2% until the second half of 2022, and is expected to drop to around 1% from the first half of 2023.
Kim, Thomas J.Y.;Kim, Hyungjung;Jung, Woo-Kyun;Lee, Jae Won;Park, Young Chul;Ahn, Sung-Hoon
Journal of Appropriate Technology
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v.5
no.2
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pp.70-81
/
2019
The garment industry is one of the most labor-intensive manufacturing industries, with its sewing process relying almost entirely on manual labor. Its costs highly depend on the efficiency of this production line and thus is crucial to determine the production rate in real-time for line balancing. However, current production tracking methods are costly and make it difficult for many Small and Medium-sized Enterprises (SMEs) to implement them. As a result, their reliance on manual counting of finished products is both time consuming and prone to error, leading to high manufacturing costs and inefficiencies. In this paper, a production tracking system that uses the sewing machines' energy consumption data to track and count the total number of sewing tasks completed through Convolutional Neural Network (CNN) classifiers is proposed. This system was tested on two target sewing tasks, with a resulting maximum classification accuracy of 98.6%; all sewing tasks were detected. In the developing countries, the garment sewing industry is a very important industry, but the use of a lot of capital is very limited, such as applying expensive high technology to solve the above problem. Applied with the appropriate technology, this system is expected to be of great help to the garment industry in developing countries.
This study aims to examine the causal relationships between sales and employment for public technology-based startups. Although there is a limit to statistical generalization due to the poor understanding of the actual conditions of public technology start-up companies, these companies were analyzed by classifying them into high-growth companise, potential growth companies, and other companies. In order to understand the causal relationship, and to estimate the time required to be effective, panel vector autoregression was applied. As a result, the performance creation mechanism was identified as government supoort and private investment was mutually causal with employment, sales did not cause employment, and employment caused sales. In other words, it was found that employment plays an mediator role in public technology based startups' performance mechanism. In addition, private investment had the effect of improving employment and sales in the short time than governments support, and showed that firms with high employment can attract government support and private investment. This study are academically meaningful in that they empirically revealed the process of performance creation, whereas previous studies had only shown whether there was an effect on performance. It also has a policy contribution by suggesting the need for effective policy promotion by considering the 'employment' factor, such as human resource support, as more important.
To Republic of Korea in the Indo-Pacific region, the stability and prosperity of the area are directly coupled with national survival, interest. Currently, on account of strategic competition between U.S.A, and China in this area as well as supranational·non-conventional threats, the security environment is unstable, required joint/allied responses. So, lots of states inside(U.S.A., Japan, ASEAN, etc.), also, out of this Indo-Pacific area like EU-NATO, open their own strategy related in Indo-Pacific issues to be involved. R.O.K. government took its own line with publishing self strategy following this international trend, it can be shown korean government's strong intend to join in the pending security issues in this region with 'strategic clarity'. Now, R.O.K. Navy has to back up governments, policy. First, R.O.K. Navy should strengthen the relationship inside and take part in the multilateral cooperation of security. Second, to convey this deterrence message to potential threats, Navy is required to show of forces and have combined exercises. Also, as naval forces of advanced countries, Korea, Navy should be taken action in non-traditional threats, and help developing states improve their sea power. To fulfill this tasks in the wide ocean area, Navy need five inherent characteristics(mobility, flexibility, sustainability, capability of presence and projection). In the end, this paper propose the development plan following operational environment (SWOT) analysis as well.
This study examined the mediating role of collective self-esteem in the relationship between personal self-esteem and career aspiration, and the mediating effects of personal self-esteem and collective self-esteem on the link between social support and career aspiration. Also, This study explored whether the development of career aspiration differs by gender. A total of 316 undergraduate students(155 male and 161 female) completed measures of social support, personal self-esteem, collective self-esteem and career aspiration. Structural equation modeling results provided support for the mediating effects of personal self-esteem and collective self-esteem, In addition, the relationship model differed by gender. The results showed that the full mediation model fit of collective self-esteem in the relationship between individual self-esteem and career aspiration was better than the partial mediation model fit. Next, in the relation of social support and career aspiration, the partial mediating effect of individual self-esteem and collective self esteem was significant. Lastly, when the model of social support, individual self-esteem, and collective self-esteem, and career aspiration was tested to examine gender differences, the relations among these variables were found to be different according to gender-difference. These results suggest that evaluations and perceptions on the individual's social group as well as the individual influedced to career aspiration, interacting with the environmental factors. Also, the gender-difference of relationship model indicates that it might be different from men and women in psychological mechanism in the career aspiration formation.
This study examines the vocational adjustment experiences of elderly men who chose a creative occupation after retirement. The aims are to understand the related meanings and to provide specific empirical data on the elderly who hope to start a creative occupation. Five men aged 65 years or older who chose a creative occupation after retirement were enrolled in the study. Data were collected through in-depth interviews with the participants. The collected data were qualitatively analyzed, and a total of 7 categories, 25 subcategories, and 132 concepts were identified. The seven categories were "challenge led by a sense of freedom," "reflection of the need for 'fun,'" "difficulties and limitations felt by a non-expert," "concerns and effort to afford the increasing expenses," "joy for accomplishment," "ways to utilize my creativity," and "reward from increased social participation." The participants felt that adjusting to a creative occupation was a process by which their potential creativity was expressed. They felt the joy of working that they had not felt before, and the series of processes by which they overcame difficulties during work and increased their social participation were in line with the goals of creative aging. In order to help older adults in Korea to choose and adjust to creative occupations in their older adulthood, there is a need for creative-occupation-related education prior to retirement and for various policies and practical efforts that consider the change of social environment. Furthermore, our findings suggest that choosing a creative occupation after retirement is an effective measure for promoting successful aging among the elderly in Korea.
Journal of Practical Agriculture & Fisheries Research
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v.19
no.1
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pp.99-108
/
2017
It is Lespedeza cuneata. G. don used as a remedy for cough, asthma, premature ejaculation and so on, though it has been used for a long time. In order to investigate the possibility of using Lespedeza cuneata. G. don as a raw material for functional food, we examined useful substances through analysis. In the study, 124 useful substances were analyzed and 84 of them were found to be functional. In 6 species, 6 of them were found to be functional and 5 of them were functional. In the present study, the other useful substance, D-pinitol, also confirmed its functionality. Potassium isolespedezate and Potassium lespedezate act as antibiotics, Trifolin acts as an antibiotic and hepatoprotectant, and Vitexin acts as a hepatoprotectant. D-pinitol has shown excellent efficacy in patients with prediabetic and insulin-resistant diabetes. As it contains a large amount of useful substances, it can be utilized as a highly functional food.
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