• Journal of Life Science
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• v.18 no.1
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• pp.75-83
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• 2008

This studies were designed to elucidate whether inhibitors of topoisomerase regulate function and activity of topoisomerase, and gene expression in HL-60 human leukemia cells. HL-60 cells were treated with 10-hydroxycamptothecin or doxorubicin, total RNA was isolated, and expressed genes were investigated with human oligonucleotide microarray containing 10K gene, respectively. Expression profiles of the human leukemia HL-60 cells treated with 10-hydroxycamptothecin (10-CIT) or doxorubicin associated with signal transduction,. cell adhesion, cell cycle, cell growth, cell proliferation, cell differentiation, transcription and immune response, especially genes related with transcription and cell growth. In HL-60 cells treated with 10-CPT, the expression of topoisomerase III${\alpha}$, III${\beta}$ and I gene from oligo chip microarray analysis were increased over, but the expression of topoisomerase II${\alpha}$ and II${\beta}$ gene were decreased over. In contrast, the expression of topoisomerase II${\alpha}$ and II${\beta}$ gene were increased over in HL-60 cells treated with doxorubicin, whereas the expression of topoisomerase III${\alpha}$ and III${\beta}$ mRNA remained no significant change. These results suggest that these data may be useful for novel therapeutic markers.

• The korean journal of orthodontics
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• v.39 no.3
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• pp.146-158
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• 2009

Objective: The purpose of this study was to reveal the position of the incisive foramen in relation to the incisive papilla and cusp tips. Methods: Plaster models and CT images of 25 adult orthodontic patients were used to measure the width of the incisive canal and positions of the anterior and posterior borders of the incisive foramen in relation to the incisive papilla. Results: The palatal surface distance from the interdental papilla between the maxillary central incisors to the posterior border of the incisive foramen along the palatal surface was 1.7 fold of the distance from the interdental papilla between the central incisors to the posterior border of the incisive papilla. The distance between the posterior border of the incisive papilla and posterior border of the incisive foramen along the palatal surface was 6.15 ${\pm}$ 1.75 mm. The anteroposterior position of the posterior border of the incisive foramen was slightly anterior to the lingual cusp tips of the maxillary 1st premolars. The width of the incisive foramen was 4.03 ${\pm}$ 0.64 mm, therefore it is recommended to position the mini-implant more than 3 mm laterally when placing a mini-implant lateral to the incisive foramen, from the center. Conclusions: These results can be used as a reference in presuming the position of the incisive foramen when placing mini-implant in the anterior palate area.

• Journal of Ginseng Research
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• v.30 no.4
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• pp.212-219
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• 2006

Research literatures (e.g. research report, scientific paper and thesis, published between 2001 and 2005) of 332 collected from KISTI, KISS, ARPC databases were investigated and analyzed to give an overview of domestic ginseng researches. Most of recent ginseng researches have been performed by private nonprofit institutions and individuals, which suggests that a role of public institution fur ginseng researches needed to be enlarged. In terms of research fields, cultivation and agricultural researches have been mainly accomplished in ginseng research. Cell physiology and reproductive function researches occupied large part of pharmacological studies, but clinical studies were relatively limited. Studies on general food products development have taken the main part in fields of food products including functional foods. As the result of analysis of 312 domestic ginseng patents by classifications of world international property organization (WIPO), it was categorized into food technology, medicinal fermentation development technology, fermentation technology, and agriculture-fisheries technology. This integrated overview of the widely scattered ginseng literatures shows current general research trends in Korea and will be able to suggest further needs on cultivation, studies and industralization of ginseng.

• Journal of the Korean Institute of Gas
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• v.20 no.6
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• pp.16-22
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• 2016

Coating pipe(PLP) has been generally used in buried site for protecting the corrosion. To prevent the damage by occurring the defect, other construction or execution works, an anti-oxidation environment was forcibly made by using protective potential. Coating and protective potential are applied simultaneously, but corrosion rate or defects are not easy to observe because soil composition has many uncertainty. Also, defect of coating pipe can not be directly observed. A corrosion coupon can easily measure a corrosion rate directly. The corrosion rate was measured with 6 scenarios using corrosion coupon during about 1 year(6 scenarios are based on soil type and protective potential or not in this research. Resultingly, the corrosion coupon has not occurred in the case of protected by potential current, but corrosion has occurred in a non-protected site. The corrosion rate was measured at least in the clay, and the propensity of corrosion rate was similar in other soil(sand and loams). The local corrosion has occurred in the clay because of high water content. On the other hand, general corrosion was occurred in sand and loams. Commonly, sand is not to corrosive soil. Although, corrosion occurred in sand can be estimated by chemical component and valid with chemical analysis report.

• Journal of Digital Convergence
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• v.17 no.7
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• pp.377-386
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• 2019

The purpose of this study is to identify effective strategies for promoting psycho-social adjustment by examining the mediating effects of self-esteem (SE) and moderating effects of social participation (SP) and discrimination experience (DE) in predicting social competence (SC) with acceptance of disability (AD). The subjects of the study were 1943 adults with a physical disability (1338 males and 605 females) and 233 adults with brain lesions (160 males and 73 females) aged between 19 and 65 years. Data were analyzed using SPSS and Process macro software, and conditional process analysis (model 18) in which the degree and onset of disability were controlled was performed. The results are as follows. First, SE was found to partially mediate the relationship between AD and SC. Second, the relationship between SE and SC was found to be moderated by SP but not by DE, and the relationship between SP and SC was found to be moderated by DE. In addition, the mediating effects of SE, which was moderated by SP, were found to not be moderated by DE. The clinical implication and suggestion for future research is discussed.

• Korean Journal of Occupational Therapy
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• v.26 no.4
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• pp.127-143
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• 2018

Objective : The purpose of this study was to compare with the effects of driving simulator and Dynavision training after stroke through the test of cognitive ability and driving performance. Methods : Twenty-one stroke patients were randomly classified to the driving simulator training group (N=11) and Dynavision training group (N=10), and were carried out respectively training for 15 times. The driving performances was measured by the driving simulator test, and cognitive-perceptive abilities was measured by the DriveABLE Cognitive Assessment Tool, Trail Making Test-A, Trail Making Test-B and Mini Mental State Examination-K. Results : The driving simulator training group showed significant changes in all cognitive tests and most of driving performances. The Dynavision training group also showed significant changes in all cognitive tests except for Trail Making Test-A and some driving performances. The significant differences on both groups were found regarding the estimated degree of results on the on-road evaluation, the number of off road accidents and collisions. In addition, the causal influence of the two training methods on these variables was analyzed to be more than 20%. Conclusion : The driving simulator and Dynavision training were found to be effective intervention in the driving rehabilitation after stroke. In particular, it was confirmed that the driving simulator is an effective training to improve overall driving ability of stroke patients. In addition, the difference in training effect between the two training methods was found to be more than 20%.

• The Journal of the Korea Contents Association
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• v.22 no.3
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• pp.593-605
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• 2022

The purpose of this study is to investigate the personalized treacmill exercise analysis using a smart mirror based on Kinect sensor. To evaluate the performance of the development system, 10 health males were used to measure the range of the hip joint, knee joint, and ankle joint using a smart mirror when walking on a treadmill. For the validity and reliability of the development system, the validity and reliability were analyzed by comparing the human movement data measured by the Kinect sensor with the human movement data measured by the infrared motion capture device. As a result of validity verification, the correlation coefficient r=0.871~0.919 showed a high positive correlation, and through linear regression analysis, the validity of the smart mirror system was 88%. Reliability verification was conducted by ICC analysis. As a result of reliability verification, the correlation coefficient r=0.743~0.916 showed high correlation between subjects, and the consistency for repeated measurement was also very high at ICC=0.937. In conclusion, despite the disadvantage that Kinect sensor is less accurate than the motion capture system, Kinect is it has the advantage of low price and real-time information feedback. This means that the Kinect sensor is likely to be used as a tool for evaluating exercise prescription through human motion measurement and analysis.

• KIPS Transactions on Computer and Communication Systems
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• v.10 no.10
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• pp.285-290
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• 2021

In the medical field, disease diagnosis and prediction research using artificial intelligence technology is being actively conducted. It is being released as a variety of products for disease diagnosis and prediction, which are most widely used in the application of artificial intelligence technology based on medical images. Artificial intelligence is being applied to diagnose diseases, to classify diseases into benign and malignant, and to separate disease regions for use in identification or reading according to the risk of disease. Recently, in connection with cloud technology, its utility as a service product is increasing. Among the diseases dealt with in this paper, liver disease is a disease with very high risk because it is difficult to diagnose early due to the lack of pain. Artificial intelligence technology was introduced based on medical images as a non-invasive diagnostic method for diagnosing these diseases. We describe the development of a web service to help the most meaningful clinical reading of liver cirrhosis patients. Then, it shows the web service process and shows the operation screen of each process and the final result screen. It is expected that the proposed service will be able to diagnose liver cirrhosis at an early stage and help patients recover through rapid treatment.

• Childhood Kidney Diseases
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• v.4 no.1
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• pp.17-24
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• 2000

Purpose: MCNS is found in approximately $85\%$ of the idiopathic nephrotic syndrome in children and shows good prognosis with initial steroid therapy. However in FSGS, there is poor prognosis with initial therapy and shows higher rate of progression to chronic renal failure and relapse after kindney transplantation. We have experienced 8 patients who were diagnosed as MCNS on initial renal biopsy and then progressed to FSGS on follow-up biopsy. So we have investigated their clinical course and risk factors for transition of MCNS to FSGS. Methods: We conducted a retrospective study with a review of histopathologic findings and clinical manifestations of 296 cases of MCNS and FSGS that were diagnosed from January 1988 to May 1999. We classified them into 3 groups according to the histopathologic finding; MCNS, FSGS, MCNS progressed to FSGS in follow-up biopsy. Results: The number of children was 296 cases comprising 241 cases($81.4\%$) showing MCNS, 8 cases($2.7\%$) transition group, 47 cases($15.9\%$) FSGS. The mean onset age was $6.0{\pm}2.6$years in MCNS, transition group $8.3{\pm}2.3$years, FSGS $7.2{\pm4.3$years, and the gender (M:F) ratio was 3.7:1 in MCNS, 3:1 in transition group, 1.8:1 in FSGS. Comparing the presence of initial hematuria, hypertension,24 hour urine protein, serum albumin, serum creatinine, there were significant difference between the transition group and the FSGS group in the following points; 24hour urine protein $684:342mg/m^2/hr$(P<0.05), serum albumin 1.92: 2.47g/dL(P<0.05), serum cholesterol 494:343mg/dL(P<0.05). Refractoriness to steroid therapy was 13.3$\%$ in MCNS. $12.5\%$ in transition group, $29.6\%$ in FSGS; significantly higher in FSGS(P<0.05). Immunosuppressant therapy was performed in $58.5\%$ of MCNS, $100\%$ in transition group, $80.8\%$ in FSGS; transition group showed significantly higher .ate(P<0.05) comparing with MCNS. Mean number of relapse and duration from onset to first relapse showed no significance difference between these groups. Conclusion: 249 patients with MCNS have been followed and $3.2\%$ (8 patients) of them has shown change in pathologic diagnosis from MCNS to FSCS. The risk factor for transition could not be found. Our results point to the need for a follow-up biopsy to certify the possibility of transition to FSCS in some MCNS cases with refractory cases to steroid therepy, frequent relapsing cases, or in case of no remission in spite of vigorous immunosuppressant therapy.

• Childhood Kidney Diseases
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• v.9 no.2
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• pp.167-174
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• 2005

Purpose : Relapses are a major problem in children with steroid responsive nephrotic syndrome(SRNS). This study has been performed to determine the predictive factors for relapse in children with SRNS. Methods : The study group consisted of 7,3 children with SRNS who had been admitted to the Department of Pediatrics, Kyungpook National University Hospital, over 6 years from 1996 to 2001. The medical records were reviewed retrospectively and analyzed to determine significant relationships between selected variables[age at onset, sex, laboratory data, the rapidity of response(days to remission), interval to first relapse] and the frequency of relapse. Results : The age($mean{\pm}SD$) of patients was $4.53{\pm}2.53$ years old. The male to female ratio was 52:21. In 95$\%$, 39 out of the 41 children had a renal biopsy, and the final diagnosis was minimal change nephrotic syndrome. There was no significant correlation between the frequency of relapse and the following variables age at onset, sex, and presence of hematuria. However, the rapidity of response correlated well with the frequency of relapse, especially during the first year after the onset of the disease(P=0.005). Conclusion : The rapidity of response is expected to be one of the predictive (actors for relapse in children with SRNS. (J Korean Soc Pediatr Nephrol 2005;9:167-174)